godfather of surgery

Chapter 1001: Blind Men and the Elephant
Yang Ping already had a general understanding of the whole process, but from a rational and objective point of view, this was far from enough to make a definite judgment about Guan Ruyan. Next, he had to wait for the defense meeting arranged by President Rao, allowing Guan Ruyan to defend his several key topics and papers face to face alone. At that time, it would be clear what level Guan Ruyan was at, because at a real defense meeting, no one could cheat, unless the experts participating in the defense were letting him down or the experts themselves were not very good.

Lu Xiaolu is indeed a rare talent. It is a pity to let him go to waste. Yang Ping decided to find a way to keep him. He is actually a victim as well.

The defense meeting proposed by President Rao will begin soon. All the outstanding young scientists candidates in the entire Nandu Medical University system must attend the defense meeting, and all questions in the defense meeting must be answered by the project leader himself. Assistants cannot replace him, even if reminded. President Rao said that the purpose of doing so is to allow the defense experts to truly understand the content of the project. Assistants often do not have a deep understanding as good as the leader, so the lazy behavior of letting assistants answer on behalf of the leader must be eliminated.

This notice made Guan Ruyan anxious. Lu Xiaolu's body has not recovered yet. He has already told Guan Ruyan that he has had diarrhea and dehydration for several days and his body can't bear it anymore and he needs to rest well.

Guan Ruyan is now in a state of panic. If this defense meeting is really carried out according to Principal Rao's requirements, the assistant will not be able to help at all. Even if he brings Lu Xiaolu to the defense meeting, Lu Xiaolu cannot answer on his behalf. At most, Lu Xiaolu can help pass notes or something, but in this kind of occasion, he cannot accept notes while standing on the stage.

If wearing headphones is a good idea, then Lu Xiaolu can help remind him, but then Lu Xiaolu will probably have to be in the audience, with people everywhere around him, and there will be no way for the answers to reach his ears. So now Guan Ruyan has no idea what Principal Rao means by doing this.

All candidates for the Young Outstanding Scientist Award must participate and defend their previous major scientific research achievements. It seems that this is not targeted at Guan Ruyan alone. I heard that this was proposed by Academician Xiang, who has proposed it several times, but President Rao has never agreed. However, this time President Rao agreed.

After Yang Ping talked to Lu Xiaolu, he decided to talk to Guan Ruyan again, so Principal Rao arranged for Yang Ping to visit Guan Ruyan's laboratory, and Principal Rao personally instructed Guan Ruyan to receive him in person.

Guan Ruyan is now very worried. He calls Lu Xiaolu and asks him to come quickly to deal with Professor Yang's visit. However, Lu Xiaolu says that he can hardly stand up steadily, so how can he go to deal with the visit? There is really nothing he can do. He is powerless.

After Yang Ping visited Guan Ruyan's laboratory and came back, he was almost 100% sure that Guan Ruyan's famous scientific research results could not have been produced by himself. In fact, to reach the top of the scientific research pyramid, the research scope is very narrow and very deep. At this time, it cannot be achieved by reading a few books or studying a few papers. You must have a very deep understanding of this profession.

So taking the opportunity of the visit, Yang Ping communicated with Guan Ruyan about his research field. Guan Ruyan was indeed good, but only slightly better than an ordinary professor, which was far from matching his current scientific research results.

Lu Xiaolu is just the opposite. He has a very deep understanding of this profession. Lu Xiaolu is a true young talent.

Yang Ping is in a very difficult situation now. If he attacks Guan Ruyan now, it will hurt Lu Xiaolu's heart. Yang Ping still wants to keep Lu Xiaolu. Besides, without Lu Xiaolu's help, it is really difficult to determine the true situation of Guan Ruyan.

At the home of Academician Xiang, President Rao, Yang Ping and Academician Xiang met again to exchange information about the matter and discuss what to do next. In any case, before it is truly determined, the matter must not be made public and can only be limited to a small circle of three people.

Yang Ping expressed to Principal Rao his intention to keep Lu Xiaolu. Principal Rao told Yang Ping not to waste time on this matter and to leave it to him, as he knew how to handle it. At the same time, he would keep Lu Xiaolu.

Since Principal Rao agreed, it means he must have a way. Yang Ping doesn't want to waste time on this. His own project is at a critical period and he can't afford to be distracted, nor is there any need to be distracted.
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Fu Xiaotao is currently being treated for Castleman's disease. The results of his follow-up examination after using cetuximab have come out. Yang Ping has also been following this case. Judging from the indicators of the follow-up examination, the drug has no effect at all. After glucocorticoid treatment, he had entered a period of remission, but now all indicators have begun to deteriorate again. It seems that a large amount of hormones are still needed to control the symptoms. "Cetuximab is useless?" Song Zimo was very puzzled.

"This time, the oncology department used hormones again but it was useless. Only chemotherapy could stabilize the condition." Yang Ping said, staring at the medical records on the computer.

"From the perspective of the pathogenesis, isn't interleukin-6 the culprit? If so, theoretically, cetuximab should be able to control the disease. Why doesn't it have any effect at all?" Song Zimo was also puzzled and immediately became interested in this case.

Yang Ping leaned back in his chair and thought for a moment before saying, "Either the medicine has a problem, or the disease model has a problem. One of the two must have a problem, because the theory is useless in the face of real cases, so the theory must have a problem."

Questioning is the basis of progress. There is nothing that cannot be questioned, so even things that have been recognized need to be questioned. The naked facts are here: medicine is useless.

"But cetuximab is very effective in other diseases based on interleukin-6, and there is a lot of reliable literature to prove it," Song Zimo continued to ask.

Yang Ping just reviewed a lot of literature: "So I think the pathogenesis of Castleman's disease must be wrong. The root cause is not interleukin-6. I have read all the papers on Castleman's disease. They are almost like blind men touching an elephant. Everyone only sees one side of the disease. No one has ever seen the whole picture, and they all think they are right."

"Find a student to go to the oncology department and get all of Fu Xiaotao's medical records, including those from other hospitals." Yang Ping felt that he had to spend some energy on this disease because he had already seen some doubts. If he didn't clarify them, it would obviously not suit his personality.

Song Zimo sent his students to the Department of Oncology to get all of Fu Xiaotao's examination data. Fortunately, all of Fu Xiaotao's examination data were well preserved, and he copied all of his medical records every time he was hospitalized.

Yang Ping looked at the information one by one, and then connected all the information as a whole, abandoning the inherent thinking in his mind. In fact, since the onset of the disease, almost every doctor has been very serious and has tried his best to complete the examination from his own perspective, trying to uncover the truth of the disease. Lymph node puncture examinations have been done several times, and various blood tests are also available.

In order to better review the medical records, Yang Ping brought everyone to the conference room and placed the examination sheets one by one on the conference table. Because the conference table was relatively large, it was the only one that could hold so many examination sheets.

"But the changes in various indicators I just saw are indeed consistent with the pathogenesis model of interleukin 6?" Song Zimo felt that there was nothing wrong with the pathogenesis model.

Yang Ping lowered his head and kept adjusting the checklists. "That's because you only see the results of each attack. You only touch the part of the elephant. If you expand your vision, from the first checklist to the last one, without missing any one, you will find something different. You see, six months before the second symptom appeared, the T cells in his body had begun to activate abnormally. Three months before the second relapse, his vascular endothelial growth factor level had increased, which is a signal for the immune system to speed up. Can this be considered that the entire chain of disease is completely different from the recognized interleukin 6?"