godfather of surgery

Chapter 1018 It’s a misunderstanding, wife!

Yang Ping feels very relieved to have Lu Xiaolu as the director of the tumor laboratory. Lu Xiaolu's research field itself is basic research on tumors, and this person is indeed a rare talent. His previous achievements were obtained under a state of depression, but now that his body and mind are completely liberated, it is easier for him to achieve scientific research results.

After returning home from get off work, Yang Ping played with his son for a while. After changing his diaper, he held him in his arms and told him about the surgery he had performed in the hospital. The boy did not cry or make a fuss, but smiled as he listened, and his limbs kicked around with excitement.

Xiao Su is working out in the gym at home. Her postpartum recovery is going very well. Yang Ping's mother and Mrs. Su are cooking together in the kitchen. Professor Su and Yang Ping's father are chatting in the living room, as if they are commenting on a war movie. The family gets along very harmoniously.

The advantage of having a system is that you can start working at any time. After Yang Ping finished telling a story to his son, he put him in the crib. The little guy blinked his eyes, probably because he was tired, and fell asleep after a few blinks. At this time, Xiao Su finished his exercise.

"Let me look after him, you take a rest." Xiao Su said.

"I'll just take a nap here." Yang Ping said.

Xiao Su knew Yang Ping's habits. He liked to use fragmented time to rest, so he was as energetic as a bull all day long.

Yang Ping took a nap on the chair in the bedroom, and then he started to work. He used his spare time to enter the system space laboratory, and bought various equipment from the system mall according to the needs of the experiment. Soon all the hardware needed for the experiment was completed.

In order to use the M13 phage to carry the K factor, we must first study the structure and function of the M13 phage. Only by studying it thoroughly can we better transform it and make it work for us.

Through the special camera system of the electron microscope, the M13 bacteriophage appears on the electron screen, showing a unique and fascinating morphology.

From a morphological point of view, the M13 phage appears slender and uniform, like a delicate line, and the ratio of its length to diameter makes it extremely eye-catching under a microscope. The outer shell is composed of the main outer shell protein p8, which is tightly arranged together to form a protective layer of the phage. Under a microscope, these layers of protein structures can be clearly seen. They are arranged in an orderly manner to protect the internal genetic material of the phage.

For the first time, Yang Ping felt that the microbial structure assembled by this protein was so beautiful. Yang Ping couldn't help but marvel at the precision and beauty of living things. It even looked more harmonious and beautiful than any man-made machine.

The activities of M13 phages are also very distinctive. When they encounter suitable host cells, such as E. coli containing F plasmids, they will show their ability to infect. Under a microscope, it can be observed that M13 phages attach to the F pili of E. coli through their minor coat protein p3, which is the first step of infection. Once attached, M13 phages will begin to inject their DNA into the host cell.

After the DNA is injected, the M13 phage uses the host cell's resources to replicate. Under a microscope, changes can be observed inside the infected cell, and new phage particles are gradually assembled inside the cell. This process is essential to the life cycle of phages and is key to their reproduction in nature.

It is worth noting that after infecting host cells, M13 phages do not cause host cell lysis like some phages. Instead, they secrete new phage particles from infected cells, while host cells can continue to grow and divide. This characteristic makes M13 phages uniquely valuable in biological research. But for Yang Ping, this is not an advantage, but a disadvantage.

The electronic screen continued to broadcast the morphology and activities of M13 bacteriophages under a microscope, which was like a fascinating journey of exploration. Their delicate structure, unique infection method and distinctive life cycle all demonstrated the wonders of nature and the charm of biodiversity.

If such a simple virus is so exquisite, one can imagine how exquisite the complex human body is.

Looking at the phage on the screen, Yang Ping fell into deep thought. He couldn't wait to complete the entire experiment quickly, but he didn't expect that starting over would open up a whole new world. If it is transformed into a killer that can infect tumor cells, it will not infect E. coli now, but will be precisely adsorbed on the outer membrane of tumor cells, and then injected through the long filamentous tail, not just DNA, but DNA and K factor. K factor begins to take effect inside the cell, initiating apoptosis of tumor cells, while DNA allows the phage to divide and grow stronger.

If the M13 phage can be modified according to the target, it will show unique characteristics. They will no longer be simple parasites, but become "intelligent warriors" that can actively attack tumors. This process involves precise genetic engineering, which enables these tiny organisms to play a vital role in the battle against cancer.

However, the transformation process is destined to be difficult and complicated. The process of transforming the M13 phage is complex and delicate.

First, it is necessary to determine which genes or proteins need to be modified or added to achieve the anti-tumor effect, which usually involves precise editing of the phage genome, including inserting, deleting or replacing specific gene fragments.

But for Yang Ping, it obviously doesn't need to be so complicated, because he has mastered the K factor that initiates apoptosis of tumor cells. He only needs to combine the K factor with the adhesion protein on the surface of the M13 phage, and then allow the phage to recognize and contact the tumor cells. The rest of the work will be a natural process. If it is done more advanced, the K factor can be mixed with the DNA inside the phage, and after the phage infects the tumor cells, the K factor mixed with the DNA can be injected into the tumor cells.

The K factor can initiate apoptosis of tumor cells and eventually kill them. In this process, DNA can also recycle substances inside the cells to split and strengthen the phage itself.

After designing the experiment, Yang Ping handed it over to the laboratory's robotic arms to complete the rest of the work, asking them to continuously modify the phages, and then to pair the phages with the K factor. It is estimated that hundreds of millions of different phages can be obtained through the modification of the M13 phage. Which one can adhere to the K factor and which one can recognize tumor cells? This is a huge trial and error project. Trial and error is the strength of the System Space Laboratory. Yang Ping handed it over to automated equipment to complete it.

Coming out of the system space, Yang Ping yawned. Dinner was probably not ready yet. Xiao Su asked curiously, "How come you seem to be full of energy after sleeping for just a while?"

"I'm thinking about a question." Yang Ping said.

"What's the problem?" Xiao Su asked curiously.

"I was wondering how bacteriophages inject DNA into cells. The long tail of the bacteriophage is like a thick tube. When it finds the cell it wants, it immediately locks onto it and then inserts its tail into the cell, forcefully injecting DNA into the cell. I've been thinking about this problem just now, so the more I think about it, the more excited I get." Yang Ping had indeed been thinking about this problem just now.

As Xiao Su listened, she felt the description was becoming more and more wrong. Then, as if she had realized something, she punched Yang Ping's chest muscle with her pink fist.

"You're full of energy! You're still thinking about injecting DNA after a long day of surgery?"

"Wife, I was really just thinking about injecting DNA into your body. Oh, no, I mean how bacteriophages inject DNA into cells." Yang Ping was so excited that he mixed up his words.

It’s a misunderstanding, wife!

My thoughts are pure and I was really thinking about scientific research just now.