Go back in time and be a chaebol

Chapter 1225 From a Trade-Based Nation to a Technology-Based Nation (Third update, please subscribe)
"Havana has compromised! They have agreed to allow expatriates to leave with their personal belongings."

After receiving this report, Li Yian did not smile, but just nodded slightly and said:
"Pity……"

The reason why Li Yian said it was a pity is that there is not much Nanyang can do about the "nationalization" of Cuba.

According to normal practice, Nanyang should directly "strike hard", smash Havana to pieces, or even bring Caracas directly to Nanyang and bring him to court, just like what the Americans did in Panama.

Then let the whole world understand one thing - the steamed buns from Nanyang are not delicious.

But the problem is - we can't do that now, because Cuba has not yet become a pawn of the United States, and Cuba has not yet completely become a pawn of the Soviets.

Only after the Soviet Union deployed nuclear missiles in Cuba did Americans realize how terrible it would be for their country to have a Russian ally.

"It's a pity. We could have killed the chicken to scare the monkeys, but the chicken actually knelt first."

Li Guoren said with a smile.

"I thought they would fight to the end, but I didn't expect them to kneel so quickly."

When he said this, his tone was proud. Only as a diplomat, he knew what was behind this compromise - it was a reflection of the country's strength, and more importantly - they had never compromised in the face of pressure from the United States.

But in Nanyang, people have become very "rational".

"That's because we really throw punches! So, they understand what the price of not compromising will be."

Li Yian said casually:
"If we strike hard at Cuba now, the Americans won't feel the pain, and they will certainly stop our actions in other regions, such as Jakarta..."

After a brief pause, Li Yian continued.

"For Nanyang, Cuba is just a problem, but Jakarta is a real threat. In the past few years, with the help of the Soviets, Jakarta has not only established a modern army, but also gradually eliminated local anti-government forces.

It can be said that Jakarta’s military power is now far stronger than in history, and the threat to Southeast Asia is increasing day by day.

It is for this reason that resolving the Jakarta threat has always been Nanyang’s top priority. However, the United States once stepped in to stop Nanyang.

At that time, they did not feel the pain of hara-kiri. Now, let the Americans feel it in Cuba, so that they can understand that some things must be dealt with with a heavy blow, and there can be no slackness. "

This is America - the America today is actually not much different from later generations, both of which want to be whores and also want to be virtuous.

They had no idea that on some issues, compromise would never be tolerated. It was not until after the Cuban Missile Crisis that the United States finally understood one thing - core security must not be compromised.

Later, the United States invaded Grenada and Panama basically for this reason.

"Sir, now..."

"We must continue to negotiate with the Cubans. We must do our best to ensure the interests of the expatriates. At the same time, we must send a signal to the world that we will not tolerate anyone touching things in Nanyang."

Li Yian thought for a while and said:
"Let the Americans feel the pain first."

……

"…After long negotiations, the Ministry of Foreign Affairs reached an agreement with the Cuban authorities yesterday on the repatriation of Cuban expatriates. According to the agreement, the Cuban authorities allow Nanyang to send aircraft and ships to repatriate expatriates, and allow each expatriate to carry personal belongings weighing no more than 100 kilograms…"

Listening to the news on the radio, Zhang Zhiquan's mouth curled up, although the news only mentioned the mediation of diplomatic officials.

But as a PhD in organic chemistry, when I consider the failure of the US operation in Cuba last month and the news of the naval fleet "visiting" North America, the answer is obvious.

"It should be said that the naval exercise scared them. It turns out that this world is still afraid of power."

Although power is not good, at this moment, when Zhang Zhiquan came to a conclusion in his heart, he felt more of a sense of national pride.

This sense of pride comes from the heart!
Like many young scholars from Nanyang, Zhang Zhiquan also attended high school in Tangshan and was admitted to Nanyang University. At Nanyang University, he studied organic chemistry from undergraduate to master's level, and then went to the United States to study for a doctorate.

It was this experience that made him full of gratitude to Nanyang. After all, if it were not for Nanyang, he would not even have the opportunity to go to college.

Therefore, he has a very strong sense of belonging to Nanyang, and it is this sense of belonging that makes him feel so proud.

America is not Nanyang, and Nanyang is not America!

Just because the United States cannot do something doesn’t mean that Nanyang cannot do it - Nanyang has successfully protected the property of its citizens, at least to a certain extent.

Just like that, while listening to the news on the radio, Zhang Zhiquan drove into the company. As a researcher in Saz Laboratory, he had been conducting some research in the past two years.

As early as when he was a graduate student, he had developed a strong interest in the biosynthesis of cholesterol. For this reason, he wrote a letter to Conrad Bloch, expressing his hope to study under his guidance. Bloch was an authority on the biosynthesis of cholesterol and fatty acids.

In the United States, Zhang Zhiquan noticed that there were many elderly and overweight people in the United States. In the community where he lived, there were many elderly couples living alone. He often saw ambulances coming to take elderly people who had heart attacks to the hospital. Coronary heart disease is the leading cause of death in the United States. At that time, the number of Americans suffering from high cholesterol, a precursor to coronary heart disease, had exceeded 1000 million.

The experience of studying with Bloch made him understand that there are two main sources of cholesterol in the human body, which can be synthesized by the body or absorbed from food. Studies have shown that in humans, the cholesterol produced in the liver far exceeds the cholesterol absorbed from the diet, and HMG-CoA reductase is a key enzyme in the cholesterol synthesis process and has been shown to be the enzyme that controls the rate of cholesterol synthesis. Based on these facts, Zhang Zhiquan speculated that cholesterol synthesis inhibitors, especially HMG-CoA reductase inhibitors, would be effective agents for lowering cholesterol. The situation at the time was that there were many types of lipid-lowering drugs on the market, but none of them were considered safe and effective. Moreover, countries had not yet developed HMG-CoA reductase inhibitors.

Zhang Zhiquan, who has a very high scientific acumen, realized the importance of developing cholesterol-lowering drugs. After successfully completing his studies in the United States, he returned to Chang'an to continue to tackle this problem.

After returning to China, the Saz Lab gave Zhang Zhiquan a lot of freedom, giving him the opportunity to work on projects of his own choice.

It was here that a bold idea was put forward: to look for substances in fungi that can inhibit HMG-CoA reductase.

When Zhang Zhiquan walked out of the car and headed for the elevator, Lin Yongsheng, who had just been assigned to the laboratory, asked curiously while sorting out the fungal samples to be used today:

"Why are we studying fungi? Can we find substances in fungi that can inhibit HMG-CoA reductase?"

Bai Longkang asked back:

"How did our laboratory come about?"

Lin Yongsheng replied: "It was streptomycin invented by Mr. Saz."

"In fact, Dr. Zhang chose this direction because of the inspiration of Mr. Satz, who believed that bacteria, like humans, also need cholesterol to keep their cell walls together. Therefore, some fungi may have evolved something as a defense mechanism against microorganisms that need sterols to grow.

Now we just need to find the right fungus.”

So with the support of the laboratory, they began their work. Inspired by Fleming's success with mold, Zhang Zhiquan's team began to use a large amount of fungal culture fluid to screen for suitable compounds, which also involved complex detection technology.

Everyone knows that this is just like buying a lottery ticket, it's just a gamble.

Over the past two years, Zhang Zhiquan and his team have shown amazing perseverance. They have been working day and night in the laboratory.

After screening thousands of fungi, they did not get any satisfactory findings, but they still did not give up. Perhaps it was God's blessing that one year later, after screening the 3800th fungus, they found that the culture fluid of the mold showed strong inhibitory activity.

The active ingredient was shown to be a known substance, citrinin, which strongly inhibited HMG-CoA reductase and reduced serum cholesterol levels in rats. However, the study was suspended due to its toxicity to the kidneys. Nevertheless, this preliminary screening experience gave them great hope and courage, and strengthened their confidence that they could discover better active substances in the future.

Recalling some of the achievements made in the past two years, Zhang Zhiquan said to himself:
"It's just 99% sweat. Now I may have only sweated 50%..."

It may be only 98%, just the finishing touch. Now they are doing hard work every day until they are exhausted.

Over the past two years, they have tested as many as 6000 fungal cultures.

"PhD,"

As soon as Zhang Zhiquan entered the laboratory, Long Baikang introduced:
"This is Lin Yongsheng, a graduate of Yongping University, who has just joined the laboratory."

"Hello, Doctor."

"Welcome to join us."

After welcoming, Zhang Zhiquan asked:
"How is it? Are all the samples for today ready?"

"Everything is ready,"

While answering, Lin Yongsheng introduced the origin of the samples, and soon they started working.

As usual, after briefly understanding the origins of these samples, Zhang Zhiquan examined the petri dishes. Suddenly, he said in surprise.

"Pen-3751 is ready for separation."

Hearing the doctor's surprised voice, Lin Yongsheng asked:
"What is Pen-3751?"

"Pen-3751 isolated a fungus from a rice sample we collected from a grain store in Chang'an, which is a blue-green mold that contaminates fruits such as oranges and melons. But because the production rate of active compounds is very low, this petri dish has been used for almost a year,"

On the same day, they finally found a second fungal culture fluid with activity.

Finally, in July of that year, Zhang Zhiquan isolated the inhibitory compound ML-7B, also known as mevastatin. Thus, the first statin was born in Nanyang.

At this time, Jianmin Pharmaceutical, as the investor of the laboratory, did not know that on this day, they had obtained the medicine they had been waiting for for a long time - in the future, statins will not only save tens of millions of patients, but will also bring hundreds of billions of yuan in revenue to the company.

Many times, countless inventions and innovations are the result of chance and occasional discoveries. In the development process of Nanyang, there are always too many scientific researchers like Zhang Zhiquan. Their wisdom and sweat are changing this country little by little, turning this country from a "trade-based country" to a "technology-based country."

The consistent emphasis on education over the past 15 years has enabled a new generation of scholars to finally display their talents in various fields. The vast majority of these people would have been buried due to war or education, or would have remained unknown due to circumstances.

But now, after they have received modern higher education in Nanyang, with the rise of Nanyang, especially Nanyang's investment in science and technology, they have been able to achieve amazing achievements in many fields.

Sometimes, their achievements change not only their own destiny, but even the destiny of mankind.

(End of this chapter)