This doctor has a system

Chapter 265 254. The topic is too high-end and people are too impetuous

It was very quiet on the high-speed train. No one had any fractures, no chest pains, and no one. The group arrived in Beijing smoothly.

"No, why are you all in room 888 and I am in room 398?" Wang Zemin expressed his dissatisfaction.

"Is there any difference between 888 and 398?" Ai Hongkai asked.

"Is there no difference?!"

"I don't think so."

"Then let's switch." Wang Zemin said.

"I won't trade with you."

"Zemin, we came here for the purpose of studying, not for comfort. No matter how expensive the room is, its function is just to let people sleep." Xu Yinghui said.

"Yes, Wang Zemin, why do you have so many things to do?" Li Xun said.

"You guys." Wang Zemin wanted to retort a few more words.

"Okay, let's check in quickly. Don't let the layout be so small." Ma Huilan said, "Wang Zemin, if you feel you can't accept it, I'll change with you."

Now that the lesbians have said this, Wang Zemin can only keep quiet. He is not that thick-skinned.

Damn it, I seem to have entered the "high rape" den!Wang Zemin felt something was wrong, and decided to be more honest during the rest of the trip to avoid being tricked and causing some jokes.

"I didn't do this." Li Youliang explained, "It's over there."

"I didn't say it was you who did it." Gao Feng was a little confused. Wang Zemin only had a place to live. How could he have any objections to prostitution for free? Besides, what could he do if he had objections?

Gao Feng met Academician Bao the next day, and he took the time to talk to him for half an hour and fully expressed his importance.

"Who is that young man?" Professor Zhang Zhihe of West China Medical College was very curious.

"Gao Feng from Hnan Provincial People's Hospital." Someone said next to him.

"Oh, it's him." Professor Zhang suddenly realized that no wonder he received the courtesy from Academician Bao. It turned out to be this strong man.

Yes, Gao Feng is now considered a well-known figure in the respiratory world. Many people have shown great interest in him who suddenly appeared. In everyone's eyes, he is an out-and-out genius.

"I heard that you are developing original drugs?" Academician Bao said with a smile, "It's still an EGFR inhibitor."

"Yes, we did it together with Xinhua Pharmaceutical and Zzhou University."

"How is the progress?" Academician Bao asked casually, "Original drugs are not easy to make. You must be mentally prepared to encounter setbacks and difficulties."

"It's not bad, the progress is quite smooth, and the investigational new drug (IND) application should be filed by the end of the year."

"What?" Academician Bao was startled. He adjusted his glasses subconsciously, "Are you kidding me?"

"The preclinical research is almost completed?" He looked at Gao Feng suspiciously.

"We have reached the end. We are advancing step by step. Some links have been prepared in advance. The next experimental process will be faster than before." Gao Feng explained.

Academician Bao was silent for a long time, "What a terrible young man!" he sighed, and then he lost interest in talking to Gao Feng.

"Were you hit?" Gao Feng was a little unsure, probably not, since he was an academician after all.

Academician Bao was really shocked. He had previously developed the original drug. After many twists and turns, he spent a lot of energy and finally stopped at Phase III clinical trials.

The difficulties he encountered during the development period were beyond his imagination, and he is still frightened when he thinks about it now. Later, he changed the track and paid more attention to research on drug pharmacology and toxicology.

Targeted therapy has become more popular in recent years, and Academician Bao has also developed a huge interest in it. His project is related to research on lung cancer target genes.

So far, gratifying discoveries have been made. A top publication cannot escape. This time, it is also a bit of a show off for everyone to come and see the latest results.

"It is well known that the L858R mutation that is common in lung adenocarcinoma is a type of EGFR gene mutation. It means that an amino acid mutation has occurred in exon 21 of the EGFR gene, making it sensitive to targeted therapy with phosphokinase inhibitors, leading to tumor progression. Occurs. About 40% of EGFR gene mutations are in exon 21."

"For patients carrying the L858R mutation, targeted drug treatment with gefitinib, osimertinib, dacomitinib and other drugs can significantly extend survival time, reduce pain, and achieve certain tumor control."

"."

Xiong Huaxin is reading ppt in the large conference room on the 19th floor. These are commonplace knowledge and cannot arouse everyone's interest.He knew it himself, so he spoke quickly to prevent anyone from falling asleep.

It was very embarrassing last time. He was speaking passionately on the stage when suddenly he heard snoring from below.

"Shu Zian dares to insult me!" Xiong Huaxin was furious. He looked angrily at the audience and found that the person snoring in his sleep was Director Ding of the Department of Respiratory and Critical Care Medicine.

This was a great guy, and he obviously couldn't afford to offend him. The situation was a little awkward at one point, so he had to bite the bullet and finish the rest of the story.

"Xiao Xiong said it well." Director Ding also praised him after the meeting.

That is, you snored from beginning to end, and sleeping at home would probably not be so comfortable, Xiong Hua complained confidently.

"Teacher, you don't know how to mess with me by calling him," Xiong Huaxin even complained to Academician Bao at that time.

"That's enough." Academician Bao said with a smile, "Ahem, Old Ding is tired of hearing all the rubbish you talk about. He's already giving you a lot of respect by sitting down and sleeping."

Since then, Xiong Huaxin's lecture style has become much more capable, and his tone of voice has also become more yin and yang, with significantly fewer people falling asleep in the audience.

"Okay, my report is over. I would like to ask my teacher, Academician Bao, to bring you new results in targeted therapy."

The applause suddenly became enthusiastic. Everyone came to Beijing this time just for this moment.

Gao Feng's consciousness also immediately withdrew from the system space. The first few people including Xiong Huaxin also talked about something, but obviously not much.
"With the advancement of next-generation gene sequencing technology, we can now clearly know which gene the ALK gene has fusion mutations with, and where the break occurs. Today, more than 90 ALK genes have been identified in non-small cell lung cancer The fusion partner of the gene. However, although these are all called ALK fusion mutations, they still have certain differences."

“大多数的ALK融合突变是在EML4和ALK之间发生的，占所有ALK融合突变的85%。但EML4和ALK之间的融合也有很多的断裂和融合形式，目前EML4-ALK突变的4个亚型分别被标记为不同的数字：V1、V2、V3a/b、V4。”

“但经过我和手下的工作人员这2年研究，再度发现了3个亚型，我把他们命名为V5a/b、V5’、V7。”

As soon as Academician Bao finished speaking, there was a commotion in the venue.

"What?"

"Zun Du and fake Du?" "No! Are there so many subtypes that haven't been discovered yet?"

No wonder everyone is so shocked. You must know that since the discovery of the ALK gene in 2006, early scientific researchers have developed great enthusiasm for comparison. However, despite exhausting manpower and material resources, they have only found 4 subtypes.

Moreover, the current targeted drugs for ALK mutations are all based on these four subtypes. Now you suddenly say that there are other subtypes, is it not shocking?
Gao Feng originally thought that Academician Bao would take it step by step, but he didn't expect that the other party would directly face him and open up, catching everyone off guard.

sneak attack!

Seeing this scene, Academician Bao on the stage showed an implicit smile. Sure enough, I am still a treasure trove.

"Academician Bao, I would like to ask, have these subtypes been verified by professionals?" A person stood up.

His words directly shocked the attention of everyone who was still chattering. Academician Bao's results need to be verified by professionals?Are you afraid that you are going crazy?
Academician Bao frowned. Where did this idiot come from to question this academician!Simply outrageous.

Is it possible that I can fake it?You're thinking shit.

Gao Feng looked at the elder brother who stood up with a look of reverence. He liked this kind of serious person the most.

"We are all strict medical staff." The eldest brother was sweating on his forehead. "I just asked casually." He sat down quickly.

Hey, everyone felt regretful that they couldn't see anyone toughing out the academicians today, otherwise they would be bragging about it for the rest of their lives.

"It's okay. It's normal to ask questions. I'm not used to it if everyone sings the same praises." Academician Bao said with a smile, "The latest results will be published in the next issue of Nature, so remember to read it!"

He then described the four newly discovered mutation subtypes in detail, "Unlike the targets discovered in the past, we found that the latest classification can be used to guide the development of targeted drugs. Instead of general use, it will definitely speed up the development of targeted drugs. Renewal of ALK gene mutation-targeting drugs!”

Gao Feng listened very carefully. Li Youliang on the side saw the boss like this and hurriedly recorded the whole process. The main thing was his thoughtfulness.If the boss wants to ask questions later, you can turn over the audio in time to avoid any delays.

Coming out of the venue, a smile suddenly appeared on Gao Feng's face, "Youliang, do you have any thoughts after listening to Academician Bao's lecture?"

Not at all, Li Youliang thought, he didn't understand it at all. In this high-end game, he was nothing but cannon fodder. Just listening to a lot of medical terms made him feel sick.

On the other hand, Ai Hongkai gained a lot, "It is definitely a great boon for patients with lung squamous cell carcinoma who have ALK mutations. The four new targets are undoubtedly a new hope for survival for those patients with drug resistance!"

"And the drugs will definitely be updated based on new targets in the future."

"Yes, Academician Bao also mentioned diamond mutation." Gao Feng said with a smile, "I am very interested in this. We can also work hard in this area after we return. I have a hunch that we will definitely be able to find something!"

"In addition, can we participate in the development of drugs targeting ALK gene mutations?"

Li Xun originally wanted to say something to show off, but when he heard about the development of a new drug, he immediately shut his mouth.

Li You's heart skipped a beat. Was he taking a step too far?Our third-generation egfr inhibitors are still in progress. Are we going to launch a new project?
No, I have to persuade him!

But seeing Gao Feng's confident look, he chose to remain silent. There was Manager Zhao anyway, so why not go back and let him give advice? We are not good at this either.

Gao, just blow as hard as you can, Wang Zemin thought to himself, although I don’t dare to get angry or speak out, but in my heart I think you are just trying to get shit done.

Looking at everyone's reactions, Gao Feng was a little helpless. The topic was too high-end and people were too impetuous.
"Jiaran."

"What's wrong? Brother Youliang."

"Is the project progressing smoothly recently?"

"It went well!" Hu Jiaran was very happy. "We have been progressing very quickly recently. We encountered some problems during the process, but they were all resolved quickly!"

"The two newly recruited doctors and a few talented people in the school. Let me tell you."

"That's good." Li Youliang perked up, "Today I heard from my boss that we are going to start a new project, which is the research result of Academician Bao on the targeted drug for ALK gene mutation."

"Hey, Jiaran, are you listening?"

"Listen." Hu Jiaran responded with difficulty, "Do we have to wait? Or let others do it!"

"I guess it has to be you, you have experience." Li Youliang said, "I just want to give you a message in advance. If not, you can communicate with Manager Zhao and recruit more people in advance?"

"Manager Zhao, you are the company's talisman!" Hu Jiaran said, "It's obviously unreliable to fight from both ends. I guess it's just a super large multinational pharmaceutical company that dares to launch two original drug development projects at the same time!"

“Aren’t we small and micro companies seeking death by doing this?”

"When the boss comes back, you must persuade him in time and give up such fanciful thoughts!"

"Okay! I will definitely. Hey, no, can't you persuade me?" Zhao Xingye reacted immediately, "Oh, let you do all the good things, and let me say all the bad things, right?"

"I'm not going!"

"You are the general manager of the company!" Hu Jiaran said quickly, "It is your obligation and right to control the strategic direction of the company."

"We all have to listen to you!"

These words sounded so comfortable, and Zhao Xingye immediately felt a sense of responsibility. Yes, the boss could not be allowed to have too many whimsical ideas. He wanted to give direct advice, but Gao Feng could not let Gao Feng bring the company to bankruptcy!
Hu Jiaran returned to the dormitory in a bad mood. He was mentally and physically exhausted during this period. He felt that he had finally ushered in the dawn of victory, but now someone told him that he might have to repeat the same old path again.

"No! I won't be happy if this continues."

Mr. Hu spreads his sorrow here, and his subordinates discuss playing basketball there.

"Brothers, do you usually dunk?"

"Button it."

"Aren't you talking nonsense? Dunking is an essential skill in basketball, right?"

Some people said they had never dunked before, "My golf buddies don't like this very much."

"You can dunk, but you must pay attention to safety! Some baskets are very fragile and are not suitable for explosive dunks. I suggest you control the rhythm and strength appropriately."

Someone selflessly imparted their experience, "In addition, if it is your own court, you must regularly maintain the basket. It is best to wear protective gear on your hands when dunking. It is not to protect yourself, but to protect the basket." . "

"If it's a wild field, it's relatively casual."

(End of this chapter)