This doctor has a system

Chapter 369 435. Is there something wrong with your brain?

Xinhua Pharmaceutical is still very active in this matter, and they see the hope of getting a share of the pie.

The Kingdom of Denmark, referred to as Denmark, with its capital Copenhagen, is located in northern Europe. It borders Germany to the south, the North Sea to the west, and Norway and Sweden across the sea to the north. It has a temperate maritime climate.

The country has 5 regions, 98 cities and two autonomous territories, Greenland and the Faroe Islands. Denmark has a total population of approximately 600 million people.

"There are too few people." Zhao Kang said, knowing that the population of H South is about to exceed the 1 million mark.

"Despite the small number of people, we are a developed Western industrial country, and its per capita GDP ranks among the top in the world." Lu Yingtao chatted with Zhao Kang about various opportunities.

He still has great concerns about this trip to Denmark. Clinical trials are not a trivial matter, especially since most of the subjects of this clinical trial are children. If something goes wrong, it may not end well.

Young Zhao Kang didn't think much about it. He was still thinking about having fun in Denmark if everything went well.

If you meet a beautiful Danish girl again, something embarrassing happens that all adults would like.

Oh, how beautiful!

"You want to eat shit." Lu Yingtao attacked, "All you think about is fairy tales."

But isn’t Denmark the kingdom of fairy tales? Zhao Kang thought to himself that when we were young, everyone learned from the little girl who sold nuclear bombs.

"By the way, are there any requirements for injection speed and duration?"

Professor Laurie Hunt, an expert in pediatric spinal muscular atrophy, has spent his life trying to solve the disease, but has clearly achieved little.

"Hey, why is this shower gel from Dior?" He wondered, "Don't Dior sell perfume? Does it also make shower gel?"

"Oh, sorry." Professor Hunter apologized for his stupidity.

Lu Yingtao and the others were not professional clinicians, so they were only responsible for synthesizing the medicine. The specific injections were completed by Professor Laurie Hunter of the Royal Danish Medical College.

The plane landed at Copenhagen International Airport, which is Denmark's largest airport. Copenhagen International Airport is also the largest aviation hub in Scandinavia and Northern Europe.

"It requires intrathecal administration through lumbar puncture." Lu Yingtao continued, "When the patient is relatively young, it is recommended to use ultrasound or other imaging technology to assist."

"This is absolutely no problem." Professor Hunter was very confident. He was very skilled in lumbar puncture and intrathecal administration.

"Chartered flights are comfortable." Lu Yingtao felt stunned for a moment. Sure enough, the lives of rich people are so short and happy.

Lu Yingtao didn't answer, but looked at him with strange eyes. What's going on with this old man? Aren't we just doing clinical trials?

There are currently only two recruitment subjects for the clinical trial, one is Marshall's beloved son, and the other is Zhou Xchang's grandson.

"We conducted animal experiments on mice, and the results showed that the full-length functional SMN protein was significantly increased."

"Professor Hunter, let me introduce this drug to you." Lu Yingtao said in fluent English, "This is an antisense oligonucleotide drug that can modify SMN2 gene splicing and promote full-length functional SMN protein. produce."

They don't deserve to use such a good thing. Dry rubbing in the bath is perfectly fine.

"Does that work in humans?" Professor Hunter asked.

"I don't know." Zhao Kang picked it up and looked at it, then searched on an e-commerce app, "Just this small bottle costs 1300."

The two looked at each other and put it into their backpacks tacitly.

"Damn it, this bathroom is bigger than the house I rented in Shanghai!" Zhao Kang tried his best to urinate more.

As a wealthy man, Maurice Marshall indeed has the temperament of a wealthy man, and the hotel where Lu Yingtao and the others live is too luxurious.

That night, Maurice Marshall also held a grand welcome dinner for the entire team in the hotel. Of course, there was no alcohol in it. After all, work would start early tomorrow morning.

Lu Yingtao felt ashamed looking at him like he had never seen the world.

"I really can't answer this. When we inject mice, it usually takes more than 1 minute." Zhao Kang said at the side.

"The side effects currently observed in mice include vomiting, diarrhea, thrombocytopenia and abnormal coagulation, which may lead to hydrocephalus in very special circumstances."

"But the above symptoms are all mild." Lu Yingtao added.

Hearing this, Professor Hunter was convinced. He had participated in many clinical trials. Adverse reactions were definitely unavoidable, but as long as they were not serious adverse reactions, they would undoubtedly be acceptable.

“高教授建议在于第0天、第14天、第28天和第63天给予4次负荷剂量，此后每4个月给予一次维持剂量。”赵康紧接着拿出了一项临床试验计划治疗方案，“当然，这需要取得汉特教授您的同意。”

Professor Hunter had no choice but to disagree. He was not responsible for the development of the drug. He had no way of knowing its effects, so he could only cooperate with the other party.

Soon, everyone reached a consensus.

The first injection was carried out at 3 o'clock in the afternoon. It must be said that Professor Hunter of the Royal College of Medicine did have two brushes. He was very good at intrathecal administration of lumbar puncture. The operation process could be said to be very smooth.

"Okay, let's observe for 2 weeks and then give the second injection." Lu Yingtao announced. Next, Professor Hunter is the main force. They need to monitor the vital signs and biochemical indicators of the two children. Lu Yingtao and the others only need to record these data.

It seems like a very simple clinical trial, but many people from the outside world have turned their attention to it.

"Lloyd, I think you should try it." Lloyd's mother said to him, "Maybe it really works."

Lloyd is a patient with SMA type III (juvenile type). His performance in infancy was completely normal. He only developed slowly worsening generalized muscle weakness when he was 13 years old. Now he is 27 years old and has lost the ability to walk. ability.

The family doctor told him some time ago that he should cherish the good time with his family.

He understood what the other party meant. If nothing else happened, he should be 27 or 28 years old.

"Mom, I don't want to bother anymore." He said laboriously after taking off the ventilator. Lloyd had also participated in a clinical trial with high hopes, but the experience that time was particularly bad.

After taking the medicine, he developed severe nausea and vomiting symptoms, and his stomach almost vomited out during the medication, but he did not see any good effects.

"Don't say that yet, we can wait and see." His mother was silent for a while and said. Lloyd didn't say anything, but just put the ventilator on again. After a while, he already felt some chest tightness.

Two weeks passed quickly. The vital signs of the two babies were stable and nothing special happened.

This makes everyone very excited. You know, the side effects are what need to be the most vigilant at the beginning. If there are serious adverse consequences, the experiment cannot continue.

"Professor Hunter, do you think our two babies' conditions have improved after taking the medicine?" Zhao Kang asked.

"It's really hard to say." Professor Hunter hesitated and said. These two patients are not even three-year-old children. They have low academic qualifications, communication barriers, and inaccurate assessments.

"We will definitely not see any effects in the short term." Lu Yingtao said with a smile, "As long as there are no obvious side effects, it has exceeded our expectations."

After saying that, everyone began to prepare for the second lumbar puncture and intrathecal administration. Because Zhou X's grandson was a little older, he had some unpleasant memories of the last injection. This time he started crying when he saw the old man with yellow hair coming over. It was useless to cry. The more he cried, the harder Professor Hunter became.

At this time, Lloyd's mother was doing her son's ideological work.

"No obvious side effects have been found so far." She said to her son with a hint of joy, "The two children are both under 2 years old. A person as old as you can definitely tolerate it."

"Try it?" After his mother said this, she looked at him expectantly.

To be able to get the results of clinical trials so quickly, Lloyd is definitely not an ordinary family. In fact, he is indeed rich and noble. He gets up from a 500-square-meter bed every day.

That was before.

Now he can't get up at all, his muscles are weak, and he has to rely on equipment to even breathe and needs help when peeing.

"Okay, mother." Looking at his mother's eyes, he finally couldn't refuse.

Professor Hunter was very happy about Lloyd's arrival, and Lu Yingtao didn't have any objections. For clinical trials, the more people, the better.

"Great, finally here is someone who can talk." Professor Hunter patted his thigh. They have recently received many applications from patients. It is expected that 5-7 patients will arrive in Denmark next week, but they are all children. , adults are really rare.

Lloyd had his own professional private medical team, and Professor Hunter quickly injected him with medicine after contacting him.

"It seems that the progress is relatively smooth." Hu Jiaran was very happy on the phone. "If you have any difficulties there, you must contact me as soon as possible. Don't you also have the phone number of our embassy?"

"Yes, yes." Lu Yingtao replied, "Someone came over to see it a few days ago. Everything is going well so far."

Hu Jiaran finally felt relieved, and he immediately reported the specific situation to Gao Feng.

The latter is writing articles, and natuer has currently serialized 4 articles. Among them, endogenous reverse transcription of tumor genes has just been published, but it has caused a huge sensation in the industry.

Nature chose a screenshot of this article as its cover, which shows how much it attaches importance to.

"Chinese scientists analyze tumors from the level of gene transcription." BBC

"Can a breakthrough be made in the treatment of tumors in the short term? Can the genetic sequence of tumors be completely sequenced?" Efe News Agency

"Big news: Chinese scientists have revealed for the first time the origin of reverse transcription of tumor genes." World News Service

“The Chinese have mastered tumor genetic weapons.” Agence France-Presse.

"Shocked: These people actually did this to tumor cells!!!" UC News.

Academician Bao's phone is being flooded with calls. The old man has never received so many calls from talented people in his life.

"Yes, yes, yes!"

"Yes, it is."

"Yes, Gao Feng is studying for my doctorate. This is just the result of my slight training."

"Let me tell you, the main reason is that my former students were ineffective and my teaching level has not been fully utilized!" Academician Bao said to an old friend on the phone with a smile on his face.

The helpless Xiong Huaxin couldn't help but roll his eyes.

Gao Feng was calm here, and he was in a good mood after hearing Hu Jiaran's report.

In fact, he initially decided to go there in person, but Li Youliang strongly opposed it. He was mainly worried about some uncontrollable factors. After thinking about it for a while, he finally decided not to go. But now it seems that Lu Yingtao and Zhao Kang are relatively smooth there.

"Give them money." He instructed Hu Jiaran.

The latter indicates receipt.

Giving money is obviously the most substantive encouragement.

Is there anyone in this world who doesn’t love money?

The answer is yes, but very little. You should be able to find some of it by going to a mental hospital.

Zhao Kang was sitting on the bed and worrying. The hotel delivered new toiletries every two days, and he couldn't even fit them in his small bag.

Seeing that bottles of goodies worth 1300 yuan could not be stuffed in, he became worried.

"Is there something wrong with your brain?" Lu Yingtao said speechlessly.

"Oh, I really haven't seen the world." Zhao Kang was very ashamed. Before he could finish his words, Lu Yingtao threw a big backpack over.

"Don't you know how to buy a bigger bag?" the other party said, "It's just a mental illness."

Zhao Kang.

"But what about the security check when we bring so many things back?" he asked.

"We must be taking a chartered flight. Then we can just pack it and note it as experimental consumables."

Soon, Zhao Kang had seven more bottles of shower gel in his bag, which also meant that it was time for the next injection.

"Lloyd, how do you feel?" Professor Hunter was assessing the patient.

"I don't feel anything obvious." Lloyd's mental state is not bad, and he did not have any adverse reactions after taking the medicine this time.

"The course of your disease is relatively long, so even if there is an early effect, it probably won't be too obvious." Professor Hunter reassured.

Lloyd nodded. He was not particularly disappointed. Because he had no hope, he would not be disappointed.

Professor Hunter asked some more questions, and he responded cooperatively. Soon, the other person left.

Lloyd sat by himself for a while and then motioned to the nanny to put the ventilator on for him.

"Sir, you seem a little better today." The nanny said cautiously.

"Well, why did you say that?" Lloyd was a little strange. Due to his illness, his personality became more and more withdrawn, and the nanny rarely spoke.

The two of them sometimes went a day without speaking a few words, and Lloyd's mother always felt like there were two boring donkeys in the room.

"I see that you haven't been on the ventilator for a long time today, but you haven't gasped as loudly as before." The nanny said.

(End of this chapter)