This doctor has a system

Chapter 467 530. I really want to be a professor
"I will send you the follow-up information later." Gao Feng said.

"Is it really true?" Victor's voice was trembling. What is a surprise with a special code! He came to the right place today.

In fact, he spent two days mentally building up for today's submission.

After all, admitting defeat in front of so many people is simply more uncomfortable than killing him for a person like him who attaches great importance to reputation.

But seeing what was found in the laboratory, Victor was shocked and painful.

What is shocking is that the information given by the other party is of great value, but what is painful is that it is incomplete.

But even so, he felt that he could study them for most of his life just based on the newly discovered mutations in MET and BRAF.

But people are like this, and it is difficult to satisfy their desires.

You know something is worth 1000 million, but you only get 10 of it.

Although you were just a pauper before, even 10 yuan was still a huge sum of money to you, but you were always unwilling and had expectations.

This is also the reason why Victor risked his life to come to the academic lecture hall.

Gao Feng naturally knew the purpose of his visit. Seeing that the other party gave up so easily, he decided to give him a small surprise.

This was not an act of kindness. In fact, Gao Feng did this on purpose.

"But why?" Li Youliang was very puzzled, "This old boy was very arrogant when he came on stage. Now that he has tasted the benefits, he knows how to curry favor!"

"We won't be fooled by him!" He was very dissatisfied with Victor.

"It's too small." Gao Feng said.

"What's too small?"

"The structure has become smaller." Gao Feng said, "Youliang, what is the purpose of holding an academic exchange meeting?"

"Get famous." Li Youliang replied subconsciously, looking up to see Gao Feng's calm eyes.

"No. No, it's to exchange knowledge and technology with foreign scholars." He said quickly.

"That's right." Gao Feng said, "Although Professor Victor has mediocre qualifications, since he has met me, he naturally wants to guide him."

Li Youliang understood immediately.

"Hey! The boss is still a big boss!"

As we all know, Victor is a professor at New York Medical College. Although he has not made any major achievements in recent years, he usually writes a lot and has certain qualifications in the medical field.

The achievements of such a person in life could be seen at a glance, but now there are twists and turns. The reason is that he received a piece of information.

Who gave this information?

What is written in the information?
What magical power does it have that can turn decay into magic?
Let a third-rate professor discover first-rate results!

If you are also a scholar doing relevant research, are you curious?

"It's more than just curiosity." Li Youliang said with a smile, "It can make people anxious to death."

"The boss is mighty!"

"What did you write in the information you gave Victor?" Professor Needham Burton asked.

"It's just a few gene mutations in lung squamous cell carcinoma." Gao Feng replied, "There are some related to MET, BRAF, ALK, and ROS1. I marked a few of them, but it took a lot of time to do them, so I gave them to him."

"What!" Professor Temple Markus was anxious, "How could you do this!" His eyes were red, "How can a nobody like him deserve such a valuable thing!"

"This is Professor Temple Marcus from Emory University School of Medicine." Professor Needham Burton introduced to Gao Feng, "My good friend."

"Hello, Professor Temple Markus." Gao Feng shook hands with him.

"Let's quickly find a place to talk about genetic mutations!" Professor Temple Marcus was very anxious. "Burton, hurry up and make arrangements!" He turned to Professor Needham Burton and said.

"This is not good." The latter said he was "embarrassed." "Before coming, you said that private meetings would affect my judgment and easily affect the fairness of the Lasker Award selection."

"I drafted" Professor Temple Markas sent his kind greetings to the family of Professor Needham Burton.

Professor Temple Markas, whose research focuses on morphological analysis of tumor cells, is head of the School of Basic Medicine at Emory University School of Medicine.

"My laboratory is also working on genetic mutations in lung squamous cell carcinoma." He said to Gao Feng, "We are our own people, and we cannot let outsiders like Victor get benefits."

"Besides, how can he compare with me!" Professor Temple Markas expressed his disdain for Professor Victor.

"Gao Feng, Marcus likes to belittle others the most." Professor Needham Burton said with a smile, "Don't pay attention to him."

Professor Temple Markas
Professor Temple Markus was gone, and he was impatient. Gao Feng will naturally not disappoint him. After all, the other party has said: We are our own people.

Gao Feng is the most generous to his own people, as Li Youliang can attest to.

"Professor, I've been here for so long and I haven't visited your laboratory yet." Gao Feng said to Professor Needham Burton.

"That was my mistake." Needham Burton said with a smile, "Now we can go over there."

Professor Needham Burton's research direction is related to small cell lung cancer, which is why he has not had in-depth exchanges with Gao Feng. Because judging from the articles published in the past, Gao Feng seems to rarely cover this area.

Generally speaking, many clinicians like to divide lung cancer into two major categories: small cell lung cancer and non-small cell lung cancer.

From this point we can see the particularity of small cell lung cancer.

Small cell lung cancer (SCLC) accounts for 15% to 20% of all lung cancers, and the vast majority of patients are diagnosed at an advanced stage. According to statistics, about 67% of SCLC patients have obvious extrapulmonary metastases when diagnosed, while only 33% % of patients with localized disease have lesions limited to a single radiation field in the chest
This is also one of its characteristics: transfer occurs earlier.

Another characteristic of it is that it is highly sensitive to chemotherapy. Many patients will quickly experience short-term remission after applying chemotherapy drugs.

There are many patients who took etoposide + cisplatin on the same day, and the swollen lymph nodes in the neck and supraclavicle shrunk by half the next day.

However, the prognosis of small cell lung cancer is extremely poor. Systemic chemotherapy can certainly prolong survival and improve symptoms. However, due to drug resistance, the usual remission period is less than one year, and the 1-year survival rate is extremely low.

The laboratory is the frontier of scientific exploration, full of rigor and order. Professor Needham Burton's laboratory is located in a quiet corner of the medical school, away from the hustle and bustle.

The entire space is reasonably designed, spacious and bright, making it easy to place and operate various experimental equipment.

When entering the laboratory, the first thing Gao Feng sees is rows of advanced instruments and equipment, such as high-performance liquid chromatography, gas chromatography, mass spectrometer, nuclear magnetic resonance instrument, etc.

The strong strength of New York Medical College is fully reflected. The busy figures of scientific research workers, the sound of operating instruments, and the atmosphere of inquiry in the air together create a unique atmosphere in the laboratory. This is a palace of knowledge, a hotbed of innovation, and a battlefield for scientists in their pursuit of truth.

Since 4 years ago, Professor Needham Burton's team has been studying the genetic mutations that can cause small cell lung cancer, but until today, there is still no valuable discovery.

Is 4 years a long time?

For the average person, long.

But when looking at scientific research, 4 years is only a short period of time.

Many professors have been working diligently on a certain topic throughout their lives, but in the end Mao didn't discover it.

This is still the norm.

They have worked hard all their lives, only to prove that their research is worthless.

This is undoubtedly heartbreaking.

Professor Needham Burton is also feeling tired of this research direction. He told Gao Feng that if there is still no valuable discovery in the next year, he will terminate this project.

"Professor, you are here." The assistant came over. He also said hello to Gao Feng.

"How is it? Is there anything special?" Professor Needham Burton asked casually.

The answer was, as usual, disappointing.

Gao Feng carefully looked at everyone's operations and found that the skills of several scientific research workers were very good, and their techniques and operations were very standard.

"Oh my God, he has become a reputable scholar in the industry at such a young age." A migrant research worker sighed, "I am still dealing with test tubes and pipettes all day long!"

"William, don't be depressed." A colleague comforted him, "Chinese people are responsible for being worshiped by the world, and you, my brother, you have to plan to be a scientific research worker for the rest of your life."

"No one is idle. From this aspect, we are all contributing to this society."

"Thank you for your comfort." William put down the pipette in his hand, "Send my regards to your wife."

As a very common pathological type of lung cancer, small cell lung cancer has attracted much attention from experts and scholars.

In fact, like Professor Needham Burton, many people are doing research in this area.

But compared with the huge and exciting discoveries in lung squamous cell carcinoma and lung adenocarcinoma in recent years, no scholar has found any valuable results in small cell lung cancer.

Gao Feng had paid attention to this phenomenon before. He specifically searched for related research in the system space, but did not find any findings on gene mutations.

The absence of genetic mutations means that related targeted drugs cannot be suppressed.

"Professor, I actually think there is no need to waste another year." Gao Feng expressed his opinion, "There are many scholars in China who have done research in this area, but they have all failed."

"My teacher, Academician Bao, he."

Gao Feng's words undoubtedly made Professor Needham Burton a little frustrated, but he was already prepared for this in his heart, so he was not unable to accept it.

"What a pity" Professor Needham Burton sighed. The application and promotion of this project consumed a lot of his energy.

"Actually, you can change the direction." Gao Feng said, "Professor, do you have any relevant research on receptor tyrosine kinase inhibitors?"

"Yes, but not very deeply," Professor Needham Burton replied.

"I have a project that can be carried out based on the existing experimental conditions." Gao Feng continued, "Synthesize a multi-target receptor tyrosine kinase inhibitor so that it can inhibit various growth factors in blood vessels." The production of receptor kinases acts as an inhibitor."

"Oh!" Professor Needham Burton suddenly became interested.

The mechanism of multi-target receptor tyrosine kinase inhibitors against tumors mentioned by Gao Feng is not complicated.

Angiogenesis is very important for the growth of solid tumors. Tumor tissues obtain oxygen and nutrients through newly generated blood vessels to achieve continued growth and metastasis.

New blood vessels are composed of a variety of cells including endothelial cells, pericytes and smooth muscle cells. Under hypoxic conditions, three signaling molecules produced by tumor tissues, namely vascular endothelial growth factor (VEGF) and platelet-derived growth factor ( PDGF) and fibroblast growth factor (FGF).

The above substances can bind to tyrosine kinase receptors distributed on the surface of endothelial cells, pericytes and smooth muscle cells and activate signaling pathways that promote angiogenesis.

It is known that VEGF plays a major role in the angiogenesis pathway, but when the VEGF-related signaling pathway is blocked, tumor tissue can upregulate the expression of other cytokines, such as FGF and PDGF, through mechanisms such as escape and bypass activation to maintain tumor growth. Nutrient supply.

This means that blocking the downstream signaling pathways mediated by VEGFR, FGFR and PDGFR at the same time can more comprehensively inhibit tumor angiogenesis and thus exert an anti-tumor effect.

Multi-target receptor tyrosine kinase inhibitors play this role.

"It sounds very exciting." Professor Needham Burton was very pleased. "I can't wait to customize a five-year plan for it!"

high wind
"Professor, um. In fact, I have already done part of the work."

Li Youliang, who was following behind, quickly handed Professor Needham Burton a piece of information. The latter was stunned for a moment, then opened it.
"This" Professor Needham Burton was completely stunned.

Just like a good student, he was determined to get a good score in the final exam with extremely difficult questions.

To this end, he is about to make a very detailed study plan, which includes getting up at 5:7 every morning to start morning reading, then going to have breakfast at 8:12, studying from to o'clock, taking an hour's break at noon, and then studying until late at night.
Just as he was sharpening his knife with passion, someone came over.

"Brother, where is Ganha? Do you want the answers to the final exam?"

"If you want, add me on QQ and I'll send you a copy."

Professor Needham Burton is in this state now.

He finally understood Victor's situation. No wonder the old boy had no shame and bowed to him as soon as he came up. Who could withstand this?
Although you can do it slowly by yourself, and you may feel a little more at ease inside if you do it slowly, but how can I say that having the answer will make the world and the sky wider.

"I'll go back and take a look." Professor Needham Burton's ecstatic expression was a bit unbearable. He turned around and left, almost falling down.

"Professor, please slow down." Gao Feng shouted, looking at the receding background, a smile appeared on his face.

Okay, the bait has been spread out, just sit firmly on the fishing platform.

Gao Taigong is fishing, and those who are willing will take the bait.

"Brady, can I see the information that Professor Gao Feng sent you?" Raglan Bunir asked.

"Sorry, I can't spread the word without his permission." Tyler Brady decisively refused.

Sorry, Raglan Bunir, I really want to be a professor! he shouted in his heart.

(End of this chapter)