Super Dimension Technology Era

German Federation, Berlin.

Robert Koch Institute (RKI).

The institute just completed the construction of a BSL-4 laboratory this year. [Note: Internationally, biosafety is divided into four levels, Bio-Safety-Level 1-4, BSL-4 is the fourth level laboratory, also known as P4 laboratory].

The P4 laboratory of the Robert Koch Institute is used to study the molecular properties and modes of transmission of various pathogens, including not only bacteria and viruses, but also fungi, parasites and prions like the BSE (mad cow disease) pathogen.

Originally, according to the original plan, the Robert Koch Institute planned to upgrade the institute's BSL-3 laboratory to a BSL-4 laboratory in 2020.

But the rice plague that broke out in 2015 frightened the whole world. No one expected that a rice plague would indirectly kill more than 50 million people.

No one can guarantee whether there will be untreatable wheat plague, bird flu, swine flu, or even human plague in the future.

Therefore, major powers have upgraded their domestic biological laboratories to prevent the emergence of super viruses in the future.

The German Federation originally only had one BSL-4 laboratory at the Institute of Tropical Diseases in Hamburg. Last year, it invested huge sums of money to upgrade the BSL-3 laboratory at the Robert Koch Institute.

Don’t think that BSL-4 and BSL-3 are just one level apart. In fact, there is a huge difference in construction and maintenance costs between the two.

For example, the most advanced high-risk virus laboratory was the Jean Mérieux BSL-4 laboratory in Lyon, Gaul.

This laboratory began operations in March 1999. In addition to studying the most virulent and latest viruses, it also conducts in-depth research and documentation of old and mutated viruses in history, and finds treatments.

The laboratory with an area of ​​only 600 square meters cost 40 million francs, of which the instruments and equipment are worth 10 million francs. The annual operation, maintenance and experimental costs are 1.9 million francs.

Taking into account inflation, the cost may now increase by about 10 times.

The reason why it is said to be the most advanced BSL-4 laboratory in China is that China's Qinghai Lake Institute of Biology, Qinling Institute of Virology, and Daxinganling Institute of Genetics are more powerful than the Lyon laboratory.

…

At this time, in the BSL-4 laboratory of the Robert Koch Institute, the head of the laboratory, Dr. William Z. Baker, was leading a group of researchers to study P. cinerea and P. oryzae obtained from Tianzhu and Southeast Asia.

After browsing the genetic analysis map data, William Z. Baker couldn't help but frowned, turned his head and ordered to his assistant: "Kalia, immediately conduct a complete genome determination of the genes of Pyrosporum oryzae in 15 regions."

Kalia Schneider, who wore glasses and squinted his eyes, asked hesitantly: "Doctor, is it Pyrosporum oryzae from 15 regions?"

"Do as I tell you." William Z Baker said seriously.

"Okay, doctor."

Watching the assistant leave, William Z Baker turned his head and looked at the report on the table in silence.

As a senior virus bacteriologist and geneticist, William Z Baker has obviously seen some very terrible problems.

Among the samples collected from 15 rice areas in Tianzhu and Southeast Asia, there were obvious differences between Pyrillospora cinerea and Pyrillospora oryzae.

Pyrosporum cinerea and Pyrrhosporium oryzae are both fungi that can cause rice blast, and they belong to different states of the same species.

Generally speaking, there are no obvious genetic differences between Pyrosporum cinerea and Pyrosporum oryzae.

But the problem arises here. The situation of Pyrosporum cinerea is very normal, and the whole-genome measurement results are almost the same as the previous data. However, the whole-genome measurement of Pyrosporum oryzae has results that make William Z Baker unbelievable.

2015—There was a huge 34.6% difference in the genes of Pyrosporum oryzae and the ancient-Pyrisporum oryzae.

Obviously, no matter how powerful the mutations of viruses and bacteria are, it is impossible for them to mutate 34.6% of their genes in a short period of time (within ten years).

What's more, he checked the 2014 genetic data of Pyrosporum oryzae from the Rice Research Institute of the Chinese Academy of Sciences. Compared with the ancient Pyrosporum oryzae, the mutation rate between the two was only 0.00064%.

Such a huge mutation can no longer be said to be a mutation, but can be said to be a mutation. 2015-Pyrisporum oryzae and ancient-Pyrisporum oryzae are already two different biological species.

This situation makes William Z Baker very uneasy, because there is only one situation that meets this level of genetic mutation, and that is "transgenic".

2015—Pyrosporum oryzae is most likely a product of artificial modification, which is why he asked his assistant to arrange for whole-genome analysis of all samples.

If someone does such a bottomless thing, it is absolutely unforgivable.

As a scientist with integrity and bottom line, William Z Baker could not tolerate someone using biotechnology to create biological and chemical weapons. This is why he refused invitations from several biological laboratories in the United States.

He is a political novice, but that does not mean he is a fool. Whoever is the biggest beneficiary of the rice plague outbreak may be the mastermind behind it.

The 2015 rice plague incident directly crushed the economy and society of Tianzhu, Bangladesh, and the Southeast Asia Thousand Islands, and seriously affected Southeast Asia and Northeast Asia. If China had not responded in time, it would not have been much better.

So who is the biggest beneficiary? The answer is self-evident.

…

During the subsequent research, they indeed found a large number of signs of artificial modification in 2015-Pyrosporum oryzae.

Among the genes that can currently be matched, of the 34.6% mutated genes, 11.2% of the genes belong to HIV gene sequences, 12.6 genes belong to Staphylococcus aureus gene sequences, and the remaining genes are still being matched. middle.

"God, the guy who created this fungus should go to hell." William Z. Baker angrily smashed the report on the table.

The restless William Z. Baker walked around, and finally he made up his mind to write a paper to expose the incident, and ordered his assistant: "Kalia, you go make arrangements, and we are going to write a paper."

"Write a thesis?...Okay, doctor." Kalia Schneider turned around, with a trace of struggle in his eyes.

…

Ruta Schneider, the general manager of the institute, immediately changed his expression after listening to his nephew's report.

Ignoring the coffee spilled on his shirt, he rushed to the virus laboratory and called the institute's network security department, asking the network security department to immediately cut off the institute's external communications.

If William Z Baker's paper is released, I don't know if William Z Baker will have anything wrong with him, but he is probably at the end of his career as the general manager.

The paper must not be sent out, otherwise it will be over, Ruta Schneider thought frantically in his heart.

He rushed into the peripheral office of the virus laboratory in a panic and shouted loudly: "Inform Dr. William to stop the experiment and come out to see me immediately."

"Um...Okay." The person in charge of contact was not surprised. He quickly picked up the internal phone and notified William Z Baker to come over.

More than an hour later, William Z. Baker, who had passed through 10 isolation doors and had been fully disinfected, belatedly appeared in front of Ruta Schneider.

Before the other party could speak, Ruta Schneider said seriously: "Doctor, stop research on rice plague now. This is not a request, but an order."

"Schneider, why?" William Z Baker asked angrily.

Ruta Schneider stared into the other person's eyes and replied: "Why? Because I don't want to die, and I don't want you to die either. Do you understand?"

"I am willing to die for truth and morality!"

"Enough!" Ruta Schneider was furious.

He immediately gave up arguing with William Z. Baker, used his own authority to clear all experimental samples and data, and deleted the paper by William Z. Baker and others on the artificial modification of Pyrosporum oryzae.

Let security personnel temporarily restrict the freedom and external communications of William Z. Baker and others.

William Z Baker watched all this in silence, and in the end he only said one sentence:

"When science is used by Lucifer, all silence will promote darkness, and the demonic fire of hell will eventually burn everyone."

Thank you for your support, and thank you book friend "Yu Ming Taoist" for your reward (ω｀)