Begin from the original form of torture and become immortal

Chapter 20 Genes
The problem is far from simple.Genomics has developed to this day, and the discussions and controversies surrounding it, from structural and functional genomics, to the evolution of life, to philosophy, and even to the division of the political map of academic resources, can tell a very interesting story.

Existence is reasonable.

This is correct.

But is it useful if it exists?For example, our appendix and wisdom teeth are of little use and troublesome. They are more of relics left over from the process of human evolution and are by no means treasures.

The 98.5% non-coding sequences in the human genome must also be viewed dialectically.

As early as the 20s and 70s, people began to refer to non-coding sequences as "junk DNA."

However, people soon discovered that many non-coding sequences are closely related to the transcriptional regulation of genes.

Garbage is not garbage, and life is by no means the only central dogma.

So what are the good things in non-coding sequences?Classic non-coding DNA elements in textbooks, such as promoters and enhancers, mobile genetic elements, and biologically active small RNAs.

In the early days of the development of molecular biology, scientists designed ingenious biochemical experiments in order to peer into the black box of life, which truly amazed future generations!

In this new century where high-throughput and big data are king, the main force in non-coding DNA research is undoubtedly the ENCODE project.

This is a model of a global large-scale collaborative scientific research project and a pioneer of biological big data.

Dozens of scientific research teams around the world use newly developed high-throughput experimental methods to systematically and comprehensively scan the biological activities of all non-coding DNA in various tissues of humans and other organisms.

The methods they used include ChIP-seq (detecting the interaction between chromatin and proteins), RNA-seq (sequencing all RNA molecules in the cell as a whole), and DNase-seq (sequencing the DNase-sensitive regions of chromatin). , that is, the regions with looser and more exposed structures are sequenced), etc.

It is a pity that CRISPR did not exist at that time, otherwise it would be very suitable to detect the function of genomic regions (whether coding or non-coding) (Canver et al., 2017).

Now people are starting to follow.

In 2012, ENCODE’s research results erupted intensively.

Elizabeth Pennisi, a reviewer at Science magazine, concluded: "Thirty papers were published this week in journals such as Nature and Science, declaring the death penalty for the junk DNA theory. The ENCODE project has discovered that humans 80% of the genome is useful."

Of course, there were many overturning and even targeted remarks later. Chang Wei did not dare to make rash judgments because he did not know enough.

Are you kidding me? How ridiculous is it for a wise man of an era to transcend the accumulation of civilization and find the ultimate answer?
Chang Wei does not feel at all that he is a genius and has inspiration comparable to Einstein. If we talk about the accumulation of knowledge, then Chang Wei is not lacking.

But he feels that most of the knowledge may just accumulate dust in his mind, rather than colliding with each other and stimulating sparks of inspiration.

"Jason Green...the location is Vandenberg Air Force Base, but it's a military secret." Chang Wei held a struggling guy in his hand. That was the supreme commander of Black Watch, General Randall!

"General, do you know where this base is?"

Chang Wei asked with a smile.

"You...you...nuclear bomb..."

Randall never expected that Chang Wei would suddenly appear and instantly kill his defense. The Black Watch soldiers seemed to be like ants that could be easily crushed in front of him, and then they were really crushed to death.

Even the super soldier couldn't bear it. Chang Wei was shattered to pieces with one punch. What surprised him even more was, where did Chang Wei know this name, Doctor?But isn’t the doctor already...

"It's very difficult to step over an ant without killing it, General."

Chang Wei said.

"The nuclear bomb has been...activated, you are this madman..."

General Randall was not so frightened that he peed his pants and begged for mercy. After Chang Wei loosened his fingers slightly to allow him to recover from the suffocation, this was his first sentence.

"Inflating yourself like a pufferfish sometimes just attracts predators more, and who told you that a nuclear bomb could destroy me?"

Chang Wei was a little disappointed. He knew that the nuclear bomb had been activated and it was impossible to reverse it, but he didn't care.

He can now accelerate himself to supersonic speeds in a short time using the same flight principles as a jet fighter. And because of its size and its own "material strength", a fighter jet cannot break through the higher Mach of the thermal barrier, but Chang Wei can do it.

The speed of the nuclear bomb explosion cannot keep up with his speed, so...why should we be afraid?
"I don't want to break my bottom line. After all, I am different from Alex's virus. If you continue not to say it..."

Scarlet light appeared in Chang Wei's eyes.

General Randall looked as if he was ready to die.

"Then I can only let the hunter tear you apart and eat you first, and then I will eat the hunter."

General Randall's eyes widened, no, shouldn't you give me a good time?

(End of this chapter)