Krafft's Anomaly Notes

Chapter 288 New Drugs
In the homeland of otherworldly spirits, there are usually many steps required to bring a new drug to market.

Experimenters need to identify a drug target from a vast number of options, and then search for compounds that can act on this target. The source may be long-term research and development, or it may be due to an unrelated experiment.

After completing the difficult or European development, the experimenters proved at the cellular level and animal experiments that the drug can indeed solve the disease and will not solve the patient at the same time. After a lot of lengthy but necessary ethical approvals, it may be able to enter the market. Clinical trials, from experimental animals to humans.

In the early barbaric development era when security awareness and conditions were not sufficient, developers occasionally used themselves as substitutes. Of course, that's not recommended.

After approval, the drug enters what is known as Phase 3 clinical stage. The first phase is to test the pharmacokinetics of the drug in the human body and clarify the safe dosage; the second phase is to initially evaluate the effectiveness and safety of the drug to provide a reference for subsequent trials.

In the third phase, the trial will be expanded to further verify the effectiveness and safety through a large-sample double-blind randomized controlled trial. It needs to be carried out by multiple medical centers under the strict supervision of doctors.

Only a lucky few can spend years going through these steps, and are finally approved for production and marketing. They can benefit one party as a patient savior, or harm the other party as a fish that slips through the net.

Although on a longer time scale, there will always be fish that slip through the net in various senses, this is still an important line of defense to ensure life safety.

In the current North, the situation is much simpler.

As long as a person who claims to be a doctor comes up with a new drug through research and development methods including but not limited to personal thinking, literature research, pharmacological derivation, taking supplements according to what he eats, and dreams from gods and men, etc., then he can submit it to the doctor on the same day. Colleagues in the industry, friends and family, and ignorant patients announced the good news.

This drug will then enter markets of different sizes and be applied to different groups of people depending on its personal influence.

The effects and consequences of drugs, as well as the resulting social problems, are left to doctors and patients to decide.

Digitalis is a drug with a toxic dose that is close to the effective dose. It is a drug that needs to be used with diagnostic capabilities. Unlike ether, it is purely natural and requires almost no threshold for preparation.

At present, most doctors with a similar level to David only prescribe medicine for edema. However, in addition to edema caused by heart failure, there are also nephrogenic edema, nutritional edema, and allergies and inflammation can also cause edema.

When he feels that a drug should be effective but is actually ineffective, taking David as an example, his first reaction will definitely not be that the diagnosis is wrong, but that he will increase the dosage of the drug.

If they dare to announce the ingredients today, they will create a large number of cases of digitalis poisoning the next day. At that time, instead of thinking about how to treat it, it is better to go directly to the priest to learn about medieval hospice care, which is more cost-effective and reduces doctor-patient conflicts.

For the sake of people and himself, Kraft felt that it should be tried on a small scale first, and then introduced in conjunction with the diagnostic criteria for heart failure.

Therefore, there were only rumors among individual patients that there was some kind of special medicine for edema in that special clinic. This was nothing compared to "tuberculosis treatment" and did not attract much attention.

Green raised his forehead, which was pressed with red marks by the folds of his sleeves, and found that the light of the candle on the candlestick was already weak. The flames were falling along the snake-shaped twisted black line, and were about to be submerged into the mass of molten wax.

There are several documents spread out on the table, which were just delivered today. This month's expense accounts, pensions for martyred monks, daily reports, and official letters from the bishops' conference.

He didn't seem to have finished processing it all before falling asleep.

He had already read the last one, which was given to him personally by his direct superior. His attitude changed slightly from before, saying that the matter was over, and suggested that he take some rest before devoting himself to other matters.

A few days have passed. Unexpectedly but reasonably, the bishops' conference has not made any substantive punishment for the casualties. It only issued written accusations, prohibited participants from talking about related topics, restricted the scope of movement for two weeks, and went to the hospital regularly every day. The small prayer hall reflects under the gaze of the Father.

It's more of a comfort than a punishment.

Looking at this development trend, things are really going to pass like this, stranded calmly in the tributaries of time, left far behind, just like those things that happened in the past.

From a personal point of view, I inevitably feel a little reluctant, but rationally speaking, Kraft's attitude is right. Letting those things continue to be buried deep underground and never come into contact with them is the best way to deal with them. As for himself, now he needs to tie up the matter, arrange the pension work, explain to the families of the deceased that they dedicated themselves to the Father, and go to the perfect country first.

He felt very awkward every time he read these words, and the thoughts of those who firmly believed in embarking on the road to "end all pain" and the smiles cast on their faces repeatedly appeared in his mind.

"The paranoid pursuit of metaphysical concepts, and the expectation that a supreme external force will intervene to achieve it." This experience gave rise to a deeper feeling in his heart. He felt that he should write it down, "It never ends in tragedy."

Except for a few documents on the table, there was no extra paper at the moment, and not even a bookmark could be found.

"Wardin, can you get me some more paper?" Green called out the door and continued to open the report sent by the monk. Wading had just delivered this, and he was still outside helping to sort out the rest of the paperwork.

Since the attack on the clinic, the heretics have not organized any activities that can be noticed. Probably their main members are, as Kraft judged, entering the other world and never coming back. Naturally Toward self-destruction, no need to pay much attention.

However, the sentries around the clinic have not yet been removed, so part of this report was sent by them. There is no new discovery, and the main content is just one thing.

[A professor recently started using a new drug, which is said to have remarkable effects]

Green put his cold hands on his face, trying to wake up his brain that was not yet fully awake. How could it be such a coincidence that a new drug was developed within a few days of returning with the sample?
No, you have to go and see.

"Wardin, can you come here?" The priest read the next two sentences. They were all anecdotes and invalid information collected from the patients. Someone had to go and look at them.

"Wardin.?"

Green pushed the chair away and looked at the half-open door. This was the second time he called Wadin. A strange feeling arose, as if the stones thrown into the pool failed to cause normal ripples, and there was no sound of falling into the water.

Maybe he didn't want to be disturbed and left early?
"." A voice, a vague voice.

Before I could distinguish its location, it disappeared, evaporating like water mist, as if it had never appeared. It's not Wading. His voice is very young, like a child who has not yet reached the stage of voice change.

"Who? Are you still out so late?" There are indeed children in the church, but they are all in the choir, have fixed residences, are strictly controlled, and rarely wander to other places.

If he got lost, he'd better send the person back as soon as possible, otherwise the little guy would be reprimanded lightly.

Taking a step towards the door, the strangeness became more obvious, and turned into a sense of violation that could not be ignored. Wading should not leave without closing the door.

"." A breath-like air seeped out from the cracks in the floor tiles, old and shriveled, blowing into the ears.

Fear makes the heart tighten, the spirit tightens, and the force is exerted subconsciously. However, as soon as his feet were free, the floor shattered and pulled away, and everything around him flew away quickly, falling into the boundless thick darkness. The feeling of weightlessness made the body tremble instinctively.

The fall lasted only a moment, and a feeling of support appeared under the folded arms.

Green raised his head, the stinging pain from the folds of his sleeves still lingering on his forehead, and the candlelight flickered in front of his sleepy eyes. The pitter-patter droplets blew into the room with the night wind, wetting the manuscript on the table and falling on the face.

it's raining outside.

(End of this chapter)