medical road with you

Chapter 112 New Directions
After hearing this, Lu Ping was startled. After careful recollection, it turned out to be the case.

Professor Fu really deserves to be a university student, and he can look at problems from a higher perspective.

"Lu Ping, have you heard the story of Troy in the Greek legend?" The professor began to persuade again.

"I've heard of it." Lu Ping simply sorted out his words: "The Greek coalition forces besieged Troy for ten years and still couldn't take it down. Finally, they made a giant wooden horse and sent it to Troy city, but the wooden horse was filled with the Greek coalition forces. In the end, the Greek coalition forces took the city of Troy together.”

"Yes, you are quite right. Sometimes, when we face an extremely tenacious enemy, we cannot attack with direct firepower, and we have to find another way."

"Find another way?" Lu Ping still didn't understand what Fu Tong meant.

"Lu Ping, just now I heard you say that your method of inhibiting virus replication is a very traditional and commonly used method. Although it has changed its appearance, it is still the principle of antagonists in the final analysis. Using antagonists to suppress the virus is like the Greek coalition forces Attack the city of Troy with firepower from the periphery. Viruses are very cunning, and they have encountered various antagonists for hundreds of millions of years of their birth, so they quickly mutated to avoid this antagonism. Therefore, we Do you want to change the direction, can you use the method of inducement to make it mistakenly think that you are beneficial to it, so that it will not try to resist and avoid it."

Lu Ping didn't speak, she was thinking about Professor Fu's words.

"There is a saying that the hardest thing to defend against is sugar-coated bullets." Professor Fu said meaningfully again.

Trojan horses, sugar-coated shells, and inducements.

These words circled repeatedly in Lu Ping's mind.

Suddenly, there seemed to be a light flashing over Lu Ping's head: "Professor, I understand what you mean, I shouldn't just try to suppress the replication of the virus, I can try to speed up the replication of the virus, but this acceleration will cause The virus replicates incorrectly, and the final result is that after one or two generations of replication, the virus dies completely because of the wrong gene sequence."

Professor Fu nodded with satisfaction: "Yes, the general idea is like this, but how to implement it depends on your own research."

"Okay, I've taught you everything I can, so go get busy."

Knowing that Professor Fu was going to hang up the phone, Lu Ping hurriedly asked, "Professor Fu, would you like to come to Liangcheng?"

Liangcheng can be said to be a dangerous city now, but based on Lu Ping's understanding of Professor Fu, his enthusiasm for scientific research far outweighs his fear of the epidemic.

"No need, I'm already old and I can't move anymore. This world belongs to you young people."

Fu Tong understands Lu Ping's intention. If this research is really successful, if he participates in it, he will surely become famous and wash away the stains of the past.

"Teacher Fu, take care of yourself and wait for my good news."

For the first time, Lu Ping called Mr. Fu Tong.

"Student Lu, do your best."

The words "Do it well" made Lu Ping's blood boil: "Don't worry, teacher, I will."

After hanging up the phone, without any warning, Lu Ping suddenly remembered the failed experiment when she and Yue Jin were working together on PCR amplification of RNA.

At that time, she compared the original gene sequence with the amplified gene sequence, and there was no relationship.

Perhaps it was just an error in replication caused by adjusting the reagents. This is her final summary of the failed experiment.

She did not continue to study the error that occurred in the replication, what the error was, and whether the error could be reproduced.

However, all she needs now is for the virus to make mistakes when it replicates.

Lu Ping quickly took out the USB flash drive and inserted it into the computer.

Now, she is really thankful that all the materials from that time have been preserved.

Original base sequence: GAUC
Amplified base sequence: GAAC
Before, Lu Ping had been following the strict principle of complementary base pairing, right? Lu Ping didn’t find any rules, but now that he let go of his thinking, Lu Ping quickly discovered the rules, and most of the base U sequences were wrong.

In Lu Ping’s eyes, the principle of complementary base pairing for nucleic acid replication and codons for protein translation have always been the laws of life established by God when he created life. There is no doubt that they are unshakable, that is, because he believes too firmly in these two laws Lu Ping did not discover the hidden laws in that failed experiment.

However, after opening his horizons and changing his thinking, Lu Ping found out.

Lu Ping suddenly thought of a sentence, inheritance is relative, mutation is absolute and eternal.

If this set of life laws has never made mistakes, then life will only stay in a single cell, and the birth of human beings itself is produced by mistakes.

Variation, the variation caused by mistakes is the driving force for the continuous evolution of life.

Of course, the vast majority of mutations lead to their own demise.

What Lu Ping needs now is for the virus to mutate and lead to its own demise.

Lu Ping carefully read the data she recorded. In that experiment, she adjusted the PH value of the environment much higher than others.

Could it be that the pH value can affect the pairing of the base U? Lu Ping immediately found a way.

**
Yesterday, Lu Ping left the laboratory like an eggplant beaten by frost. Ye Mei thought that Lu Ping still couldn't cheer up today, but when he arrived at the laboratory, he saw a figure in a white coat.

"Doctor Lu, it's so early!" Ye Mei greeted cautiously.

Lu Ping, who was busy, turned his head: "Doctor Ye, I have found a new direction."

Lu Ping's eyes were full of unconcealable excitement.

Finding ideas is still a long way from finding the right method.

The pH value is only an influencing factor. Why the base U cannot be paired with the base A correctly, is there a problem with the RNA reverse transcriptase, or is it due to other factors.

These, Lu Ping needs to find out one by one, she wants to make such accidental mistakes inevitable.

Inevitability, reproducibility, this is science.

Tianhai couldn't count how many days in a row, Lu Ping spent nearly eighteen hours a day in the laboratory.

Tianhai didn't try to persuade Lu Ping, and he couldn't persuade him now.

Not only in Liangcheng, but also in several other cities, the epidemic is becoming more and more serious, and it feels faintly out of control.

Lu Ping devoted himself to research, and what Tianhai could do was to take good care of her as much as possible.

Put safe meals into her mouth and put clean clothes on her body. Sometimes she couldn't hold on anymore and fell asleep lying on the floor in the laboratory. Tianhai took her back from the laboratory to her residence and helped her wash Feet, wipe face.

That day, it was past one o'clock in the morning, Tianhai sat on a chair and fell asleep, and a burst of cheers woke him up from his dream.

"I made it, I made it!"

Tianhai opened his eyes, and vaguely saw a figure with his hands raised high, shouting there.

Tianhai rubbed his eyes, and the figure ran towards him.

Holding Tianhai's hand with one hand, and pointing at the experiment platform with the other, Lu Ping's hand was shaking, and his voice was also shaking: "I succeeded."

"Yeah." Tianhai smiled.

"I succeeded." Lu Ping said again.

"it is good."

"I verified it several times, and I really succeeded! It's true, I succeeded!..." Lu Ping fell into an endless loop.

Tianhai didn't say anything anymore, and listened to Lu Ping repeat those four words over and over again with a smile.

The deep bags under the eyes and the raised cheekbones all show how haggard and tired Lu Ping is now, but these are not important anymore, the joyful light of those eyes covered them together.

Tianhai was also infected by this joyful mood, and smiled very happily.

It's great, it's great to be able to share the joy of success with her.

Lu Ping didn't know when or how she fell asleep, she only knew that this was the most peaceful and comfortable sleep she had had since she came to Liangcheng.

When he opened his eyes, the sun had already crept to the edge of the bed.

Lu Ping stretched his waist, turned his head and looked around.

"Tianhai, Tianhai, where are you?"

It's become a habit, when she can't see anyone, she will call his name first.

However, after shouting twice and no one answered, Lu Ping's heart began to panic, and he immediately grabbed his clothes and put them on his body.

Just as Lu Ping's feet hit the ground, there was a "squeak" sound of the door opening.

"Tianhai, is that you?"

Lu Ping hurried up to meet him.

It was Tianhai, he came in with a gloomy expression on his face.

"What happened?" Lu Ping panicked even more.

"Wang Lei..." Tianhai raised his eyes: "He has been diagnosed, and now he has a high fever."

'Om', Lu Ping felt as if his head had been slammed, a little dizzy and heavy.

"When did it happen?" Lu Ping didn't even know how he asked this sentence.

"Last night." Tianhai's voice was very low and deep: "Last night he was on the night shift and passed out in the ward."

"Does Chi Na know?"

Lu Ping didn't dare to think about Chi Na's reaction when she got the news.

"I don't know yet, the team leader asked me to inform."

What a tough job.

Tianhai was silent for a moment, looked at Lu Ping and asked, "You said last night that your research was successful, does that mean you know the cure for this disease?"

Lu Ping looked serious: "It's just that the experiments in the laboratory were successful. A drug has to go through animal experiments from the laboratory research and development to the market, and the first phase and second phase clinical trials. It usually takes one or two years for this process to go through. .”

There seemed to be a little anger on Tianhai's gloomy face: "At such a critical moment, can't the process be faster?"

"Even if it is urgent, it will take a month or two."

For a month or two, Wang Lei simply couldn't afford to wait.

Tianhai suddenly remembered the words he said to comfort Chi Na: Wang Lei should be fine.

Should, what a weak modifier.

They had been in Liangcheng for more than a month, and he stared at Lu Ping every day with fear, and Chi Na couldn't see Wang Lei's face, so he didn't know how he suffered every day.

"Can we do a phase one clinical trial on Wang Lei directly?" Tianhai suggested.

"It's too risky. The drugs on the market have side effects, such as liver damage and kidney damage, let alone drugs that have never been tested on animals." When it comes to designing academic things, Lu Ping is rigorous and rigid.

"Can the risk be greater than Wang Lei's current danger?"

Lu Ping began to waver at Tianhai's words.

Lu Ping understands the principle of treating a dead horse as a living horse doctor, but doing so is a bit too nonsense and completely inconsistent with the regulations, and the hospital will definitely not agree.

"This matter is of great importance. Neither you nor I can make the decision for Wang Lei, only Chi Na can."

"Okay, let me ask Chi Na."

Tianhai took out his phone.

Before hearing the ringtone, the phone was connected.

"Hi, it's me, Jiang Tianhai."

"Is Wang Lei infected?" Chi Na asked at the first sentence.

After arriving in Liangcheng, Wang Lei would send a text message to Chi Na every morning to report her safety, but not today.

"Yes." Tianhai didn't hide anything: "He was diagnosed last night, and now he has a high fever."

Ah, there was an extremely depressed exclamation on the phone.

Tianhai knew that Chi Na was holding back her tears: "However, Lu Ping just developed a drug last night that can kill the virus somewhat."

Chi Na remained silent.

"As you know, the drugs that have just been developed in the laboratory have not been tested on animals, and there are many potential dangers."

Chi Na hummed.

"Now, we want to secretly give Wang Lei experimental drugs, do you agree?"

Pneumonia has a certain fatality rate, but some people have survived it, and the dangers of this new drug are unknown.

This is a life-threatening decision, and Chi Na has the right to choose.

Chi Na didn't make a sound, she was in pain now, she had just heard a shocking news and asked her to make such an important choice.

too difficult.

"Chi Na, do you trust Lu Ping?" Tian Hai was helping Chi Na make a choice.

"I believe."

If anyone Chi Na trusted most in her life, it was Lu Ping.

When Lu Ping was doing things, Chi Na could rest assured.

"Okay, then this time, give her more trust and let Wang Lei try." This sentence, every word, Tianhai said with great difficulty.

"it is good."

Chi Na hung up the phone, Tianhai looked at Lu Ping: "Chi Na agreed."

Lu Ping pulled up her clothes and was about to go out, Tianhai stopped her: "Where are you going?"

Lu Ping explained: "Go to see Wang Lei and collect samples from him. Even if you can't do animal experiments, at least confirm that my medicine is effective for the virus on his body."

Lu Ping made a lot of sense, but Tianhai was very worried: "It's too dangerous in the ward."

Tianhai could imagine that that room should be the most dangerous place.

Lu Ping stared at Tianhai: "Tianhai, Chi Na has entrusted her husband's life to me. At this time, can we still only care about our own safety?"

Tianhai let go of his hand, he had no position to stop Lu Ping, he was the one who persuaded Chi Na to agree.

"Okay, I'll go with you."

After putting on the protective clothing and checking that there was no damage, Lu Ping and Tian Hai entered the ward.

Wang Lei lived in hospital bed No. [-]. As he lay there, his originally fair face was now frighteningly thin, and his lips were peeled due to the high fever.

Two more people haven't seen him, he has changed completely.

Hearing a voice, he opened his eyes.

"Lu Ping, Tianhai, you are here." He took a breath and continued, "Don't worry, I will try my best to make it through."

After closing his eyes and resting for a while, he said again: "This place is too dangerous, you should leave quickly."

Lu Ping felt extremely uncomfortable. The always cheerful boy was tortured into this state by the disease.

Suppressing the pain in his heart, Lu Ping took out the test tube and cotton swab: "Wang Lei, open your mouth."

"What are you doing?"

"Open your mouth." Lu Ping almost ordered.

Wang Lei opened his mouth, deep in his throat, Lu Ping wiped it a few times with a cotton swab.

Putting the cotton swab into the test tube, Lu Ping said seriously: "Wang Lei, don't worry, I will bring you back to Chi Na."

Wang Lei smiled reassuringly.

He didn't have the strength to speak anymore, but he believed Lu Ping's words.

Holding the sample, Lu Ping went straight to the laboratory.

After processing the sample, Lu Ping first observed it under the electron microscope, and the field of vision was full of virus particles.

There is no need to do nucleic acid testing, Lu Ping can confirm at a glance that Wang Lei has a new type of pneumonia.

(End of this chapter)