I really don't want to be a doctor
Chapter 79 The Lancet
Chapter 79 The Lancet
It was already eight o'clock in the evening when Jing Xiaoran returned to the dormitory. Just as he was about to wash up, the counselor Shen Xiaorong called and told him about the recruitment of lab personnel.
"Jing Xiaoran, you should inform everyone about this matter, and report five places to me after the military training."
"Also, find some boys tomorrow and come to the first floor of the school library to pick up the textbooks for this semester."
"Good teacher."
Sure enough, she had exactly the same idea as Luo Xin, Shen Xiaorong finally let Jing Xiaoran decide the number of these five people.
After hanging up on Shen Xiaorong's phone, Jing Xiaoran remembered that he forgot to call his parents today.
"Beep beep..."
He dialed the phone and was connected after five rings.
"Xiao Ran, how is your situation like that?"
His mother's familiar voice came over the phone, Jing Xiaoran said with a smile, "Mom, I'm fine here, I had a class meeting today, and I met my teachers and classmates."
"That's good." Mother Jing instructed, "You must remember to eat on time at school and don't stay up late at night. Now your home is not like before, and you don't have to always think about going out to work part-time, just study hard."
"Mom, don't worry, I know what's going on. Where are Dad and Xiaoxiao?" Jing Xiaoran said.
"Your father went to visit Uncle Wang's house next door." Mother Jing said, "Girl Xiaoxiao, you have to comfort her later."
Jing Xiaoran's expression tightened, "What's wrong with Xiaoxiao?"
"Xiaoxiao is fine, it's not all because of you." Jing Mu said.
"Me?" Jing Xiaoran was puzzled.
"You promise Xiaoxiao that you will call her when you come to school. She stayed by the phone today except for eating and sleeping, and she just went back to her room."
Jing Xiaoran blamed herself a little, "Mom, go and call Xiaoxiao here, I'll talk to her for a while."
"Okay, wait a minute."
Then Jing Xiaoran heard his mother calling Xiaoxiao.
After a while, Jing Xiaoran felt that the phone on the other side was picked up again.
"Xiaoxiao?"
"Brother...I miss you so much."
Originally thought that Xiaoxiao would be awkward again for a long time, but she didn't expect that the first sentence was to miss him.
Jing Xiaoran's heart warmed up, and he said slowly: "Brother misses you too, there are too many things to do today, so I didn't have time to call you."
After comforting Xiaoxiao, the little girl immediately became happy.
"Brother, is college fun? I heard from Wang Qiang that he has a cousin who is also going to college. Every summer when he comes to his house, he will bring him a lot of fun, delicious food, and..."
How could Jing Xiaoran not know what this little girl Xiaoxiao was thinking, "Don't worry, brother will definitely bring you a gift when he comes home."
"That's great~" Xiaoxiao's cheerful voice came from the microphone.
Jing Xiaoran continued: "But you have to eat and take medicine on time, and you must listen to your parents. You can call me when you are bored."
"Uh-huh."
After talking with Xiaoxiao for about 20 minutes, the phone came back to Jing's mother, and after asking her to pay attention to Xiaoxiao's bleeding while taking anticoagulants, Jing Xiaoran hung up the phone.
……
the next day.
Jing Xiaoran found a few boys in the class, and moved all the textbooks for the first year back to the downstairs of the dormitory.
There are many courses for medical students, and there are more than ten courses in the first year. The courses about medical systems mainly include systematic anatomy, histology and embryology, and cell biology.
Afterwards, Jing Xiaoran called Ji Ying and asked her to inform the girl to go downstairs to pick up the books.
After working all morning, the textbooks were distributed to that classmate.
After Jing Xiaoran took his textbooks back to the dormitory, he went directly to the electronics city near Ning'an Medical College and bought a smartphone and a laptop.
It's time for his "elderly phone" to retire, and his laptop is a must-have for writing his thesis.
After returning to Ning'an Medical College, Jing Xiaoran spent the first time in the library, and he wanted to finish this review on "Immune Checkpoint Inhibitors" as quickly as possible.
Half a month of military training passed quickly, Jing Xiaoran spent every day in the library except for the daily military training.
During this period, Jin Miao, Zhou Zukun and others rarely contacted him, and everyone should be busy with military training.
On the day when the military training ended, Jing Xiaoran's review was finally completed.
A nearly ten-page review in English covers the concept and definition of immune checkpoint inhibitors, their potential mechanisms, indications and side effects.
In terms of drug mechanism, Jing Xiaoran added a new channel for drug molecules based on the existing ones in this world.
In the traditional sense, tumor immunotherapy is treated by inducing or strengthening anti-tumor immune responses. However, due to the existence of immune checkpoints and other inhibitory immune responses, it often cannot produce lasting and effective anti-tumor effects, which is equivalent to "stepping on the gas pedal while stepping on the gas pedal". , step on the brake" effect.
If it can effectively prevent the inhibitory effect of immune checkpoints such as PD-1/PD-L1, it is equivalent to "releasing the brakes and stepping on the gas pedal", thereby indirectly strengthening the anti-tumor immune response.
At the same time, Jing Xiaoran stated in the review that this is only a preliminary idea and has not been verified by the laboratory, which is in line with his current situation of no laboratory conditions.
The finalization of the review is only the first step. Submission, peer review, and retreat are still required, which cannot be completed in a month or two.
Jing Xiaoran searched the Internet for more authoritative journals in the field of tumors during this period.
No.1: CA-A Cancer Journal for Clinicians, IF (impact factor) 131.723, a journal that exists like God.
Jing Xiaoran ruled out this magazine at first. In order to be listed in this kind of magazine, in addition to the breakthrough discovery or progress of the article, what is more important is the internal relationship.
The "family concept" in the academic field is very deep. When you first enter the academic circle, your background is more important than your level!
No.2: Nature Reviews Cancer, IF 34.244, a review journal of oncology under Nature.
Needless to say, as long as it is a journal about Nature, it is not something that ordinary people can publish.Some second-rate and third-rate professors even only need the name of a Nature article to be able to eat for a lifetime.
No.3: LANCET Oncology, IF 26.509, a sub-journal of The Lancet Oncology.
No.4: Cancer Cell, IF 23.214, a special issue on cancer under Cell Magazine.
No.5: Journal of Clinical Oncology, IF 20.902, Journal of Clinical Oncology (JCO).
Jing Xiaoran included these three types of magazines in his choice, and also chose several other backups.
Even though the difficulty of these three magazines is less than that of the top three, the difficulty is still very high.
You must know that an article with an IF of 5 or more can make a doctor graduate, let alone these journals with more than 20 points.
There were two days of rest after the military training, and Jing Xiaoran spent the next two days collecting information from these magazines, and finally made a decision.
He chose LANCET Oncology, IF 26.509, a sub-journal of The Lancet Oncology.
"The Lancet" is named after the surgical knife "Lancet" (Lancet), and "Lancet" also means "pointed dome window" in English, implying that the journal is determined to become "Illuminate the bright window of the medical world".
In his previous life, Jing Xiaoran only published one IF 6 article at most, and none of his mentors published an article in a top magazine like "The Lancet".
(End of this chapter)
It was already eight o'clock in the evening when Jing Xiaoran returned to the dormitory. Just as he was about to wash up, the counselor Shen Xiaorong called and told him about the recruitment of lab personnel.
"Jing Xiaoran, you should inform everyone about this matter, and report five places to me after the military training."
"Also, find some boys tomorrow and come to the first floor of the school library to pick up the textbooks for this semester."
"Good teacher."
Sure enough, she had exactly the same idea as Luo Xin, Shen Xiaorong finally let Jing Xiaoran decide the number of these five people.
After hanging up on Shen Xiaorong's phone, Jing Xiaoran remembered that he forgot to call his parents today.
"Beep beep..."
He dialed the phone and was connected after five rings.
"Xiao Ran, how is your situation like that?"
His mother's familiar voice came over the phone, Jing Xiaoran said with a smile, "Mom, I'm fine here, I had a class meeting today, and I met my teachers and classmates."
"That's good." Mother Jing instructed, "You must remember to eat on time at school and don't stay up late at night. Now your home is not like before, and you don't have to always think about going out to work part-time, just study hard."
"Mom, don't worry, I know what's going on. Where are Dad and Xiaoxiao?" Jing Xiaoran said.
"Your father went to visit Uncle Wang's house next door." Mother Jing said, "Girl Xiaoxiao, you have to comfort her later."
Jing Xiaoran's expression tightened, "What's wrong with Xiaoxiao?"
"Xiaoxiao is fine, it's not all because of you." Jing Mu said.
"Me?" Jing Xiaoran was puzzled.
"You promise Xiaoxiao that you will call her when you come to school. She stayed by the phone today except for eating and sleeping, and she just went back to her room."
Jing Xiaoran blamed herself a little, "Mom, go and call Xiaoxiao here, I'll talk to her for a while."
"Okay, wait a minute."
Then Jing Xiaoran heard his mother calling Xiaoxiao.
After a while, Jing Xiaoran felt that the phone on the other side was picked up again.
"Xiaoxiao?"
"Brother...I miss you so much."
Originally thought that Xiaoxiao would be awkward again for a long time, but she didn't expect that the first sentence was to miss him.
Jing Xiaoran's heart warmed up, and he said slowly: "Brother misses you too, there are too many things to do today, so I didn't have time to call you."
After comforting Xiaoxiao, the little girl immediately became happy.
"Brother, is college fun? I heard from Wang Qiang that he has a cousin who is also going to college. Every summer when he comes to his house, he will bring him a lot of fun, delicious food, and..."
How could Jing Xiaoran not know what this little girl Xiaoxiao was thinking, "Don't worry, brother will definitely bring you a gift when he comes home."
"That's great~" Xiaoxiao's cheerful voice came from the microphone.
Jing Xiaoran continued: "But you have to eat and take medicine on time, and you must listen to your parents. You can call me when you are bored."
"Uh-huh."
After talking with Xiaoxiao for about 20 minutes, the phone came back to Jing's mother, and after asking her to pay attention to Xiaoxiao's bleeding while taking anticoagulants, Jing Xiaoran hung up the phone.
……
the next day.
Jing Xiaoran found a few boys in the class, and moved all the textbooks for the first year back to the downstairs of the dormitory.
There are many courses for medical students, and there are more than ten courses in the first year. The courses about medical systems mainly include systematic anatomy, histology and embryology, and cell biology.
Afterwards, Jing Xiaoran called Ji Ying and asked her to inform the girl to go downstairs to pick up the books.
After working all morning, the textbooks were distributed to that classmate.
After Jing Xiaoran took his textbooks back to the dormitory, he went directly to the electronics city near Ning'an Medical College and bought a smartphone and a laptop.
It's time for his "elderly phone" to retire, and his laptop is a must-have for writing his thesis.
After returning to Ning'an Medical College, Jing Xiaoran spent the first time in the library, and he wanted to finish this review on "Immune Checkpoint Inhibitors" as quickly as possible.
Half a month of military training passed quickly, Jing Xiaoran spent every day in the library except for the daily military training.
During this period, Jin Miao, Zhou Zukun and others rarely contacted him, and everyone should be busy with military training.
On the day when the military training ended, Jing Xiaoran's review was finally completed.
A nearly ten-page review in English covers the concept and definition of immune checkpoint inhibitors, their potential mechanisms, indications and side effects.
In terms of drug mechanism, Jing Xiaoran added a new channel for drug molecules based on the existing ones in this world.
In the traditional sense, tumor immunotherapy is treated by inducing or strengthening anti-tumor immune responses. However, due to the existence of immune checkpoints and other inhibitory immune responses, it often cannot produce lasting and effective anti-tumor effects, which is equivalent to "stepping on the gas pedal while stepping on the gas pedal". , step on the brake" effect.
If it can effectively prevent the inhibitory effect of immune checkpoints such as PD-1/PD-L1, it is equivalent to "releasing the brakes and stepping on the gas pedal", thereby indirectly strengthening the anti-tumor immune response.
At the same time, Jing Xiaoran stated in the review that this is only a preliminary idea and has not been verified by the laboratory, which is in line with his current situation of no laboratory conditions.
The finalization of the review is only the first step. Submission, peer review, and retreat are still required, which cannot be completed in a month or two.
Jing Xiaoran searched the Internet for more authoritative journals in the field of tumors during this period.
No.1: CA-A Cancer Journal for Clinicians, IF (impact factor) 131.723, a journal that exists like God.
Jing Xiaoran ruled out this magazine at first. In order to be listed in this kind of magazine, in addition to the breakthrough discovery or progress of the article, what is more important is the internal relationship.
The "family concept" in the academic field is very deep. When you first enter the academic circle, your background is more important than your level!
No.2: Nature Reviews Cancer, IF 34.244, a review journal of oncology under Nature.
Needless to say, as long as it is a journal about Nature, it is not something that ordinary people can publish.Some second-rate and third-rate professors even only need the name of a Nature article to be able to eat for a lifetime.
No.3: LANCET Oncology, IF 26.509, a sub-journal of The Lancet Oncology.
No.4: Cancer Cell, IF 23.214, a special issue on cancer under Cell Magazine.
No.5: Journal of Clinical Oncology, IF 20.902, Journal of Clinical Oncology (JCO).
Jing Xiaoran included these three types of magazines in his choice, and also chose several other backups.
Even though the difficulty of these three magazines is less than that of the top three, the difficulty is still very high.
You must know that an article with an IF of 5 or more can make a doctor graduate, let alone these journals with more than 20 points.
There were two days of rest after the military training, and Jing Xiaoran spent the next two days collecting information from these magazines, and finally made a decision.
He chose LANCET Oncology, IF 26.509, a sub-journal of The Lancet Oncology.
"The Lancet" is named after the surgical knife "Lancet" (Lancet), and "Lancet" also means "pointed dome window" in English, implying that the journal is determined to become "Illuminate the bright window of the medical world".
In his previous life, Jing Xiaoran only published one IF 6 article at most, and none of his mentors published an article in a top magazine like "The Lancet".
(End of this chapter)
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