Genius of the Rules-Style System

The last time Zhao Yi reviewed several experiments by Li Ming and Zhang Wei, he determined that they were focused on the dissimilation reaction of E. coli, that is, studying the reaction between E. coli and antibodies, and the process of E. coli being digested by the immune system.

However, in the past month, the team's research has made no progress.

On average, every one or two days, Zhao Yi would go to the laboratory to check out the experiments and data. It was true that there were no new discoveries, and his mentality was not bad.

Although it is said that there has been no progress for a long time, most research is like this. Let alone one month or two months. It is normal for similar research to have no progress for a year and to be shelved in the end.

But the group still hopes for results.

First, the prospects for drug development are indeed very good. It is a large project directly cooperating with pharmaceutical companies and involves many interests.

The second reason is also because of comparison.

The teams of Han Hui and Ai Lixin are conducting research on replacing the human immune environment, and have produced results one after another. They have reduced the cost of producing 2CV-bihydrogen molecules by simulating the human environment in experiments to about three times the original price.

This achievement can be described as ‘remarkable’.

Pharmaceutical companies are very satisfied with the results of reducing experimental environment production costs, because the same technology used in research and development will reduce a lot of experimental funding investment.

If there is no way to mass-produce 2CV-bihydrogen molecules in a short period of time, reducing experimental production costs is also an alternative, but the price of the drug will be very high after it is put on the market.

In addition, the R\u0026D centers of pharmaceutical companies have entered the ‘drug experiment’ stage.

They found ten AIDS patients and injected them with a certain amount of 2CV-bihydrogen molecules every week to observe the spread of HIV in their bodies.

If it is determined that the therapeutic effect of 2CV-Binghydrogen molecules is very good, and it is impossible to find a mass production method in the short term, then pharmaceutical companies may choose to produce 2CV-Binghydrogen molecule drugs at high cost under experimental conditions.

This is also an impossible choice.

2CV-Bing Hydrogen Molecule is not a new substance. As long as a little bit of news is spread, it will be known to others. The timeline for research and development will be extended, and confidentiality will be a major issue.

After making a comprehensive evaluation and reducing experimental costs for production, the drug can at least be launched on the market. Even if the price is very high, the good effects are very attractive.

Therefore, the research conducted by Han Hui and Ai Lixin's team on reducing the simulated human test environment is still very meaningful.

The teams of Han Hui and Ai Lixin were better, and they achieved a lot of results. However, neither Han Hui nor Ai Lixin were big talkers. If they had any results, they would just talk about them in normal meetings.

Dai Tianqing's group is different.

The teams of Dai Tianqing and Chen Zhigang are doing research on the immune response of vertebrate mammals to bacilli. They hope to find a small protein that can replace the 2CV-Bing hydrogen molecule, or hope to make other discoveries.

This is indeed a good idea.

2CV-Binhydrogen molecules are small protein molecules produced by human immunity against bacilli. Other vertebrate mammals may also produce similar small protein molecules for sensation.

Dai Tianqing's team soon made a discovery. From the blood of a strong chimpanzee, they extracted a small protein molecule similar to the 2CV-binhydrogen molecule. However, after testing, it was found that this small protein molecule is resistant to HIV. It has almost no effect.

"Maybe it's because chimpanzees are already very resistant to HIV."

Many people have come to the conclusion knowing the results.

Although this discovery is not of great significance, it still gives people hope. Dai Tianqing seems to think that the research is promising, and he keeps saying, "I think our team will make a big discovery soon."

"Zhao Yi, do you want to come to my group?"

"Lao Ai, I think you made a mistake by following that old woman Han Hui!"

"Zhang Wei, I brought you here. Don't worry. When we decide to study together and publish the paper, I will take more care of you."

"..."

Every time Zhao Yi saw Dai Tianqing, he had the urge to kick him in the face.

Zhang Wei was a little better. At least she was the one being cared for. She just smiled quietly and politely expressed her gratitude, but she must have been feeling very uncomfortable.

Li Ming...

As a person sitting in the corner and being ignored, he just thought about drawing blood for people in Dai Tianqing's laboratory in the future. The first injection would definitely be inserted hard into the nerve line.

Anyway, several people in Zhao Yi's group were very depressed.

So when Zhao Yi learned that the experiment had made new discoveries, he immediately put down the research work at hand and couldn't wait to come to the laboratory.

"here!"

"This is it, Experimental Tank No. 3." Zhang Wei, wearing a white coat, shouted through the glass window.

Zhao Yi disinfected his whole body, put on a white coat and walked in. He stood in front of the No. 3 experimental tank and observed the mixed substances inside.

Zhang Wei explained, "A few days ago, Director Han Hui submitted a new detection method for E. coli labeled by antibodies. It can be used to detect how many E. coli are labeled."

"We conducted experiments using this method, and found that this experimental tank, which is also the fourth generation of E. coli, was injected with the same bacilli antibody. The number and proportion of labeled cells were significantly less than those in other experimental tanks."

"Professor Li Ming and I discussed it, and we both felt that there was a mutation in the antibodies against the bacilli."

Zhao Yi nodded and approved Zhang Wei's judgment, "Indeed, I think it should be a mutation."

What he said was 'I think'. In fact, he has already made a judgment using the Law of Causality. It is indeed the fourth generation of E. coli that has been bred, and some kind of targeted mutation has occurred in response to the harsh environment that has been 'marked' by antibodies for a long time. .

this is normal.

Viruses and bacteria often mutate. Influenza viruses are an example. In the process of spreading, various mutations will occur. Because of frequent mutations, the composition of influenza vaccines will also be targeted every year. Make adjustments and improvements.

A voice came from behind, "Mutation is just a possibility."

It's Li Ming.

Li Ming has been working on the left side, still holding a pen in his hand to take notes. He just said hello to Zhao Yi and really had no sense of presence at all.

After listening to Zhang Wei's explanation, he raised his head and added, "We cannot completely rule out other factors, such as Mrs. Han... Director Han's dyeing detection method, or subtle errors during the experiment. , mistakes, etc.”

"Um."

Zhao Yi nodded gently. The "Law of Causality" confirmed the existence of mutation, and other explanations lost their meaning. He just nodded lightly to express his recognition of Li Ming's professional ability, and continued to observe the experimental tank.

Zhang Wei asked, "Now that it is confirmed to be a mutation, should we study this finding?"

"let me think again."

Zhao Yi asked, "Are there any relevant experimental records?"

Zhang Wei immediately said, "Yes, it's outside. I'll bring it to you when I get out soon, but it's nothing special."

"no……"

Li Ming couldn't help but remind him, "Mutation is only one possibility, there are other possibilities."

"I know."

"Um."

Zhao Yi and Zhang Wei had the same reaction. They almost confirmed that it was a mutation, and those that were not mutations were excluded.

Li Ming was suddenly depressed.

He stared at the two people with confusion, not understanding why Zhao Yi mentioned that it might be a mutation, but Zhang Wei seemed to agree with it, and seemed to be sure that it was a mutation, and did not consider other possibilities.

If we were just doing experiments with him, or discussing it together normally, the situation would change when Zhao Yi came.

"Is it... love?"

"Zhang Wei is also single, in her thirties, maybe because of Zhao Yi? It is said that women in love will have lower IQs..."

"Maybe!"

Li Ming really couldn't understand what Zhang Wei was thinking. As for Zhao Yi, he didn't think about it at all. He was self-aware and knew that his talent was limited and he mainly relied on experience when doing research.

Zhao Yi happens to be the complete opposite.

From the beginning of the project to the present, he has not come to the laboratory a few times, but he has clearly grasped the research direction, let alone whether it is correct or not. Such decisiveness is not possessed by ordinary people.

Li Ming could only stand aside and feel depressed.

Zhao Yi carefully observed the No. 3 experimental tank, and then went out to read the recorded data. It mainly recorded the rate of E. coli being labeled and the situation during the dyeing experiment.

In addition, the completed dyeing experiment principles and procedures are also available on the computer.

That was the result of Han Hui's team.

There are many studies on E. coli in the world, but there is no staining study on the process of being labeled by bacilli antibodies. It is also a very good result to be able to track the bacilli and stain the labeled E. coli.

Zhao Yi read it carefully and found that the key point in the method was to grasp the labeling properties of bacilli antibodies.

Various antibodies in the human body generally have only two functions. One is to mark pathogens, which means they play a 'detective' role, allowing cells with cleaning functions to know which ones need to be cleaned.

Another function is to directly eliminate pathogens, but the latter is not very effective.

The reason why HIV cannot be killed by human immunity is mainly because the virus works by hijacking special proteins in the immune system, causing the immune system to be unable to produce corresponding antibodies, that is, it cannot label HIV and the immune system cannot recognize it. Naturally, There is no way to clean it up.

Han Hui's team tracks bacillus antibodies and uses the antibodies to label E. coli to track and stain them.

After Zhao Yi read the entire information, he began to study it carefully. His research method was also very simple.

"Law of Cause and Effect"!

"Contact Rate"!

After learning a lot of conditions, "Contact Rate" can help complete the details, and he quickly discovered an important piece of information--

The mutation of E. coli will produce a new substance that neutralizes the bacterium antibodies. The structure of the new substance is very similar to the 2-CV hydrogen molecule. The neutralization process is to combine with the bacterium antibodies to form a very Complex organic waste.

It may be protein, or it may be other substances. The production of organic waste makes the experimental tank turbid.

"Similar to the molecular structure of 2-CV bihydrogen?"

Zhao Yi immediately grasped the key and said clearly to Li Ming and Zhang Wei, "These observation experiments will continue. At the same time, we must focus on studying the bacterial flora in the No. 3 experimental tank and what exactly happened."

"Let's do the training first."

"Under the same environment, cultivate one or two more generations, and then do research carefully."

He expressed his opinion clearly, "I think that maybe the mutation caused the bacteria to secrete a certain substance that prevents the bacterium antibody from labeling, or simply reacted with the bacterium antibody."

"This substance must be found."

Zhao Yi made the explanation but did not leave. Instead, he discussed with Li Ming and Zhang Wei how to design the experiment next.

…

For several days in a row, Zhao Yi went to the research institute and spent most of his time in the laboratory, doing research with Li Ming and Zhang Wei.

Everyone in the institute was surprised.

From the perspective of people at the Institute of Biomedical Sciences, the work in the laboratory is only done by Zhao Yi as a "incident". His main scientific research direction is still in the theoretical research of mathematical physics. After all, compared with his mathematical results, the laboratory work is The results were nothing at all.

Internationally speaking, many people don't know that Zhao Yi is also a researcher in a biomedical laboratory, and think that he is a pure mathematician and theoretical physicist.

In recent times, Zhao Yi has also been mainly engaged in the research of particle mathematics. He used particle boundary theory to demonstrate supersymmetry issues and introduced the logic of mass. His results in particle mathematics shocked the world.

The Science and Technology Department also sees it this way.

The relevant responsible departments of the Science and Technology Department have been discussing the research issues of the 'Particle Boundary Theory', because the 'Particle Boundary Theory' has spread all over the world and has been valued by universities and scientific research institutions in many countries. They also hope to show their support for the 'Particle Boundary Theory' 'Research emphasis.

That's why Du Defa and his assistant went to Yanhua University to specifically ask Zhao Yi and propose the establishment of a 'Particle Mathematics Research Center'.

Research in the field of theoretical physics has always been at a backward level in China. Finally, a theoretical physicist who is considered reliable has emerged and created a new set of theories. The results have been recognized internationally. As a result, there is no support in the country. Why? It doesn’t make sense either.

After Du Defa returned to the Science and Technology Department, he did his normal reporting work. He said that Zhao Yi did not agree to be in charge of the Particle Mathematics Research Center, which surprised everyone else.

"Zhao Yi actually disagrees?"

"Why?"

"This is his theory. Wouldn't it be good to develop it?"

Someone pondered the reason and said, "Maybe it's because of biological research? I heard that Zhao Yi likes biomedical research and has produced good results. The project he led the team won the National Science and Technology Progress Award."

"Yes, I know too!"

"It was awarded at the beginning of this year to Zhao Yi's team. It seemed to be about AIDS research. However, Zhao Yi himself won the natural science award based on his mathematical theory."

"This is not doing your job properly!"

The leader of the Science and Technology Department, who is also Du Defa's superior, is named Li Zhenhua, who is specifically responsible for the innovative field of theoretical research.

Li Zhenhua frowned and sighed, and continued, "In my opinion, Zhao Yi should specialize in mathematics instead of biomedicine. What can medicine be researched? Can it still reach the top international level?"

"Our domestic medical research is limited, and most scientific research equipment is imported from abroad. It is too difficult to come up with results in this field."

"It's not a big deal that Zhao Yi is not in charge of the Particle Mathematics Research Center. He is still young and focuses on academics. It is normal that he does not want to participate in administrative work. He just needs to continue doing research on particle mathematics."

"But he has to do it wholeheartedly and cannot do it half-heartedly."

Li Zhenhua finally made the decision, "Let's do this. If we can talk through Zhao Yi and let him concentrate on studying mathematics and establishing a center for particle mathematics, we will give our full support."

"Otherwise, let's study again..."

There is a fan title event in the book review area. It seems that there are several titles to be given out. The deadline is the 12th. If you are interested, you can participate.