godfather of surgery

Chapter 1016: Outsiders

As for the wedding, Yang Ping and Xiao Su hardly worried about it. They went to work as usual and took care of the children as usual. Their work and life were not affected at all.

Originally, the couple wanted to have a simple wedding and didn't want to make it so complicated, but things didn't go their way at all. No matter what aspect, they didn't agree with them having a simple wedding. But as long as they didn't have to worry about it, Yang Ping and Xiao Su spent some time retaking the wedding photos, and didn't care about anything else. They had no idea what stage the wedding preparations had progressed.

Yang Ping went to work as usual every day. After a full day of surgery, he sat down in the doctor's office to rest. Song Zimo reported that the results of the second follow-up examination of Castleman disease patient Fu Xiaotao had come out.

Yang Ping always kept this case in mind, because a questioning overturned the theory that had long been recognized by the medical community. This made Yang Ping begin to realize that there is nothing that cannot be questioned and nothing that cannot be tried.

Song Zimo opened the outpatient system in the computer and retrieved Fu Xiaotao's examination records. Yang Ping reviewed them one by one and compared them with the results of the previous examination.

After Fu Xiaotao took sirolimus alone, the results of the second follow-up examination were better than the first, and various indicators were better. According to this trend, Fu Xiaotao's Castleman's disease can be cured in about one or two years. The treatment results proved that blocking the mTOR signaling pathway to treat Castleman's disease is very correct, and the previously recognized pathogenesis of interleukin-6 is actually wrong.

This period of time allowed Yang Ping to adjust his thinking about his tumor laboratory. It was not that his method was wrong, but it was very likely that the entire direction was wrong from the beginning. If the direction was wrong, no matter how perfectly he did things, he would not get the expected results in the end.

This proves the saying: Do things right first, then do things well.

During this time, Yang Ping thought about his tumor experiment. It was impossible to succeed by relying solely on the system. Now he had to rely on his imagination to solve the problem. Imagination is something the system cannot provide. It can only provide time and resources.

In the history of human evolution, it is a long process for certain microorganisms to coexist with humans, which cannot be achieved in a short time. The protein structure of K factor is regarded as a foreign object and attacked by the immune system when it enters the human body. K factor does not have the ability to self-amplify, and the only outcome under the attack of the immune system is annihilation. If the approach of increasing investment is adopted, excessive K factor can cause over-activation of the human immune system and cause life-threatening danger.

But why can some viruses exist in the human body for a long time? For example, hepatitis B virus, HIV, etc. can exist in the human body for a long time without being eliminated by the immune system. This is because they have the ability to replicate themselves and have the skills to learn by themselves to evade the immune system, and this evasion ability is inherited during the iteration process.

Thinking of this, Yang Ping suddenly had an idea. Why not obtain a virus, modify the virus to make it harmless, then integrate the K factor with the virus, and inject the new "virus" into the human body so that this new virus has the ability to fight the human immune system and kill tumor cells at the same time? Moreover, let this virus exist harmlessly in the body for a period of time so that it can kill the revived tumor cells at any time.

After this bold idea came into Yang Ping's mind, Yang Ping immediately planned to redesign the experiment and began to conduct research according to this idea. With the experience of treating Castleman's disease, Yang Ping became more confident in his bold ideas. There is no need to worry about any consequences when doing experiments in the system space. The most serious result is just a waste of points, which is no big deal.

"Continue taking sirolimus?" Song Zimo asked.

Yang Ping nodded: "Continue to take it, and check your liver and kidney functions every month. As long as your liver and kidney functions are normal, continue to take it until you are cured."

"Okay." Song Zimo wrote it down.

There was nothing special, so Yang Ping returned to his office, turned on his computer to check new emails, and found that Professor Mannstein had sent him a new email.

"Dear Professor Yang Ping, hello. Your spatially guided gene research is very popular. Everyone has always believed that this is an epoch-making achievement. It will change medicine and the world. It is the first time that a human organ has been successfully cloned locally in vitro. It is no exaggeration to say that it will usher in an era of independent organ cloning. In the future, the treatment of human organ failure will become cheap and easy. Replacing an organ is as normal as replacing a part of a machine, and there will be no rejection reaction. Once in a private salon of mine, several Nobel Prize winners in medicine and biology proposed that they wanted to go to China with me to attend your wedding. They wanted to meet you, a great doctor, and become friends with you. In addition, we have a difficult problem here - the case of an outsider. She is the granddaughter of Mr. Bryan, a Nobel Prize winner in medicine. The poor little girl has not found a suitable surgeon so far because no one dares to perform this operation. I have the audacity to recommend you to him without your consent. Please forgive me. The information of this case is in the attachment." Professor Mannstein's friend, a Nobel Prize winner in medicine and biology, has a six-year-old granddaughter who is an out-of-heart patient. The surgery for her heart malformation is very complicated, so until now he has not found a suitable doctor for her granddaughter. He once went to the United States to find a doctor. American doctors have performed many similar operations, but after seeing his granddaughter, they could only shake their heads. The difficulty is greater than they had imagined.

The normal position of the heart should be in the chest cavity, protected by the thorax which is supported by the rib cage. However, the heart of a person with heart failure is not in the chest cavity, but outside the chest cavity. The entire heart is separated from the outside world by only a thin layer of skin. This is no different from being exposed. The outline of the heart can be seen from the outside, and even the outline of the blood vessels on the surface of the heart is clearly visible.

Any accidental impact to an exposed heart would be fatal. Mr. Brian had been trying to find a doctor who could perform surgery on his granddaughter, but to no avail until Mannstein recommended Professor Yang from China to him.

Attached is a video sent by Professor Mannstein. In the video is a little girl named Chelsea, who is an outsider. She is wearing a hard carbon fiber chest shield to protect her heart from being hit when it is exposed outside the body in daily life. After removing the shield and lifting her clothes, her bulging and beating heart can be clearly seen. The close-up video shows that the heart is only separated from the outside world by a thin layer of skin.

Yang Ping came from his office and stood at the door of the doctor's office: "Everyone who is not off work, come over here."

No one knew what was going on, so they all gathered in the director's office. The video was playing repeatedly on Yang Ping's computer screen, and everyone stared at the screen hoping to see every detail. Xia Shu was a doctor of cardiology, and he was even more interested in this case.

"This is a case from Europe. It is very rare. The operation is very difficult and the postoperative maintenance also requires very high skills. Everyone should get in touch with this case. If you have time in the next few days, check the information and discuss it."

Yang Ping told everyone.

"This is a heart malformation, scientifically known as Cantrell's Pentalogy. This disease has five coexisting malformations: sternal cleft, defect of the lower sternum, semilunar defect of the anterior diaphragm, absence of pericardial wall layer communicating with the abdominal cavity, defect of the abdominal wall above the umbilicus, and umbilical hernia. It is the coexistence of these five malformations that causes the heart to be exposed through the skin. The operation is very difficult. The operation not only needs to correct the deformity, but also put the heart back into the chest cavity. Putting the heart back into the chest cavity requires considering the suspension problem, straightening out the large blood vessels connected to it, and so on. It is even more difficult to solve the problem in one operation."

"Which type of Cantrell's pentad is this?"

"Type 1! All five deformities are present."

"In addition, the accompanying malformations include dextrocardia, double outlet right ventricle, ventricular septal defect, atrial septal defect and pulmonary valve stenosis. The difficulty in treatment lies in how to correct the heart malformation and reposition the heart."

"We have never dealt with a case like this before, and one with such a complicated outsider."

"Do you know why our department is called the Surgical Research Institute? Because some of the surgeries we perform are research-based. We are the first to try new things. We are a department that combines research with clinical practice."

"There are not many surgeries in China at present. In the past, there were probably more than ten cases in Fuwai and Anzhen combined. I have never seen such a complicated one. There are only about 200 surgeries in the world."

Everyone immediately started discussing this case.