This doctor has a system

Chapter 417 482. New direction for tumor treatment?
"You can keep yourself busy if you are busy." Wang Liang said quickly, "But the business is not very easy to do."

There is too much competition in the field of testing now, and the surrounding markets are almost saturated, so it is really difficult to attract business.

He went to a hospital and asked about it. The receptionist was polite and enthusiastic, but he didn't know anything about it.

I found an acquaintance who understood and understood, but there was nothing I could do.

He caught the person in charge of the other company and explained his own advantages. The result was: grateful, grateful, but sorry.

"I don't know what went wrong." Wang Liang said distressedly.

"There could be something wrong." Hu Jiaran smiled, "I didn't do my job well."

"Or you just haven't found the right person."

When he said this, Wang Liang understood.

"I'll ask later." He stood up and left.
-
"Nannan, how about you be my girlfriend?" Liu Zhuocang mustered up the courage to grab Qi Nannan's chubby hand, "I like you."

Academician Bao

In 2002, scientists discovered that PD-L1 exists on the surface of many tumor cells and can also bind to PD-1 on T cells, allowing them to evade attack by the immune system.

"Oh, you made a careless friend." Academician Bao sighed, "Actually, it's not a big deal, and it's not worth your special trip."

"That Xiao Liu is a bit short-sighted."

Academician Bao valued the accomplishments of Cancer Research UK professors and paid the price.

Academician Bao was old and was very angry when he learned the news. He immediately contacted the other party.

"As a great professor at Cancer Research UK, I can find these things very reasonable." Tojan Russ said shamelessly, "Please don't disturb my research again in the future."

When Tojan Rath returned home, he trumpeted in China that he had discovered a new direction in tumor treatment, and he took part of Academician Bao's research results as his own.

Liu Zhuocang was very nervous. He had never even touched a woman's hand in more than 20 years.

"I'm fine, I just have the same old problem." Academician Bao said weakly. His heart has always been bad, and this time he got myocarditis after catching a cold, which is quite serious.

"Stoyan Las?" This was the first time Gao Feng heard this name.

"Actually, there's nothing to be sad about." Gao Feng said, "I saw that these things are not important results."

"I was made angry by a foreign devil." Xiong Huaxin became extremely angry when he mentioned this, "That Stoyan Ras is simply a villain!"

Academician Bao feels that this is a new direction. If something can be discovered, it will have a huge impact not only on the treatment of lung cancer, but even most tumors.

In 1992, Japanese professor Tasuku Honjo accidentally discovered that on the surface of the cell membrane of T cells, there is a protein that can cause T cell apoptosis, named PD-1 (programmed death receptor-1).

"Xiao Liu is an honest person." Hu Jiaran glanced at her with disgust, "Be nice to others."

In 2000, scientists discovered a protein that can bind to PD-1 on the cell membranes of other human tissue cells, and named it PD-L1 (programmed death receptor ligand-1).

Qi Nannan was speechless. This was her first time with a partner.
-
"Gao Feng, come to the capital quickly." Xiong Huaxin called, "The teacher is sick."

Gao Feng was shocked, why did he suddenly become ill? He just had a phone call with Academician Bao a week ago, and the other person was nice and full of energy.

Yes.

Because that’s how you came here too!
Hu Jiaran was quite shocked about Qi Nannan's divorce.

He had a lot of ideas in the past two years. He mentioned some of these things to Tojan Lass in his letters, and then the latter became interested.

If you can't speak, you don't have to speak, Xiong Huaxin thought.

The old man was so angry that he caught a cold that night, which lasted for a few days and turned into myocarditis.

"Shut up if you don't know how to speak." Qi Nannan was carefully putting the roses given to her by her boyfriend into the glass bottle.

Gao Feng and Li Youliang arrived in the capital soon. Academician Bao was really sick, lying on the bed in a hospital gown, looking sickly.

After Xiong Huaxin's narration, Gao Feng finally clarified the context of the whole matter.

"Okay, I'll rush over right away."

Damn it! It’s not in vain that I spend so much time thinking about you every day! Qi Nannan was overjoyed.

This Stoyan Ras is a professor at Cancer Research UK, and Academician Bao met him when he visited abroad five years ago.

you know!

The team led by Academician Bao has been committed to research on lung cancer. In the past two years, he has focused his work on programmed death receptor-1.

"I told him before that I made a novel discovery."

"That's what I came here for this time." Xiong Huaxin said, "The teacher didn't think too much at the time."

"We have had many exchanges before." Academician Bao looked depressed when he mentioned this, "I have always thought that this person is pretty good and capable."

This is a protein distributed on the surface of cells and is an important immunosuppressive molecule.

"Why did this happen all of a sudden?" Gao Feng asked.

One careless moment caused the entire team's two years of hard work to be in vain. Academician Bao was mainly stuck in this situation and could not recover.

He is a young man with a strong body, strong blood, and normal sexual orientation. Do you know how he came to be here after all these years?

Last week, Stojan Ras came over from the UK to talk to him about old times. Academician Bao felt very happy at the time, but he later discovered his intentions.

The other party said that he was not familiar with him and that he had put a lot of effort into making these things, so he asked him not to make trouble.

"Although it's not a big achievement, I just feel uncomfortable." There are no outsiders here, and Academician Bao doesn't pretend anymore.

"When I think about what this British devil might accomplish by following my ideas, I feel pain in my chest."

Although Tojan Rath's quality is low, he is a professor at Cancer Research UK, so his level is very high. Academician Bao's worries are likely to come true.

"How about you take us to do this too." Xiong Huaxin said to Gao Feng after leaving the ward, "You can definitely do it."

Gao Feng nodded, he had exactly what he meant, and he couldn't let Tuoyan Lass succeed at any cost.

"Old Bao made a mistake this time." Someone said, with a very gloating tone.

"He deserves it." A person next to him agreed, "The British devil has always had a bad reputation, and he didn't check it out."

"You are a bad person, so you don't know how to remind Lao Bao."

"I have nothing to do." The man said cheerfully, "Old Bao is getting older, so this disease may be cured."

When an academician spot becomes available, maybe there will be hope for him.

Human nature has both a sunny side and a dark side. We can neither view human nature as too ugly nor think of it as too beautiful.

Gao Feng has been intensively studying the knowledge related to programmed death receptor-1 in the past few days, and there is a direction that interests him. If targeted drugs directly kill tumor cells, then programmed death receptor-1 may have a slightly more tortuous action against tumor cells. It achieves its goal by enhancing the body's immunity.

In fact, it is not just Academician Bao who is doing research in this area, some scholars from European and American countries have also set their sights in this direction, but unfortunately, no particularly great progress has been made so far.

The main reason is that this mechanism is not fully understood.

Gao Feng was naturally clueless, but he could cheat.

In fact, he didn't really want to rely on the system this time, but he was not very familiar with Toyan Lass, and he didn't know the opponent's level.

It would be terrible if the other party was really lucky and did something. Academician Bao was just right now, but there is no guarantee that he would get seriously ill again.

He always thought that Academician Bao was a generous person, but he didn't expect that he was also a petty person.

However, it is normal to be emotionally unable to accept being deceived by someone you trust.

At 9 p.m., 20 years ago, everyone would have been asleep at this point, but now the nightlife has just begun.

Gao Feng lay on the bed and entered the system space. He entered the keyword: programmed death receptor-1 with anticipation, and a large amount of information suddenly appeared.

Gao Feng was overjoyed after taking a look at it. This was not the useful but limited stuff that his teacher, Academician Bao, had spent two years developing. What was displayed on the screen was all practical information.

"PD-1 inhibitor?"

Gao Feng never expected that the harvest would be so great. Not only was it supported by the concept, but drugs would even be developed based on this principle at some point in the future.

A complete one-stop service! The system is a little bit awesome.

What else is there to say?
Copy and learn from it!
B cells and T cells, these immune cells, are like police, responsible for identifying and destroying invading foreign objects and tumor cells.

Tissue cells are like inhabitants of the cellular world.

After being identified by the police, they will receive a "good guy card" and live and work in peace and contentment under the protection of the immune system.

Tumor cells are like bad molecules in the cellular world.

They cannot be identified by the police and do not have a "good guy card". They hide around all day long. Once they are discovered, they will die.

However, some tumor cells were not eliminated. They did not know how to get the "good guy card."

In this way, tumor cells escape the supervision of the immune system. Medically, this situation is called immune escape.

"We must first understand the mechanism by which tumor cells acquire immune evasion." Gao Feng talked to everyone, "This step should not be difficult. As long as we overcome the difficulties, I think one month is enough."

Academician Bao's team, including Xiong Huaxin and other disciples, waited with a straight face for him to assign tasks.

At this time, everyone has not realized that what follows will be the most difficult years of their lives.

Many years later, an academician specifically mentioned this stage when delivering his election speech.

"It was at that time that I awakened to the Holy Body of the Houtian Cow Horse." His eyes suddenly became moist. "At that time, I had just entered the first year of graduate school and joined Academician Gao Feng's research team with my teacher without any preparation."

"I was so tired that I wanted to cry."

"But I didn't cry."

"Too busy to care."

He once thought that all medical graduate students were like this, but later he found out that they were the only ones like this.

"After the project ended, I got used to being abused. When everyone competed later, no one could beat me."

"So, you are very grateful to Academician Gao Feng now, right?" a reporter asked.

"Yes."

Thank you so much, the academician thought to himself. Every time he thought about it, he wanted to stab him a few times.

"Let me give you a direction. There must be traces of immune evasion of tumor cells." Gao Feng said, "I suggest starting with cell membrane proteins."

To put it simply, there are various protein "pendants" hanging on the cell membrane of cells, and they rely on the "pendants" to recognize each other.

T cells have a "pendant" called PD-1, which is a bit like a card reader.

On the surface of some tissue cells, there is a "pendant" called PD-L1, which is a bit like a residence permit.

The tissue cells raised their own PD-L1 and pointed at the T cell's PD-1, beeping, "I'm one of you, give me a good guy card."

Normally, T cells encounter tumor cells, recognize them, and kill them directly.

Some tumor cells also grew PD-L1 "pendants". When they encountered T cells, they immediately took out their residence permit, but were mistakenly issued a "good guy card" by the T cells.

This is the immune escape mechanism of tumor cells. Everyone here can also imagine it, but the difficulty lies in discovering what "pendants" the tumor cells have grown.

There are many proteins on the cell membrane, and their functions are diverse. In addition to playing the role of "identifying friend or foe", they also have other functions.

After spending 100 skill points, Gao Feng already knew the protein fragments used by tumor cells to escape immunity. He was thinking about how to let everyone know about it.

There are too many smart people in the team, and some things are not obvious yet.

Thinking of this, Gao Feng had a headache. Who said it would be easier to deal with smart people?

"There are so many protein fragments, we have to find out when to go." Someone complained in a low voice.

It is not as simple as everyone thinks. The cell itself is a very small unit. Now it is necessary to separate the substances in this small unit. It is not easy when you think about it.

"Use PCR to amplify it." Gao Feng said. Fortunately, the current PCR technology is very mature, otherwise the workload would be 10 times greater.

During the first week's work report, Gao Feng was shocked.

"Currently, our group has discovered that fragments of the &3-7 fragment can generate chimerism with T cells."

"We also found a group!"

Gao Feng silently crossed out two sets of results, and at the same time he was in hesitation.

Everyone seems to be cheating, so why don't we just stop cheating?
But it turned out later that he had overthought it, and no one gained anything in the second week. However, according to estimates, such a clip would require at least 6-8 sets.

"I have found a group and have verified it." Gao Feng said, "Don't be discouraged, just move forward step by step."

"Hua Xin, please wait a moment." He gave the other party a note.

"This is it?" Xiong Huaxin was stunned for a moment.

"You lead people to work hard on these fragments in the expected directions."

"Okay." Xiong Huaxin didn't think too much. Now is the stage of casting a wide net. He can do anything.

(End of this chapter)