This doctor has a system

Chapter 420 485. Most likely it is a rare disease
He really has a sense of crisis. It seems that there are still people doing research in this area. If something goes wrong, it will be great fun.

The next step is to figure out how tumor cells with extra protein fragments combine with T cells, what changes happen to them after binding, and why immune cells no longer attack them?
"The time is tight and the task is heavy." Gao Feng said solemnly to everyone, "But I believe that as long as everyone works hard, we will definitely be able to complete the goal of this stage as soon as possible."

The expressions of everyone below were also very solemn. They had nothing to say. They must be working overtime every day.

"Huaxin, I transferred a group of people from the company." Gao Feng said to Xiong Huaxin, "They have been tested for a long time and are very good at producing results in a short period of time."

If Hu Jiaran were here, he would definitely agree with him.

Yes, yes, you are right, we are all born with the Holy Body of Ox and Horse, and we like to work overtime the most.

The team leader from Fengxin Technology was Dr. Gong. On the day he arrived, he received a small note from Gao Feng.

"I have already made some trivial discoveries. You can take someone to verify them." Gao Feng warned, "If the results are okay, then the process should be reasonably improved."

Dr. Gong nodded in understanding.
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"Gao Feng, come and see a patient." Director Fan called, "I feel it is most likely a rare disease."

Gao Feng was a little skeptical. Are there so many rare diseases? During this period, he followed Director Fan to see many patients. Most of them could be considered difficult and complicated diseases, but they were far from rare diseases.

Director Fan introduced Gao Feng to Director Yang again, and the other party acted a little casually. Gao Feng could feel that Director Yang didn't take him seriously at all.

"I didn't hear that a rare disease clinic has been opened here, so we just wanted to come and have a look."

"I feel it should be a genetic disease." Gao Feng thought about it and said to Director Fan, "There may be a problem with the genetic program that controls the inflammatory response."

"I don't know what's going on." Lele's mother's hair has turned a lot whiter. "I looked everywhere, but I can't find out what the cause is."

In fact, inflammatory response is a manifestation of the body's normal physiological defense mechanism, just like fever is the result of our body's fight against bacteria and viruses.

"Gao Feng is a student of Academician Bao, the youngest Yangtze River Scholar and the winner of the National Award." He added.

Director Fan was very embarrassed. He could understand these words, but when they were put together, he couldn't figure out what they meant.

Since the cause cannot be found, symptomatic treatment can only be used, and of course the effect will definitely be poor, so the patient suffers a lot.

Chronic relapsing multifocal osteomyelitis is an autoinflammatory disease, but relevant examination results show that none of the existing disease-causing genes are the "culprit" in Lele's illness.

From childhood to the present, have you ever experienced the following: recurring fevers, frequent oral ulcers, rashes, swollen lymph nodes...

"This is Director Yang from the Department of Orthopedics." Director Fan introduced to Gao Feng, "The patient was hospitalized at his hospital last time."

"It has nothing to do with genes or anything."

From then on, Director Yang became disgusted when he heard about genes. He always felt that it was a waste of money to check for orthopedic diseases.

After all, he is an older doctor with rich clinical experience, but he is still somewhat inexperienced with some of the new technologies that have emerged in recent years.

As soon as these words came out, Director Yang, who was originally casual and even perfunctory, was obviously stunned for a moment.

The most exquisite creation of nature is the human body. The human body is like a precision instrument that operates regularly. Various physiological reactions occur in our body every day. Among them, the inflammatory reaction is one that we are familiar with. Another strange one.

But just as things go to extremes, excessive inflammatory reactions will bring a heavier burden to our bodies. This is an autoinflammatory disease, such as repeated fevers, rashes and even ulcers, arthritis, etc. - these are all symptoms of autoinflammatory diseases. .

You may think that these are very common diseases, but they actually have a professional medical name - autoinflammatory diseases.

Gao Feng disagreed with his opinion. The patient has never been able to find the cause of the disease, and he has no way to start a good treatment.

"Hello, Professor Gao." He took the initiative to extend his hand.

At the same time, Lele cannot run, and it is very difficult to even walk or stand up. This pain and inconvenience has seriously affected her normal life.

Gao Feng learned that Lele had been hospitalized in the orthopedics department here before. He had done a lot of examinations at that time, but in the end he was discharged with disappointment.

Now the child is crying out in pain every day, which makes her heartbroken and powerless.

Just as there are always two sides to everything, for lucky people, some common autoinflammatory diseases can get clear medical explanations and effective treatments, but for some unlucky people, some rare autoinflammatory diseases Disease is comparable to an "incurable disease".

First we need to understand what inflammatory diseases are.

The patient, Lele, is a 12-year-old girl. Logically speaking, this should be a carefree age, but she is listless and in unspeakable pain due to repeated joint swelling and pain for more than ten years.

"I was diagnosed with chronic relapsing multifocal osteomyelitis at a top orthopedic hospital," Director Fan said, "but the cause of the onset has never been found."

"I don't know what to do now." Lele's father is still relatively strong. Over the years, he has taken his children everywhere to seek medical advice and has almost visited these top hospitals.

At this point, many people must think that inflammatory response is a bad sign, but the fact is exactly the opposite.

What he said is well-founded. When the patient was hospitalized here, he also had a multidisciplinary consultation, and the relevant disease-causing genes were all checked. Although a lot of money was spent, nothing of value was produced.

"What kind of genetic disease? It's quite mysterious." At this moment, a middle-aged man in a white coat came over.

While other children are gathering their strength to "run away", Lele's height is only 122cm, which is probably only enough for a 7-year-old child.

"It does look very strange." Gao Feng conducted a careful physical examination on Lele. Why does multifocal osteomyelitis recur many times?

Director Fan, who has matured with age, also felt it.

Gao Feng shook hands with Director Yang.

"Really, I have a hunch." Director Fan said to Gao Feng, "I will admit the patient to the hospital first. Come take a quick look after you are done."

"It's better to spend the limited money on follow-up treatment."

The thin body and dull eyes all revealed to Gao Feng the patient's misfortune.

Lele's current situation is no different from suffering from an incurable disease.

"I think the patient has refractory multifocal osteomyelitis." Although Director Yang glanced at Gao Fenggao, his mind would not change.

No wonder everyone likes to hold some academic posts concurrently and always makes their names long. It is indeed beneficial.

Some diseases do not need to find the cause. For example, for general infections, we do not need to figure out what the causative bacteria are. Is it a fungus? bacteria? Virus? Or some other microorganism.

Because as soon as ordinary antibiotics are used, the infection is under control.

In this case, there is no cost to find the cause.

But Lele's situation is obviously different. The cause of her illness is very strange and she is plagued by diseases.

The child is 11 years old, as tall as a little bean curd, and her body is still so thin that her eyes have no light left.

If the cause of the disease is not found quickly and effective treatment is provided, Gao Feng feels that this patient will have no future.

She is like a leaf that has lost its nutrients. One day a gust of wind blows and it may wither.

"Don't think that genetic testing is so magical." Director Yang said in a serious tone, "There are many diseases for which the cause cannot be found." He knew the patient's family situation very well, and they could not afford expensive examinations.

However, Director Yang still admired the patient's parents. He thought that the latter would give up soon, but he did not expect that several years later, the family members were still rushing around for the patient's condition.

From this point of view, Lele’s parents are very competent.

Gao Feng didn't want to have any dispute with Director Yang, and there was no need.

"If it doesn't work, transfer to us." He said to the patient's parents, "We will conduct a detailed screening of the child."

Lele's parents haven't spoken yet, but Director Yang on the side is unhappy.

"Why should the patient be transferred to a different department if you are doing well!" He said dissatisfiedly, "I have called on everyone to raise part of the fee for the patient, and then I can apply for some exemption from the hospital."

This will reduce the burden on family members.

It can be seen from this that Director Yang has a cold face and a warm heart.

Gao Feng was thinking about what to say, but Li Youliang on the side was unhappy.

what does it mean? Are you going to pay us?
No, do you have that qualification?
"We still need to transfer to a different department." He stood up and said, "We have cooperation with a company over there, and there is a large cost subsidy for such patients."

Lele's parents quickly processed the transfer. They were very grateful to Director Yang, but they still wanted to check again.

"This is the last time. If it doesn't work out, we will go back to our hometown."

"Surprise: Some people are born to be stubborn, and they always think that their own rules of conduct are correct. Please use professional medical technology to let Yang Zhifeng know that he has fallen behind the times. You can get 50 skill points by completing the task." System Posted the task.

It can't be seen that Director Yang is still a small boss and has given quite a lot of skill points, but this also shows that the cause of the patient's disease is relatively complicated.

In the next few days, Gao Feng consulted a large amount of information.

"Director Fan, are you wondering if there is something wrong with the IL-1R1 protein?"

Seeing that Director Fan was confused, Gao Feng had no choice but to explain.

The IL-1R1 protein located on the human cell membrane is like an important signal receiver. When our body is infected and damaged, IL-1R1 will receive the relevant stimulation signal and transmit it to the cell in time. Within the body, immune cells and defensive inflammatory responses are activated, just like quickly mobilizing "defense troops" to help the body fight infection.

When the task is completed, IL-1R1 will receive the safety signal and release the "withdrawal" command, so that the inflammatory response that has completed the defense task will be "braked" in time.

"I think the key to Lele's condition is probably related to the mutation of this crucial signal receiver."

"Is this easy to check?" Director Fan asked with interest.

Of course it's not good, it's quite difficult to do, at least it can't be done by Gao Feng alone.

Soon Hu Jiaran came to the capital with a team of 7 people.

"If we work harder for myeloma, maybe we can make a breakthrough." He complained to Gao Feng, "If this person withdraws, he will probably be pushed back again."

"Just drag it." Gao Feng said casually, "Do this first."

The leader's words can cause the subordinates to run away and break their legs.

Hu Jiaran contacted the laboratory, ordered experimental supplies, and asked people to raise white mice.

"This is a charity run by the boss." Li Youliang said to him, "It definitely won't make much money."

To be exact, they lost money, and a lot more.

Hu Jiaran thought it didn't matter. The boss was rich. If they spent some money and got happiness from it, then it would be worthwhile for them to do what they did.

"Damn it, I haven't seen you for a while, you are so enlightened!" Li Youliang said in shock.

"That's right." Hu Jiaran was very impressed by his compliment, then turned around and called Qi Nannan again.

"I'm raising rats, come on."

Qi Nannan's boyfriend was also in the team. Seeing that he couldn't go back in the short term, he thought of asking Qi Nannan to come over as a way to make use of the waste.

"The quality of your batch of mice is not good, give me a new batch!" Qi Nannan got into work very quickly, "These hairs fall off as soon as you brush them, and these ones are even worse, with scars all over their bodies!"

"Then there's no problem with this part, right?" The young man who gave away the animals said dissatisfied.

"no!"

"Those eyes aren't bright enough!"

"You" the young man who gave the animals was trembling with anger, "you are picky!"

"If you don't understand, don't talk nonsense." Qi Nannan said fiercely, "Go back and ask the professionals yourself."

In fact, when choosing a mouse, there is a certain saying about observing the eyes.

Eyes are the windows to the soul. Eyes are very important when choosing a mouse. Check whether its eyes are bright and big enough, and whether it can rotate flexibly.

If these points are met, it means it is healthy. On the contrary, if its eyes are dull and there is eye droppings in the corners of its eyes, then nine times out of ten, such a white mouse is unhealthy. Let alone doing experiments, it will be fine when raised. Inexplicably, it fell off.

"Your main task is to analyze the patient's IL-1R1 gene to see if there are any abnormalities compared with normal people." Gao Feng said to Hu Jiaran.

It has to be said that Hu Jiaran and the others were very efficient, and they made a discovery after half a month.

"This should be a new mutation. I checked, and there are no relevant reports in the past." Dr. Lu reported to Gao Fenghui uncertainly, "Of course, further analysis is needed to confirm."

"Analyze it as soon as possible, and then induce and observe it in mice." Gao Feng felt very excited. He had not expected to make a discovery so quickly.

"Jiaran, give everyone some extra bonuses," he explained, "and then take everyone out to relax."

The so-called relaxation means eating, drinking, and having some fun.

But everyone was very tired and didn’t want to move after eating. Later someone suggested going for a massage.

Naturally, those who are not regular would not dare to go there, so Hu Jiaran specially asked people to find a massage parlor for the blind.

With the technician's compressions, he quickly fell into a drowsy sleep. When he woke up, more than 3 hours had passed.

Hu Jiaran stretched and then found a technician wearing sunglasses playing a game, his fingers clicking.

"Hey! Aren't you blind?" he asked.

"You are blind when you are busy, but you are not blind when you are not busy." The technician replied casually.

(End of this chapter)