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Chapter 462 New Year's Gift
Time soon came to the thirtieth of the twelfth lunar month, the day of family reunion, but on this day, the institute was still brightly lit, and everyone seemed to have forgotten what the New Year was.

Time is never wasted in vain. On this day, at the moment when the New Year's bell rang, a big news came from Cheng Ran's laboratory.

Found a special protein that is sensitive to cobalt chromium, which is a substance extracted from KM mice.

The discovery process is also very simple, that is, to make models for experimental animals such as KM mice, guinea pigs, rabbits, and domestic pigs. It is required to inject a certain amount of cobalt-chromium free substances in the body, but these cobalt-chromium free substances need to be specially processed. Radioactive labeling is carried out to observe the sites where these substances enter the animal's body mainly.

This is a method Bai Ye came up with. Although he has found these substances through [Deep Scan], it does not mean that he can tell others clearly.

Therefore, the first thing is to put forward various hypotheses. Through observation and analysis, Bai Ye found that the main attachment sites of cobalt and chromium elements are still nerve cells, blood vessel walls, liver and kidneys.

While analyzing the various screenshots, Bai Ye suddenly discovered a strange phenomenon, that is, how cobalt chromium ions entered the white matter of the brain!

By comparing thousands of screenshots of different sizes, Bai Ye discovered an interesting thing, that is, on the cell membrane of vascular endothelial cells, there is a cobalt ion embedded in a protein channel, which is pure in free form. , and did not react with other substances.

This aroused Bai Ye's curiosity.

Continuing to observe other photos and information, this time, he found a magical secret, that is how cobalt enters the neurons in the white matter of the brain through the blood-brain barrier!

You must know that the blood-brain barrier is one of the strongest defense systems of the human body!

It is a barrier between plasma and brain cells formed by cranial capillary walls and glial cells, and also a barrier between plasma and cerebrospinal fluid formed by the choroid plexus.

And these barriers happen to prevent certain substances from entering the brain tissue from the blood, and most of these substances are harmful substances, as if the human body has the function of identifying harmful substances and can reject them.

A variety of solutes in the blood enter the brain tissue from the brain capillary, which is difficult or easy; some pass through quickly, some slowly, and some cannot pass through at all. This selective permeability phenomenon makes people imagine that there may be restrictions on solute permeability. This structure can make the brain tissue less or even not damaged by harmful substances in the circulating blood, so as to maintain the basic stability of the internal environment of the brain tissue and play an important biological role in maintaining the normal physiological state of the central nervous system. significance.

Therefore, when Bai Ye was observing how cobalt ions pass through this barrier, he suddenly discovered a mysterious protein!
There are pathways in the cell membrane, including some protein channels. Obviously, this cobalt element penetrates the blood-brain barrier through this protein, causing damage to neurons and some damage to myelin.

This discovery is crucial!

So he proposed an animal model to look for this protein. Since cobalt can pass through the blood-brain barrier of the human body, other animals must also exist.

For this reason, Bai Ye asked the experimental team to increase the amount of cobalt, even to the limit and the maximum lethal amount.

As long as the animal can not die, continue to increase cobalt ions, hoping to increase this probability by observing the high concentration environment.

These people are professional scientific researchers, they know a lot, and they are fast.

A gentle man with eyes and a tall classmate of Cheng Ran's experimental group discovered a protein together during the experiment. He has a certain affinity with cobalt ions. This protein is very rare. A specific protein found in KM mice.

This made the two of them excited instantly!
This is definitely big news. After getting the news, the two quickly reported it.

It was already almost twelve o'clock, and in any corner of China, people would welcome the arrival of the New Year with joy, but many rooms in Bai Ye Research Institute were still brightly lit.

Of course, the vast majority of people are at home, and not many people are in the laboratory.

Because Bai Ye's family is in the United States, he naturally didn't go back to the Puze family building to celebrate the New Year. Li Ziyan invited Bai Ye to go home to celebrate the New Year, but Bai Ye refused.

Because now is the critical time of the experiment, Bai Ye doesn't want to relax at this time, after all, there are still a lot of people abroad waiting to see the joke!

Gao Yueyang received an invitation to go to the Spring Festival Gala this year, and Liu Boli wanted to accompany his family. After all, at such an old age, he already needs to take care of his life, and Cheng Ran will go to the Spring Festival Gala this year to receive awards. As a leader in science and technology, the country Some individuals are honored each year.

Bai Ye was lucky enough to go there, but because he went to Mai Country, his mother took him on his behalf.

Anyway, most of the experts, professors and academicians are going home to celebrate the New Year at this time, and it is these young people who stay in the institute. They are hard-working and aggressive, and they have a vision for the future.

Just like Chen Yu, a man with glasses, and Qin Yue, a tall classmate, Qin Yue, they basically spend all their time in the experiment except for their rest time every day.

Doing experiments is not done all the time, most of them are doing experiments—waiting for results—doing experiments—new results.

In the middle of waiting for the results, they used to look up the information, which was very fulfilling.

When they reported the news to Bai Ye, Bai Ye ran directly to their laboratory.

Seeing Bai Ye coming, the two of them spoke excitedly and were a little awkward!

"Dean, we found a substance that is a special transporter on the cell membrane. His KM mouse... We found that he has a certain affinity and specificity for cobalt ions. This specificity allows proteins and ions to form A special state that allows cobalt ions to penetrate the cell membrane and enter the organs."

Bai Ye's eyes lit up, and he quickly looked at the microscope. Sure enough, under the high-power field of vision, he found a cell membrane with a special shape, and the cobalt ions were specially marked, so they could be found under the electron microscope!

Bai Ye's spirit suddenly lifted: "Where did you find it?"

Qin Yue said excitedly: "It was found on the microvessels of the kidney."

Bai Ye understood that they found this substance on the blood vessel wall of the kidney, and the shape was exactly the same as that of the human body in the [Deep Scan] of the human body.

good news!
Definitely good news!
His discovery was actually confirmed by these two young people, and the more Bai Ye thought about it, the happier he became.

At this time, the sky was gorgeous.

Bai Ye looked up, the new year is here!
(End of this chapter)