Rekindle 2003

Chapter 540: I am sick

Can't keep it secret?

Qing Yun didn't care at all about this issue.

What he wants is no way to keep it secret.

Patting the two of them on the shoulders, he smiled weirdly and said, "Just do it. If others see it, it's not your fault."

Liu Shiheng was dumbfounded when he heard this. He felt that the CPU in his brain was about to burn out.

Bai Le over there figured out a little bit about it.

However, he was not sure whether this was a public matter or a private matter.

Qing Yun, who saw Liu Shiheng's expression, smiled and said nothing. He glanced at Bai Le, who had some understanding over there, and said, "What do you think?"

Bai Le pondered for a moment after hearing the words, "Mr. Xiaoqing, you must have done it intentionally. You want to use the mouths of these people to leak the news."

Qing Yun nodded, "Smart, what do you think should be arranged?"

Bai Le did not answer in a hurry. He considered it carefully before speaking, "Mr. Xiaoqing, it is better to say it is an internal audit within the group. This way we can arrange the office in a legitimate manner and also give you a certain amount of exposure."

Qing Yun nodded slightly with satisfaction, "Okay! Then go ahead and make arrangements. I'll go upstairs in 20 minutes."

Bai Le's arrangement is in line with the norm, but it is also inconsistent with common sense.

But, this... is exactly the effect he wants to achieve.

……

Saturday morning at Yanjing Branch of Yanhuang Group was actually very leisurely.

Branch offices are naturally not as functional as subsidiaries, and they are newly built. They mainly serve sales.

In fact, if there is no business, it is okay not to work on weekends.

But if there is no holiday, employees will have no choice. If you are in sales, and you are in the consumer goods market, how can you have the concept of weekends?

The branch has just been established, and it is the stage of establishing rules. They are not newbies in the workplace, and they will not find any uncomfortable confrontation.

Fishing with pay is actually very enjoyable.

Everyone is tacitly ‘busy’.

It’s not that there’s nothing to do. A company has a lot of things to organize, file, and post invoices. You can do it on weekends to pass the time.

And there are interns here, so weekends are the best time to direct these college students.

However, today, the tranquility of Yanjing Branch was suddenly broken.

After the company boss Liu Shiheng came back from downstairs, he hurriedly announced in the office that the internal audit department of the group company would come in in 20 minutes, asking everyone to get started and prepare materials and documents that should be prepared. Prepare the voucher and ask the general department to quickly lead the interns to clean up the small conference room.

Welcoming inspections is a big deal in any company.

Regardless of agencies or enterprises, state-owned enterprises or private enterprises, even foreign companies cannot escape.

For foreign branch companies, this is the most important thing throughout the year, bar none.

No matter how good you are at your job, if you find nothing but mistakes, it will be like a year's work in vain.

Although the new employees of the Yanjing branch were surprised that the business was not inspected, they also knew that this kind of inspection was very random. Maybe someone else took advantage of the newly established company to check the start-up funds, expense reimbursement, etc. Daily style.

Everyone in the office suddenly became busy, which made Zhang Li a little confused.

Frankly speaking, the office atmosphere in the company just now was very similar to what it was like in government agencies when her parents had not resigned from their official positions when she was a child.

She had just gained some experience of daily work, and this sudden change caught her off guard.

Liu Shiheng, who was standing in the middle of the big office, saw this, patted his head, and quickly said loudly, "Xiao Zhang, you are responsible for receiving internal audits with the General Department. Be smart and sweet. You can buy some drinks and fruits these days." Send it over and report it to your sister Liu, remember to issue an invoice."

After that, Liu Shiheng started instructing other people on how to arrange the green plants, collecting the debris in the aisles to the warehouse, and asking people to buy cigarettes, place ashtrays, make tea and so on, making it all busy.

No one had any doubts about arranging for Zhang Li to receive the internal review.

The pretty girl does the reception and it's a pleasure to watch.

It’s not that there’s anything shameful about it, it’s just that he is an image engineer, majoring in flight attendants, and the most beautiful and elegant graduate who has never been in an airline company. However, in large companies, this is still the trend brought by Hua Wei.

But Zhang Li herself had doubts.

Let her do the reception?

Is this appropriate?

Isn't Mr. Liu afraid of being beaten by the big bad guy?

In the exchange last night, she had already understood how perverted the possessiveness of the bad guy was, so her clothes today were very conservative, even old-fashioned.

After thinking about it, Zhang Li could only shrug her shoulders helplessly, turned around and followed Liu Shiheng's instructions.

After all, in the eyes of others, she is just a sales intern, which is what Qing Yun has made clear to her.

Although she didn't know what arrangements he would make for her, Zhang Li knew very well that Qing Yun could not treat her harshly.

The skin-to-skin contact in the car last night and Qing Yun's last-minute braking were very regrettable in Zhang Li's opinion, but they also represented his respect for her.

If it was just to play with her, there was no need to go back to her dormitory last night.

Therefore, she is still confident about this. He wants to be together for a long time, and so does she.

At this moment, I felt aggrieved as much as I could. Anyway, I just wanted to prevent others from taking advantage. In the end, he found out that Liu Shiheng was the one who died. What did it have to do with her?

20 minutes is neither short nor long, and the time is up soon. The office has a completely new look, the windows in the small conference room are clear and clear, and the urgently purchased drink and fruit trays are in place on the conference table.

Qing Yun, who was wearing sunglasses on the bridge of his nose, led someone to go upstairs. Liu Shiheng led someone to meet him at the elevator door.

Zhang Li, who was standing in the crowd, rolled her eyes delicately, but the corners of her mouth turned up involuntarily.

It turned out to be the case.

He probably misses me too, right?

Zhang Li, whose pretty face was slightly red, suppressed a smile and listened to the greetings in front of her.

Qing Yun...oh, no, his name is Mr. Qin at this time, senior project manager of the Internal Audit Department of Yanhuang Group.

Zhang Li spat at the little liar in her heart, but her heart was filled with joy.

Husband and wife means husband and wife.

Damn scumbag!

Really good at flirting!

After giving him a vague look that said, "Sister likes her very much", Zhang Li followed Liu Shiheng's instructions, and like a polite lady, she guided Qing Yun and his party to the small conference room in a graceful manner.

Afterwards, there was a closed-door meeting. In the Yanjing branch, only Vice President Liu Shiheng, who was in charge of daily work, and Sales Director Bai Le participated. Even Zhang Li was invited out by Yang Bingnan.

Knowing that the man had something serious to talk about, Zhang Li didn't show any pretense. She just took advantage of the door closing to give him a soft wink with her peach blossom eyes.

Emperor Yun, who was wearing sunglasses, felt suddenly in his heart.

I have to say that Zhang Li's expression and demeanor were professional. The emperor's expression made him feel like a cat scratching a dog.

Many people are sick and need medicine, mainly because they are too...

itch!

How about copying this song out some other time, forming a girl group with your own women, and singing it to yourself?

Shaking his head, Qing Yun drove Qisi out of his mind and took the time to talk about business.

Since Zhiliu considers himself a grindstone, he won't be polite.

Although he still can't do anything to Zhiliu, Qingyun feels that it is the duty of the young people of our generation to allow the elderly to move their brains more and avoid Alzheimer's disease.

Opposite him, Liu Shiheng was giving a formal work report. Qing Yun listened for a while before interrupting him and started asking questions.

There is not much business. When it is first established, it is all about establishing rules and regulations. For these things, the group company has a template. It is nothing more than taking medicine according to the order. Many things require the business to be operational before problems will arise.     At the moment, the most important problem of Yanjing Branch, besides business, is personnel.

The team is unstable and there is no business to be done. Less than a month after joining the company, 20% of the staff have been lost. This ratio is actually very scary.

In ancient times, if the casualty rate exceeded 10%, the army would collapse. The same is true in modern companies. If the turnover rate exceeds 10%, the company will be disorganized.

This situation caused the hair on Liu Shiheng's head to decrease visibly during this period, and he naturally cried out in pain in front of the chairman.

A fussy child will be fed milk, no matter where you put it.

After listening, Qing Yun tapped her fingers rhythmically on the table, and after a while, she made a phone call.

Liu Shiheng and Bai Le over there were smiling happily.

When people are idle for a long time, they actually look forward to something.

But as they listened, they couldn't understand it anymore.

What the hell is this...

Qing Yun hung up the phone and pointed to Liu Shiheng and Bai Le's computers on the table, "Mr. Guo has sent the plan to your mailbox. The display prototype will be in place on September 9th. When it is in place, it will be launched immediately. You will prepare materials and sales team skills training based on this.”

Bai Le swallowed his saliva with difficulty, then licked his lips, and after hesitating for a long time, he finally spoke, "Mr. Xiaoqing, I understand your intention, but our current problem is that the people in our hands, we We have no idea who the traitor is. We can't keep this kind of thing a secret.

and……"

He gritted his teeth and continued, "What's even more difficult is that from the 11th to the 15th, there are only 4 days left, and I can't organize a new team."

……

"Judging from the plan jointly discussed by Fudan Fuhua and the health department, the consistency evaluation of generic drugs is completed through bioequivalence testing."

In the conference room of Fantasy Group, Zhao Linhuan, one of the five young marshals in charge of investment in the pharmaceutical sector, was reporting to Zhi Liu and other members of the executive committee of the group's highest decision-making body.

"The news we have received so far is that Fudan Fuhua's specific operation method is to recruit a group of healthy volunteers. The number is initially estimated to be about 200, and divide them into two groups. They will take generic drugs and original drugs one after another, that is, one group of volunteers One group of volunteers took the generic drug first, and then took the original drug after a period of time; the other group of volunteers took the original drug first, and then took the generic drug after a certain period of time.

Based on the comparison between the maximum blood concentration Cmax of the drug and the exposure dose AUC of the drug in the body after healthy volunteers take the generic drug and the original drug, the bioequivalence is determined.

If the Cmax of the generic drug reaches 70-143% of the original drug, and the AUC of the generic drug reaches 80-120% of the original drug, if this standard is met, it can be concluded that the generic drug is bioequivalent to the original drug and has substitutability. "

Zhao Linhuan knew very well that the group of people at the conference table did not understand these specific terms and indicators at all. After briefly introducing Fuhua's operating methods, he directly talked about his concerns.

"Actually, these two indicators are not too high. The drug concentration and exposure dose only meet the minimum standards of 70% and 80%, and they can pass the consistency evaluation.

From this plan, we can see that the country has actually made an opening and does not require these two indicators to reach more than 95%. This has given many manufacturers a chance to breathe and objectively reduced the difficulty. "

Li Qin, the second uncle of Fantasy Group, said with a confused expression, "Xiao Zhao, let me interrupt. Do you think I can understand this? The concentration of the drug is only 70% reaching the standard of the original drug. Does that mean that the drug itself The... impurities are inconsistent with the original drug?"

Zhao Linhuan smiled and nodded, "Yes, Mr. Li, you understand correctly."

Li Qin hissed, with a look of confusion on his face, "Does that mean that this medicine... is still ineffective. For example, 80% of the dosage is needed to solve the problem, but the medicine can only provide 70% of the dosage, which cannot cure the problem. threshold."

Zhao Linhuan hurriedly explained, "No, no, no, it is completely different from the previous ineffectiveness. In the past, there may be very few or even no active ingredients in the medicine. The current consistency, the minimum standard is to solve the problem. It just means that at the same dose, it is better than the original research." The medicine is slower, and at the same time, the blood drug concentration can be solved by the intake of drug dosage.”

He scratched his head and continued, "Let's put it this way, for example... Mycoplasma pneumonia infection, children need macrolide drugs such as azithromycin dry suspension, domestic generic drugs, you used to take More actually doesn't work either.

Now, after passing the consistency evaluation, using the imported azithromycin dry suspension, a total of 1000 mg of azithromycin dry suspension is taken for three days of standard treatment, while domestically produced azithromycin may require 1500 mg, which also solves the problem. "

Zhiliu smiled and added next to him, "It's okay, as long as the problem can be solved. Our Chinese country has a phobia of insufficient firepower, and we like to eat too much."

He knew a little about this aspect, and he was focused on the economic accounts. Now it seemed that the country had no intention of killing everyone, and he was finally relieved.

Generic drug consistency evaluation, this policy caught him off guard.

The previous investments in the Fantasy Medical sector were all small pharmaceutical companies, with the concept that they are the favorite "small but fine" companies in the capital market. After listing, there is huge room for imagination.

The consistency evaluation of generic drugs targets this type of enterprise.

At first, what he was most worried about was the high-standard consistency evaluation imposed by the state. After they counted the assets of the companies they invested in one by one, they tragically discovered that if they followed the 95% minimum standard, none of the companies they invested in would survive. .

Then, not only the billions invested by Fantasy Group will be wasted, but the tens of billions of leveraged funds formed through funds will also be liquidated.

For Zhiliu, this is a matter of life and death.

Not only did the comprador not make any money, he also lost his principal. It is strange that the master behind him wanted to kill him.

Now that Yanhuang Group's acquisition of TOP has become a reality, Zhiliu spent a lot of energy and connections to smoothen the relationship during this period. Now he finally breathed a sigh of relief and started joking.

The conference room burst into laughter.

Mainly because everyone saw Zhiliu smiling, and they laughed too.

The air pressure of fantasy is so low during this time that some laughter is needed, otherwise everyone will be out of breath.

The knowledgeable Zhao Linhuan laughed the most on the court.

He had no choice but to know what he was doing. If he didn't smile, he would be openly slapping Zhiliu in the face.

Zhao Linhuan felt that his head was not that hard.

So he didn't bother to explain more.

After the laughter subsided a lot, Zhao Linhuan continued, "Returning to the investment perspective, the country's original intention of doing this is to enhance public confidence in domestic generic drugs and reduce public drug prices through this operation. expenses and promote the development of the pharmaceutical industry.

Then, whether it is the intensity of policy implementation or the level of national and social attention, it will not be trivial. Therefore, the consistency evaluation of generic drugs aimed at improving the quality of my country's generic drugs will definitely have a disruptive impact on the pharmaceutical industry.

For domestic generic drug manufacturers, the consistency evaluation of generic drugs, referred to as GCE in the industry, is a matter of life and death.

According to statistics, the GCE cost of a single generic drug, including drug research, bioequivalence testing and other costs, ranges from 500 million yuan to 1000 million yuan, regardless of the result. Once a generic drug fails to pass GCE, the company will gain nothing. Some small businesses have had to withdraw from the game because of this concern.

Due to economic considerations, even big pharmaceutical companies have chosen to abandon generic drugs that are not competitive in the market. It is foreseeable that the next few years will witness the disappearance of countless generic drugs.

For those who come out on top in this massive competition, they will receive better equipment to compete against branded opponents.

This is for domestic and foreign multinational pharmaceutical companies. The impact of GCE on their business is long-term.

In theory, when the patent of a brand-name drug expires, any generic drug can enter the market at a more competitive price, thereby reducing the price of the original drug, leading to the so-called 'patent cliff' phenomenon.

In the Chinese market, almost no brand-name drugs produced by multinational pharmaceutical companies have truly experienced the patent cliff.

This is because the Chinese government has always given preferential treatment to patented brand-name drugs in order to encourage multinational pharmaceutical manufacturers to introduce more innovative drugs into our country.

Nonetheless, I believe that the rise of generic drugs in our country will inevitably reduce the necessity of this historic policy and eventually make it history.

The country's ultimate goal is to maintain innovation while keeping medicines affordable and effective. To achieve this goal, it is necessary to have both brand-name drugs and trusted generics.

In essence, GCE is a step towards our country’s future patent cliff.

So I personally have a conclusion on this matter. The final result of the consistency evaluation is a major reshuffle of the industry. The concentration of the entire industry will be significantly concentrated, and the number of players on the track will be significantly reduced.

The pharmaceutical industry is a process of supporting industrialization. The increase in shipments will drive the production of all raw materials, packaging materials and upstream fine chemical products, and the process can be continuously optimized. For example, the excipient process, API process, and the quality and process of upstream fine chemical products are all pushed hard. A product that passes the consistency evaluation can only be achieved if all products in the industry chain meet the standards!

Eventually, the entire industrial chain will be upgraded.

Therefore, I strongly suggest that we need to increase investment in the pharmaceutical sector to protect the projects we invested in earlier..."

Guo Wei, who was sitting on the side, touched his chin with a look of pain on his face.

……

(End of this chapter)