godfather of surgery

Chapter 1044 A Super Gold Mine

Yang Ping's tumor treatment project is ongoing. His current goal is to use a certain virus combined with factor K to create an oncolytic virus. This method is oncolytic virus therapy, abbreviated as OVT in medicine.

The current mechanism of oncolytic virus therapy is to stimulate the immune system to attack virus-infected tumor cells, increase the number of tumor B cells, T cells, macrophages and other immune cells, and allow these immune cells to fight and attack tumor cells.

However, Yang Ping's idea is different. His virus is just a delivery vehicle. It is the K factor that attacks tumor cells, and the mechanism is the principle of cell apoptosis.

So, strictly speaking, it should be given a completely new name instead of being called oncolytic virus therapy.

It should be called virus-delivered K factor-intolerant targeted therapy, or anti-tumor virus therapy.

Beata Halasi, who successfully used oncolytic virus therapy to treat triple-negative breast cancer, used measles virus and vesicular stomatitis virus, which can infect the types of breast cancer-derived cells and have been used in clinical trials before.

The experience of his predecessors made Yang Ping more confident. At least he could choose from more viruses than his predecessors, because many viruses had been tested by his predecessors. Even if some of them were not effective, they were at least harmless to the human body, or the side effects were controllable within an acceptable range.

For example, measles virus strains are widely used in childhood measles vaccines, and vesicular stomatitis virus will only induce mild flu symptoms in the worst case scenario, so they are very safe for the human body.

Safety is the most basic condition for using viruses as a means of delivery.

When Beata Harasi used these two viruses, she did not use them as delivery vehicles, but let them infect tumor cells and directly activate the human immune system to attack the virus. Because the virus and tumor cells are combined at this time, these immune cells attack the tumor cells while attacking the virus.

Yang Ping now regards the virus as just a delivery vehicle, and leaves the task of killing tumor cells to the K factor, just like a missile carrying a nuclear warhead. The missile is just a delivery vehicle, and the nuclear warhead is the weapon that exerts the ultimate destructive effect.

Although this method also uses viruses to fight tumors, it is completely different from oncolytic virus therapy and is a new type of tumor treatment.

When choosing this virus, we need to consider whether the virus can infect the original cells of the tumor. For example, Sisi's primary tumor is osteosarcoma, and the source cells of osteosarcoma are osteoblasts, so the virus used to treat this tumor must be able to infect osteoblasts.

In oncolytic virus therapy, there is a method of injecting the virus directly into the tumor to stimulate the increase in the number of immune cells and use the immune cells to attack the tumor. This is the method used by Beata Harasi. At that time, she herself had triple-negative breast cancer. After traditional surgery and chemotherapy, it relapsed. After the relapse, there was no reoperation. Her body could no longer withstand chemotherapy. She herself is a virology expert, so she cultivated the virus to treat herself and achieved good results. And published a paper in a well-known medical journal.

Of course, her paper was rejected by more than a dozen journals at the time due to ethical issues, because using oneself as an experiment is ethically controversial.

Yang Ping reviewed his research topic again. His thoughts became clearer and his confidence was strengthened. The most urgent task was to screen out a suitable virus and then transform the virus to carry the K factor. Once this step was completed, theoretically, the matter would be half successful.

Several large laboratories are located on the floor above the ward of the Surgical Research Institute, which makes communication between Yang Ping and the laboratory researchers very smooth. He can go to the laboratory at any time to take a look, take a walk, and grasp the latest status of the experiment.

Yang Ping looked at the time. It was still early. The first few operations today were performed by Song Zimo, Xu Zhiliang and Xia Shu. He could just take some time to go to the laboratory to ask about the current progress.

The building where the Institute of Surgery is located has eight floors, which is sufficient for the current situation and has ample space. The stem cell laboratory and tumor laboratory each occupy a separate floor, and the hardware conditions in all aspects are world-class.

Scientific research consists of three elements: talent, equipment and environment. The environment is mainly a humanistic environment. The humanistic environment for scientific research must have a scientific and engineering temperament and be simple, relaxed, free and equal.

If the researchers in the laboratory have to flatter, engage in drinking culture, form cliques and engage in intrigue every day, then it will be useless even if the hardware conditions are the best in the universe.

People who are truly engaged in scientific research have neither the interest nor the desire to study wine culture; they just want to make a name for themselves in their own little field.

Therefore, Yang Ping attached great importance to the cultural construction of the laboratory. The establishment of cultural traditions is particularly important for the future survival and development of the laboratory. When he went to the laboratory, everyone had already started working and started their own work.

These people did not put down their work to come and watch or line up to welcome Yang Ping. Yang Ping not only did not feel that he was neglected, but was pleased that the laboratory culture was taking shape.

"How is the virus screening work going?" Yang Ping was sitting in Lu Xiaolu's office.

Lu Xiaolu stood up and walked to a whiteboard, on which were hung many small cards. Each small card was a picture of a virus. There were more than a dozen such cards hanging on the whiteboard.

"Currently, this is what's left after our screening. It will take some time for us to find a few suitable viruses and start modifying them. We have already come up with several modification plans for bacteriophages, but the efficiency of manual modification is too low. Our entire team estimates that we can only come up with dozens of plans a year. Professor He is making a model over there. They said they would first give us a simple model, and then use the large artificial intelligence model after the artificial intelligence model comes out. Professor He said that using his temporary small model, he could successfully come up with tens of thousands of plans for us in an hour. If we use his large model in the future, we could have hundreds of thousands or millions of plans in a second. All these virus models can be run in his virtual model for optimization and elimination." Lu Xiaolu replied.

Yang Ping nodded. Today's scientific research is different from that of one or two hundred years ago. The era of relying on simple experimental conditions to achieve results is gone. Today's scientific research must rely on advanced tools, and the application of artificial intelligence in scientific research can save a lot of time and free researchers from heavy work.

"I think so too. In the future, we need to introduce artificial intelligence into our scientific research and try to use artificial intelligence to replace repetitive, boring, and non-imaginative work, so that everyone can focus their time on high-value work."

"Are you getting used to the work here recently? If you need anything, please tell me. How is Principal Ding?" Yang Ping asked with concern.

Speaking of Principal Ding, Lu Xiaolu's expression became serious. "I visited him last week. Now I visit him every month and send him some things. He is in a good mood in prison now, but he is worried about Ding Xinyu."

It's pitiful that parents all over the world care about their children. Even though he was in prison, Principal Ding still missed his daughter. "Ding Xinyu is doing well now. She is a teacher in a vocational and technical school. The school attaches great importance to her. I also visit her and her child every weekend. The child is still young and has suffered great psychological trauma. Teacher Ding always told me to take good care of Yuxin. This is what he misses the most."

"There has been no news about Guan Ruyan. Some people saw him wandering in Los Angeles, but the truth of this is still unclear. He deserves what he has done. Throughout his life, he has always used others. Everyone is his tool. He abandoned those who loved him one after another. Now he also has a taste of the feeling of being abandoned by others."

Talking about these, Lu Xiaolu couldn't help feeling a little sad. After all, he and Guan Ruyan had studied and worked together for so many years, and they had some feelings for each other. It wasn't realistic to tear her away from his heart all of a sudden.

Lu Xiaolu is an introvert and has had no friends since childhood. If he could be considered a friend, it would only be Guan Ruyan and Ding Xinyu. After all, they had studied together at Nandu Medical University, and then studied abroad in Germany together. The student days at that time were still very good. Some things can only be missed and can never be returned.

"I plan to marry Ding Xinyu." Lu Xiaolu said suddenly.

This surprised Yang Ping. Lu Xiaolu said, "I don't have many friends, so I can only talk to you. Ding Xinyu is a joke in everyone's mind. In everyone's eyes, she is stupid and self-inflicted. But in my eyes, she is Teacher Ding's daughter, my junior sister, and the woman who needs the most care. I don't care what others think. I must marry her as long as she agrees. I don't know if this will affect the reputation of our laboratory."

It turned out that Lu Xiaolu was worried about this. Yang Ping stated on the spot: "This is your private matter and has nothing to do with work. So, do whatever you want. As for how others see you, you just have to bear it yourself."

Lu Xiaolu breathed a sigh of relief: "I understand. She needs love and protection the most right now, and the child also needs a complete family. Teacher Ding won't live for many days, I hope he can leave in peace."

"You can do whatever you want, as long as it does not break the law, does not violate your conscience, and does not affect others."

Lu Xiaolu smiled and said, "Actually, I think so too. I don't care about the gossip. I just do my best."

"Look, I'm talking to you about irrelevant things during working hours and taking up your time." Lu Xiaolu brought back the topic that had gone off topic.

Yang Ping smiled and said, "I came here just to chat with you. We can talk about whatever comes to mind. There is no rule that we must talk about work."

"We can benefit a lot from the cooperation with Brian. He is now the world's top researcher in immunology. He also said that he would introduce a professor of virology to work with us, so that I can make up for all the current shortcomings."

Lu Xiaolu admired Yang Ping's open academic spirit very much. Yang Ping's current level is also world-class, but he has never been complacent because of this. He still actively seeks exchanges and cooperation, and carries out extensive exchanges and cooperation on the basis of independence. He is neither complacent nor blindly follows others. He always learns from others' strengths and overcomes his own weaknesses, and always keeps himself at the top level of world academia. This is the true rational academic spirit.

The world's science and technology is developing so fast and covering such a wide range. Many fields require decades or even hundreds of years of accumulation. If you have to study any technology from beginning to end, it will be difficult to keep up with the pace of the top level. Therefore, learning is so important at this time. Learning from others through communication and cooperation and standing on the shoulders of others can avoid unnecessary waste.

After leaving the tumor laboratory, Yang Ping came to the stem cell laboratory. The stem cell laboratory can now successfully cultivate complete muscle tendon units. These muscles and tendons have been used in a limited way in clinical practice, such as muscle transplantation for trauma patients with muscle loss and providing transplant materials for patients undergoing anterior and posterior cruciate ligament reconstruction of the knee.

Skin augmentation technology has now begun to be promoted, providing an almost inexhaustible source of high-quality skin for burn surgeries that require large-area skin grafting. Even if there is only a piece of normal skin on the body, the augmentation technology can be used to obtain skin material that can cover the entire body.

The stem cell laboratory is intensively carrying out stem cell injection therapy and using stem cells for anti-aging treatment. Some qualification licenses are being applied for. Currently, Sanbo Hospital is a hospital directly managed by the imperial capital, and the application for these licenses is very easy, which is not comparable to that of ordinary hospitals.

Time management master Tang Shun used to always have a mobile phone on his desk. His fingers would fly, switching between WeChat avatars one after another at high speed. A top sea king must be a person with special skills.

In the words of Fatty Liang, Tang Shun is the world's top sea king. Whether it is the variety, quality or geographical distribution of the fish he raises, he is undoubtedly the top one.

But today, Tang Shun did not have a mobile phone on his desk, and his fingers were not flying at high speed. He sat quietly behind his desk, holding a stack of information in his hand, and was checking some data.

Seeing Yang Ping coming in, he immediately stopped what he was doing: "Professor!"

"I came over to see you and chat with you."

"Professor, look? This is the latest information about our anti-aging project. We haven't started it yet, but many laboratories and companies in many countries around the world that make money from it want to pre-order our products. I just checked and they can collect more than 4 billion US dollars in advance. These people are really rich. We are completely relying on a mountain of gold. We just released this news. Our surgical institute now has a strong reputation in the world medical community."

It turned out that Tang Shun was doing the accounting. What can you say about this guy? He is just so awesome. He is an all-rounder with high professional level and organizational skills. Most importantly, he can make money. Since he took over the management of the laboratory, this laboratory is like a gold mountain, an inexhaustible gold mountain. Every once in a while, he can come up with some fancy ways to make money, and the money is earned in a fair and honest way, and there is nothing wrong with it.

"Look, this is an American tech mogul, this is a Russian oligarch, this is a British financial giant. All of them are asking about our stem cell lab. As long as they can prolong their lives, money is nothing to them. I haven't accepted their formal consultation yet. Once this door is opened, money will flow in like water from the Three Gorges Dam."

"However, Professor, we must upgrade our security measures. These foreigners are more cunning than the others. They started out as pirates, and robbing and stealing are ingrained in their bones. They will definitely send a lot of spies to infiltrate us. Who wouldn't want to control this gold mine in the medical field?"

Tang Shun was a little excited that the new project was so popular, but this was also expected.

"We are currently replacing the computers in our laboratory, from the system to various software, and strive to gradually achieve domestic control. These basic things are not often seen, but they are vital at critical moments. We cannot leave our vital points in the hands of others. I have already talked to Mr. Huang, and they will complete these tasks."

Tang Shun shook a list in his hand and handed it to Yang Ping.