Super Copy of Great Power Technology
Chapter 488 Animal Experiments
Qiao Ruida took out a sealed glass test tube and showed it to Shen Jiajun. Inside was dozens of hair-thin DDAT threads. "This is DDAT. Professor Shen, can you perform nerve cutting and nerve anastomosis surgery? I hope to verify the nerve signal transmission performance of DDAT through animal experiments as soon as possible."
"If I'm doing a nerve anastomosis surgery on a human, I'm not very good at it. If I'm just operating on experimental animals like mice and rabbits to do nerve anastomosis, then I won't be afraid. If my technique is not good, I'll just do a few more cases. There will always be a chance that it will succeed." Shen Jiajun took the test tube and looked at the DDAT thread inside. His eyes were so eager that they were almost glowing.
"Mr. Qiao, you know, if this DDAT material is proven to be able to match animal nerves and transmit nerve signals, it will at least be a Nobel-level invention. Even if I do animal experiments to verify it, I can publish two papers in CELL."
In response, Qiao Ruida just smiled calmly and didn't express anything special. He has come up with more than one Nobel-level invention. The graphene chip and graphene battery have reached the Nobel Prize level and have a great influence. However, he has not won any award so far, and has not even been on the Nobel Prize candidate list. Affected by the international environment, it is really difficult for Chinese people to win the Nobel Prize, especially the Nobel Prize in natural sciences.
"Do animal experiments to verify it as soon as possible. You can publish the paper if you want. Don't worry about anything." Qiao Ruida patted Shen Jiajun on the shoulder and said.
"Okay, Mr. Qiao, wait for my good news. Xiao Fang, go catch two rats and two rabbits. Song Jia, come with me to the laboratory to prepare for the animal experiment."
In the medical laboratory, organ culture and drug efficacy verification are often done. There are all kinds of experimental animals, and surgical scalpels, sutures and other items are also ready-made. Shen Jiajun brought two assistants into the laboratory, and after a little preparation, he began to perform surgery on rats. First, the main nerve of the rat's hind leg was cut, and then a piece of DDAT material was used to suture the two ends of the nerve break, and then the outer skin was sutured and bandaged. In order to avoid poor suturing techniques and cause experimental failures, Shen Jiajun performed the same operation four times in a row, two rats and two rabbits. Suturing nerves is a delicate job after all, and it is quite time-consuming even if it is done on animals. When they came out of the laboratory, it was already noon.
"How was the operation? Did the experimental animals have any rejection reaction?" Qiao Ruida, who had been waiting outside the laboratory, hurried over to ask.
"The operations on the four experimental animals have been completed, and at least no rejection reaction has been found so far. This DDAT material is really amazing. The rat that completed the operation first, whose thigh had its nerves cut, actually showed signs of movement. This proves that the DDAT material can really transmit nerve signals, which is incredible." Shen Jiajun, who had just finished the operation, was also very excited. He gesticulated while talking.
After two days of observation, three of the four experimental animals recovered their injured legs. In the rabbit that failed, a fluoroscopic examination revealed that the anastomosis interface between the DDAT material and the nerve was not properly sutured and was broken again, which was the reason why the rabbit's thigh could not move. As for rejection, none of the four experimental animals showed any rejection, which proves that the DDAT material is quite safe and will not be attacked by the immune system.
That night, Qiao Ruida told Du Qingqing about the DDAT material and showed her the animal experiment report. Du Qingqing studied business management and could not understand much about these materials and medicine-related things, but she still understood the role of the DDAT material. She grabbed Qiao Ruida's hand and asked excitedly, "Honey, can this DDAT material be used for nerve repair? With it, my father's nerve transplant surgery does not need to take nerves from other parts of the body?"
Qiao Ruida smiled and nodded, saying, "DDAT material is suitable for your uncle's condition. However, DDAT material has just been developed and is still undergoing animal experiments. It is not certain when it can be used on humans for clinical trials."
"So, what is the success rate of using DDAT for nerve rewiring? If the procedure fails, will there be any side effects?"
"Only four animal experiments have been conducted so far, three of which were completely successful and one failed. The failure was not due to material problems, but because the suture technique was too rough, causing the interface to break. If a more skilled surgeon were to perform the operation, the success rate would definitely be higher."
"A 75% success rate? That's pretty high. Do you know how high the success rate of nerve transplant surgery is? It's only about 20%. Even if the transplant is successful, there may be sequelae such as limb numbness and limited mobility. In comparison, the 75% success rate of DDAT transplantation is already a miracle."
"Well, I will urge them to complete the animal experiments on DDAT materials as soon as possible, and then apply for clinical trials, hoping to catch up with uncle's surgery."
"It doesn't matter if I miss the surgery. I will convince my parents to wait until the DDAT material enters clinical application before the surgery. Honey, you are so kind to me, thank you." Even Du Qingqing, an outsider, knows how difficult it is to develop a new polymer material. And Qiao Ruida actually developed the magical polymer material DDAT specifically to treat her father's injuries. It is hard to imagine how much manpower and material resources this would consume.
Billy Stokes is a peer review editor for the journal CELL. He has been in this position for five years and has a wealth of experience. As one of the four top journals, CELL receives a large number of submissions every day, but only a few of them are of high quality and can be published in CELL. Billy Stokes often jokes with his colleagues that his job is to pick gold and diamonds from a pile of sand and stones.
On this day, Billy Stokes was sitting in his office reviewing manuscripts as usual.
"Shit, what the hell is this? It's bullshit. It's really beyond your ability to submit a manuscript of this level to CELL." Billy Stokes cursed angrily, then operated the mouse, closed the manuscript, dragged it into the trash can, and then opened the next manuscript and continued reviewing it.
"Hey, this is a paper about material preparation, how come it was sent to CELL? Could it be sent to the wrong journal?"
At the beginning of the paper, there were large amounts of chemical reagents, both chemical reactions and electrolysis, which clearly indicated that some kind of material was being prepared. As a doctor of medicine, Perry Stokes certainly couldn't understand these materials science related things, and wanted to just skip it, but out of good professionalism, he still went on to read it. In the second half of the paper, a new polymer material named DDAT by the author had been prepared, and then came the animal experiment part, which was Perry Stokes' area of expertise. He stared at the experimental steps and several illustrations in the paper and read it very carefully. After reading the entire paper, Perry Stokes clenched his hands, waved them in the air twice, and then shouted: "Guys, look what I found, a polymer material that can conduct nerve signals, it's incredible! If this material really exists, then countless patients with nerve damage will have hope of recovery."
Billy Stokes' words attracted the attention of his colleagues and editors, and they all turned their eyes to him.
"A material that can conduct nerve signals, is it true or not? If anyone can develop this material, they will easily win the Nobel Prize in Biomedical Sciences."
"Stop talking nonsense and quickly push the paper over here so I can see which professor wrote it."
"The first author is QiaoRuida. Who is this? I've never heard of him."
"Looking at the spelling of his name, he should be a scholar from that great country in the East." "This is amazing material. If it is real, it will be a blessing for thousands of patients with nerve damage. I hope it is not a prank."
"As for the animal experiment, except for the rough nerve suturing technique, there are no other major problems. The steps are clear, and there are pictures and texts. It doesn't look fake."
"The key is the preparation of new materials. Those of us who study biology and medicine simply cannot understand it, and it is not easy to find reviewers."
"Leave the reviewing work to me. I will find an old friend and ask him to do a replication experiment. If this DDAT material is indeed verified and its performance is not exaggerated, then this paper will be the cover article of the next issue of CELL."
Finally, the editor-in-chief spoke, and that was the final word.
Half a month later, the latest issue of "CELL" journal was launched on time. The cover article was "Preparation and Animal Experiment of a Polymer Compound That Can Conduct Neural Signals" jointly contributed by Qiao Ruida and Shen Jiajun. Once this paper was published, it caused a huge sensation in the fields of materials science and medicine. Countless materials science laboratories and medical laboratories started to reproduce the experiment as soon as possible. The preparation method of DDAT is not complicated, and there is no difficulty in reproducing it. As long as the equipment is complete and the operator has certain experience, it can be easily prepared successfully. In just one day, more than a dozen materials science laboratories issued articles stating that they had completed the preparation of DDAT materials. Next, it was the performance time of the medical laboratories. After obtaining the DDAT materials through their respective channels, they selected various experimental animals and performed nerve cutting and nerve anastomosis operations.
On this day, Qiao Ruida was in Ruida Building, listening to Zhao Hongcai's report on the preparations for Ruida Technology's spring conference, when the phone on his desk suddenly rang. Qiao Ruida picked up the phone and saw that it was from Academician Wang. Qiao Ruida and Academician Wang had previously made a verbal agreement that after finishing their senior year, they would apply to be Academician Wang's graduate student. The master-disciple relationship was set from that time on. Now that Academician Wang called him, he naturally did not dare to neglect it. Qiao Ruida made a pause gesture to Zhao Hongcai, and then answered the call.
"Academician Wang, why did you think of calling me?"
"Mr. Qiao, did you publish a paper on the new material DDAT in CELL?"
"Hey, I did submit a paper to CELL some time ago. It was published so quickly."
"You are indeed the one. I said there would be no other person named QiaoRuida in Peking University. Aren't you working on artificial intelligence chips? Why are you getting involved in the biomedical field?"
"Hehe, I came up with this by accident while doing an experiment. I originally thought it was useless, but after testing it turned out to be able to conduct bioelectric signals, so I wrote a paper and published it."
"Good boy, you are so lucky that you can produce such a magical material by accident during the experiment. By the way, Mr. Qiao, have you applied for a patent for this DDAT material? If subsequent experiments prove that this new material can be used for human nerve repair, its value will be enormous."
"Don't worry, Academician Wang, I have some patent awareness. Before I submitted the paper, the company helped me apply for relevant patents, and now it has entered the public announcement period."
"That's good. So, Mr. Qiao, please come to my office. Academician Zhang from Peking University Medical School has come to me and wants to discuss with you the clinical application of DDAT materials."
"No problem, I'll be there soon."
After hanging up the phone, Qiao Ruida gave Zhao Hongcai a few more instructions, then hurried out and drove to the Peking University campus. Half an hour later, Qiao Ruida arrived outside Academician Wang's office. He straightened his clothes and knocked on the door.
"It should be Student Qiao who has arrived. The door is not locked. Come in." The voice of Academician Wang came through the door.
Qiao Ruida pushed the door open and saw Academician Wang and an old man wearing glasses sitting on the sofa, drinking tea and chatting.
"Student Qiao, let me introduce you. This is Academician Zhang Qiang from Peking University School of Medicine. Old Zhang, this young man is the author of that paper, Qiao Ruida, who invented DDAT." Academician Wang stood up and introduced both parties.
Qiao Ruida stretched out his hand, shook hands with Academician Zhang, and said, "I have heard of Academician Zhang's name for a long time, but I have never had the opportunity to meet him. This time I finally got my wish."
"Hahaha, classmate Qiao is really good at talking. I am not as famous as you, the richest man. Previously, I only thought that classmate Qiao was good at business, but I didn't expect that he also has such achievements in the research and development of new materials. It is true that the younger generation pushes the older generation forward, and each generation is stronger than the previous one."
"Academician Zhang, thank you for your compliment. I am just lucky and it is nothing special."
"Come on, come on. If you have anything to say, please sit down and talk." Academician Wang invited everyone to take a seat. Qiao Ruida said a few polite words and sat directly on the sofa opposite Academician Zhang.
"Come, Qiao, try this Pu'er tea. You young people don't usually drink this. I wonder if it suits your taste." Academician Wang personally poured a cup of tea for Qiao Ruida, which made him flattered and he quickly took it with both hands. (End of this chapter)
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