This doctor has a system

Chapter 402 467. That’s really amazing
Two days later, the test results of psychological counselor Wang Yangguang came out. No HIV virus was found in his body.

This result shocked everyone in the laboratory department. The director of the infectious disease department also ran over, and everyone surrounded Wang Yangguang.

"Can I leave?" The latter was a little scared. So many people came over at the same time and looked at him curiously, which put Wang Yangguang under great psychological pressure.

"Of course not!" Director Zhou of the laboratory department said hurriedly, "Didn't we agree that you have to cooperate with us in doing some research."

"If you don't do it in vain, I'll give you a labor fee." The director of the infectious disease department said immediately, "This is of great research value."

Wang Yangguang was very hesitant and said he wanted to think about it.

He is a little confused about his future life plans. He originally changed his career because of AIDS, but now he seems to be able to return to his old career, which is very embarrassing.

But thinking about such an empty sister who needed him to soothe her injured heart, Wang Yangguang immediately cheered up.

"Emotional therapists have to keep doing it!"
-
Zhao Xingye also came from Zzhou in the past two days. CAR-T therapy, as a new treatment method for blood tumors, has attracted huge attention in the industry.

Thanks to the rapid spread of information, even the aunts setting up roadside stalls can now say a few words.

"I'm telling you, you don't have to worry about cancer now." The pancake seller said to Li Youliang, "Now there's a new drug or something."

"This patient is quite important to you and may affect your future development in the medical field."

When there is no choice, it will make people anxious, but when there are too many choices, it will also be easy to make people embarrassed. Now Zhao Xingye is very embarrassed.

"Okay, I believe you." Gao Feng said with a smile.

"I will do this well and live up to your expectations of me." Zhao Xingye said solemnly.

"That's really amazing." When Li Youliang paid, he gave the aunt an extra 2 yuan.

"Is it so miraculous?" Li Youliang looked curious, "But I heard that this technology is not mature yet, and it seems that it can only be used for a few types of tumors."

"Running home in half an hour!"

"As soon as the medicine was injected, I stood up on my own!"

Academician Bao came over in the afternoon. He came specifically to see Gao Feng.

"What's wrong?" Li Youliang.

"Gao Feng, do you have any plans for your future career?"

"There are many institutions now interested in our CAR-T therapy." Zhao Xingye reported to Gao Fenghui, "I have met with them in the past few days, and most of them are very sincere."

"I need to discuss something with you." Academician Bao said straight to the point, "A patient with the same refractory large B-cell tumor came to our door."

"Originally, I was almost dying just lying down, but guess what?"

"It's up to you." Gao Feng didn't want to worry about this, "We can discuss it with Jiaran."

"You don't understand this," Auntie said to him while spreading pancakes, "It's so magical."

The boss's answer was as expected by Zhao Xingye, and he was used to it.

"My third aunt and second uncle's neighbor's nephew used it the day before yesterday!"

Academician Bao's expression was quite solemn, and Li Youliang poured a glass of water for the two of them.

"The Kaka Kaka Kaka punch is inserted into you and the cancer cells are immediately eliminated."

"Well, I haven't really thought about this in detail." Gao Feng said, "But the higher the achievement, the better."

He didn't even hide it in front of the teacher.

"I think the academician definitely didn't run away." Academician Bao said with a smile, "You are just a little less qualified now." In fact, it seems inappropriate to say seniority, and it is more appropriate to say age.

"I communicated with a few old friends and everyone recognized your achievements."

"But he's just too young."

Academician Bao felt quite complicated. The only people who could be elected as academicians were uncles and aunts. If a young man in his 20s suddenly came up, some old comrades might not be able to accept it in their hearts.

"The patient's father is."

When he said this, Gao Feng immediately understood that China, or most countries, is a relationship-based society, and everything must be done based on relationships.

Everyone said that what they made was good, but some of the judges were not related professionals, and he couldn't figure out whose one was better.

It is an indisputable fact that people will definitely tend to vote for people they know well.

For example, when choosing a village chief, would you rather vote for your second uncle, or for a passerby you don’t know?

That must be my eldest son, no need to mention it.

"Let him come. Before the team evacuates, we can quickly customize it for him." Gao Feng said simply.

"Okay, I'll communicate with him when I get back." Academician Bao didn't say much more, and the two talked about some things related to becoming an academician.

Generally speaking, if you want to become an academician, you must have at least a PhD degree. At this time, most people are about 26-28 years old. This step is almost impossible to skip.

Then there is the postdoctoral fellowship (about 29-32 years old, can be skipped), and then there is the NSFC Youth Fund or equivalent fund (before 35 years old, can be skipped).

Next is the Four Youths (Qingqian, Qingba, Youqing, Qingyangjiang). Most academicians receive this honor before the age of 38, and generally cannot be skipped.

At the same time, you need to obtain funds multiple times. This step can be skipped, but most people cannot skip it. It is impossible to obtain the Four Youths without funds.

Further down are the Outstanding Youth and Yangtze River. You cannot apply for Outstanding Youth and Outstanding Youth at the same time. Generally, you must apply before the age of 45. Although there are no specific requirements for this level when evaluating academicians, almost all academicians have obtained this honor.

Next, Chief 973 (now renamed, can be skipped).

As the first person to complete the project, he won three national awards (natural science, invention, and technological progress, preferably the first two, cannot be skipped).

If all the above items are passed, congratulations, you can start applying for academicianship.

Generally speaking, in the first year, you will definitely have to run with me - you will continue to apply for the three major awards - until you are finally selected as an academician of the two academies. At this time you are already a giant, but if you are strong enough, you can continue to move forward.

Receive the country's highest science and technology award (lifetime achievement award) or the president of a key university (deputy ministerial level) - the Minister of Education or the Ministry of Science and Technology - the deputy position of the National Committee of the Chinese People's Political Consultative Conference or the National People's Congress - the end.

Gao Feng's current situation is very optimistic. He is currently a Ph.D. student of Academician Bao and will definitely graduate successfully. It is also very easy to obtain the NSFC Youth Fund or equivalent funds.

He doesn't have the Four Youths, but he is a Yangtze River Scholar directly. This is obviously more convincing.

Due to the first imitation of bevacizumab injection, it was almost certain that he would win the National Natural Science Award, and he passed this test perfectly.

From this point of view, it seems that you can apply for academicianship after you graduate with a Ph.D.
Therefore, Academician Bao is not worried at all that he will not be evaluated as an academician. He is just curious about how long it will take to achieve his wish.

"Road to Academician: Due to CAR-T treatment, your reputation in the medical community has been greatly improved, which will have a significant impact on your future career path to a large extent. The system will release a series of tasks: Road to Academician, It is recommended that you continue to work hard in CAR-T therapy and strive to become the youngest academician in the country as soon as possible," the system prompted.

The road to academician? Gao Feng was stunned for a moment, this system was more advanced than him.

However, his age is a flaw. Even though he has produced a lot of good things so far, it is not enough to become an academician at this age. He needs more achievements to convince some conservatives.

Since CAR-T therapy has attracted so much attention, it is a good choice to continue to work in this area.

Gao Feng was already thinking about what to do next.

CAR-T treatment mainly targets blood tumors and is less effective on solid tumors. Common blood tumors include leukemia, multiple myeloma, and malignant lymphoma.

There has been initial progress in malignant lymphoma, and then Gao Feng's attention turned to leukemia and multiple myeloid tumors.

Most people are more familiar with leukemia. As a malignant clonal disease of hematopoietic stem cells, leukemia cells are stagnated at different stages of cell development due to uncontrolled proliferation, differentiation disorders, and blocked apoptosis.

In bone marrow and other hematopoietic tissues, leukemia cells proliferate and accumulate in large numbers, inhibiting normal hematopoiesis and infiltrating other organs and tissues.

我国白血病发病率为3～5/10万。2015年，全国新发白血病患者约为7.53万人。在恶性肿瘤所致的死亡率中，白血病居第6位（男）和第7位（女），儿童及35岁以下成人居首位，2015年全国因白血病死亡的患者约53.4万人。

Multiple myeloma is a malignant proliferative disease of plasma cells. The disease is characterized by the unrestricted proliferation of plasma cells in the bone marrow like tumor cells. In most cases, it is accompanied by the secretion of monoclonal immunoglobulins, which eventually leads to organ or tissue damage. damage.

The disease mostly occurs in middle-aged and elderly people, and there are obvious differences in gender distribution. The proportion of men affected is higher than that of women. China currently lacks precise epidemiological data on MM. Previous data shows that the incidence rate of MM in my country is about 1.0/10. The incidence rate is lower than that in Western countries, but it has a trend of increasing year by year. The onset of multiple myeloma has a certain genetic correlation, and the patient's immediate relatives are at a higher risk of developing the disease than the general population.

There are many classifications of these two diseases. Leukemia can be simply divided into acute lymphadenitis, chronic lymphadenopathy, acute myeloid leukemia, and chronic myeloid leukemia. The types of immunoglobulins secreted by myeloma cells divide the disease into the following types: IgG type, IgA type, IgD type, IgM type, IgE type, light chain type, biclonal type and non-secreting type. It can also be further based on the light chain type. Types are divided into κ type and λ type.

Anyway, they are all quite complicated, and I’m afraid it’s not easy to do any of them.

Gao Feng decided to ask other people's opinions.

"I think multiple myeloma is better." Dr. Gong expressed his opinion. "In the final analysis, our CAR-T treatment still needs to find targets, and multiple myeloma has more advantages in this regard."

Although there is less research than leukemia, it is easier to find therapeutic targets.

"Not necessarily." Zhao Kang said, "I think there is no difference between the two. The targets are definitely difficult to find, but there are more patients with leukemia, so a larger sample size is definitely better."

Gao Feng also felt that what Zhao Kang said was more reasonable.

But he soon changed his mind because when searching the literature, he found that someone had published a target for multiple myeloma. This target called BCMA was reported 2 years ago.

The author at that time only published it as a discovery, but now it has undoubtedly given Gao Feng a guiding light.

"This is multiple myeloma." He made a decision and was ready to start immediately after the patient in his hand was finished.

The patient introduced by Academician Bao was a 52-year-old middle-aged man. His general condition was much better than that of Ran Manyun. This gave the team enough time, and Gao Feng did not feel any pressure.

This time the drug quality control was more comprehensive. Dr. Gong found many problems in viability and immune typing testing. These were analyzed and recorded by Hu Jiaran one by one and reported to Gao Feng.

Gao Feng was seeing a young female patient at this time.

"I thought you wouldn't come." He smiled.

The patient was the patient with bloody tears that he had made an appointment with before, but he did not come to see the doctor that day. He thought something had happened to him.

It's normal for a patient to change his mind. He almost forgot about it, but the patient showed up today.

"I'm sorry, Professor Gao." The patient apologized repeatedly, "The company suddenly informed me that I was going on a business trip, and I just rushed back."

She came right over as soon as she came back.

"It's okay. Please tell me first what happened to you?" Gao Feng said, "Bloody tears?"

"Yes, I've had it since I was a freshman in high school." The patient said, "I discovered it by accident while wiping my tears."

I was very nervous at the time, but I stopped crying afterwards, so there were no more tears.

Later, this situation occurred intermittently several times, but the patient did not feel any obvious discomfort and did not go to the hospital until he went to college.

That day she lived outside with her boyfriend, who was a sports student and had relatively good physical fitness.

Then, she felt so comfortable that she couldn't control it, and her tears fell all of a sudden.

Shedding tears at this time is undoubtedly a strong recognition of her boyfriend, but there is something obviously wrong with bloody tears.

This frightened the boyfriend so much that the two went to the ophthalmologist the next day. After careful examination, the doctor said that no eye disease was found.

Later, it seemed that there was nothing special about it, but in the past year or so, the frequency of blood and tears among patients has increased significantly.

The hard work of raising children, the poor relationship between mother-in-law and daughter-in-law, the husband's incomprehension, and the huge work pressure make the patient feel a little moody from time to time.

Looking at the patient's examination sheet, Gao Feng fell into deep thought. He shed tears and must have considered eye diseases first, but the ophthalmologist said that there was nothing wrong with the patient.

That's strange. Could there be other factors?

"When do you usually shed tears of blood?" he asked.

"She bleeds when she cries," the patient replied.

Great answer.

(End of this chapter)