Reborn Bao Guowei, I really didn’t want to be a great writer!

Chapter 363 Penicillin sustained-release formula! I am the Holy Body of Science!

Bao Guowei didn't know much about the sustained-release method of penicillin.

Fortunately, there is an endless database in my mind.

Through recollection and searching, he still found some ways.

A sustained-release formulation of penicillin is one of these.

In later generations, there are many ways to sustain the release of penicillin, among which ampicillin is the most typical one.

This semi-synthetic broad-spectrum penicillin antibiotic can be said to have excellent antibacterial effects.

However, this technology only appeared with the development of chemical synthesis technology in the 1960s.

To put it simply, with the current level of technology in the world, it is still a fantasy to produce semi-synthetic penicillin.

So Bao Guowei didn’t consider this at all.

The rest, such as the use of probenecid, penicillin G sodium salt, etc., needless to say, are all technologies that transcend the technology tree.

The only feasible method is intravenous drip.

But it is far less convenient than the sustained-release formula of penicillin!

The sustained-release formula of penicillin just proposed by Bao Guowei happened to be born in an extraordinary period.

During World War II, the invention of penicillin shone brightly on the battlefield.

However, the technology at that time was not mature enough. Even if penicillin of sufficient purity was produced, it still required multiple injections to maintain the concentration of penicillin in the blood.

A shot of penicillin can last for about three hours, which is considered to be of extremely high quality.

At that time, it was not uncommon for the wounded on the battlefield to receive eight or nine injections a day to prevent wound infection.

After a period of time, the wounded soldier's buttocks were pierced like a sieve.

Not to mention the risk of side effects and limited human resources after multiple injections.

Therefore, Monroe Romansky, an American military doctor at the time, creatively invented this sustained-release formula of penicillin.

It also set a precedent for the use of sustained-release drugs in modern times.

When peanut oil, beeswax, and most importantly, penicillin are mixed together and injected into the human body, the peanut oil and beeswax will be metabolized in advance.

In this way, penicillin can be slowly released into the human body.

Injections once a day have become more reasonable, while also reducing the chances of side effects and allergies.

Bao Guowei wrote down this recipe and gave a brief overview of it.

But the scientists present were all stunned.

At first, they thought Bao Guowei was kidding. What does penicillin have to do with peanut oil and beeswax?
Isn't this nonsense?
This is drug research, not food research, why add these things?
But when they calmed down, they found that this method seemed to be feasible!

Dai Fanglan spoke first and said, "It's feasible! I think it's definitely feasible! The two most important functions of sustained-release agents are to maintain the stability and effectiveness of the drug, which these two substances can satisfy. The other is the combination of peanut oil and beeswax, which is widely used in the medical field. The combination of the three can theoretically slow down the release of the drug!"

He seemed extremely excited and made a very detailed analysis of the feasibility of this formula.

After a moment of silence, the scientists present gave their affirmation from their professional fields.

"Maybe it really works!" Deng Shuqun nodded and said. "Theoretically, I can't find any problems for now. Although it may seem a bit rough academically, based on our current situation, this is one of the best formulas. I think we can try it through experiments."

Several other scientists also nodded and agreed, "We can give it a try!"

But afterwards, they turned to look at Bao Guowei, who proposed this plan, and for a moment they didn't know what to say.

Although these three recipes seem ordinary, the creation of a prescription often requires long-term accumulation of experience and countless attempts.

This can be seen from the fact that in ancient times, there were many traditional Chinese medicine families who kept those prescriptions as heirlooms.

It is precisely because of this that it is somewhat surprising that Bao Guowei was able to come up with this idea.

Tang Feifan, in particular, looked at Bao Guowei speechlessly and said, "Brother Bingwen, how could you have thought of using peanut oil and beeswax as sustained-release agents for penicillin? This is a bit..."

The latter sentence was too outrageous, so he didn't say it.

Bao Guowei's mouth twitched. He was too anxious and forgot to think of a reason.

This recipe is indeed a bit too unreasonable.

But if there are too many lice, they won’t bite. If there are too many shocking things, the originally strange events will become less strange.

Bao Guowei said a little embarrassedly: "Well, I saw some beeswax and peanut oil in some skin care products I use every day. I also read some foreign papers recently. After combining them with each other, I got some insights. I didn't expect it to be really useful. It's really surprising. Hahaha!"

But facing the scrutinizing eyes of the crowd, Bao Guowei could feel that if he didn't give a definite answer today, he would probably not be able to get through.

The only one who got used to it was Fang Xinchuan.

He had already started planning on his own the subsequent experimental process of using this formula.

As for why Bao Guowei was able to come up with this formula?
What's so strange about this? He was the one who came up with penicillin, so why would he come up with a sustained-release penicillin?

After thinking for a long time, Bao Guowei finally came up with a lame excuse.

"Well, gentlemen, is there a possibility that I am a natural born medical saint?"

He said this rather shamelessly.

Suddenly, the laboratory fell into silence.

Natural-born medical saint. For scientists of this era, this adjective is basically unheard of.

But they could still understand what it meant.

For a moment, I didn't know what to say.

If anyone else dared to say this in front of these scientists, they would beat the living shit out of them.

But if it was Bao Guowei who said this, everything would be different.

They simply don't know how to refute or question.

Because even the topic on penicillin was provided by Bao Guowei.

In a sense, there is some truth in Bao Guowei's statement that he is the Holy Saint of Science.

time is tight.

But for these scientists, even if time is not tight, as long as they can see the progress of the research project, they can forget about food and sleep and conduct experiments all night long.

The next work has nothing to do with Bao Guowei.

Bao Guowei wrote down the specific idea of ​​the sustained-release penicillin. Although it was called an idea, it was actually the specific preparation method that was circulated on the Internet in later generations.

These are obviously very important, otherwise even scientists led by Fang Xinchuan would have to take a lot of detours.

Compared with the previous difficult environment, all the equipment in the laboratory is now fully prepared. Behind the laboratory, a dormitory area has been specially opened up for the scientists working now to live in.

"President Hu is very supportive of our research. In a letter from Professor Zhu Kezhen, he did not even ask about the content of our research. He bluntly said that as long as it is beneficial to the country and the people, he, Hu Shuhua, will keep the secret for us even if it means sacrificing his life."

Fang Xinchuan took Bao Guowei to the dormitory area alone, and said with great emotion as they walked. "Principal Hu is a righteous man!" Bao Guowei praised without any hesitation.

It was not without reason that he agreed to conduct penicillin research at Tongji University.

Because the then principal, Hu Shuhua, was an extremely pure person.

He has served as president of Tongji University, Xiangnan University, Northwest University, and Wuchang University.

Over the past twenty years, he has had almost no bad records and has been highly praised by students.

During the Republic of China era, he was a rare principal who was not involved in politics.

All actions were taken for the students' sake, opposing Chiang Kai-shek's government's bloody incidents against students and greatly protecting the student group.

People are changeable, and it is difficult to see through a person.

But for Bao Guowei, he can give the other person's trust as long as he recounts the other person's life experience. This is one of his advantages.

Fang Xinchuan found the best school building for Bao Guowei, but it was still hung with cobwebs and looked a bit dilapidated.

He said somewhat embarrassedly.

"I'm really sorry, Mr. Bingwen. You'll have to stay here for one night. I'll ask someone to help you clean up and buy some furniture tomorrow."

I looked around the dormitory. It was filled with everything, except for some spider webs. It was actually no different from my university dormitory in my previous life.

There was once a joke that an old alumnus of a key university returned to his alma mater sixty years later and was very surprised to see the appearance of the dormitory building.

"Hey! Nothing has changed. We are still the same as before."

Therefore, Bao Guowei didn't care much about this and shook his head.

"It doesn't matter. Just a place to stay is enough. I'll prepare the rest myself. You guys go about your business."

Instead, he was somewhat moved and said with a sigh.

"I didn't expect your environment to be so harsh. I'm really moved!"

Bao Guowei thought about it and said instead.

"Brother Xinchuan, if there are any problems with the research, or if you are short of funds or materials, you can come to me and I will make sure to arrange it!"

Bao Guowei is no longer the poor boy from the alleys of Hangzhou.

It is still possible to grit your teeth and support this research institute with dozens of people.

Fang Xinchuan was a little surprised, smiled and shook his head.

"We don't lack anything. Brother Bingwen gave us some funds, Professor Zhu Kezhen gave us some funds, and President Hu also gave us some. We already have a lot of surplus funds. The gentlemen are even discussing what to research in the future if penicillin is discovered."

There was something strange on Bao Guowei's face. Research institutes have always been a drain on the treasury. This is why many new drugs in later generations are often priced sky-high.

The birth of a result requires a huge amount of resources.

His case is quite special. Whenever he encounters difficulties, he relies on Bao Guowei's "accidental thoughts".

"However," Fang Xinchuan said after a moment's hesitation. "We do have one aspect that requires Brother Bingwen's further support."

"Huh?" Bao Guowei looked confused.

Fang Xinchuan said with a very strange expression on his face: "I hope that Brother Bingwen can have more flashes of inspiration in the future. You really seem to be a saint of science."

Bao Guowei: "."

In the following days, Bao Guowei began a secluded life with scientists such as Fang Xinchuan, Tang Feifan and Dai Fanglan.

However, before that, Bao Guowei had obtained the penicillin drug that had been fully produced in the laboratory and undergone clinical trials, and sent it directly to Suzhou.

He also wrote a letter to Shen Shiwan, giving him specific precautions and some skin test techniques.

Let Zhang Taiyan use it in advance to prevent his condition from worsening further.

As for Bao Guowei himself, he continued to work on "The Chrysanthemum and the Sword" in his dormitory at Tongji University.

He would go to the laboratory from time to time to check on the progress, but when it came to specific operations, he really couldn't help much.

At first, Dai Fanglan and others did not believe it, but after seeing Bao Guowei's experimental operations, they immediately gave up the idea of ​​letting him join the experiment.

We have the formula, the precautions, and a group of top scientists.

Bao Guowei is very confident about the next research, and penicillin, which has already undergone clinical trials, can also delay the time.

In particular, three or four days later, Bao Guowei received news from Hangzhou that Zhang Taiyan's penicillin skin test was successful!
Next, appropriate injections can be used to suppress the further spread of the infection, coupled with the support of various means such as the "iron lung".

It can be said that Bao Guowei basically pulled Zhang Taiyan back from the brink of death.

In the simple dormitory, Bao Guowei took a deep breath.

He didn't expect that in this era, it would take so much effort to produce penicillin and cure a patient.

This is already under the premise that I have activated countless cheats.

Thinking about my previous life, the protagonists in those novels were able to easily produce penicillin, and then some big shot would immediately be cured of any disease.

Bao Guowei is just jealous! Why can't he do the same?
However, at least it has been researched. With the experience gained this time and these talents, things should be much smoother in the future.

Without pressure, Bao Guowei began his boring daily life.

There are only three things I do every day: read the latest newspaper news in the morning, go to the laboratory to observe the progress and show off in the afternoon, and go back to the dormitory to start writing and revising the book in the evening.

In fact, the book "The Chrysanthemum and the Sword" could have been completed long ago, but Bao Guowei now has higher and higher requirements for works, so it is naturally impossible to copy a book and send it out immediately as before.

Even this book "The Chrysanthemum and the Sword" contains many original parts by Bao Guowei, so it naturally takes more time.

The days at Tongji University passed quickly, and Bao Guowei enjoyed this rare atmosphere.

Of course, what I look forward to most on weekdays is reading the newspaper in the morning.

There is always a feeling that historical events are playing out before my eyes.

For example, Gandhi's various non-resistance movements in India, the progress of the Great Depression, and the follow-up progress of the Central Plains War
These are all Bao Guowei’s main concerns.

Unfortunately, Pluto was discovered as early as February of this year.

If it were one year earlier, this Pluto would definitely be named Bao.

1930 10 Month 5 Day.

Tomorrow is the Mid-Autumn Festival. Bao Guowei plans to return to Suzhou to see how Zhang Taiyan is doing and celebrate the Mid-Autumn Festival with Zhang Nianyue.

Especially when he heard that his father, Lao Bao, also went to Suzhou, Bao Guowei could no longer hold back.

But just as they were about to clean up, Cao Yanhai ran in from the door, waving a newspaper and making a noise.

"Master! Master! Latest war report! The bald guy from India, the old guy named Gandhi, has been arrested! Yan, Feng, and Wang all called Zhang Xueliang to express their willingness to cease fire!"

(End of this chapter)