This doctor has a system

Chapter 372 437. This is another price!

Nitazoxanide mainly inhibits Cryptosporidium by inhibiting the enzyme-dependent electron transfer reaction of pyruvate and ferredoxin oxidoreductase. But people with immune deficiencies are not suitable: it requires the amplification of the body's normal immune system to clear Cryptosporidium.

"MD!" Dr. He couldn't help but cursed.

Gao Feng thought about it and felt that the case reports were not completely without guiding significance. At the very least, this case also demonstrates the effectiveness of azithromycin.

Therefore, Gao Feng suggested making some attempts based on this: oral administration of azithromycin (1000 mg tid) + allicin (500 mg tid) to combat Cryptosporidium.

In the next 5 days, the patient's diarrhea improved slightly, but his liver and kidney function continued to deteriorate, and continuous CRRT treatment was started again.

On the 18th day, the patient's glutamyl transpeptidase and alkaline phosphatase continued to increase, suggesting that the patient had cryptosporidium retrograde biliary tract infection, and the previous anti-cryptosporidium infection program failed.

The patient is about to die, Dr. He feels.

"Don't be depressed!" Gao Feng said, "Now let's be a living doctor!" His opinion is very simple, that is, don't worry about the consequences and just give nitazoxanide.

Nitazoxanide is currently the only drug that has the potential to stop diarrhea and prevent the reproduction of Cryptosporidium parvum.

But it has not been launched domestically.

Faced with this complex and difficult patient, he carefully studied the condition and finally clarified the direction of diagnosis, finally achieving satisfactory results.

"It doesn't include anything else."

"My legs seem to be moving!" Lloyd couldn't help but shed tears.

Because of a bite of street snacks, 196 million was just gone.

The price is so high!

"I will never eat randomly again." The patient also had lingering fears. It was not because he was worried about money, but because he never thought he could pull diapers so well. At that time, he couldn't even hold a 5-6-layer diaper.

"Congratulations, Mr. Lloyd." Professor Hunter sent his blessing.

Thinking about it, the whole process is a bit thrilling. If the direction starts to go wrong or other problems arise in the middle, then even if the patient has the "money ability", he may not be able to recover.

The nanny quickly pulled up his pants for him.

"Don't!" Lloyd stopped.

Gao Feng looked delighted. He was very satisfied with his performance this time.

But this patient is special: he has an immune deficiency caused by artificial intervention, that is, the immune function is reversible.

Gao Feng has his own understanding of the statement that it is not recommended for people with immune deficiencies: this is based on the fact that they do not have normal immune function.

"No." Lloyd.

"How can I thank you?" Maurice Marshall said excitedly to Dr. Lu and Zhao Kang.

The room immediately fell silent.

"Please respect yourself!"

"Your outstanding performance has had a positive and significant impact on Dr. He Liang, and you have received 10 skill points."

Denmark, Copenhagen.

"We can raise his immune-related indicators and restore a certain immune function before trying to use it!" Gao Feng said.

Li Youliang looked at the patient's bill and found that he spent a total of 196 million, not including purchased drugs and outsourced examinations.

"It's the middle leg!" Lloyd's voice was trembling. "It can move! And it's very active!"

? ? ? Professor Hunter

"Mr. Lloyd, I think you misunderstood." She said, "My job is just to take care of your food and daily life."

"Don't worry, I've brushed my teeth." The nanny said with a smile showing her white teeth.

On the 28th day after admission, the patient finally overcame the danger and was transferred to the general ward.

"Really?" Professor Hunter was very pleased. "Which leg can move? The left leg?"

"Ding" the nanny picked up her phone and looked at it. The text message reminded her that 10 dollars had been credited to her bank card.

After a while, Lloyd turned his eyes to his nanny. The latter was stunned for a moment, and then his face turned red.

Gao Feng took Dr. He to study the instructions for nitazoxanide again.

"Not here!" Lloyd was anxious, "Push me back to the bedroom first!"

Doctor He shouted 666 from the side.

Based on the patient's previous treatment experience and literature references, the anti-Cryptosporidium regimen was changed to nitazoxanide 500 mg tid and allicin 500 mg tid orally; at the same time, cyclosporine was used to suppress immune function and control CD4+ T cells to 100 ~300/mm3 to achieve the purpose of eliminating Cryptosporidium.

'Lloyd what's wrong with you? Professor Hunter looked concerned, "Are you feeling uncomfortable somewhere?"

With the gradual recovery of liver and kidney function, the patient finally stopped CRRT on the 22nd day after entering the ICU and was successfully weaned from the ventilator the next day. On days 24 and 25, no Cryptosporidium was found in the patient's two acid-fast stool stains, declaring the final success of the treatment.

This is an additional price.

"Right leg?" Professor Hunter immediately looked at Lloyd's right leg.

After a detailed physical examination, Professor Hunter left with satisfaction. He found that Lloyd's muscle strength level throughout his body had been greatly improved, the most obvious one being the respiratory muscles. Now the latter no longer needs to wear a ventilator regularly. Assisted ventilation.

But the patient’s family members had the “ability to make money”, and soon someone sent the drug back from overseas.

A wonderful morning.

On the 45th day, the patient's condition was stable and he was discharged from the hospital.

"No." Lloyd.

"You have received the heartfelt gratitude of the patients and their families and gained 10 skill points."

Two days after the implementation of the plan, the patient's diarrhea gradually decreased, and everyone breathed a sigh of relief.

Professor Hunter conducted a full body assessment of his son today and the results were very encouraging.

According to Professor Hunter's estimate, after three more courses of treatment, his son will be like a normal baby. Although it requires lifelong medication, this is harmless.

He will grow up healthy and receive a good education. He will meet a beautiful girl with noble blood, get married and have children.

He will inherit everything he owns, and the noble blood of the Morris family will flow in the world for a long time.

"Our work is insignificant." Dr. Lu said modestly, "The person you should thank is our boss, Professor Gao."

"I know." Maurice Marshall smiled, "but your contribution cannot be erased."

He clapped his hands, and the butler walked in, carrying two handbags.

"This is my opinion, please don't dislike it."

After he left, the two of them couldn't wait to open their handbags.

"Mom!" Zhao Kang almost peed. "Money, it's all money!" He said loudly to Dr. Lu.

"Shut up! I'm not blind!" Dr. Lu shouted.

The two looked at each other and then began to count the money.

After a long time, Dr. Lu suddenly sighed.

"What's wrong?" Zhao Kang was a little confused.

"There are too many." Dr. Lu said, "I don't dare to ask for it."

Inside the bag is 100 million yuan.

When he said this, Zhao Kang also hesitated. He thought for a moment and felt that money was a little hot for a moment.

The two discussed it and decided to report it to the company.

Hu Jiaran was very happy about this. His employees were so aware, and he, as a leader, felt proud.

"In the face of the temptation of money, Dr. Lu and Zhao Kang were able to stick to their hearts," he told Gao Feng. "I think this behavior needs strong praise."

"It's indeed good." Gao Feng said with a smile.

"It's better to let them keep it for themselves." Hu Jiaran suggested, "I don't have much money."

Zhao Xingye on the side almost laughed angrily, nmmp, that’s 200 million! This is called not having much money!

"I object!" he said simply.

"What are you objecting to?" Hu Jiaran was unhappy. This is my subordinate. Unless the boss has different opinions, I must have the final say.

You are against this. "The drug was developed by the company." Zhao Xingye argued, "Dr. Lu and others only went to Denmark to conduct clinical trials on behalf of the company."

"All honors and benefits they obtain should belong to the company!"

"I don't agree with your statement." Hu Jiaran said, "This."

"Mr. Hu!" Zhao Xingye's voice became much louder, "Do you know how much money the company invested in the development of this drug?"

"3.5 billion!"

"Ah?" Hu Jiaran was startled.

"Not that many, right?" He didn't quite believe it. He always felt that the drug development this time went very smoothly and didn't take too long.

Gao Feng was also a little surprised. He was obviously cheating, so why did he spend so much money?

"8400 million yuan was invested in buying the equipment alone." Zhao Xingye took out the report, "One-time consumables include labor costs."

"besides."

"This is just the end of the story, let's do it next."

"Finally, I need to remind Mr. Hu." Zhao Xingye said, "Do you know the production cost of this drug?"

"How much?" Hu Jiaran was a little ashamed. He knew every detail of the drug development process, but as for the cost.

It's none of his business.

Anyway, if you need anything, just send a note to Zhao Xingye.

"According to the current situation, the production cost of a drug is as high as 16." Gao Feng was also stunned by Zhao Xingye's words.

"so tall?"

"Yes." Zhao Xingye's face was solemn. He was also shocked at first.

And after knowing the specific situation, he felt a little restless. The reason is: if this drug is made, the company will most likely lose money.

"How can we lose money?" Hu Jiaran felt a little ridiculous.

"How is it possible not to lose money?" Zhao Xingye said, "This is an orphan drug, and the demand is only that much every year!"

This means that annual sales will not be too high, which is never a good thing for a drug. This is also the reason why the development of orphan drugs has basically stalled: it is tasteless and it is a pity to discard it.

And if the development is successful, if it fails, the underpants may be lost.

"It requires very high production technology, but the market is only a little bigger every year." Zhao Xingye said, "I have thought about it. We can only make profits by increasing the selling price."

"According to the current production technology, the price is more reasonable at 70 each."

"This is too much." Hu Jiaran didn't know what to say.

Li Youliang on the side was already numb. He had told others many times that the patient with diarrhea spent 100 million some time ago.

Now it's better, it turns out that it's all about 2 and a half pills.

People should not get sick, especially such a rare disease, he thought to himself, this is too scary.

"If the medicine is given once every four months, it means that the patient spends 4 million yuan on medicine every year." Gao Feng felt a bit headache after adding up.

His purpose in developing a drug is definitely not to make profits. His original intention is to treat patients in this area.

If its application is limited because of its high price, then he thinks it is unacceptable.

But from Zhao Xingye's point of view, developing drugs is to obtain profits from them, and this is a matter of course.

From a long-term development point of view, if a company wants to achieve better development, it must pursue sufficient profits. It is not impossible to do business at a loss, but the company must gain something from it.

"Let's think about it in the long run." Gao Feng announced that the meeting was adjourned. The clinical trials are currently only done in Denmark, and we don't know what to say in China yet. Let's put it aside for now, and then come up with a charter.

We are still hesitating about pricing here, and Dr. Lu and Zhao Kang also encountered trouble in Denmark.

"What?" Zhao Kang was shocked, "The medicine is gone?"

"Has it been stolen?" Dr. Lu was anxious, "Contact Mr. Morris quickly!"

"It's been damaged." The assistant reported, "Mr. Morris already knows about this and is expected to arrive soon."

Soon, Maurice Marshall arrived at the scene of chaos.

It was an obvious revenge, and a black man from Gaul was the culprit.

His son is also a patient with spinal muscular atrophy, but because his condition is not serious yet, he has not yet been able to participate in clinical trials.

This made him feel extremely angry and felt that he was being treated unfairly because of his skin color.

Is this possible? You know that Heizi is best at zero-dollar purchases, so he decided to teach the arrogant Chinese people a lesson.

So on a dark and windy night for a month, Heizi climbed over the wall and entered the hospital area. His natural skin allows him to quickly blend into the darkness, but there are definitely security issues.

Heizi who sneaked into the medicine warehouse could not understand Chinese at all, which made him angry and smashed all the expensive medicines on the spot.

Maurice Marshall was so angry that he didn't expect that anyone would feel such a harmful thing.

He wasn't a racist before, but now he is.

Heizi was taken away by the police, and what awaits him will be severe punishment under Danish law.

With such a big event happening, clinical trials will definitely be affected, but fortunately, most of the patients have just been injected with the drug two days ago, and this period is a window period.

Dr. Lu quickly contacted Hu Jiaran to report the matter. The latter was very angry when he learned about the situation.

"The public security abroad is too bad." He complained to Gao Feng, "And this black guy has to be treated well. They always like to come out and cause trouble."

"Stop talking and find a solution quickly." Gao Feng comforted him.

Fortunately, there was stock in the laboratory. Morris Marshall specially sent a plane to transport it. At the same time, security was strengthened in the hospital area. Many high-power searchlights were installed to prevent anyone from blending into the darkness with the help of their skin.

One month later, China’s clinical trial application was finally approved.

Gao Feng thought about it and decided to add another clinical trial site in addition to the Pediatric Neurology Ward of Union Medical College.

This was the result of the strong request from Director Shi of the Provincial Medical Department of Pediatrics, and of course Dean Guo also played an important role in it.

The patient recruitment form for the clinical trial was quickly sent out, and preparations were carried out in an intense and orderly manner.

Director Shi of the Department of Pediatrics is very concerned about this clinical trial. To be honest, he has very little experience in this area. It is not his problem. The main reason is that the provincial doctors have rarely participated in such things before.

In fact, to put it bluntly, it is not qualified.

He mobilized all his strength in order to attract enough patients.

Hu Jiaran told him in advance that at least more than 10 patients should be recruited, otherwise there would be no need to set up the hospital at all.

Director Shi was still very nervous, fearing that the conditions would not be met. But what happened next was beyond his expectation.

"When I was old, I had a child here."

"Director Shi, I'm bringing the patient here."

"Director Shi, please take care of yourself!"

"When I was young, I heard about you"

The number of patients soon reached 30, and Director Shi's team was still receiving calls. Some patients from abroad even came.

Director Shi had never seen so many patients with spinal muscular atrophy, which made him a little overwhelmed.

"Stop recruiting." Hu Jiaran talked to him. "There are too many patients and medicines may not be available."

But what is troubling is that patients are still coming in a steady stream, and there are even big disputes among themselves over the issue of enrollment.

"Our child's condition is so serious that he must be admitted today!" A middle-aged man said with a firm attitude.

"No matter how serious your condition is, you have to decide on a first-come, first-served basis!" The person arguing with him was a woman. Although she looked very weak, her tone was non-negotiable.

There were people on the phone looking for connections, and the hall to the east of the pediatric department was unusually noisy for a while.

(End of this chapter)