Nineteenth Century Medical Guide

Chapter 412 408. The second visit

Newspaper news will not affect the progress of Kawei's experiment, let alone his determination to complete the experiment.

As he said in response to Holt: "It is impossible for me to go to the zoo to buy African monkeys and orangutans, and it is even less possible for me to change the rules of medical experiments and use those that greatly reduce the success rate of experiments for the sake of some people's overflowing love. Small animals."

Holt knew Kawei's temper, and the experimental subject would not change again, and most of the interest he had just raised was immediately cut off.

Personally, he doesn't care. If something goes wrong, he can take the blame and deduct the money. Even if he is fired, he won't have no work to do. After all, he doesn't agree with Kawei's radical approach, but he doesn't like the outside world's criticism of medical research.

The doctors don't care, no one cares about the news anyway. Being the target of deliberate verbal abuse might also help with sales promotion, letting everyone know that there is such a doctor following in Kawei's footsteps.

No matter what kind of person he is, it doesn't matter to Huo Te. The only thing is that the association cannot be involved. After all, the equipment, reagents, materials, and venues are all provided by the association, so they will inevitably be attacked.

The trouble is, I agreed just now, but now I suddenly change my mind and it seems very embarrassing: "Dr. Kawei, why don't you think about it again? It doesn't matter if the experiment lasts longer, if you are labeled as animal cruelty by the media."

Kawei could see that he had concerns, and if he didn't make it clear, he would be the only one to do it: "Considering the Paris World Expo and the surgery after His Majesty the Three Emperors, I personally would definitely like to do the experiment in Paris. But if Paris cannot meet my needs, If you ask for it, then I have no choice but to go back to Vienna.”

It takes a week to travel from Vienna to Paris and back. It is definitely most convenient for the experiment to be nearby, but it is not necessary.

"To do this kind of work, you have to make some friends in the media and ask them for help." Holt was also helpless, "Tomorrow I will go to the School of Medicine of the University of Paris to make room for you."

"Using dogs for experiments is a decision I made after careful consideration, and there is no room for change." Kawei said. "The patient's condition is not optimistic, and Director Landreth knows this very well. I want to get the results within a month. It's feasible." Just do the surgery directly, I don’t have much time to waste.”

"Correct."

The four of them were about to leave in a blink of an eye. Holt said something was wrong and stood up to stay: "Things can be discussed easily. You have to give me some time."

"When can we start?"

Holt's mind was spinning very fast, and he quickly thought of a way, but it was a bit shady, but he couldn't care about that much now: "Okay, I'll give you a month. As long as the experimental results can be shown in the end, even if the operation fails, it will be enough." Changed the reputation.”

"So sure?"

Carvey's experiments all require dogs.

"one month"

Unlike modern beagle dogs specially supplied for experiments, stray dogs on the street have different personalities, different sizes, and many diseases. It's nothing to fall ill. What's troublesome is rabies, which brings a high risk of arrest.

For this, Kawei paid a lot of money, and also specially asked Lex and Xiaona to wear thick cloth long gloves just in case.

"October 6th?"

"In three days."

The four of them said goodbye to Holt and left the Surgical Association.

"You want to go back?!" Holt was anxious. "You are holding His Majesty's personal invitation letter in your hand. All of Paris knows that you will attend various opening events in the next month. Now you are saying that you want to go back?"

"Okay, that's it."

"Surgery comes first, so experiments also come first."

"I can't guarantee it, but time is really tight. I will try to shorten the experiment time and perform surgery as soon as possible."

"Thanks."

Landreth finally reacted, took two puffs of smoke, and replied calmly: "This is your patient, you can do whatever you want."

Kawei winked at the internship team, and the three of them stood up one after another. He also gave Holt an ultimatum: "If I don't get the support of the Paris Surgical Association, I can only go back to Vienna. Of course, in order to be able to observe patients at all times, In this case, Bertha needs to leave with me."

"Yes, rabies, President Holt didn't think of using this to prevaricate you just now." Savarin felt strange.

"If he really said that, I guess Dr. Carvey would definitely respond with 'I'm already helping Paris eliminate rabies, what else do you want from me?'" Koch was more concerned about the safety of the experiment, "But , rabies will indeed bring safety risks to experiments.”

"To say that there is a hidden danger is still an understatement." Savarin felt that something was wrong. "Wild dogs are the source of rabies. Although the chance of encountering one is low, once you do, the chance of getting sick and dying is 100 percent."

Kawei leaned his head on the carriage window and looked out the window: "It is indeed dangerous when catching, but I can guarantee that the dogs entering the laboratory are normal."

"How to judge?"

"People who capture stray dogs will screen out dogs with abnormal behaviors, such as being extremely excited, showing obvious aggression, having strong saliva secretion, constantly chewing, and having difficulty swallowing." Kawei clapped his fingers and said one by one, "The capture was successful. Finally, we will keep them for a period of time, and then we will screen out a batch of sick dogs after the laboratory is ready.”

The two rounds of screening were considered quite rigorous at the time, but in Carvey’s view it was just a stop-gap measure. The use of experimental animals must be standardized sooner or later. Instead of waiting for others to do it, it is better to do it yourself.

"Don't worry too much. I have found several kennels on the outskirts of Paris, and I will be able to deliver a batch of safe dogs to the laboratory in a while."

"Not bad." Savarin nodded, but suddenly felt something was wrong. He looked up at him and asked, "Wait, after a while? Didn't you say it would be over in a month?"

"Do you really believe him?" Koch had already seen through the trick. "It only takes two weeks to recover after the operation. One month can only prove postoperative survival, but cannot prove the long-term survival rate. This is for a six-year-old It’s too short for a little girl.”

"Ah this."

A month's experimental time is indeed very abstract, and it can only deceive a guy like Holt who is far away from clinical practice and laboratories. But Kawei really sincerely hopes that the experiment can end within a month, and at least he should get a relatively definite answer within a month, and cut off the "bomb" in Bertha's body as soon as possible.

Kawei explained: "The pathological changes caused by allogeneic blood vessel transplantation into the body are very slow, so the experiment can never end within a month. Moreover, there are various preservation methods and processing methods after blood vessel removal, and it still needs to be continued after the operation is completed. "

"If that's the case, the investment is not small." Savarin began to worry about Kawei's financial resources. "Those kennels will increase the price if they know you are short of dogs."

"So we still can't give up this avenue of stray dogs."

Kawei thought about it for a while, looked at the time, and asked Xiang Koch: "What do you think causes rabies?"

"As far as I know, it should be an infectious disease. Scholars have done experiments as early as 60 years ago." Koch said, "Secondly, it affects the nerves and brain. Once the infection is completed, there is no cure. Maybe." "According to your microbiological research report, infectious diseases should be caused by microorganisms," Kawei asked, "Are you interested in conducting rabies experiments at the same time as the surgical experiments?"

Koch shook his head: "The time is too tight and the manpower is not enough."

"Aren't there still those doctors recommended by President Holt?" Savarin said.

"This is different. They are surgeons and are more suitable for Dr. Carvey's vascular experiments. Infectious diseases deal with small things under the microscope. Without the corresponding experimental operation foundation, it will be a disservice." Koch looked at Savarin , "I also failed more than a dozen times before I got the hang of it."

Before Koch published his treatise on microorganisms, there were very few people studying this area. Basically, it was just some guy on a whim who took a microscope and worked alone in the laboratory. The results are not only slow to come out, but also very easy to fail. Too many failures will naturally affect the mood of the experiment and lead to a vicious cycle.

"Paris is indeed a good place." Carvey said with a smile, "It happens that there is a microbiologist here."

"expert?"

Savarin was still in the dark, but Koch came to his senses and immediately thought of the academician of the French Academy of Sciences: "No wonder you asked if you wanted to meet him when I first met you. It turned out to be because of this incident. "

"Originally, I wanted to wait until the experiment was in place before going there. I saw that you were very interested in rabies, so I decided to go there." Kawei hesitated, "Although he is not optimistic about your experiment and even expressed opposition, it is undeniable. He is indeed more experienced than you and I in microbial research."

Of course Koch did not dare to deny it. He had never felt that he was better than Pasteur: "Of course he has more experience than us and is very, very capable, but his temper is too bad. After several letters with him, the results were all different. .Forget it.”

"Is that why you didn't come to Paris to see him?"

Koch rarely showed his fearful side: "I have just graduated and have only been doing research for half a year, but I don't have your fearless courage."

"Well, it would be better if it took more time. It was like this in the few months when Teacher Ignatz first met me." Kawei looked out the window and asked, "How about it, do you want to go there now? "

"Now? It's almost 10 o'clock now."

"I won't be free tomorrow." Kawei's schedule is very tight. "No, not just tomorrow, I will be very busy in the next week. Besides, if you don't attend the opening ceremony, the laboratory will not be available for a few days."

"That's not what I meant. I just think it's too late for Professor Pasteur."

"How can a guy who is always doing scientific research go to bed early." Kawei looked at the moonlight shining into the car outside the window. "A quiet night is a good time for work and the best time to think about problems."

Koch really didn't have the confidence to face Pasteur's doubts alone, so he thought about it again and again and agreed.

Cavella opened the window and said to the coachman: "Do you know where Professor Pasteur's house is?"

"I know, it's just southwest of the University of Paris, three streets away."

"Just go there."

The coachman nodded and gave each of the two horses a whip, speeding up the carriage that was about to slow down and turn.

In the old city of Paris, where stray dogs are everywhere, the incidence of rabies is not very high. It is only because of the 100% mortality rate that it has become a long-standing problem in urban governance. The reason why modern people can talk about rabies calmly is that in addition to the improvement of their cognitive level, the most important thing is the availability of safe rabies vaccines.

The purpose of visiting Pasteur this time was to put the research work on rabies vaccine into his hands 20 years in advance.

As Carvey said, Pasteur's working hours would last until after 11 o'clock in the evening. When four people knocked on the door of his house, he was organizing his desk.

This visit seemed much easier than the previous one.

When the housekeeper answered the door and saw Kawei's face and heard his name, he opened the door and invited them in without asking. Ten minutes later, the four of them finally met the world's most famous microbiology expert in the lobby on the first floor.

"Mr. Carvey." Pasteur glanced at the remaining three people, "I guess the author of the original experimental report was among them, right?"

"It's me." Koch knew he couldn't hide, so he raised his hand to announce his home, "I'm Robert Koch."

Pasteur was born in 22 and is already 45 years old. Looking at the group of young people in their early 20s in front of him, he can't help but feel a little anxious. In order to cover up this emotion, he had to ask the butler to send a bottle of wine: "This is from several wineries in Lyon."

"Thank you."

Over some nightcaps, the conversation began in earnest.

Kawei didn't want to waste time, so he got straight to the point: "We recently need to do some experiments on dogs, about blood vessel transplantation. Because stray dogs often have rabies, and in order to make the experiment safe enough, we hope you can help study rabies together." "

The amount of information in just two sentences exploded, and Pasteur had to ask a few more questions before he understood the logical relationship: "Rabies, what do you think?"

"We all believe that it is an infectious disease that damages the nervous system." Kawei first said the results. "According to the results of our research, infectious diseases and microorganisms are closely related, so we hope to find the causative pathogen through experiments. If we can It would be better to find a solution.”

"Forget about looking for pathogens. I've tried and can't find them."

Pasteur directly denied the feasibility of the first experimental goal: "As for the solution, since the pathogen cannot be found, it means that the infectious disease is not necessarily related to microorganisms. It may be that the body itself has produced some special changes."

“How does this explain the characteristics of communication?”

"Don't worry young man, I just made a hypothesis casually." Pasteur swung his glass and explained, "The solutions to most diseases have nothing to do with the causative factors. Finding the right solution is like looking for a needle in a haystack. Same. How many doctors have been trying to solve this ancient disease for thousands of years and there is no way.”

Two basins of cold water poured cold water on Koch and the others. They felt as embarrassed as when they were looking for a graduation thesis topic.

Instead, it was Carvey who proposed to come to Pasteur and he enjoyed the wine leisurely: "This wine is really good. It is different from the Burgundy and Bordeaux I have tasted before. Professor, which winery is this wine from?" ?”

"Produced in the Rhône Valley, Lyon Boulder Winery? Or St. Pierre? I forgot too." Pasteur didn't care about this at all. What he really cared about was Cavell's opinion, "Don't just drink wine. The experiment is yours, please give me your opinion."

"I am just a surgeon who operates a knife, so what can I say about internal diseases? However..." Seeing their expressions of embarrassment, Kawei still pierced the window paper, "Such a high mortality rate reminds me of Another disease."

"What disease?"

"smallpox."

(End of this chapter)