I really don't want to be a doctor

Chapter 422 Side Effects of Drugs
After sleeping at home all night, Jing Xiaoran was woken up by Xiaoxiao early the next morning.

"Brother, get up and take me to school!"

Jing Xiaoran opened his eyes ignorantly, and took out his phone, "Xiaoxiao, isn't today the weekend? You still have class?"

"That's right, I'm going to a painting tuition class." Xiaoxiao lay on the bed and started making faces at Jing Xiaoran, "Brother, get up quickly, I want to eat."

"Okay, I'll get up now." Jing Xiaoran yawned, and glanced at his watch, it was only before eight o'clock.

Jing's mother had already prepared a hearty breakfast, and after Jing Xiaoran and Xiaoxiao finished eating, they went to the nearby training school.

The training school is not far away, usually Xiaoxiao goes to and from get out of class by herself, and when Jing Xiaoran is at home, he mostly picks her up.

The two walked on the road, Xiaoxiao's steps were very brisk, chattering along the way, it was very lively.

"Brother, I want to eat a cone."

Xiaoxiao suddenly stopped and pointed to the KFC road not far from the road.

"In the early morning, KFC doesn't have cones." Jing Xiaoran smiled.

Xiaoxiao wrinkled her little nose.

This made Jing Xiaoran suddenly think of Xiaoxiao a few years ago, who liked to eat cones very much, but in recent years she ate less and less.

Maybe it's because I grew up, or maybe because I like other snacks.

Fortunately, most of Xiaoxiao's illness has been cured, and she can grow up carefree and healthy like a normal little girl.

"Brother, I'm leaving." Xiaoxiao waved her hand, and walked into the school gate with a few students from the painting class.

"Be careful in school." Jing Xiaoran shouted.

Xiaoxiao smiled and nodded towards him, then disappeared into the crowd.

After seeing Xiaoxiao off, Jing Xiaoran immediately went to the Shenzhou Laboratory.

He promised Zhu Xianqing that before going to Kyoto, he would personally participate in the "immune checkpoint inhibitor" project.

Now Shenzhou Laboratory mainly focuses on the "immune checkpoint inhibitor" project, which is a scientific research competition with top laboratories such as Bayer and AstraZeneca.

Therefore, the atmosphere in the entire Shenzhou laboratory is highly tense.

"According to the results of our current animal experiments, the main problem is reflected in the potential side effects of the drug."

At the group meeting, Zhu Xianqing summarized the problems encountered recently.

"In addition, after the combined application of two immune checkpoint inhibitors, the adverse reactions increased significantly."

Jing Xiaoran was thinking while looking at the experimental data.

Regarding the side effects of the drug, he has no good solution. He can only do as many animal experiments as possible to prevent more uncertainties in the third phase of the experiment in the future.

"Xiao Ran, what do you think?" Zhu Xianqing finished talking about all the questions.

"Mr. Zhu, don't worry." Jing Xiaoran thought deeply, "We currently don't have a particularly good solution for side effects. The ingredients of the entire drug are basically finalized, so we can only increase the number of animal experiments. Find as many potential side effects as possible. side effects."

Zhu Xianqing nodded, "I think so too. Talking about the curative effect without the side effects of the medicine is all hooliganism, but..."

"Does Teacher Zhu have any worries?" Jing Xiaoran frowned.

Zhu Xianqing said: "Xiao Ran, I asked some friends in the United States to find out that the experimental progress of Bayer and AstraZeneca should be similar to ours, or even slower than ours. I'm afraid...I'm afraid that they will be slower than us in the animal experiment. We will be able to enter phase III clinical trials ahead of schedule."

Phase III clinical laboratories are clinical human experiments.

This is the only way for every drug on the market, ranging from half a year to several years.

"Mr. Zhu, do you think it is necessary to compete for the first to enter the third phase clinical trial?" Jing Xiaoran thought for a while.

Zhu Xianqing said: "As the first drug to enter clinical trials, it will inevitably attract huge traffic, which is also good for our future development. It's just that if there are too many side effects in Phase III clinical trials, it will even affect the final drug. If new drugs are on the market, the gains outweigh the losses.”

"Well, I agree." Jing Xiaoran nodded and said, "Don't be in a hurry to enter the third phase of clinical trials, follow our pace, and don't be affected by the progress of other experiments."

Globally, there are no longer a few drugs withdrawn from the market due to side effects.

Tegaserod maleate is mainly used clinically for the short-term treatment of female patients with constipation-predominant irritable bowel syndrome to relieve symptoms, and it has been withdrawn from the market because of the increased risk of cardiovascular ischemic events.

Pergolide mesylate, which is mainly used clinically as an adjuvant treatment of levodopa in the treatment of Parkinson's disease, has an increased risk of heart valve damage, so it has been withdrawn from the market.

There are also Analgin in pediatrics, etc., which have been withdrawn from the market one after another due to side effects.

Therefore, Jing Xiaoran knew very well that he would rather make sufficient preparations for the drug than rush to market it.

"Mr. Zhu, regarding the side effects of drugs, I think we should pay more attention to the effects of the heart, such as myocarditis and heart failure."

"Myocarditis?" Zhu Xianqing asked suspiciously, "Even if this happens, the probability is not high, right? And it is very difficult to diagnose myocarditis now, I think it is not a small difficulty."

"But as long as it happens, there is a 50% probability." Jing Xiaoran said, "What's more, the mortality rate of fulminant myocarditis exceeds [-]%, we must take precautions!"

The reason why Jing Xiaoran emphasized this point is naturally because he has seen many cases of myocarditis related to immune checkpoint inhibitors in clinical practice in his previous life.

He is well aware of the dangers of such side effects. Although immune checkpoint inhibitors are good medicines, they also contain many hidden dangers.

"Okay, I will list a separate set of data and let a special person be responsible for the side effects related to the heart." Zhu Xianqing said.

After that, working in the laboratory for several days in a row made Jing Xiaoran seem to have returned to the time when he was working in Africa. He was in a state of high tension but very fulfilled.

At the same time, Jing Xiaoran also got news about the last academic exchange meeting from Ke An.

Harris, that is, the American who left halfway that day, unilaterally condemned the Shenzhou Laboratory and wanted to cancel all future academic exchange activities, but he couldn't tell the specific reason.

On the contrary, the US National Laboratory did not make any response to this matter. Any Harris who made a fuss alone did not support it, but did not stop it.

The Fancheng Health and Health Committee wanted to follow suit and cancel all subsequent academic exchange meetings, but it touched the interests of many parties. Neither the Chinese universities nor the US National Laboratory did not want to cancel these meetings.

As a result, Harris was like a solo clown, and both sides were ignored.

"Oh, I thought all future academic exchange meetings would be canceled directly." Jing Xiaoran said with some regret.

"The situation is not bad now." Zhu Xianqing smiled, "If they are discouraged, their arrogance will be less in the future, but domestic leaders are not willing to cancel these meetings, this is all a credit! "

(End of this chapter)