godfather of surgery

Chapter 1068 Disease with % Mortality
Berlin, Germany.

Professor Mannstein has not reacted yet. He sits in his office in a daze. On the table is a translated German paper pressed by a teacup. This is Yang Ping's paper on K virus therapy.

As the leader of the German translation team of the journal Medicine, Mannstein had already completed the German translation of Yang Ping's paper on the first day it was published. This is the immediacy of online paper dissemination, and paper papers cannot catch up with this speed of dissemination. On the same day, the German paper was wildly spread in the German medical circle.

The paper was not only spread in the medical community, but also reached the ears of some cancer patients. Some patients called Professor Maninstein's laboratory to inquire about the details of K virus therapy and hoped to make an appointment for treatment. The laboratory's phone was almost blown up, which made Professor Maninstein very speechless.

I have long known that such translations should be anonymous and that my name or the name of the laboratory should not be left behind. As a result, I dare not even put away the laboratory's phone and can only pick it up and put it aside.

Professor Maninstein has not yet digested the theory of space-guided genes, and now Professor Yang has come up with a K virus therapy for tumors, which makes Professor Maninstein a little overwhelmed.

What on earth is this thing? Professor Mannstein is thinking about why it has such magical powers.

This magical K virus uses a recombinant adenovirus to implant a protein structure called K factor. Adenovirus is equivalent to a missile, and K factor is the warhead of the missile. This missile carries K factor through the blood circulation to the tumor. Once it reaches the tumor, this recombinant new virus can infect tumor cells extensively. They release K factor in the cells, just like ordinary viruses release virus particles in the cells. Once K factor is released, it can start the apoptosis program of tumor cells. Using this principle, it can kill tumor cells, and this elimination is extremely accurate. It is truly a precision treatment.

It's amazing!

Professor Mannstein sighed.

Each step is a brilliant idea. For example, Professor Yang's recombinant adenovirus technology is unmatched. Based on the existing recombinant adenovirus, he genetically recombined it, avoiding almost all of the shortcomings of the original adenovirus and bringing out its advantages to the fullest, which can be regarded as a model for the use of carrier viruses.

Originally, adenoviruses like this have a very high infection rate for various cells in the human body, with an infection rate of almost 100%. This is the biggest advantage of this virus. Yang Ping took advantage of this point. If other viruses are used as carriers, they cannot infect various cells, and naturally cannot infect tumor cells. If the infection purpose cannot be achieved, there is no way to kill tumor cells.

The recombinant virus modified by Yang Ping maintains 100% infection of tumor cells, but the infection rate of other normal cells is reduced. In other words, it can distinguish between tumor cells and normal cells and give priority to tumor cells for infection.

The K factor, as a combat unit, is the weapon that many cancer experts dream of. Many teams around the world are researching cancer treatments in the hope of obtaining this factor, but it was easily solved by Yang Ping.

If spatially guided genes are so mysterious to most people, then the current K virus therapy is so down-to-earth that almost every professionally trained oncologist can understand it.

Professor Mannstein perked up and immediately called his assistant: "Book me a flight to China!"

He was originally going to attend Yang Ping's wedding, but now he decided to go early. He wanted to see what the real situation of this experiment was like. It was really exciting.
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Although the adenovirus-based K virus is not the best configuration now, it must be the best choice under the current conditions. We will slowly look for new configurations in the future. Through these experiments, the K virus therapy has basically taken shape. Although there are still many imperfections, it doesn't matter. We will slowly improve it in the future and improve it as we go. Yang Ping has seen hope for Sisi and has a glimmer of confidence in his heart. Unlike before, there is no way out with the existing treatments. Continuing with traditional chemotherapy and radiotherapy will not only fail to cure the disease, but will only accelerate the deterioration of the disease.

Yang Ping made a treatment plan for Sisi, which required regular injections of the K virus. After the K virus was injected into Sisi's body, even if it successfully infected tumor cells, it would still be attacked by the immune system later. It's just that the virus that can replicate can withstand the attack longer, but as time goes by, these viruses will eventually be eliminated by the human immune system.

It would be most dangerous if the human body had no immunity to a virus. Once it starts to cause damage, the human body is powerless to resist. This is why the human body is not afraid of viruses that it has been fighting against for a long time, but is afraid of new viruses.

For example, viruses in permafrost or alien viruses are the most dangerous once they are infected by humans, because humans have no immunity to such viruses and the human body has no experience in fighting them. Once infected, it means death.

The results of Yang Ping's own blood test have come out. The virus has been completely cleared and no virus has been found again. It seems that no matter how this virus changes, it still uses the original adenovirus as its main gene. The gene determines its nature. Because of the mutation in Yang Ping's body this time, the immune system needs a certain amount of time to adjust the battle plan and slowly eliminate them.

Now that the virus has been eliminated, Yang Ping feels relieved, and everyone else feels relieved too.

Zhao Yufan also received the same treatment as Sisi, because the K virus therapy was also successful in him. Now that the K virus therapy is safe and effective, Yang Ping plans to recruit another group of volunteers for treatment, which can also obtain more data and allow the new method to benefit patients as soon as possible, so that some people can get treatment in advance. If we wait for the real K virus therapy to be available, I am afraid we will have to go through a formal process, and even if we get the green channel, it will take two or three years.

But thinking of the previous turmoil, Yang Ping gave up this idea. He didn't want a similar turmoil to interfere with his scientific research.

Looking at the lively Sisi and thinking about those days and nights, Yang Ping felt that it was all worth it, especially because this experiment gave him the confidence that he could solve problems with his own mind even without a system.
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Yang Ping was just planning to take a rest and go home for dinner when he received a call from Professor Su.

The First Affiliated Hospital of Nandu City invited Yang Ping to an emergency consultation. The patient was a young scientist who suddenly fell ill at home while on vacation visiting relatives. He was rushed to the First Affiliated Hospital of Nandu City for treatment. Now he has been admitted to the ICU due to the severity of his condition and has been initially diagnosed with rabies.

Rabies has a 100% mortality rate. Perhaps because the patient's identity is too special, Professor Su had to invite Yang Ping to the scene.

The emergency consultation cannot be delayed, so Yang Ping set off immediately. He took the time in the car to call Xiao Su to explain the situation and could not go home for dinner.

When he arrived at the ICU of Nandu Hospital, all the experts from the hospital had already gathered in the conference room waiting for Yang Ping. Everyone looked serious. Director Luo of the ICU of Nandu Hospital immediately introduced the patient's condition to Yang Ping.

Extreme fear, fear of water, fear of wind, drooling, difficulty breathing, paroxysmal pharyngeal muscle spasms, difficulty urinating and defecation, and sweating, etc.

I was bitten by a wild dog 20 years ago, but I didn't get rabies vaccine at that time.

While listening to Director Luo's introduction to the patient's condition, Yang Ping was reading the medical records.

The final diagnosis given by Nandu No.1 Hospital was: rabies.

Whether it is medical history, physical examination or various auxiliary examinations, they all support the diagnosis of rabies, and there is no doubt about the diagnosis. However, rabies has a 100% mortality rate, and there is no way to treat it under current medical conditions.

Yang Ping decided to check on the patient first. He put on an isolation suit and gloves and performed a physical examination on the patient.

After seeing the patient, wash your hands, take off your isolation suit, go back to the doctor's office, and carefully review the patient's medical records again.

Rabies! There is no problem with the diagnosis.

Professor Su said: "This patient is a bit special. He is in charge of a very important scientific research task for our country. This task is halfway through. Without his participation, the project will be delayed for at least 5-10 years before it can be successful. But now this project is of vital importance to our country, so the superiors asked us to go all out to rescue him and find ways to save him. They specifically asked you to participate in the emergency consultation."

Originally, Yang Ping is a surgeon and should not have participated in the consultation on this kind of infectious disease, but his superiors specifically asked him to do so, so Professor Su had no choice but to do it. Professor Su is now under a lot of pressure.

The imperial capital's original intention was to transfer the patients to the imperial capital for treatment as soon as possible, but now the patients cannot be transferred at all and can only be treated on the spot.

"This is not any other disease, but rabies. No matter where you are, the mortality rate is 100%. There is nothing we can do about it. We can only do our best to allow the patient to live a few more days. How can you rescue rabies? Now we can only treat the symptoms." Director Yuan of the Infectious Diseases Department of the First Affiliated Hospital of Nandu Hospital was straightforward.

"Yes, some things cannot be changed by human power. Who can break the 100% mortality rate?" Director Luo also agreed with Director Yuan's opinion.

Professor Su said slowly: "Don't worry, our superiors will respect objective facts and understand us, but even if the mortality rate is 100%, we must make 200% efforts."

6◇9◇Book◇Bar

Yang Ping nodded: "Let me think about it."

If it were in the past, he might not have said this, but after Sisi's treatment, he wanted to try any unresolved problem, regardless of success or failure, the passion and curiosity in his mind were always stirring.

Rabies, a 100% mortality rate, what else do you want? Any new opinions?

Everyone couldn't help but wonder what new ideas Yang Ping had. He was a genius, but a genius was still a human being after all.

Thanks to the large amount of time given to him by the system at that time, Yang Ping used the system space to read a large number of books and papers. It can be said that he used the system space to the extreme. He read and studied in the system space for a long time and accumulated a lot of medical knowledge. It can be said that no one in the world would read so many books and papers as he did.

Yang Ping's fingers tapped the table lightly, of course without making any sound, just maintaining a rhythm.

He thought to himself that rabies usually causes death from organ failure caused by damage to the nervous system. First the nervous system is damaged, and then the organs fail. Yang Ping tried hard to recall the information he had read about rabies, and then summarized and refined them.

Fortunately, he was fascinated by all medical books at that time. He did a lot of research on all the specialties. He never expected that a surgeon would participate in a consultation on rabies.

Current pathological research on rabies has found that the brain damage in rabies patients is not caused by the rabies virus's direct attack on the brain, but rather comes from complications of the disease.

Yang Ping was thinking, if there is a switch that can suspend the function of the brain, it can protect the brain from complications, and keep the patient's immune system functioning normally while letting the brain sleep. In this way, although the brain is dormant, the immune system can continue to attack the virus.

In this way, while the virus is fighting the immune system, those complications will not be able to affect the dormant brain. If the virus is destroyed, will the brain be able to escape? If the brain escapes, it will not cause subsequent organ failure. In this way, can the patient be saved?

In the past, Yang Ping might have laughed at himself for being so naive and whimsical, but he wouldn’t do that now. Wasn’t Sisi saved because of his naive and whimsical thinking?
Rabies has a 100% mortality rate anyway, so what's the point of using traditional treatments? Why not try something new?

The cause of death from rabies has not yet been fully understood. One of the most important hypotheses is the "neurotransmitter disorder" hypothesis. The core idea of ​​this hypothesis is that the biological molecules in the patient's brain cannot be balanced, leading to death. Animal experiments have shown that ketamine, an NMDA receptor antagonist, seems to serve as a bridge to balance the neurotransmitters of rabies patients.

Thinking of this, Yang Ping felt that he now had some inspiration in his mind and could form some ideas, but the ideas in his mind were not yet fully formed.

"It's not that there is no solution at all. I need to think about it carefully and then I'll sort out my thoughts first." Yang Ping thought for a long time and blurted out this sentence.

Yang Ping finally understood why he was able to come up with those new ideas during Sisi's treatment. This was because he had mastered a large amount of knowledge by reading books in the system space. This knowledge could sometimes be connected and combined with each other to produce some sparks of imagination.

No, boss, this is rabies with a 100% mortality rate. Do you have any solution?

Everyone looked at each other in bewilderment. If it were anyone else, they would have laughed at her, but Yang Ping and the others didn't dare to do so because this young woman was indeed a genius and she was also Dean Su's son-in-law.

"You guys give him symptomatic treatment first and try to help him delay the time. I'll think about it and come back later."

Yang Ping's consultation ended like this, and even Professor Su was a little confused.

On the way back from Nandu Medical University, Yang Ping was thinking about this problem while sitting in the car. With a 100% mortality rate, could he change his thinking and challenge it? There was no other way anyway, so he might as well try a new idea. There would be no loss if it didn't work out.