This doctor has a system

Chapter 339 410. Do you have the qualifications?

"I will discharge your father from the hospital immediately." Wang Wenhao said, "Come and sign."

"If we don't leave the hospital, don't think about driving us away." The patient's son turned around and ran away.

A few days later, Gao Feng didn't see the patient's son again during his ward rounds. After asking about it, he found out that he had been driven home by the patient.

"This little guy just wants me to die." The patient became very angry when he mentioned this. "He talks nonsense every day in the hospital. Can this doctor pay more attention to me?"

I have to say that what he did was wise. Without the troublemaker, the subsequent treatment went smoothly. The patient took a genetic test and found that he indeed had a genetic mutation. He is now taking Iressa orally.

The next thing to do is to continue taking the medicine until resistance appears, and then think of other methods, such as changing targeted drugs or performing chemotherapy.

There are only these types of treatments for patients with advanced lung cancer. Sometimes Gao Feng feels that excessive treatment is not needed for such patients.

We cannot always pursue prolonging the patient's life. Sometimes the quality of life is very important, and it is not a good thing to keep the patient alive in pain.

However, Chinese people do not seem to be as open-minded as Westerners when facing death. We believe that it is better to live than to die.

Some elderly patients still have a strong desire to survive at the end of their lives, and in many cases family members cannot ignore the patient's choice.
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Today is the tenth day of the lunar month, the first day of work for Fengxin Technology.

After resting for more than 20 days, most people feel that they are doing well again. Some people have gained a lot of weight these days, and Wang Liang is one of them.

He was very proud this year. Not only did his year-end bonus reach a new high, his fiancée also went home with him, and his parents were so happy that they couldn't close their mouths.

"I must achieve greater success this year!" Wang Liang encouraged himself.

The research and development of third-generation TKI drugs has now entered the most critical stage. Whoever contributes more at this time will definitely gain more.

Mu Yongde from the ECMO R&D team has already driven an Audi A6L. It is said that the company also bought a large flat floor, and there are also rumors that he has a share in the newly established subsidiary.

Those are shares, which means that he has changed from a clerk to a small shareholder, and the level has changed.

Wang Liang's expectations are not that high. He just wants to solve a few more small problems. When the time comes, he will get more performance points and more money.

In fact, in the field of drug research and development, except for a few specific links, there are not many places that can really shine. Most people just follow the established experimental directions and steps.

The current difficulties are mainly in process improvement and large-scale synthesis. Xinhua Pharmaceutical has some experience in this area, but not a lot, so progress is relatively slow.

Phase I clinical trials, also known as human pharmacology, are mainly used to evaluate the safety and tolerability of new drugs in the human body and determine the recommended dosage of the drug, that is, to find the maximum dose that will not cause serious side effects on the human body.

Specifically, Phase I clinical studies mainly study drug characteristics, including tolerability and pharmacokinetics.

Among them, pharmacokinetics includes general pharmacokinetics. The influencing factors that need to be fully considered include gender, population, absorption, distribution, metabolism, excretion, etc. If it is a group pharmacokinetics, each age group, special human pharmacokinetics and patient medications should also be counted separately. generation.

In addition, the effects on cardiac QT interval, blood biochemical effects, immune system effects, drug interactions, etc. are all part of the Phase I clinical research of new drugs.

The research subjects at this stage are mainly healthy volunteers. However, when the investigational drug is considered to be cytotoxic, or is used only in the target population (such as cancer patients), it can only be used in the relevant patients. Phase I clinical trials are small-scale trials, with generally 20-80 subjects, and can be completed in a few months.

Yue Penghui has contacted the professionals from Xinhua Pharmaceutical and has formulated a specific plan, but there are differences during the implementation process.

"I think it is most appropriate to conduct Phase I clinical trials in Beijing." Qi Huiren of Xinhua Pharmaceutical expressed his opinion, "We have resources there, and the most important thing in Beijing is patients with advanced lung cancer."

There are many patients who are resistant to the first- and second-generation targeted drugs. Many of these patients flock to Beijing from all over the country to find new treatment options and drugs.

"This saves time." Qi Huiren said, "And I suggest that Phase II and III clinical trials should also be done in Beijing. We have many hospitals connected with us, so recruiting patients is very advantageous."

What he said makes sense. After all, the medical level in Beijing is unique. Patients can go there from H South to see a doctor. Do you think there are a few patients who specially go from Beijing to other places?

There may be some, but obviously relatively few.

"I need to ask the leader for instructions on this." Yue Penghui quickly reported the situation to Hu Jiaran, who was also a little undecided.

Originally, according to Gao Feng's idea, the Phase III clinical trials of this original drug would be conducted in the Provincial People's Hospital. However, after multiple analyses, it seems a bit unrealistic at present.

There is definitely no problem in the Phase I clinical trial, but the number of subjects in the Phase II clinical trial is at least 100-300, and this stage lasts at least several months. The Provincial People's Hospital has not conducted such a large-scale clinical trial in the past.

But many hospitals in Beijing are different. Several hospitals have joined forces to conduct a large-scale study before, with thousands of subjects, which is unimaginable in some areas with poor medical standards.

Director Shen and Director Zhao also suggested following Xinhua Pharmaceutical’s advice, which shows that they do not have much confidence in conducting clinical trials.

Gao Feng could have gone into the battle himself. He felt that building something from scratch would be very fulfilling, but now he has changed his mind. The birth of his son seems to have made him a little lazy, and he wants to go home after work every day.

Although I can't do anything to help, I feel happy just looking at the little hands and feet.

"Then let's put it this way, contact the people from Xinhua Pharmaceutical as soon as possible." Gao Feng said, "But our people can't just be the hands-off shopkeepers. They must be involved in the whole process."

After thinking about it, Hu Jiaran decided to let Gong Fan take a group there. The latter's ability was at work here. If there were any problems in the clinical trial, he could detect them in time.

Gong Fanshun readily accepted this task, but he had an idea of ​​his own, which was to recruit two more helpers for him.

This requirement is not excessive at all. What the company currently lacks is talent, and those who can find a place that suits Gong Fan are definitely not mediocre.

Zhao Liang is an employee of a national-level research institute in Shanghai. It was not easy to get into this company back then. He finally got what he wanted after passing five levels and killing six generals.

But it may be that joining the job has overdrawn most of his luck in life. Although he has worked hard since then, he has not made any major progress in his career and is still at the bottom of the workplace chain.

Except for having a system, he seemed to be unable to do anything else, which made him feel very confused in life.

"Xiao Zhao, which kind of livestock do you think is the best overall?" asked my colleague + senior Lao Wang.

Zhao Liang's family comes from a rural area in northwest China. Three generations of his ancestors have been farming in the fields, so they are no stranger to all kinds of livestock.

He thought about it for a moment. Cows are strong and durable and can do heavy work, but they are too slow and inefficient.

Horses can pull and run, but they have poor endurance and will easily fall down from fatigue after working for a long time.

Donkeys have good speed and endurance, but they have a bad temper and are prone to giving up.

Pigs are full of treasures, but their requirements are too high. They don't gain weight even if they have little food and accommodation, and they get sick easily.

It seems almost meaningless. Is there an animal that can work, has a good temper, eats less, is easy to get full, is efficient, has low requirements, and can take care of itself even if it gets sick?

If it existed, it would be the most advanced animal in the world.

Zhao Kang shook his head, blaming himself for being poor and not knowledgeable enough. He had never encountered such an animal before.

Until he went to the bathroom and suddenly saw himself in the mirror.

Ouch, shit! It turns out that this kind of animal is actually me.

"What's wrong with you?" Colleague Lao Wang asked with concern when he saw his face change.

"I am fine."

"It's okay." Lao Wang said, "We haven't finished our work yet. I ordered two cups of coffee. Let's remind ourselves that we will work overtime for him today."

Zhao Kang felt a little hopeless. It was really embarrassing to beat an animal like a worker, so he whipped himself with a whip.

Just as he was melancholy, the phone rang. He picked it up and saw that it was his senior brother.

"Xiao Zhao, how are you doing lately?"

"I'm okay." Zhao Kangyan said insincerely.

"The sound doesn't sound very good." Gong Fanshun knew his junior brother very well. When he was about to graduate with his Ph.D., he had a temper that was different from that of Zhao Kangcai, who was in his first year of graduate school.

Although there is an 8-year age difference between the two, they can always find some common topics every time they go out to eat. Gong Fanshun likes Zhao Kang, who has a positive personality.

"Don't you work at XX Research Institute?" Gong Fanshun said with a smile, "This is a good unit. Have you made a name for yourself in it?"

"Don't mention it, the situation inside is too complicated." Zhao Kang said depressedly, "I can't explain it in one sentence. It's really difficult to describe it in one sentence."

"I'm going back the day after tomorrow. Can we meet then?" Gong Fanshun said with a smile.

I'm still a little interested in meeting Zhao Kang. After all, I haven't seen my senior brother for a long time. The last time we chatted was when the other party declared bankruptcy.

At that time, he sympathized with Gong Fanshun, but his colleagues felt that he was mentally ill.

"People will go bankrupt only if they have assets. Why don't you worry about it?"

"With your worth, can you go bankrupt? Do you have the qualifications?"

This statement also applies to the majority of netizens who always sympathize with the bankrupt boss and pity the loss-making manager. Are you stupid?

For a person like you who doesn't have two coins in his pocket, do people need your sympathy?

I don't know if they are pitiful or not, but you are really ridiculous.

Zhao Kang made a reservation at the restaurant in advance, and Gong Fanshun also arrived as scheduled.

"I recently joined another company." My senior brother Gong Fanshun briefly talked about his current situation. "I'm doing well there. I think the company has huge development potential."

"I'm still the same." Zhao Kang was a little reluctant to mention his situation, "There hasn't been any change in the past few years."

"No way?" Gong Fanshun was a little surprised by his words, "Didn't I hear you say before that you solved a lot of problems in the office? Didn't you get promoted?"

Zhao Kang shook his head.

"The salary should at least be improved, right?" Gong Fanshun poured a glass of wine for his junior brother.

"It is said to be the crystallization of collective wisdom." After Zhao Kang said it, he laughed, "Fuck him or something!"

There are many profound and profound words in China, such as taking into account the overall situation, the crystallization of collective wisdom, not caring about temporary gains and losses, under the leadership of leaders, etc.

"Then why don't you hurry up and run away with the bucket?" Gong Fanshun was very puzzled. Where are you giving birth to a baby?

"Isn't there a system for this?" Zhao Kang said helplessly, "My family is very fond of this and has always advised me to work hard and work hard."

"This kind of organization is useless." Gong Fanshun analyzed it with him and said, "Just come out and do it. I know your ability very well, and you will be more outstanding if you come to us."

This is not to say that national-level research institutes cannot work, they certainly can, but many people may not be able to adapt to the ecological environment inside.

Instead of suffering in it, why not just jump out, maybe it will be a new world.

Facing his senior brother's invitation, Zhao Kang hesitated. After returning to the dormitory, he tossed and turned and couldn't sleep.

"What's wrong with you?" asked my colleague Lao Wang, "Are you worried?"

"Well." Zhao Kang decided to ask his colleagues for their opinions, "Brother Wang, do you think I can survive within our capabilities?"

"Your abilities are incredible. You are the best colleague I have ever seen in the past few years." Lao Wang thought for a moment and said, "Just wait a few more years."

"Can you survive for a few more years before you can get ahead?" Zhao Kang was instantly refreshed.

"You'll get used to it after a few more years."

Zhao Kang wrote his resignation letter overnight.

Early the next morning, he found his supervisor, who signed it directly for him without reading the content carefully. Zhao Kang felt a little disappointed. He originally thought that the other party would hold back a few words.

He was ready to say anything, for example: Our place is very good, but I want to change the environment, and my parents are old, I want to go back to my hometown to develop, and by the way, I can be filial by my bedside, but he didn’t even say a word of these words. Use it.

As for the higher-level leader, they don't seem to know him at all.

Is there any mistake? Some time ago, I solved a temperature control problem during the synthesis of chains and materials for the institute! At that time, this bald man even said that I was the future of the institute!

Now that the future is gone, no one seems to be responding, and Zhao Kang is very angry.

"Zhao Kang, right? I'll give you two days to clear out the dormitory." Human Resources called him, "Please clear it out as soon as possible. There are still people waiting in line to arrange accommodation."

Gong Fanshun quickly took him to the capital, but the other person was not hired. The latter was unwilling to develop elsewhere due to his own reasons. Gong Fanshun finally chose to give up after a lot of talking.

"A third-generation TKI inhibitor developed by our company has now reached the Phase III clinical stage."

"Our task is to participate in the entire Phase III clinical process and report the problems discovered in a timely manner." Gong Fanshun said, "It also means supervision."

(End of this chapter)