This doctor has a system

Chapter 426 491. Patients with psychological problems

All in all, it's a nail in the coffin.

He felt that he did it without anyone noticing, but they didn't investigate at all. They came up and said it was you, and then dealt with you directly.

"Don't think so much, just take some rest first." Vice President Zhou comforted him. After all, the other party has been sincere to him for so many years.

Li Zishi walked out with a pale face. He was angry and regretful at the moment, but there was nothing he could do.

"Isn't it a good idea to do this?" Gao Feng soon learned of this.

"That's all it takes for him." Academician Bao snorted coldly. He originally wanted to call the police directly, but thought that it would make everyone's faces look bad, so he gave up.

"You see, after two years I gave him all his academic appointments."

Dare to insult my precious disciple like this, he must let this Li Zishi know what the academic style is today.

What does Gao Feng think about this matter? At present, there is a high probability that Li Zishi committed suicide by himself, but it has not been investigated clearly yet. In this way
If you accuse someone wrongly, wouldn't it be a bit too overbearing?

"What do you think we should do?" Gao Feng asked.

"I understand a little bit." Xiong Huaxin was a little embarrassed, "But I still have a question."

No one said a word below.

"That's Teacher Sun from the school next door." Li Jingfeng said, "I understand, she is divorced now."

"do you understand?"

Seeing the confusion in the other person's eyes, Gao Feng was a little helpless.

In fact, he originally wanted to call the police directly and start a cross-province manhunt for Ya.
After solving his troubles, Gao Feng decided to start the next experiment.

Different from the situation here, Hu Jiaran's progress there was going very smoothly.

Forget it, let’s show off! I'm a dick and I won't pretend anymore.

"You still don't understand the principle." Gao Feng explained to him, "The so-called PD-1 antibody can specifically bind to PD-1, so we must start with T lymphocytes."

PD-1 is a regulatory protein of T lymphocytes, and PD-L1 is a ligand protein produced by tumor cells. It can bind to PD-1 of T lymphocytes, and the immune recognition function of T lymphocytes is inhibited, so that T lymphocytes It will not kill tumor cells carrying PD-L1, so tumors can grow smoothly.

In fact, as long as it can be deposited, Gao Feng has no requirements for this. The purpose of synthesizing this antibody is to treat Lele's condition, and there are currently no plans to produce it as a drug.

"This is indeed a direction." Gao Feng said, "But based on the current conditions, we can only choose one."

"You do this, you" he said.

"No, let's give it a try." Xiong Huaxin said weakly. To be honest, Gao Feng talked about it for a long time, but he didn't understand a lot of it.

"Okay, let's take a look first." Gao Feng said.

"I'm sorry, Brother Liang, I forgot you were married." The young employee named Li Jingfeng apologized quickly.

"Never mind him, let's just deal with him blocking our procedures, and we won't suffer any loss by dealing with him." Li Youliang said, he was happy to see this result.

"Yes, as soon as possible." Gao Feng said. Although Lele's condition is relatively stable, it should be done sooner rather than later, otherwise it may leave some irrecoverable sequelae.

"Our goal is to synthesize a PD-1 antibody." He told the crowd.

"Find a group of people to go in this direction"

"Brother Liang, I may be in love."

In fact, everyone understands this macro principle, but understanding it is one thing, but implementing it is another.

Hu Jiaran led everyone to infuse the extracted antibodies into experimental mice for three days, and the rest was observation.

"Then again."

"Based on the above principles, PD-1 antibodies can specifically bind to PD-1, thereby releasing the immunosuppressive regulation of T lymphocytes, so that T lymphocytes can kill tumor cells."

"Which child's mother are you targeting again?" Wang Liang said nonchalantly, "I advise you to be kind."

"Get out!" Wang Liang glared at him, "Li Jingfeng, are you sick?"

"I have waited for this day." Qi Nannan cried with joy. Although she did a very good job and raised these little things until they were fat and fat, it was not as comfortable as lying down while working.

"Brother Liang, do you have someone you like?"

I don’t know if it is due to the synthesis process, but despite repeated experiments, the purity of the obtained antibodies is still very low, and currently we can only rely on manual extraction and storage.

"We have synthesized the antibody, but the impurity content is very high." He reported, "There are difficulties in depositing it, and we are trying to solve it."

"So, we can start doing animal experiments?"

Now Qi Nannan's carefully selected guinea pig finally came in handy.

"I have no clue at all." A week later, Xiong Huaxin came over to report to Gao Fenghui, "Now everyone has different opinions."

The real situation is that his skill points are not enough, and it is too painful to live in the system space day and night. Gao Feng decided to make one first, and let everyone take their own time to do the rest.

In fact, this beginning is still very difficult. As I said before, everything is difficult at the beginning, it is also difficult in the middle, and it is even more difficult at the end.

"Why do we choose PD-1 antibodies instead of PDL-1 antibodies? Doesn't it mean that we just need to prevent the PD-1 receptor from binding to the ligand PD-L1?"

"Do you understand what I mean?"

Some people believe that reverse transcription should be carried out directly based on the proteins on the surface of T cells, while others believe that it is better to start from tumor cells and directly synthesize a substance that can specifically collect ligand proteins on their cell membranes.

"I think everything is fine." Xiong Huaxin replied honestly, "It all makes sense."

"No, Jingfeng, I think you need to see a psychiatrist." Wang Liang advised, "Why are you getting into trouble with the elder sisters!"

"I can't control myself. I can't control myself at all." Li Jingfeng also felt a little distressed. He didn't feel anything when he saw these young beauties, but he was excited when he saw the older sisters with a bit of charm.

It's really weird.

Wang Liang disagreed with his hobby.

"No, why don't you wait? Men like different types of women at every stage."

"But my parents are quite anxious."

Li Jingfeng is 26 years old this year. Although he is not too old, his parents have spared no effort in urging marriage.

For a while, he got annoyed and said that if he was pressed for marriage again, he would just flip the table over.

As a result, after returning for the Chinese New Year, Li Jingfeng fell into deep thought when faced with a stainless steel dining table weighing more than 200 kilograms.

"The part where the table legs are connected to the ground has expansion screws." His father proudly told him, "If you can overturn it, I will take your last name!"

"Then you give it a try." Wang Liang said. In fact, if you think about it carefully, finding a woman 7-8 years older than yourself is not a problem.

No matter what age a man reaches, he will not reject an 18-year-old girl.

"Stop chatting, come here and assign tasks." Someone shouted, and everyone who was resting quickly stood up.

Xiong Huaxin digested the knowledge Gao Feng instilled in him, and he was ready to relay it to everyone.

After he finished speaking, Wang Liang raised his hand. "Wang Liang, do you have anything to say?"

"Teacher Xiong, from your description, can I understand that this is a monoclonal antibody?" Wang Liangfa asked.

"Yes, you can say that."

"Then this will be easy to handle." Wang Liang showed a smile on his face. They have enough experience in monoclonal antibodies. Although each one is very different, they are all the same.

The principle is simply to inject immunogen into the host animal to stimulate an immune response. B cells are then extracted from the immunized animals and fused with myeloma cells to form hybridoma cells. Hybridoma cells that produce specific antibodies are then screened and selected for clonal expansion. Finally, large-scale culture and purification are performed to obtain monoclonal antibodies.

This process requires trial and error, in which luck is very important.

I am not talented, but my luck has always been very good!

Wang Liang has already seen the huge bonus coming towards him.

Seeing the silly smile on the other person's face, Xiong Huaxin was a little confused. These Fengxin Technology employees were just different from others.
-
"Hello, are you feeling uncomfortable?" Gao Feng asked.

"I've been having a fever during this period, and I've been taking infusions and medicine, but it's just not good." said a young man in his 20s. He seemed to be in a bad state of mind and coughed frequently.

The patient developed fever 2 weeks ago, and his body temperature was measured at 38.8°C at that time. After 3-4 days, he gradually began to develop cough symptoms, coughing up some yellow-white sticky phlegm.

The body temperature has been fluctuating around 38.5℃, and the highest temperature can reach 39℃.

He received infusions at a clinic outside the hospital for several days. The specific medicine was unknown.

"Here is the prescription." The patient took out a piece of paper.

Li Youliang reached out and took it, and the two of them glanced at each other, a little confused.

“Are there Chinese characters on this?”

"Haha." The patient also laughed, "I think it's a secret code between you doctors. I bet you can't understand it."

This is completely a ghost drawing. It is estimated that the doctor who wrote the prescription will not be able to recognize it after a long time.

Gao Feng conducted a careful physical examination of the patient and used a tongue depressor to look at the patient's throat, but he would later feel a little regretful for his actions.

"Let's take a CT scan." He advised the patient. "Wet rales can be heard in the lungs, which may be pneumonia."

"Okay."

The patient came to such a large hospital just for the purpose of spending money, and quickly got up to make an appointment for examination.

He didn't come back until about noon when he was about to get off work.

Gao Feng opened the movie on his computer and watched it, and his expression changed at just one glance.

The patient's CT scan showed diffuse ground-glass opacities and reticular opacities in both lungs, mainly distributed around the perihilar and middle and lower fields of both lungs. Extensive, map-like changes along the bronchi can also be seen.

Why does this damn thing look like a stuck lung!

We have also mentioned before that pneumonia is a lung disease caused by Pneumocystis jiroveci infection. It is common in patients with weakened immune systems, such as AIDS patients, organ transplant recipients, and patients who use immunosuppressants for a long time.

"Do you have a girlfriend?" Gao Feng asked.

"Yes. What's wrong?" The patient was stunned for a moment.

"You need to check for another infectious disease." Gao Feng said to him, "The performance on CT is very similar to a disease. We need to identify it again."

The patient's compliance was still very high, although he felt something was wrong with the doctor's expression.

Just after I got to work in the afternoon, the phone in the clinic rang.

Li Youliang picked up the call. The caller was a doctor from the laboratory department.

"That Li Jiang is suspected to be HIV-positive. We need to ask him to come over and draw blood again."

The patient named Li Jiang soon came to the consulting room, accompanied by a girl, who was his girlfriend.

"I want to talk to you about my condition alone." Gao Feng said to him.

"Then let's go out first." Li Youliang greeted the patient's girlfriend.

"Is this necessary?" The patient was a little confused.

However, his girlfriend didn't ask any questions, got up and followed Li Youliang out.

"You probably have pneumonia caused by Pneumocystis jiroveci infection." Gao Feng had already put on a mask at this time. Although AIDS is not transmitted through droplets, he still felt a little worried.
"Isn't it easy to cure?" The patient was very nervous.

"This is not the key to the problem." Gao Feng said, "Generally, people with immune deficiencies are susceptible to this disease, such as AIDS patients."

"Then why do I have this disease?" the patient asked.

"The laboratory just called and said that there was something wrong with your infectious disease test and that you were suspected of being HIV positive." Gao Feng tried to make his voice calm and natural.

The patient was stunned and his face suddenly turned pale.

"Have you had multiple girlfriends before?" Gao Feng asked.

"I only have one girlfriend." The patient's mind went blank at this moment, "but I have two boyfriends."

"It's best to ask them to come and check." Gao Feng suggested.

"Okay." The patient replied, and then he said, "Doctor, can you please stop telling my girlfriend about this?"

"Okay, we will keep this a secret for you." Gao Feng reassured. In fact, even if the patient didn't tell him, he would not disclose this situation to the patient's girlfriend.

From a legal perspective, this is to protect patient privacy.

However, from an ethical point of view, relevant personnel should be informed as soon as possible after the disease is diagnosed.

Most doctors will explain the serious relationship to patients and encourage them to take the initiative to inform their partners of the situation so that the disease can be detected as early as possible to avoid delaying the treatment of the disease due to personal will.

"We'll talk about it later," the patient said. "I'm very confused right now."

"I'm afraid this is not good. It's best to check it out as soon as possible." Gao Feng said.

"She shouldn't have. We just met not long ago." The patient said casually.

Gao Feng suddenly felt a chill on his back, and he couldn't understand what the patient meant.

"Then you should have her checked out. It's a good thing she's not infected."

"I don't want to tell her now. I'll confess it after we get married." The patient said, "Lest she dislike me."

What the hell!

I met a scumbag today.

Li Youliang soon discovered that the boss's face was gloomy and a bit scary.

"What's going on?" he asked cautiously.

"That Li Jiang has a mental problem." Gao Feng told him the situation.

(End of this chapter)