Back to Ming Dynasty with Industrial Revolution System

Chapter 1546 Normal Saline
This little episode happened, and the investigation team did not stop their research on Vibrio. In fact, two days after Xiao Xiuer and Sophia recovered miraculously, bacteriologist Koch and several doctors researched The mechanism of vibrio pathogenicity.

"When a large number of Vibrio bacteria enter the body, they are almost completely killed by the stomach acid secreted by the body, but maybe a few Vibrio bacteria reach the small intestine safely, and they secrete a toxin that acts like a water pump to pump chloride ions from the small intestinal cells. Pump out. This result will lead to the combination of chloride ions and sodium ions in the lumen of the small intestine. The outside of the cells becomes a high-salt environment, while the inside of the cells is low in salt. The cells of the small intestine absorb water from elsewhere in the body, and then drain it again into the lumen of the small intestine. In just one day, the toxin is able to suck up to 6 liters of water from the body through the cells of the small intestine, which explains why the patient becomes violently dehydrated."

"The vibrio is also gaining nutrition and energy, and multiplying in large quantities. They flow into the river or sewer along with the foreign matter discharged by the patient, forming pollution. The sailor discovered by Xiao Xiuer was the first pathogen, but the contaminated It's definitely not just the water he brought back, he has become a breeding ground for germs."

Koch roughly studied the mechanism of vibrio pathogenicity, and announced their research results to the investigation team together with other researchers.

This discovery is an amazing development.

Xiao Xiu'er's previous investigation blocked the spread of Vibrio, but some people will inevitably be infected with the plague, or this type of plague will break out again in the future, and the research on pathology is closer to the problem Essentially, they can directionally find a way to heal.

"Based on this, what is lost is not just water, but also chlorine, sodium and potassium ions needed to maintain cell function. I understand why patients suffer from numbness in hands and feet, muscle twitching, and organ failure." Xiao Xiao Xiu Er has experienced the pain of severe diarrhea first-hand, so she has a better understanding of this disease.

She tried to propose a treatment method: "The pathogenic principle of Vibrio is very simple. It causes a large amount of water and ion loss. If we can provide patients with a certain solution in time to replenish water and salt for the human body at the same time, it will be Isn't it effective in relieving symptoms, restoring the body's water-salt balance, and at the same time giving the body's own immune system enough time to kill or expel Vibrio?"

Numerous physicians and biological experts looked at each other, argued over the details one after another, and finally planned to carry out the experiment according to Xiao Xiuer's suggestion.

The treatment method proposed by Xiao Xiuer is not difficult, but extremely simple.Compared with those diseases that require surgery, if it is just to supplement the solution that the human body lacks due to severe diarrhea, it is really simple.

They soon began intense clinical trials.

First they need to prepare the right solution, which must be as close as possible to the electrolyte concentration the patient is losing.

After a strong request from the investigation team, the government provided them with salt, sugar and clean water.

"It's strange, why did the investigation team ask us for salt and sugar? Could it be that they can treat patients suffering from the plague with only these common things?"

"Unless they're going to turn the rotten into the magical, it's unimaginable."

Regarding the request of the investigation team, officials in the government yamen, such as Monk Zhang Er, were puzzled. They could not understand the relationship between salt, sugar, water and the plague.

"First boil the water to avoid vibrio in the water, and then the ratio is about 1 liter of water to add 1 teaspoon of salt and 8 teaspoons of sugar."

After more detailed research, Xiaoxiuer and others developed a solution for treating Vibrio using a very simple method.

Buckets of the solution were carried to the plague area, and they made the patients drink the solution, treating the sick patients as clinical experiments.

People who were still suffering from the plague seemed to see a savior, scrambling to be guinea pigs and pouring down this sweet-smelling solution.

In the face of a plague with a fatality rate of nearly 50%, they are willing to try even if there is a chance of survival.

A miracle happened. When people accepted this simple treatment, the death rate of patients who were still struggling was greatly reduced, most people's diarrhea symptoms were relieved, and more and more patients finally healed themselves.

On the 10th day of the plague, the plague that broke out in Tianjin Wei was finally controlled and cured after mercilessly killing 500 people.

On the 15th day that Chu Yun was in Tianjin Wei, no new patients were reported. As for the patients, except for those who died, the rest of the patients got over the difficulties with the help of normal saline and entered the stage of recovery.

The panic of the plague that permeated the whole city disappeared, and order was restored in the city. People no longer feared the plague. As long as they cooked food and water, they could avoid being infected with the plague.

Even if you are infected with the plague, there is also an oral solution to treat the plague, which can greatly reduce the death rate caused by the plague.

Because of the outbreak of the plague and the implementation of the strategy of boiling water, woodcutters selling firewood and coal factories made a fortune from the plague business, and their firewood and coal were very popular.

Some poor people could not afford a lot of firewood and coal. In order to control the plague, the government also needed to distribute free firewood and coal to the poor.

After thousands of years of development in North China, the supply of firewood has become less and less, and the demand for coal is greater. This plague also indirectly promoted the further development of the coal mining industry.

The matter is not over yet, and aftermath measures are equally important. The investigation team needs to disinfect the vibrio-infected water wells and sewers, cremate the sick bodies that died from the plague, and concentrate on treating the patient's excrement.

However, when they were finishing the plague, the investigation team encountered an unprecedented difficulty.

When they planned to cremate the sick bodies infected with the plague to prevent the survival of Vibrio, they encountered strong resistance from the families of the deceased.

This matter became more and more troublesome, until Chu Yun personally came forward to appease the people in the city, moved them with emotion and reason, and asked the government to issue a pension to each family member, so that the pathogen was completely eliminated.

Chu Yun doesn't think there's anything wrong with people's generally conservative ideas. It's still a long way to go before the common people of this era can accept advanced common sense, so we can only take it slowly.

On the 30th day of the plague, only one month after the outbreak of the plague, the finishing work came to an end, and the investigation team prepared to return to the capital after ensuring that there were no abnormalities.

(End of this chapter)