Director: The special effects are too expensive, so I had to make real shots

Chapter 38 Tyrosine Kinase Inhibitors in the $24000 Box
"Guan Ju, I'll give you some key words, see if you can analyze what kind of disease it is."

"Let me try."

“关键词有.9号和22号染色体，编码P210、P230和P190蛋白，还有Bcr融合基因什么的。”

Xu Nuo told Guan Ju some of the key words on the paper that he had memorized.

"BOSS, according to my analysis, this should be a Ph chromosome formed by the patient's balanced translocation of the long arms of chromosomes 9 and 22, thus forming the Bcr-Abl fusion gene, because the Bcr-Abl fusion gene encodes P210, The P230 and P190 fusion protein interferes with the normal physiological functions of cells, leading to excessive cell proliferation and inhibition of cell apoptosis, which leads to chronic myeloid leukemia."

"Chronic myelogenous leukemia!"

Xu Nuo was shocked when he heard this.

It turned out that the assistant Wen Ruohan went to the hospital for an examination and was found to have chronic myelogenous leukemia.

It's no wonder that she's not the same as before these days, and she has completely lost the lively and cheerful energy she used to have.

"How can such a young girl have such a disease?"

Xu Nuo felt it was a pity.

"Compared with overseas patients, domestic patients with chronic myelogenous leukemia are younger, but usually the age of onset is 40-50 years old. It is really rare for people like Wen Ruohan to suffer from the disease in their early 20s."

Even the tone of Guan Ju's answer contained a trace of regret.

"Chronic myelogenous leukemia. Is it the disease in "I'm Not the God of Medicine"?"

Xu Nuo suddenly thought of "I'm Not the God of Medicine".

No wonder this leukemia sounds familiar.

When Xu Nuo was on Earth in his previous life, after watching "I'm Not the God of Medicine", he still had deep feelings.

"Guan Ju, how many CML patients are there in China?"

Xu Nuo asked.

Guan Ju: "CML patients account for about 15% of leukemia patients, and there are about 400 million leukemia patients in my country, so the number of CML patients is about 60."

"So many. Ugh."

Xu Nuo couldn't help sighing, and then asked: "Then what is the best drug in the world to treat this chronic myelogenous leukemia?"

"Imatinib mesylate, a tyrosine kinase inhibitor drug developed by European Nori Pharmaceutical Group, is currently the world's mainstream targeted drug for the treatment of chronic myeloid leukemia."

"How much is the domestic price?"

"24000 yuan/box, one box is one course of treatment, and the average patient needs to maintain one course of treatment a month."

"It's so expensive, isn't it covered by our domestic medical insurance?"

"Boss, due to the large number of chronic myelogenous leukemia patients in China, and the number is increasing year by year, the negotiations between the European Nuori Pharmaceutical Group and the domestic medical insurance have been deadlocked and no progress has been made, and there is little hope in the future."

Guan Ju replied.

"Twenty-four thousand a box, without medical insurance, who can afford it?"

Xu Nuo shook his head after listening.

The price of this drug in China is sky-high. If ordinary people suffer from chronic myelogenous leukemia and want to survive, they will really lose their fortunes.

Especially my assistant Wen Ruohan, who originally had a bright future by following him, but now it seems that this disease has shattered all the good illusions.

"In our country, is there no pharmaceutical company developing domestic tyrosine kinase inhibitor drugs?"

Xu Nuo stroked his chin and began to ponder.

"Because of the long drug development cycle, high cost and high risk, domestic pharmaceutical companies have not carried out in-depth research and development on tyrosine kinase inhibitor drugs, and patients can only buy imatinib mesylate from the European Norry Pharmaceutical Group. .”

Guan Ju explained to Xu Nuo.

"Is that so, is there any generic imatinib mesylate sold in China?"

Guan Ju: "The sale of generic drugs is an illegal act. According to online information, there have been many gangs who sold generic imatinib mesylate drugs in the past, but they were quickly brought to justice."

Naturally, Xu Nuo would not sell generic drugs.

Even if I want to work hard on chronic myelogenous leukemia and make a film "I'm Not the God of Medicine", it's still to develop our own domestic tyrosine kinase inhibitor drugs.

But Xu Nuo didn't have the ability to develop drugs.

This is completely inconsistent with Xu Nuo's major.

Without huge biomedical knowledge as a basis, even if the new drug technology of tyrosine kinase inhibitors is exchanged from the system, it is a castle in the air.

Therefore, Xu Nuo does not plan to develop drugs by himself, but can let his own company do it. Then the company needs a medical laboratory, a group of high-quality students in biomedical research and development, and a sum of money.

Biomedicine, human health, this is also a promising field of science and technology.

In the next second, Xu Nuo pulled out the system panel.

"This biomedical technology-[new generation tyrosine kinase inhibitor] needs 2 entertainment points to redeem, so how many entertainment points can I get after my movie "Terminator" completes the box office task of 20 billion? "

Xu Nuo asked his own system.

""Terminator" completes the 20 billion box office task, and can get +5 entertainment points. As of today, the real-time box office of "Terminator" is 12.71 billion yuan."

"It will take a few days to get these 5 entertainment points, but it doesn't matter, it takes a long time to develop drugs."

Xu Nuo first put this idea into his plan.

It seems that if I want to get more black technology in the future, I should make more movies to earn entertainment points.

While Xu Nuo was pondering, his assistant Wen Ruohan entered the office.

"Boss, here is your itinerary for the Rabbit University of Science and Technology and the City Science and Technology Expo." Wen Ruohan handed the completed itinerary to Xu Nuo.

"Put it here."

Xu Nuo nodded, then couldn't help but glance at Wen Ruohan: "Xiaowen, you."

After thinking about it, Xu Nuo decided not to tell Wen Ruohan about her chronic myelogenous leukemia for the time being. After all, it was a big blow to him.

As long as the disease persists in taking medicine, it can remain stable, no different from normal people.

The only problem is that for patients, the financial pressure is really too great. After all, a box of imatinib mesylate tablets produced by European Nori Pharmaceutical Group costs 24000 yuan.

But Wen Ruohan’s monthly salary is only more than 1 points, and the rest has to be filled at home, but he has to eat one box a month. Even if he is a well-off family, he will have to be dragged down by this disease. .

Xu Nuo still remembers a sentence in the movie "I'm Not the God of Medicine" in the previous life on Earth, which probably means that no matter what family, if you get this chronic myelogenous leukemia, the end result is to take medicine all the time and then sell your house and car, and your family is ruined. .

"Boss, what's the matter?"

Wen Ruohan asked suspiciously.

Now she has put away her depressed mood, showing the same optimistic and cheerful personality as before, with a smile on her face, because she knows that to work in the company, she still has to be active.

"It's okay, I just thought, since you joined the job, you have been doing a good job. During the filming of "Terminator", you also followed the crew to complete various daily tasks for me. I can see your efforts. "

"Hee hee, boss, this is what I should do."

Wen Ruohan laughed happily when she heard the boss praised her ability again.

"Hippie smiley face, huh?"

Xu Nuo glared at his assistant Wen Ruohan, and then said: "Now our "Terminator" is doing well at the box office, and the company has a few new orders, and everything is booming in a good direction, so I thought For a moment, I am going to give you a wave of salary increases."

"Wow, salary increase, really boss?"

Wen Ruohan became even more excited when he heard that the boss was going to raise his salary.

"Can I still make a cake for you? Now your salary is [-], right, and I will give you an increase of [-]."

"Thank you boss, I feel more energetic at work (*^▽^*)"

(End of this chapter)