I really don't want to be a doctor

Chapter 67 Immune Checkpoint Inhibitors (Popular Science)
If you ask what disease is the scariest, I believe most people will answer with one word.

Malignant tumor!
According to the statistics of the World Health Organization, the number of deaths due to malignant tumors is 8927.4 million worldwide every year, which is the second leading cause of death after cardiovascular and cerebrovascular diseases.

There are nearly 400 million new cancer patients in China every year, 7 people are diagnosed with cancer every minute, and nearly 300 million people die of cancer every year, and this number has been increasing year by year.

In the past ten years, the number of cancer deaths has increased by 17.8%.Malignant tumors have become an important killer that endangers the health of all human beings.

And just in 2011 in the previous life, a new tumor treatment method appeared abroad - tumor immunotherapy, which is mainly immune checkpoint inhibitor drugs.

The pathogenic mechanism of cancer cells is to use the "deficiency" of the human immune system to inhibit immune cells and escape from the human immune system to survive (one of the ways cancer cells escape).

Drugs called immune checkpoint inhibitors can remove this inhibition, allowing immune cells to reactivate and destroy cancer cells.

Former US President Jimmy Carter miraculously recovered after trying immune checkpoint inhibitors after suffering from melanoma that spread to his brain.

Tumor immunotherapy can extend the lives of cancer patients by months or even years.For some patients, it is even possible for their tumors to disappear completely.

Moreover, the scope of application of immune checkpoint inhibitor drugs ranges from melanoma and lung cancer at the beginning, to lymphoma, kidney cancer, bladder cancer, and gastrointestinal tumors, involving a very wide range of tumors.

Therefore, tumor immunotherapy has repeatedly staged a Jedi counterattack in clinical treatment, and the miracle of curing patients whose original methods are of no avail was rated as the first of the top ten scientific and technological breakthroughs of the year by Science.

The feeling of this medicine for all medical workers is that money can really buy your life!
but……

Immune checkpoint inhibitors were introduced in China after nearly 10 years of clinical application abroad.

There are many reasons for this, such as the long patent protection period of drugs, and the backwardness of cutting-edge medical technology in China's medical field.

This is not only a missed opportunity for the Chinese medical community, but also a huge regret for the majority of Chinese people.

The review that Jing Xiaoran wants to write is the immunotherapy of this tumor - immune checkpoint inhibitors.

There are three reasons that prompted Jing Xiaoran to have this idea,
First, Jing Xiaoran's master's thesis in the previous life was about immune checkpoint inhibitors. He knew this drug very well and wrote it with ease.

This thesis may have been suspected of irrigation in the previous life, but when viewed now, it is definitely a sensation in the entire global medical community.

Second, the introduction of immune checkpoint inhibitors in China in the early years may save more people.

It takes more than a year and a half for a new drug to enter the market and be applied clinically.

Third, tumor immunotherapy has enough influence, and writing papers in this area will definitely get the most attention.

What Jing Xiaoran has to do now is to consult the relevant literature to learn about the latest developments in tumor immunotherapy.

This is also the reason why Jing Xiaoran came to the library directly on the first day of school report, he wanted to grasp all the information on tumor immunotherapy as soon as possible.

For a whole afternoon, Jing Xiaoran flipped through the main medical journals, and then went to the electronic reading room to use the computer to look up relevant literature.

"It's a little troublesome." Jing Xiaoran looked at all the documents in front of him, "Writing such a review may be much more difficult than I imagined."

Jing Xiaoran learned that research on immune checkpoint inhibitors has been carried out in the United States, and a small number of papers on tumor immunity can be found.

However, its research progress is still in the early stage, and the mechanism and target of the drug are still controversial, and mainstream medical scientists hold their own opinions.

The clinical trials of the drug have not yet been carried out, and its effectiveness and side effects are even more impossible to talk about.

This is good news, because the drug is still in the research and development stage, and its patent has not yet been applied for.If there is an opportunity, Jing Xiaoran may be able to participate in it and introduce immune checkpoint inhibitors to Huaxia in advance.

But it's also bad news, because Jing Xiaoran doesn't have much to write. Once the content he writes exceeds the current research level without laboratory data support, his summary will definitely be questioned by everyone.

In this way, the gain outweighs the loss. If he is labeled as a fake paper, it will not be conducive to his future development.

"It seems that we need to study carefully how to grasp the speed of writing a review."

After working for a long time, Jing Xiaoran forgot to eat dinner, it was Jin Miao's phone call that brought him back from his busy thoughts.

"Xiao Ran, what are you doing? It took so long to answer the phone?"

After answering the phone, Jin Miao's loud voice rang out.

"Just now in the library, I can't answer the phone." Jing Xiaoran said.

"Xiao Ran, what's wrong with you? You're going to be a top student on the first day of reporting?" Jin Miao's voice was slightly exaggerated.

"I have my own plan. What can you do if you call me?"

"Isn't it already agreed before! Let's get together tomorrow, and Lin Xuantong will also come, so you will soon forget?" Jin Miao said.

"Well, I see. Just let me know when the meeting place is found."

Jing Xiaoran was about to hang up the phone when another male voice came from the phone.

"Xiao Ran, remember to call Ji Ying out together!"

Jing Xiaoran smiled: "Kunkun, this is not very good, you have just known each other for less than a day, and you are going to make an appointment?"

"It's not my appointment!" Zhou Zukun said.

"Ok?"

"I asked you to make an appointment, not to mention that I asked her on the train, if we have time to go out together, Ji Ying agreed!"

"Don't you have her phone number?" Jing Xiaoran said.

"That... Aren't I a little shy, besides, didn't you promise me to be my wingman?"

"Have it?"

"Hey, in order to prevent you from going back on your word, I recorded what you said this morning with my mobile phone, do you want to listen to it again?"

"..."

After hanging up the phone, Jing Xiaoran saw that it was getting late outside the library, so he sorted out his documents and left.

He can't finish this review in a while, and he has to spend a lot of thought.

After eating a bowl of rice at Little Sun Restaurant, Jing Xiaoran went back to the dormitory.

There was no one in the dormitory, and it looked a little deserted. It seemed that Zhou Baolin and the three were still playing games in the Internet cafe.

Thinking of tomorrow's party, Jing Xiaoran took out the elderly phone and called Ji Ying.

"Jing Xiaoran?" Ji Ying's tone was a little surprised, "Why did you think of calling me?"

"Well. Zhou Zukun asked me to tell you, how about going out for a stroll around Fancheng tomorrow?" Jing Xiaoran would of course sell Zhou Zukun, after all, this girl is not the girl he wants to chase.

"Zhou Zukun? Who is it?" Ji Ying asked doubtfully.

"It's that handsome boy on the train today." Jing Xiaoran reminded, and at the same time felt a moment of silence for Kunkun, Ji Ying had already forgotten him in less than half a day.

Ji Ying was even more puzzled, "A handsome boy? Have I met him before?"

　This chapter is popular science, you can skip it if you don’t like it,
　　Tumor immunotherapy, the most cutting-edge, and real progress in tumor treatment, is not fabricated by the author.

　　It can really be said to be a breakthrough in human medical technology.

　　However, it has just started in China, and many people may not understand it, and this medicine is very expensive.

　　The feeling that this medicine gives us medical workers is that money can really buy your life.

　　
　
(End of this chapter)