godfather of surgery

Chapter 448 Animal Experiment Base
Hermes was hospitalized again, and his leg was saved. After three to four weeks of rehabilitation training, the external fixator can be removed, and the whole treatment is over.

Huang Jiacai was entrusted by Yang Ping and began to strategize. He already had a mature plan in mind.

First set up a development company in the name of Yang Ping, which is actually an investment company, focusing on investment in the pharmaceutical industry, and then plans to use this investment company to hold Ruixing and hold more companies in the future.

In this company, Yang Ping holds 90.00% of the shares, Xiaosu holds [-]% of the shares, and the registered capital is [-] million. Huang Jiacai acts as the CEO and legal representative and becomes Yang Ping's agent to help Yang Ping handle business matters.

Huang Jiacai is ambitious. He has a grand blueprint in his heart, and he will realize it step by step.

After Li Baosheng's operation, Yang Ping does not need to do other operations for the time being, and Song Zimo and Xu Zhiliang can complete the other operations.

Xu Zhiliang can't do difficult surgery now, but it's not a problem for general surgery to be the sole surgeon, and he can do it beautifully.

In this way, Song Zimo's burden can be greatly reduced, and he can concentrate on difficult operations.

When he was free, Yang Ping took the time to go to Guilin, Guangxi, and inspect the laboratory of Xiehe in Guilin.

For the laboratory in Guilin, Yang Ping had to have a detailed grasp of the situation before he could design an animal experiment program based on the conditions of the laboratory.

It is very convenient to go from the southern capital to Guilin, Guangxi. The high-speed rail only takes three hours, which is not much different from the time of the plane. What's more, you can enter the system space laboratory to read books and do experiments on the way.

Arriving in Guilin, Director He of the laboratory came with a driver to pick up Yang Ping in a Haval H9.

The laboratory is located in Yanshan District, Guilin, where there is a breeding base for experimental monkeys. In order to facilitate the acquisition of experimental monkeys, Concord established the laboratory here.

"Professor Liang called me a few days ago and repeatedly explained that we must do a good job in reception."

Director He was very enthusiastic. When he received Yang Ping at the high-speed rail station, he shook hands and grabbed his backpack.

Lao He is the director of the laboratory. He used to work in the animal department of Guangxi Medical University. After the establishment of this laboratory, he applied to work here. This laboratory has no staff, but the salary is much higher, and the work is interesting, which is very suitable for the old man. What life expectancy.

Before changing jobs, he also knew that this laboratory was established by Xiehe, and the plan existed for a long time, so he quit his original job and joined this laboratory.

Director He used to be a graduate of veterinary medicine. He likes animals and often studies them. He is an expert in experimental animals. He is familiar with the purchase, breeding and care of experimental animals, and is also familiar with the production of most medical models.

In addition to Director He, there are more than a dozen resident staff in the laboratory. Including the rotating researchers, the laboratory usually has 30 staff.On rotation, some come from Xiehe, some come from Hong Kong, and occasionally foreign researchers come here, and they generally stay for no more than three months.

Along the way, Lao He introduced the situation of the laboratory. The Haval car did not know how long it had been going. It stopped in the yard in front of several small buildings. There was a shed in the open-air parking lot, and at least ten cars could be parked under the shed at the same time. The parking spaces are all painted standard parking spaces.

Old He opened the door and Yang Ping got out of the car.

These small buildings are very beautifully built, all with three floors, the yard is very large, and the trees inside are tall and big.

"The front building is the office and dormitory, the second building is the laboratory, and the last building is the breeding ground for experimental animals." Director He pointed to the distance.

Because the third building is relatively far away, it is located on an artificial island, and a wide and deep trench has been dug around it. In the past, a bridge has to be crossed, and an iron gate on the bridge is locked.

"I have already prepared the baby monkey you want, and the model of scoliosis is also ready. Now it is hard to find a monkey. The supply company is in charge of my classmate. I told them, no matter what, we The supply needs to be guaranteed here, it’s not that they are complaining, it is true that the supply of experimental monkeys is in short supply, the last time a company in the United States asked for [-] monkeys, they refused, and there is no way to deliver.” Director He told several large-scale experiments here in Guangxi Animal farms are all familiar.

Darwin said that humans evolved from monkeys, so monkeys are highly similar to humans in terms of genes, anatomy, immunity, physiology and metabolism. Therefore, monkeys are very suitable for medical and biological research experiments.

Especially in the pharmaceutical industry, the dependence on monkeys is more obvious. Every drug has side effects. What are the side effects?Carcinogenic, disease-causing, teratogenic, toxic, mutagenic, disabling, or even fatal?The best way to obtain data before human application is to obtain data from monkey experiments.

But not all monkeys are suitable for experiments. To become an experimental monkey, many conditions need to be met. At present, the commonly used monkeys are rhesus monkeys and cynomolgus monkeys. These two monkeys are relatively close to humans in terms of anatomy and physiology. The most popular medical laboratory animals.

In Europe, it costs about 5000 euros to raise a marmoset, and 20000 euros to raise a relatively large macaque, but in China, it only costs 8000 yuan to raise a macaque that can only be used for medical experiments.

The low cost of Chinese experimental monkeys determines that the price will be even lower, which is a huge temptation for foreign research institutions and pharmaceutical companies.

This kind of monkey, which costs 8000 yuan, can be sold for 12000 yuan in the market, with a gross profit of 50%.

With such a large profit, it is natural that some people are willing to earn money from monkeys. As a result, many "monkey raising" bases have emerged in China.

Guangxi, Hainan and other places are places where monkey breeding bases are relatively concentrated. The breeding of experimental monkeys also requires professional knowledge. As a monkey for scientific research, it not only needs to be healthy physically, but also mentally healthy, so their breeding conditions are very strict. it is good.

"Now our laboratory has made a profit. It not only meets our own experimental needs, but also earns money. In our free time, we rent out part of the laboratory to some biomedical research and development institutions for drug and toxicity experiments. The fee is charged by the day. A project charges as little as Hundreds of thousands, a few million more." Director He was obviously very happy.

"I ate in the cafeteria at noon. There is a pig farm nearby. The boss is very familiar with me. I asked him to help me go to the slaughterhouse to buy some fresh meat and pig offal. It will be there later, and the ingredients will be cooked as soon as they arrive."

According to Lao He's introduction, there are usually dozens of people eating in this laboratory, and the chef in the cafeteria is his wife.

Later, Lao He took Yang Ping to visit the laboratory. The equipment in this laboratory is not only complete, but also very advanced. There is an operating room with excellent surgical anesthesia equipment, including extracorporeal circulation equipment, which means it can simulate heart surgery.

"When the scoliosis model is in a hurry, they usually remove the erector spinae muscles to make the scoliosis model. Professor Liang said that the model made by this method is not suitable for your experiment, so we selected For the experimental monkeys, remove all these types of monkeys, and prepare monkeys with scoliosis caused by drug-induced teratogenicity during the embryonic period, so that the soft tissue structure of the entire spine remains intact." Director He is very professional about these.

Those who are interested in their work and have a sense of professional honor will definitely be able to do a good job.

"Our suppliers have mature technologies for producing other disease models, such as Parkinson's disease models, diabetes models, obesity models, middle cerebral artery occlusion models, hypertensive monkey models, and renal failure models. There are experimental monkeys carrying specific genes, which are used to create special models such as AIDS. But for scoliosis models, they are not very skilled in making them, so I have to participate in the guidance every time. My method of making scoliosis models is Professor Liang taught me." Old He talked eloquently, and when he talked about experimental animals, his eyebrows were beaming.

The business of experimental animals is also very professional. For example, the production of these models requires special feeding or drug injection to make monkeys suffer from the same diseases as humans, so that they can be used to study related drugs for treating diseases.

The specific method has a high technical content. The use of drugs to make models, when to use drugs, what drugs to use, and how much to use are very particular. It is not easy to make a high-quality disease model.

After visiting the laboratory, Lao He took Yang Ping for a walk around the laboratory. With a little development, this place can be used as a tourist attraction.

It was estimated that the laboratory invested a lot at that time. The animal island alone was artificially built, and the surrounding isolation river and animal rest area were all done very well.

In the animal rest area, there are swings, slides, seesaws, wooden houses, etc. for these monkeys to play and play.

Around lunch time, Lao He received a call that fresh ingredients had arrived. He entrusted the owner of the pig farm to get them, so he ordered the driver to drive to pick them up, and told the driver not to delay. Put the ingredients in the cockpit, turn on the air conditioner, and get the ingredients Immediately hand it over to the kitchen when you come back. The other ingredients are fine. The offal must be fresh to make it delicious.

The driver went out again in that Haval. In fact, the traffic is quite convenient. The road surface is all cement. Compared with the cement road in the countryside, it is much wider, and it is still a standard two-lane road.

Yang Ping was very relieved about the conditions of this kind of laboratory. If he hadn't come here in person, he wouldn't know the details. After inquiring like this, he was completely at ease, and many animal experiments could be entrusted to them in the future.

In terms of technology, there is no need to worry at all, Lao He and these staff are very professional.

Those who are actually engaged in research work are all graduate students from Xiehe, so there is no problem.

A few young people came back in a pickup truck, and Lao He said: "These are doctors from Xiehe. They can play. They often go fishing after work. I heard that you came today. I asked them to catch some fish and come back." , I don’t know what the harvest will be.”

The young man parked the car, and there was a big bucket in the pickup truck, and two people climbed up to lift it down.

"Let me see, it's not bad."

Lao He walked over with Yang Ping, and there were several big fish in the bucket, making water splash everywhere.

"Send it to the kitchen." Old He ordered.

"This is Dr. Yang!" Lao He remembered to introduce.

Several young people immediately greeted Yang Ping respectfully. They may be familiar with Yang Ping's situation and were personally recommended by Professor Liang, so they seemed rather restrained.

"I bought all the drinks? Beer, beer is indispensable."

Old He yelled, and it could be seen that he usually got along very well with these young people.

"This car is so dirty, go wash it." Old He felt sorry for the car.

The young man drove the car aside, picked up the tap, and started washing the car.

"Look, what else is needed for the experiment, you can just say it."

Lao He took Yang Ping to read it and asked Yang Ping.

Every experimental project has its own specific requirements, and Lao He needs to prepare in advance.

"Usually, if monkeys are used for spinal surgery, is there a spinal surgery posture frame for immobilizing the monkeys?"

Yang Ping did an inventory just now, and this was the only thing missing.

"Yes! There are several, in the warehouse."

Lao He knows the equipment like the back of his hand.

"That's good. Our experimental product of spinal external fixator has not yet left the factory. Once it leaves the factory, I will contact you and send it by express delivery. We will do the external fixation surgery. You should help to adjust it every day." Yang Ping said simply. Talk about division of labor.

Lao He said: "Well, in the afternoon, I arranged a time for you to give lectures to everyone, and the Ph.D. students from Xiehe will be responsible for your project."

In the kitchen, Lao He's wife sent a message to ask Lao He for help.

"You go to work, I will turn around by myself."

Yang Ping looked around in the laboratory yard by himself, and several doctors came to strike up a conversation.

(End of this chapter)