godfather of surgery

Chapter 1003 The life-saving medicine is right beside you

Although Fu Xiaotao's mother always had an unfriendly expression on her face, Yang Ping didn't care about it at all and didn't spend any extra energy to pay attention to this issue. If it were another doctor, he would definitely pay attention to the attitude of the family members. If the family members objected or did not trust, the treatment would be put on hold unless it was life-saving emergency treatment.

Not long after Yang Ping left the Department of Oncology, a doctor brought an informed consent document regarding scientific research treatment for Fu Xiaotao to sign. Of course, when signing, Fu Xiaotao had to argue with his mother, because his mother believed that experimental treatment was using her son as a guinea pig. If he signed, it would be equivalent to selling her son's health to the hospital and to Professor Yang, which was absolutely unacceptable.

But my father's opinion was exactly the opposite. He thought that since traditional treatments had been proven to be ineffective, why not try new methods? This way there would at least be a glimmer of hope. Fu Xiaotao had been to so many hospitals for his illness without getting a correct diagnosis, but here he was quickly diagnosed through pathological examination. He had every reason to believe in the doctor's ability.

The two-to-one advantage allowed Fu Xiaotao to complete the signing smoothly. In fact, Fu Xiaotao did not disrespect his mother's opinions, but her opinions were often based on biased subjective judgments and were completely irrelevant. She even asked to take Fu Xiaotao to meet a master, but Fu Xiaotao did not go. His mother went alone and spent 60,000 yuan to buy a pillow that could cure diseases.

The money was spent and the pillow was bought, but it did not have the desired therapeutic effect, and in the end he had to be sent to the hospital for life-saving.

At this critical moment of life and death, Fu Xiaotao still had his own ideas. He signed the informed consent form to participate in the experiment and was successfully transferred to the Institute of Surgery. There, Fu Xiaotao drew many tubes of blood and conducted some examinations that had never been done before. Many of the examinations were not routine hospital tests at all, but biochemical tests to study various pathways of the human immune system.

These tests simply cannot be completed in other hospitals, and these hospitals would not even think of doing these tests. It is only because Sanbo Hospital has several strong basic medical laboratories that it has the ability to conduct these tests.

A few days later, all of Fu Xiaotao's test results came out. Yang Ping went to the laboratory to check the results in person. Tang Shun pulled up the results of the study from the computer: "From these biochemical analyses, the key to the disease should be the mTOR signaling pathway."

Tang Shun is not a clinical doctor. He is good at basic medical research. For a PhD who is proficient in basic medicine, it is obviously very easy to use these tests to find out what the signal pathway is, because this work is commonplace for them. However, for clinicians, the study of signal pathways is a high-tech technology that is rarely involved. Even some clinical medicine practitioners who are good at scientific research seriously lack complete biochemical knowledge. This is the gap between professions.

Yang Ping carefully analyzed each test result. Everything was so obvious. Indeed, the key to the problem has been found, which is the mTOR signaling pathway. If the mTOR signaling pathway can be blocked, can the disease be cured? In theory, it must be so.

This bold idea made Yang Ping very excited. He had found a new idea for Castleman's disease. Whether it would work or not still needed to be tested in practice.

Tang Shun is now in a dilemma: "But what drug can be used to block the mTOR signaling pathway?"

"Sirolimus, which is used to prevent rejection after kidney transplantation!" Song Zimo blurted out, because this is a very familiar drug for clinicians.

If sirolimus is used to block the mTOR signaling pathway to treat Castleman disease, no approval surgery is required at all, because sirolimus is not a new drug. It should have been in clinical use for a long time. It is used to block the mTOR signaling pathway in the anti-rejection treatment of kidney transplantation.

"Should we stop chemotherapy and give him sirolimus?" Song Zimo also became excited. No doctor would not be excited at this moment.

Yang Ping said decisively: "Stop all chemotherapy, stop hormone therapy, and only use sirolimus for treatment, starting immediately."

Without a rich combination of basic medical knowledge and clinical medical knowledge, it is impossible to overturn the recognized pathogenesis model of interleukin 6. This shows the importance of comprehensive knowledge in the medical field, because without comprehensive knowledge, doctors will always be trapped in their own professional knowledge cocoon. The gap between basic medicine and clinical medicine is very huge. When clinicians encounter problems in clinical practice, they can only use very limited basic medical research methods, not to mention those high-tech methods. Basic medicine has no idea what specific problems clinical medicine faces. Very few doctors who can cross the two fields can easily make amazing academic achievements. For example, a professor of anesthesiology at West China University of Technology used his knowledge of pharmacology and clinical knowledge to develop a new local anesthetic.

Back in the ward, Yang Ping talked to Fu Xiaotao again. The conversation took place in the meeting room instead of the ward, so as to avoid unnecessary interference.

"We have found a new pathogenesis and new therapeutic drug for Castleman's disease. Fortunately, the new drug is actually a mature drug that has been used for many years. It has never been used to treat Castleman's disease. Instead, it is used to fight against rejection after kidney transplantation. Judging from its performance in the anti-rejection reaction of kidney transplantation, it should be effective for your disease because it targets the same mechanism." Yang Ping introduced his discovery to Fu Xiaotao.

Song Zimo also added: "We plan to start a new treatment for you as soon as possible, and stop all the previous chemotherapy, hormones, etc."

Although Fu Xiaotao had read a lot of information about Castleman's disease, he was still a layman compared to doctors, so he said without hesitation: "I will cooperate with your treatment plan. If you want to sign, I can sign at any time."

"Sirolimus!" Fu Xiaotao suddenly remembered something.

"Yes! Sirolimus!" Yang Ping was very sure.

Fu Xiaotao recalled: "Once I was hospitalized and the patient in the bed next to me was a renal transplant patient. He had been taking simulosin. I was wondering why he looked so familiar." It turned out that the life-saving medicine was right next to him and was so close to him.

Since Fu Xiaotao cooperated so well, the subsequent treatment was very easy to handle. Everything proceeded according to the new plan. On the same day, Fu Xiaotao's chemotherapy drugs were stopped and he started taking sirolimus. Time waits for no one, and Fu Xiaotao's condition does not have much time to wait.

News came from Nandu Medical University that President Ding was admitted to the ICU of Nandu First Affiliated Hospital due to illness. Some brain cancers are like this sometimes. When there are no symptoms, the patient is the same as a normal person, but once symptoms appear, the patient will die or be in critical condition.

Principal Ding's incident was a bit sudden. Lu Xiaolu really treated Principal Ding as his father. When he heard that Principal Ding suddenly fell ill and was admitted to the ICU, he waited outside the ICU and kept in contact with Yang Ping, asking Yang Ping to help see if Principal Ding could still be saved.

Another brainstem tumor!
Yang Ping didn't know whether this was the nth brainstem tumor he had encountered. Perhaps it was because this type of surgery was too difficult and risky, and patients did not have many doctors to find or hospitals to go to, that this convergence effect occurred.

There is absolutely no way to treat this kind of brainstem tumor at Nandu First Affiliated Hospital. Apart from Sanbo Hospital, only Tiantan Hospital has the ability to perform surgery.

Soon after Lu Xiaolu sent Principal Ding's CT scan, Yang Ping received a call from his father-in-law, Professor Su, inviting him to an emergency consultation with Principal Ding. Just after hanging up the phone, he received another call from Principal Rao, who was still talking about Principal Ding's condition.

Principal Ding has actually made many contributions to the school and has achieved fruitful academic results. However, he dotes on his daughter too much and gives excessive help to his son-in-law. After learning about his illness, he is still paving the way for the future of his daughter and son-in-law.

PS: This case is based on a true story: In the United States, a medical student contracted Castleman disease. At that time, it was incurable and he was thought to have no more than two years to live. However, the medical student refused to accept his fate and decided to save himself. He devoted a lot of energy to studying the disease while suffering from the disease and being on the verge of death several times. Through a lot of research, he overturned the pathogenesis of interleukin 6 and believed that the real mechanism was the mTOR signaling pathway. He firmly believed in his judgment, so he stopped chemotherapy and started taking sirolimus. After half a year, a year, and two years, his Castleman disease was cured and never recurred. He went from a dying, haggard patient to a spirited and healthy Castleman disease expert - the world's top expert. This is an inspirational self-help story of perseverance and refusal to accept authority.