Krafft's Anomaly Notes

Chapter 297 Drug Induction
Digitalis and belladonna are the only two natural botanicals that are truly confirmed to be effective, and their mechanisms are relatively clear.

The former is a fresh plant that was recently picked and delivered; the latter is a souvenir from the trip to Westminster, which has been dried and preserved, and may have a few unpicked blueberries mixed in.

Of course, while they were still fresh and the difference could be seen, Craft had no time to distinguish them carefully. After drying, it can only be said that it is exactly the same thing, almost like strawberry seeds falling into a pile of white sesame seeds.

Fortunately, there are no accuracy requirements now, and I believe the sample will not mind whether the reagent has a fruity aroma.

Take two teaspoons of dried fruits and boil them in the remaining hot water. The shriveled fruit swells, and the liquid is dyed with a layer of light purple, which looks very beautiful in a highly transparent white glass container.

In fact, when belladonna appears at a banquet, it is not always the proud work of assassins, but also becomes a dangerous cosmetic.

Due to aesthetics that Kraft could not understand, some people insisted that larger pupils would make the eyes brighter and more charming. It happened that some wizard discovered that belladonna poisoning can cause pupil dilation.

As a result, belladonna eye drops have become a popular beauty product. Drop a little before going out and you can have sparkling and charming large pupils. Although there are always accidents with varying consequences, there are still only a lot of fans.

This is probably one of the earliest examples of belladonna's medicinal use, and nicely explains its pharmacological mechanism as an anticholinergic drug. Since cholinergic receptors are widely distributed in many smooth muscles and glands, belladonna can affect a very wide range.

The pupillary sphincter, which controls pupil constriction, is of course one of them. It has to be said that topical use as eye drops is a relatively wise way to use it - the wisest way is not to use it blindly. "To use blindly" here can be used in a literal sense.

Craft used a quill to absorb a small amount and dropped it on the sample that had returned to normal. The surface without the protection of cuticle quickly absorbed the liquid, and the purple color penetrated into the translucent software, slowly spreading and fading.

Following the color diffusion trajectory, you can see some small capillary tubes that are invisible when the color is not developed. The absorbed liquid is transported along with the tube system and quickly penetrates a corner of the sample, then stops abruptly.

With a small but complex fluctuation, the flow of body fluids suddenly got stuck. It seems that the valves in the pipeline are closed, forcibly limiting the drug to a certain range, and the diffusion rate is greatly slowed down.

"Is this okay?" The valves in normal blood vessels should function as one-way valves to prevent blood from flowing backward, but in the sample, this simple structure seems to have been modified and can control opening and closing as needed.

You can choose to control the poisoning locally, instead of being absorbed and spread throughout the body through blood circulation like people.

Kraft tried to pour more liquid, but it became "smart" and did not choose to absorb it. Instead, it formed the same cuticle as before to isolate itself from the outside world.

This cannot dissuade the professor from continuing the experiment. Since it doesn't absorb, inject the drug into it.

He didn't have a syringe in the strict sense yet, and he hadn't thought about getting one before. From his perspective, there are basically no drugs suitable for injection.

Unfortunately for patients, the concept of intravenous injections emerged long before drugs suitable for intravenous administration were available.

Some people have long tried to inject drugs into blood vessels to speed up their effects, but of course they did not use syringes. In theory, it only requires a thin pointed tube and a container that can provide pressure.

"Next time I should really ask the Higo family if they can make a syringe. Digitalis will make them agree." Due to limited conditions, Kraft used the ancestor of the syringe provided by the clinic - which uses animals to temporarily store liquid metabolic end products. A skin bag made from organs.

"Uh, that thing looks a bit like..." Kupp felt that the shape and liquid storage method of this tool were a bit off.

"You are right. If I ask for it, David will not be able to use it on patients." Kraft connected the needle and balloon, sucked up the belladonna solution, and injected the liquid into the sample.

In order to prevent difficulty in spreading, he deliberately injected at different points and depths in batches.

The sample ball, which was completely dyed lavender, expanded and contracted violently, with a significantly accelerated frequency. However, the digestive vesicles inside became stagnant and sluggish. Some parenchymal granules and small masses of different colors proliferated and became larger, and there were abundant new blood vessels. Maintaining their supply is suspected to be the compensatory enlargement of the secretory glands.

As expected, there was another complex wave of fluctuations in the field of spiritual senses that could not be analyzed. Presumably, target receptors are everywhere, causing the entire body to adjust.

It took some time for the sample to adjust. The intensity of the fluctuations was even stronger than when encountering high temperatures, but it was also more chaotic. For imbalances in different systems caused by the same drug, it chose to simply respond with changes in multiple pathways.

The assistant noticed confusion and a little disappointment in the professor's seriousness.

"Make the juice from the stems and leaves of the purple bell flower, hurry up." He ordered. No one is turning the hourglass anymore, but there seems to be some other timer urging it.

"Please wait, it will be ready soon." Coop threw the whole plant into the washboard-like juicer, pressed it down to squeeze out the fresh juice, bottled it and handed it to his eager employer.

After a simple four-fold dilution, digitalis injection was squeezed into the sample that had just calmed down.

Unlike the brightly colored belladonna tea, the light yellow-green solution is difficult to distinguish and impossible to trace after entering it.

Kraft subconsciously widened his eyes and waited for the result. As time passed, the familiar pain and discomfort unexpectedly became less severe. On the contrary, an uneasy feeling of ease developed.

It should be almost time, but physically it wasn't there yet, and he wanted to see it again.

The overall activity of the sample slowed down, but the amplitude became larger, as if it changed from a short gasp to a deep breath. Those rhythmically moving muscle fiber bundles powerfully pulled the surrounding tissue and contracted inwards.

The strengthened contraction squeezes the body fluids in the pipeline and pumps them to all parts of the body at high speed, affecting more muscle bundles, so the contraction becomes more powerful.

After this trend reaches a certain limit, the situation is reversed, and the frequency of contractions begins to accelerate and the intensity becomes weaker.

When the frequency reaches a certain level, the scale of contraction is reduced to an extremely unsatisfactory level. Rather than relaxing and contracting, it is more like spasming and trembling. High-frequency, shallow and fast contractions can no longer effectively generate pressure.

Conditions that occur in humans also appear in samples, manifesting themselves in similar ways.

If this is used to explain the electrophysiology of myocardial cells, it is extremely intuitive and will be a good teaching aid. The contraction of myocardium requires maintaining a certain ion concentration difference between extracellular and extracellular cells, and digitalis' sodium-potassium pump inhibitory effect will destroy this state due to changes in potassium ion concentration difference after reaching a certain level, resulting in a decrease in resting potential.

For anyone who happens to remember a little bit of the basics of cellular electrophysiology, it doesn't take long to figure out what this means—increased excitability.

It manifests itself in the heart, which is getting faster and faster. When it reaches a certain level, like a twitch, its contraction no longer produces effective pressure, just like a hand that is constantly twitching cannot lift anything.

【Ventricular fibrillation】

The most fatal arrhythmia is formed, and the entire process is visualized. The professor looked at Coop regretfully, but it was a pity that the only teachable subject here was far from learning this level.

"Let me see, how are you going to deal with it now?" Kraft observed the sample with interest, his concentration increased to the extreme.

The entire circulatory system of the sample should have been completely shut down by now, and it would be useless to create any new tissue unless it could reverse this critical problem.

His expectations were answered.

A new wave of waves overflowed from the moon's skeleton. It may not be very strong, but it was not accompanied by too much clutter, so that it stood out in a brief moment and reached a recognizable level.

The always-prepared mental organ senses it and burns this ripple that cannot be described in other sensory forms into precise memory.

Visibly to the naked eye, the twitching of the myocardial bundle branches within the sample was controlled.