This doctor has a system

Chapter 460 524. I have grandchildren, I have grandchildren!

"Director, do you want to call a few more people?" the nurse said. The patient looked tall and thick, and it would probably take a lot of effort for one person.

"It's okay." Gao Feng was very confident in himself. He stepped forward and easily pushed Gao Xiuwei onto the bed.

The latter was talking to himself blankly, and immediately started to resist after being teased.

But in Gao Feng's hands, he was like a little chicken. He couldn't turn over even though he tried his best, but he was kicked so hard that the bed rattled.

"Put it in." Gao Feng said to the nurse.

The nurse quickly came forward with a blood collection needle.

"Comrade, what are we doing?" This movement woke up the man in the bed next to him. What he saw when he opened the curtain was Gao Feng in a white coat holding down the patient, who was struggling desperately.

"Measuring blood sugar." Gao Feng said to him.

"Isn't that true?" The uncle was confused. He also has diabetes and has been testing his blood sugar every day recently.

Thanks to my active cooperation! The uncle thought to himself, but this hospital is too bad. Isn’t this a case of forced buying and selling? Director Gao usually seems kind and kind, but unexpectedly
He decided to leave the hospital in two days, which was so scary!

"Blood sugar 2.1mmol/L." The nurse was stunned for a moment and then reported, "Hypoglycemia?"

"Wait a minute, I'll get another machine and test it again."

The repeated result is 2.0mmo/l.

Now Gao Feng understood that this "strange disease" was caused by hypoglycemia. He immediately asked the nurse to give Gao Xiuwei two high-sugar pills, and the latter quickly woke up.

"Hypoglycemia?"

"Yes." Gao Feng explained that when many people hear about hypoglycemia, the symptoms that come to mind are palpitations, sweating (mostly profuse sweating), tremors, and hunger.

But in fact, many patients are accompanied by changes in their mental state, some are even manic and hit others, and some show sudden personality changes.

Gao Xiuwei's performance was very confusing, and the doctors who treated him before didn't think about it at all.

Originally, a blood sugar test would reveal the problem during an attack, but because he didn't cooperate, something went wrong.
"But why did hypoglycemia suddenly occur?" Gao Xiuwei was very puzzled. "My blood sugar is normal during the day, but I have never had hypoglycemia."

"We still need to do a checkup tomorrow." Gao Feng said, but he already had a definite direction in mind.

Gao Xiuwei's hypoglycemia at night was definitely not for no reason. The human body is a very precise machine. Each organ never operates independently. It is a whole.

But if blood sugar is so low at night, there must be excessive secretion of insulin at this time, and the organ that directly secretes insulin is the pancreatic beta cells.

Most likely it's insulinoma.

Early the next morning, Gao Feng asked Gao Xiuwei to undergo an MRI. The results were as expected. The enhanced MRI showed that there was a 1.5 cm tumor on his pancreas.

"It's over! It's over!" The third grandfather was so frightened that his face turned pale. His precious son was about to die!
"Third Grandpa, don't be anxious." Gao Feng said quickly.

"No rush, yes! Yes! I'm not in a hurry." The third grandfather murmured to himself, "I have grandchildren, and I have grandchildren!" It's a shame that my son got married early!
"No, what I mean is that this insulinoma is not as serious as you think." Gao Feng explained, "Its malignancy is relatively low."

Insulinoma is the most common functional islet cell tumor and is a disease characterized by episodic hypoglycemia syndrome caused by secretion of large amounts of insulin. Clinically, it is characterized by recurrent episodes of fasting hypoglycemia.

Surgical resection is the only effective method to treat insulinoma. Once diagnosed, surgical treatment should be performed as soon as possible.

Otherwise, long-term hypoglycemia will affect the function of brain cells and even cause permanent damage to brain cells.

In the advanced stage, even if the tumor is removed through surgery, only the symptoms of hypoglycemia can be solved at this time, and the mental symptoms that have already occurred cannot be changed.

"You mean surgery will be enough?" Third Grandpa was still worried. "I remember that Dashan in our village had a tumor last year, and he died within half a year."

"I went to eat with your father at that time."

"There are differences between tumors." Gao Feng explained to him briefly.

"No problem, just turn around." Director Hu from the General Surgery Department said easily, "Just do a minimally invasive procedure."

In the end, Gao Xiuwei underwent laparoscopic islet cell tumor resection. Thanks to his young age and good physical condition, he recovered quickly and was discharged from the hospital.

Gao Feng had arrived in the capital at this time, and Xiong Huaxin reported the current progress to him.

Except for a few specific points, it's generally lackluster.

But from the other party's words and expression, Gao Feng could feel that Xiong Huaxin was still very satisfied with the current progress. Gao Feng could understand that the other party had not seen much of the world after all.

"You can't do this, you're too slow."

"Isn't this too slow?!" Xiong Huaxin said in disbelief. He felt that he had achieved quite a lot during this period.

"They are all trivial things." Gao Feng said, "They can't even be published in a top journal."

Xiong Huaxin's mind was buzzing. Are you treating the top issue as cabbage?
"Forget it, I'll stay in the laboratory for a few days." Gao Feng decided to give some guidance on the spot, "Go and call Jiaran over. I'll see him if I have something to do."

Hu Jiaran arrived soon.

"After you've finished your own work, why don't you share it with your teacher Xiong?" Gao Feng asked.

"He didn't mention it either," Hu Jiaran replied. It was inappropriate for him to approach someone without asking. Besides, he was not idle either. That Wu Bufan kept coming to him, which was quite annoying.

"What is he looking for you for?" Li Youliang said with a smile, "Has he been released by his wife recently?"

"This man is quite motivated and takes me to see the laboratory every day." Hu Jiaran said helplessly. Because of Gao Feng's instructions before leaving, he was too embarrassed not to go.

"Since this is the case, let's call him over later and find something for him to do first." Gao Feng pondered for a moment and said that the preliminary preparations for the project can be left to Wu Bufan, who is not capable of scientific research, but due to identity issues , has great advantages in coordination.

The name of the project is the mechanism related to the action of PDL-1 antibodies. Yes, it is still a study related to PD-1. This was reported to Academician Bao by Gao Feng after considering it for a long time.

1 week later, Philadelphia

The University of Pennsylvania, referred to as Penn (English name UPenn, Penn), is located in Philadelphia, Pennsylvania. It is one of the Ivy League schools, a founding member of the Association of American Universities, and a member of the Global University Presidents Forum.

Founded in 1740, the university is the fifth oldest institution of higher education in the United States and the first modern institution of higher learning in the United States to engage in science, technology and humanities education. The school was founded by Benjamin Franklin, one of the famous founding fathers of the United States of America.

By the way, this is a private research university. To date, a total of 28 alumni, faculty and researchers have won Nobel Prizes.

"The hepatitis B vaccine was invented here." Prampedi told Gao Feng at the door of an experiment. "The laboratory conditions at that time were far from as good as they are now, but it did not prevent excellent people from making great results."

"Gao Feng, you are such a person."

"No, no, I really can't bear your praise." Gao Feng replied quickly.

"Really, it's beyond my expectation that you can achieve such results at your age." Although Professor Pulanpedi knew Gao Feng's age, he still felt a great shock when the other party appeared in front of him.

"I was still studying for a Ph.D. when I was the same age." Professor Prampedi recalled that he was already somewhat famous at that time. Of course it is definitely incomparable to Gao Feng.

"A total of eight Nobel Prize winners in medicine were born in this school. I will take you to visit one of them."

"It seems that Professor Pulanpedi is not very popular." Li Youliang on the side whispered, "Among the eight people, only one has a good relationship with him."

"No." Professor Pulanpedi said. He actually understood Chinese, which made Li Youliang extremely embarrassed.

The University of Pennsylvania has a large number of students from diverse ethnic and cultural backgrounds. In 2013, 43% of the admitted freshmen were Asian, Hispanic, African American or Native American. 53% of the students in school are girls.

In 2013, 6 international students applied for undergraduate admission, of which 428 were admitted. 429% of first-year undergraduate freshmen are international students, and of these international students, 13% are from Asia.

This is also the reason why Professor Pulanpedi can understand Chinese.

"We can't see the others right now," he explained.

"Why?" Li Youliang wondered.

"Because they are all dead," said Professor Prampedi.

The person they are going to visit soon is Professor Stanley Bruschner. Bruschner was born in 1942 and received his doctorate in medicine from the University of Pennsylvania in 1968.

In 1972, Bruchner treated a female patient with Creutzfeldt-Jakob disease—his first encounter with the “mysterious pathogen.”

This strange pathogen surprised Bruchner, and he was determined to uncover the true face of this pathogen and decipher its molecular structure.

Bruchner spent 2 years studying all the relevant literature he could find, and established a laboratory in 1974, preparing to study the "mysterious pathogen" starting from sheep scrapie. However, the research on this type of pathogen is very difficult, with high technical requirements, lengthy test cycles, and huge expenditures.

The 1997 Nobel Prize in Physiology or Medicine was awarded to Professor Stanley Bruchner of the University of California, San Francisco.

This award recognizes Professor Bruuchner's contribution to the study of the pathogen causing Guzfeldt-Jacob disease, which causes neurodegeneration and dementia in humans. In recognition of his discovery of prion protein and his outstanding contributions to the study of its pathogenic mechanism.
Professor Bruchner is 73 years old this year, but he seems to be in good spirits.

"Pulampedi, you know, I have been away from medical research for a long time now." Professor Bruschner motioned for several people to sit down. "It is not a wise choice for you to come to me now."

He glanced at Gao Feng, with surprise in his eyes, "Young man, are you Japanese?"

"I'm Chinese," Gao Feng said.

"I'm so sorry." Professor Bruchner said, "You know, Japan is still... in terms of medicine."

This is indeed a fact. Although Xiao Daozi is not a good character, he is still quite capable.

"Professor Bruschner, this is China's top talent, you must know him." Professor Prampedi believed.

"What!" Professor Bruschner was shocked, "Why are you so young?" He turned to look at Prampedi: "Are you sure? There are many Chinese people with the same name. I have several named Jianguo. Friends of China.”

"You are worrying too much." Professor Prampedi smiled.

"This is incredible." Professor Bruschner was greatly shocked. "I have read the article you wrote. It is very good!"

Obviously the other party has not stayed away from medical research for many years as previously said.

He chatted with Gao Feng for a while and focused on CAR-T treatment.

"Although it cannot be applied in large-scale clinical applications due to cost issues, it is still a great invention and innovation."

In the end, he invited a few people to lunch. To be honest, it was not delicious. The steak was only 7% cooked, and there was blood even after Gao Feng took one bite.

He swallowed hard.

"Where did this foreigner learn the habit of eating raw food?" Li Youliang complained to Gao Feng after returning to the hotel. He was feeling upset at the moment.

The next day, Professor Prampedi took Gao Feng non-stop to visit another important person.

"We're going straight to the state hospital, my friend Richard seems to have some problems."

Effie Richard has been very upset recently. His wife is in some trouble.

In August last year, my wife developed a cough. At that time, she thought it was just a cold, but she was still unable to recover.

So I went to a local hospital and had a chest CT examination. The result showed "right upper lung infection", but the anti-infective treatment was not effective.

Seeing that the coughs were becoming more frequent, both of them became a little worried.

This time he took his wife to the state hospital. Several experts specially called in took a look and suspected tuberculosis, so he gave his wife a nucleic acid test for Mycobacterium tuberculosis, and the result was indeed positive.

"Tuberculosis?" Effie Richard said she didn't want to believe it.

Unlike the situation in China, the incidence of tuberculosis in European and American countries is extremely low. Many respiratory doctors have not seen a single case for several years.

"Didn't your wife go to Africa to work for a period of time last year?" a doctor asked. "It was probably at that time that she contracted the infection."

Effie Richard's wife is a journalist, and she did go to Africa with the team to do a program in April last year.

"That's it." Effie Richard quickly accepted this explanation, and his wife quickly took anti-tuberculosis drugs.

Now that half a year has passed, he took his wife for a reexamination. The new film showed that the lesion area in the right lung had not shrunk, but had increased significantly.

Moreover, multiple patchy, ground-glass-like increased density shadows were seen in both lungs, especially in the middle lobe of the right lung, with partial consolidation, suggesting infection.

"What's going on?" Effie Richard was a little confused. His wife's cough symptoms had obviously been relieved, so why did it say it was getting worse.

(End of this chapter)