godfather of surgery

Chapter 669 Cross-Blood Heart Transplantation

Yang Ping sent his wife to the gate of Sanbo Hospital, and then drove to Nandu Fuyi.

He was already familiar with Fu Yi, so he parked his car when he came to Fu Yi, and called Professor Yao, who immediately went downstairs to greet Yang Ping.

The Organ Transplant Center of Nandu Attached First enjoys a high reputation in China because of Professor Yao's non-ischemic transplant technique.

Professor Yao brought Yang Ping to the doctor's office. The doctors here are not very familiar with Yang Ping, unlike the orthopedics department, almost everyone knows this Professor Yang.

"This is Professor Yang from Sanbo Hospital!" Professor Yao introduced Yang Ping to several chief physicians in the department.

Several chief physicians just nodded symbolically. I have never seen such a young professor before, and he must not be a very special person.

Professor Yao asked the doctor in charge of the bed to bring the medical records, and Yang Ping read the medical records in detail, not letting go of every word.

Xu Jiujiang, male, 45 years old, diagnosed with dilated cardiomyopathy.

Since 3 years ago, Mr. Xu would feel palpitations, shortness of breath, and hypoxia as long as he moved a little bit. He was diagnosed as dilated cardiomyopathy by a local university affiliated hospital. After 3 years of treatment, his condition has not improved. Four months ago, Mr. Xu's condition began to deteriorate, with frequent episodes of chest tightness, palpitations, shortness of breath, dizziness, and he was unable to lie down or eat.

This made Mr. Xu feel deeply desperate, knowing that his time is short, but the child is still in high school, and Mr. Xu is not reconciled.

In order to find a chance of survival, Mr. Xu went to Nandu Fuyi to find Professor Yao after many inquiries. Professor Yao conducted a series of inspections on him.

Among them, the color ultrasound of the heart showed that the diameter of the left ventricle had expanded to 76 mm, while the left ventricle of a normal person was about 45 mm, and the volume of the heart was more than twice that of a normal person. The heart function was very poor, and the left ventricular ejection fraction had dropped to 2. %, and at least 28% for normal people, this kind of heart is already in jeopardy.

After he was hospitalized in Nanduyiyi, Professor Yao actively treated him with anti-heart failure, but Mr. Xu needed dopamine and norepinephrine to maintain blood pressure due to fluctuations in his body circulation and disturbance of his internal environment.

In order to alleviate the condition and gain a chance to wait for the heart, Professor Yao installed an intra-aortic balloon counterpulsation device on Mr. Xu to assist the left ventricle.

Yang Ping already knew the basic condition of Mr. Xu, and now he revisited it to become more familiar with it.

"There is only one chance for a heart transplant, so please come over and discuss with me. I once performed a heart transplant with a different blood type. It was a donor with type O blood transplanted to a patient with type A blood, because type O blood is "compatible" with type A. Blood, coupled with the use of new drugs, the risk of rejection is relatively controllable, so we dared to try at that time, now the patient has type B blood, and the possible donor is type A blood, completely incompatible blood type, in heart transplantation On, we dare not try."

"If it is a child, the immune mechanism in the body is not yet complete, you can try a transplant operation across blood types, and it is possible to "cheat" the immune system, but adults, with a complete immune system, cannot try it."

Professor Yao was very polite and shared his difficulties and worries.

At present, it still seems a bit rough and inappropriate to apply the same method of cross-blood type transplantation in kidney transplantation to heart transplantation.

Yang Ping admired Professor Yao quite a lot. His technique of non-ischemic transplantation is world-class, but it will take some time to perfect it. Put yourself in the position of learning.

Professor Yao really has everyone's demeanor, Yang Ping decided to transfer some of his experience to Professor Yao without reservation.

ABO blood type is the basic principle of organ transplant matching. If the blood type is incompatible, the transplant recipient will have a strong immune rejection reaction after surgery.

If a cross-blood type transplant is to be carried out, the antibodies must be thoroughly washed, or the immune system must be strongly suppressed, so as to ensure that no strong immune rejection occurs, so that the transplanted organs can live in peace with the human body and integrate into the human family.

Several chief physicians around did not understand why Professor Yao respected this young man so much.

Yang Ping thought for a while and said:

"Professor Yao, in fact, this case still needs to use the blood washing method, but it needs a more advanced blood washing method. At present, there is a new method. The research team of the University of Toronto in Canada uses two enzymes, FpGalNAcdeacetylase and FpGalactosaminidase, to clean blood types. Antibodies, which can thoroughly cleanse AB blood group antibodies, transform organs into universal donors, and this technique is recommended."

Ordinary blood-washing techniques can no longer complete such a difficult blood-washing, and can only use new technologies.

"I have also read this paper, but it is still an experimental technology. I don't know whether the technology is mature, and it is impossible to obtain this set of enzymes and related technologies." Professor Yao is quite embarrassed.

It is not realistic to use this cutting-edge technology, not to mention anything else, it is a difficult problem to get this set of enzymes.

"Now there are only two ways for this patient to be rescued. One way is to get a heart donor with a matching blood type, and the other way is to get this method from the University of Toronto. Which one do you think is more likely? The former is completely dependent on luck. The luck of winning 500 million lottery tickets, and the latter can be achieved with hard work. If Professor Yao is willing to give it a try, I can help contact the team at the University of Toronto and invite you to visit Professor Li Zehui of Cleveland Medical Center and his brother Dodge, both of whom are North American cardiac surgeons. You can contact the University of Toronto for help." Yang Ping suggested that Professor Yao give it a go.

Yang Ping had calculated that if this patient did not undergo a heart transplant, he would have no chance.

Of course, there is another way, to perform an artificial heart transplant, gain a buffer time, and wait for the heart transplant, but the cost of an artificial heart suitable for this patient is not affordable for ordinary people, and even if they wait, there is still no chance to get a heart of the same blood type.

Professor Yao pondered for a moment, and decided to follow Yang Ping's words and give it a go.

"Then I have to trouble Professor Yang to help me contact the team at the University of Toronto?"

Ever since he lent a machine to perform surgery on Yang Ping and got to know Yang Ping, Professor Yao found himself leaning on a big tree.

"Okay, I'll send an email later, and you will take the time to fly over and learn their techniques. In fact, I am also familiar with their techniques, but you need to get two blood-washing enzymes from them. If It will take a long time to prepare these kinds of blood-washing enzymes."

Yang Ping's words are to reassure Professor Yao that he is not recommending new technologies to him based on a paper.

Yang Ping is indeed very familiar with this new technology.

Because in the system space, when Yang Ping reads papers, he will find a way to do experiments in the system laboratory whenever he sees interesting new results.

The several chief doctors who stood by and listened to Yang Ping and Professor Yao discussing the disease were like listening to a scripture.

What about the team at the University of Toronto, if you say contact, contact, and Li Zehui and Dodge in Cleveland seem to be his brother-in-law. It seems that when he sends an email, others will definitely save face.

And when he said this, he seemed very domineering.

Prof. Yao is very excited to be able to learn the latest washing AB antibody technology from the University of Toronto, and to get two state-of-the-art enzymes.

Based on this point, I can take several steps forward in the field of organ transplantation.

(End of this chapter)