This doctor has a system

Chapter 365 430. Was Mr. Hu also a scientific research migrant worker before?

"This is also caused by this." Gao Feng said with a smile, "I have seen a similar patient before. After a few months of treatment, everything returned to before."

"Huh?" My cousin was very disappointed.

? ? ? Gao Feng was very surprised. Wouldn't it be good to go back to the past?

Cousin Ma Ju gave his wife a sharp look.

"Really, what's the difference between 1 minute and 30 seconds?" My cousin muttered in a low voice. She didn't miss the past at all.

high wind

I really can't believe that my cousin, looking at such a strong physique, turned out to be a silver gun and a wax head - something that looks good but is useless.

Now that the cause has been found, there is a clear direction for treatment.

The first thing to do is to solve the problem of nighttime sleep apnea. Otherwise, the body will always be in a state of hypoxia, let alone bedwetting, and it is likely that cerebral infarction, hypertension, and diabetes will occur in the future.

"You can wear a non-invasive ventilator when you sleep at night." Gao Feng said, "Do you know this thing?"

"I don't know." Cousin Ma Ju replied, "Is this thing easy to carry? I travel a lot, so it's too big."

"Well, it's okay." Gao Feng said. He was about to introduce a few words when he saw that Li Youliang had already brought a box over. The packaging box said Yuyue non-invasive ventilator.

"Mindray's is out of stock right now. Let's make do with this domestic one first." As he spoke, Li Youliang tore open the packaging box and assembled it.

In fact, in terms of ventilators, domestically produced ventilators have begun to exert their strength at this time. Single-level non-invasive ventilators do not have any particularly advanced technology, and the domestic brand Yuyue is completely sufficient.

Generally speaking, patients with sleep apnea need to do a pressure titration before wearing a non-invasive ventilator, so that the pressure parameters can be better adjusted according to the index.

However, young people do not have to do this. At least cousin March did not feel any obvious discomfort after wearing it.

The next day, as soon as Gao Feng arrived at the department, he saw his cousin-in-law sitting on the bedside with dark circles under his eyes, drinking tofu nao, while his cousin Ma Qi was in good spirits.

"I didn't wet the bed last night." He said excitedly to Gao Feng. Not only that, he used to feel dazed and sleepy when he woke up, but when he woke up this morning, he felt refreshed and comfortable. Extremely.

"That's good." Gao Feng was also happy that he didn't wet the bed.

"Cousin, what's the matter with you? You didn't have any rest at night, okay?"

"Don't mention it, I didn't sleep all night." Cousin-in-law yawned.

Her husband used to snore all night long. She was not used to it when she first started snoring, and she couldn't sleep well due to the noise. As time went by, I gradually got used to it. Yesterday, I suddenly couldn't hear his snoring. I couldn't sleep well and woke up many times during the night.

People are like this. After being abused a lot, they get used to it.

There was nothing going on today, so Gao Feng decided to go to the laboratory. Hu Jiaran had already called him several times.

The elevator quickly went down to the first floor. As soon as Gao Feng walked out, he saw doctors from the emergency department and several family members entering the elevator with a brain injury patient who had been intubated.

Gao Feng glanced at it subconsciously, and then was stunned for a moment.

"What's wrong?" Li Youliang asked strangely when he saw him standing still.

"That patient." Gao Feng hesitated.

"It should be sent to the neurosurgery intensive care unit." Li Youliang said, "From our elevator to the 7th floor, you can go directly there through the air corridor."

"That patient has a problem." Gao Feng said, "Are you familiar with the doctor over there?"

"I can't say I'm familiar with it, but I have the ward's phone number." Li Youliang said quickly.

"Hello? Hello, Neurosurgery Critical Care Unit." Nurse Wang Xi from the Neurosurgery Intensive Care Unit answered the phone.

"Will the emergency department send a patient to him soon?" Li Youliang asked, "There is something wrong with his tracheal intubation, it should be inserted into the esophagus.

"Ah?" Nurse Wang Xi was stunned for a moment, "Who are you? You have to tell the doctor about this."

"How can I have that time?" Li Youliang said unceremoniously, "You should immediately notify the doctor on duty and tell him about this matter."

When Wang Xi heard the beeping sound, she quickly called the doctor on duty.

The neurosurgery doctor on duty had just performed a tracheotomy and was finishing the operation when he heard this and was stunned.

"No way? Is it inserted into the esophagus?" "Where is the patient?"

"It's not here yet, it should still be on the way." Nurse Wang Xi said.

While the two were staring at each other, the doorbell rang.

"Doctor Si, the patient with brain trauma in the emergency room is here. Come and take a look." The nurse shouted.

Si Junwu hurried over. He took a look at the patient and saw that the tube had indeed been inserted, but he was still breathing on his own.

Seeing him staring at the endotracheal tube, the emergency doctor was a little confused.

"Old Si, help me, what do you mean by standing still?"

"Who did this tracheal intubation?" Si Junwu asked.

"Me." The emergency doctor said matter-of-factly, "What's wrong?"

"Is there a possibility that you were inserted into the esophagus?"

"How is that possible?" the emergency doctor looked dissatisfied. "I've inserted this thing so many times. To put it bluntly, it's impossible to check the wrong position with your eyes closed."

"But someone called just now and said you were plugged in by mistake." Si Junwu hesitated and said.

"Who?" The emergency doctor was stunned for a moment, who was joking, who would make such a call out of nowhere.

"I don't know, it was a call from a mobile phone." Nurse Wang Xi said.

"Bring the stethoscope." The emergency doctor was a little confused, but he was not a particularly arrogant person. Someone suddenly said this, which made him feel a little unsure.

As the nurse squeezed the mask, a clear gurgling sound sounded from the patient's abdomen.

The emergency doctor suddenly broke into a sweat.

"Fuck!"

"I heard a gurgling sound. It must have been inserted into the esophagus." Gao Feng said to Li Youliang.

The latter was actually a little confused. The environment was very noisy at the time. He also saw the patient, but he couldn't hear any grunting sounds at all.

But he chose to trust his boss unconditionally.

Z, laboratory.

"So will we meet again?" Wang Liang sent a message.

"Oops, I'm sorry, I forgot about you." The other party apologized, "Just wait a moment, I'll be there soon." "It doesn't matter, I'm not that important in the first place." Wang Liang continued to send the message, "I can't stop you from running. To someone better than me.”

"I was wrong, brother." The courier was speechless. "Next time you place an order, I will be the first to deliver it."

"So, you don't know how to cherish it until you lose it?"

Courier.

"Wang Liang, what time is it? Why are you still eating?" As soon as Gaofen arrived upstairs, he saw Wang Liang squatting in the corridor eating hot dry noodles.

"Are you having breakfast or lunch?" Li Youliang asked.

"Breakfast." Wang Liang replied weakly, "I got up late in the morning and I'm very hungry now."

Hu Jiaran walked over and gave him a fierce look. This troublesome mentally retarded man even let the big boss see him, which really embarrassed him.

"How's the progress?" Gao Feng asked.

"It's okay." Hu Jiaran replied, "Although the advancement speed is average, it is generally smooth. There is no place that makes people feel stuck."

The company's talent pool has also gradually increased. We can always come up with solutions to some problems by brainstorming together.

Logically speaking, this kind of R&D process is very healthy. Employees can learn a lot from it and it can train people very much.

But Gao Feng is not willing to wait like this, otherwise the day lily may be cold by the time the drug is developed.

Next, we need to speed up.

"Find a few people to come over and follow me from today onwards."

Hu Jiaran responded quickly and gave him a look. Yue Penghui on the side quickly ran out.

Soon, Dr. Lu, Zhao Kang and others came to the laboratory.

"Zhao Kang, can you tell me why we choose intrathecal administration?" Gao Feng asked.

"Because administration through intrathecal injection can deliver drugs directly into the cerebrospinal fluid (CSF) around the spinal cord, this is where motor neuron degeneration occurs in SMA patients due to insufficient levels of SMN protein." This question Naturally, Zhao Kang cannot be troubled.

"Why do we synthesize short chains of nucleotides?"

"Because it can be used to selectively bind target RNA and regulate gene expression." Zhao Kangyan answered concisely and comprehensively.

"That's very good." Gao Feng was extremely satisfied with his answer. "Then how are you going to synthesize short antisense oligonucleotide chains?"

"This." Zhao Kang couldn't answer now.

In fact, they tried several methods, but the results were not satisfactory.

"Have you tried antisense technology?" Gao Feng asked.

"We have tried it," Dr. Lu said. "This technology was initially tested, but when applied, we found that there were too many difficulties."

They tried many times but couldn't get a clue, so they chose to put it on hold temporarily. What is currently being tested is the gene cut-and-paste method, which is more cumbersome than antisense technology, but the technology is relatively mature and there are ready-made examples of its application at home and abroad.

"Is there any progress?" Gao Feng became interested.

"There has been some progress." Dr. Lu considered it and said, "A part of the substrate was synthesized, but we found that the fragment synthesized by the cut-and-paste method has poor stability and is easy to break."

Some people think that the test conditions are wrong and need to be explored again.

"The cut-and-paste method doesn't work." Gao Feng said straightforwardly, "This method itself is not suitable for synthesizing long-chain gene fragments, not to mention that the substrate we want to synthesize needs to go through secondary transcription."

As soon as he said this, everyone stopped saying anything, but Gao Feng sensitively felt that some people had some disdain in their eyes.

"Let's do this. Let's temporarily divide into two experimental groups." Gao Feng felt that it was a bit overwhelming to ask everyone to change the experimental plan directly. "One group will continue to move forward according to the original process, and the other group will follow me to develop this antisense technology." .”

Now everyone is satisfied.

Hu Jiaran also took action personally, and it was natural for him to join Gao Feng's group.

Are you kidding me? Do you choose not to trust your boss at this time?

Antisense technology uses the principle of base complementation to interfere with all aspects of gene unwinding, replication, transcription, mRNA splicing and processing, and even output and translation, thereby regulating cell growth and differentiation.

Antisense oligonucleotides are a type of oligonucleotide fragment expressed by artificially synthesized or constructed antisense expression vectors, mostly 15-30 nucleotides in length.

According to different binding sites, they are divided into antisense DNA (asDNA), antisense RNA (asRNA), and autocatalytic ribozymes (ribozyme). Antisense RNA refers to RNA molecules that are complementary to mRNA.

Its advantages include its theoretical high target specificity (base complementarity), ease of design, and multiple properties. In contrast, antisense reagents work at the level of mRNA (DNA), preventing its translation into protein.

To be honest, Hu Jiaran is really confused about this theory.

But fortunately, this doesn't require him to think hard, he can just do whatever Gao Feng tells him.

The new employees' eyes widened. They didn't expect that the person who was hiding the most in the laboratory was Mr. Hu, who had nothing to do all day long.

Watching his dexterous fingers flying up and down, the pipette seemed to have a life of its own, many people were stunned.

"Was Mr. Hu a migrant worker in scientific research before?" an employee asked.

"This is so skillful." Someone next to him said, "It's just eight steps ahead of our team leader." The team leader on the side was also amazed, and immediately felt that he was greatly offended.

Obviously there are no 8 streets, but they are at most 3-4 times faster than me!

"Learn." Hu Jiaran was very proud. He couldn't help it. This was his talent. Even though he hadn't touched these tasks for a long time, he could still use his fingers like an arm.

Even Gao Feng couldn't help but admire this. He had practiced in space for a long time, but he still couldn't catch up with the former. In fact, even if Hu Jiaran can't meet him, he can become a hot potato even if he enters any laboratory.

But how should I put it? Undergraduate students generally cannot enter experiments because their academic qualifications are too low.

Under Gao Feng's guidance and Hu Jiaran's sharp operation, they quickly caught up with the progress of the other group.

At around 7 o'clock in the evening, Gao Feng left with Li Youliang, while Hu Jiaran took everyone to dinner.

The issue of bride price came up for some reason during the dinner, and everyone expressed their opinions one after another. The betrothal gifts here in H South vary greatly in form and amount depending on the region.

Zzhou City and several nearby counties have relatively good customs, and usually do not have high requirements for betrothal gifts. In some places, rummaging is popular, which means that the woman will be given double the dowry money.

But in most areas, it is usually the man who pays unilaterally, and sometimes the woman's side requires more money as a gift.

"It's not just you H-Nan, it's the same over there." A Gansu employee said while taking a bite of food.

"I found out that the wedding I got married last year didn't include the three gold medals, and the wedding gift cost 20 yuan."

"But what can I say, the woman also returns the favor."

"Hey, what do you say?" Everyone was curious about what the dowry was.

"I got a quilt back," said the employee from Gansu. "I'm so old. I cover my head and cry at night, but I can't hear it from outside."

(End of this chapter)