godfather of surgery

The next morning, when Yang Ping went for ward rounds, Sissi's left limb was already able to move. She was happily playing with her toys on the bed, not knowing that she was almost left with a lifelong disability.

Professor Chen Jianliang also came over early in the morning to see the results of the surgery and followed the ward rounds. He was very happy to see such good results. After all, the patient was admitted through his consultation, and he would not feel sorry if there were any problems.

For a child who is only two years old, if the infarction is relieved in time, the ischemic brain tissue will quickly return to normal, and the sensation and movement of the left limb will naturally recover quickly.

Therefore, whether it is adults or children, the therapeutic effect of cerebrovascular ischemic disease depends on the time it takes to restore blood supply. The faster the recovery, the better.

"Sissi can be discharged from the hospital in one week." Yang Ping told Sissi's father.

For a two-year-old child, one week is enough time for the anastomotic blood vessels to stabilize.

"Thank you, can you be discharged from the hospital so soon?" Sissi's father couldn't believe it.

"Don't worry, she can be discharged from the hospital in one week. Remember, let her drink more water during this period and don't let her inhale second-hand smoke." Yang Ping told them that there are certain things that must be told well.

If you drink less water, it will easily lead to blood concentration. Inhaling secondhand smoke, nicotine will reduce blood oxygen content and easily cause vasospasm, which will lead to blood vessel blockage.

Although Yang Ping is very confident in the quality of the blood vessels he anastomosed, to ensure the success of the operation, the quality of the blood vessel anastomosis is only one aspect, and there are other aspects that must be paid attention to.

Sissi's parents were very happy to see Sissi recover so quickly, but Sissi's grandmother stood aside and was unhappy, always muttering that she would actually be fine without surgery. Of course, she just said secretly that she wouldn't. Say it in front of the doctor.

However, even if she said it in front of Yang Ping, Yang Ping would not pay attention to him, because he was not a patient or a family member who could make decisions for the patient. Yang Ping would not pay attention to irrelevant people at all, otherwise it would be a waste of time.

Because his daughter suffers from moyamoya disease, Sissi's father Wang Chengpei also checked some information online and gained some preliminary understanding of the disease.

He understood that if he did not undergo emergency surgery as soon as possible, he might have been permanently disabled, so he was very grateful for the move and called Guo Peihua specifically to express his desire to treat him to a meal and thank him for his advice at that time. His suggestion, how could Wang Chengpei move so casually, since it was not close to Sanbo Hospital, and he really didn't know what the consequences of his daughter's condition would be.

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Song Zimo and Xu Zhiliang's visit to Europe went very smoothly. Not only did August personally act as a guide, but Maninstein also actively provided as much help as possible. With the help of these two people, their visit to Europe was basically It can be said that there is no obstruction, and all laboratories treat them as guests.

They received such a grand reception. In addition to Mannstein and August, another reason was Yang Ping's 13 previous papers and the scientific research results brought by this academic conference.

During these days, Song Zimo and Xu Zhiliang visited almost all the top hospitals, medical universities and medical laboratories in Europe.

They have a comprehensive and in-depth understanding of the latest developments in European medical research and the advanced management of scientific research, which is very important.

For ordinary people, they may not have the opportunity to visit this kind of laboratory in their lifetime, but Song Zimo and Xu Zhiliang can visit it at will, and they are accompanied by experts from the laboratory throughout the process, introducing the research situation and answering questions. This time the world is a bit different. big.

Several of Maninstein's own laboratories were all open to Song Zimo and Yang Ping.

He made a request to Song Zimo, hoping to replicate Yang Ping's experiment.

Song Zimo told him that if you want to replicate Professor Yang's experiment, you must use a special protein factor from Sanbo Laboratory. This protein factor is currently confidential, and its structure and mechanism cannot be disclosed for the time being, but the finished product can be provided for use in replication experiments.

Maninstein understood that no matter what the protein factor was or how it worked, as long as it could be used to replicate the experimental results, then Yang Ping's theory must be true.

Of course, Maninstein has no doubt about the authenticity of Yang Ping's experimental results, but from a scientific perspective, this experiment must be repeated, and if he wants to recommend Yang Ping's results for the Nobel Prize, he also needs to repeat this experiment.

Yang Ping made a major breakthrough in the field of organ cloning. This achievement also has a huge impact on Mannstein's current project.

Maninstein's current main topic is studying the repair of spinal cord injuries, which is also closely related to stem cells, because his research idea is also to use stem cells to repair damaged spinal cords.

He gave his theory a name - protocell welding repair.

If there is indeed a spatial guidance factor, Maninstein speculated, then the spatial guidance gene of the spinal cord can be found, and then its initiating factor can be found, as well as the interaction between the initiating factor and the gene. If the research proceeds along this path.

They can use this method to manipulate the repair of original cells in the injured spinal cord, so that the nerve cells of the spinal cord can grow oppositely from both ends of the section and then connect with each other.

The so-called original cell repair refers to which tissue cells are damaged and which tissue cells are used for repair.

Primary cell repair is the best way to repair human tissue damage, but unfortunately, after most tissues in the human body are damaged, the main way to repair is non-primary cell repair.

The most common one is our skin repair. When the skin is cut and cracks appear, during its healing and repair process, the main tissue component involved in the repair is scar tissue, not skin tissue. Only a very small amount of skin tissue participates in repair.

If all the tissues involved in repairing skin breaks are skin tissues, then the skin wound will be exactly the same as before after healing without any scars.

There is one organ in our human body that can perform original cell repair, and that is the bone. The tissue components involved in the repair after a fracture are all bone tissue.

Except for bones, other organs and tissues cannot be repaired by original cells after damage.

Song Zimo and Xu Zhiliang were visiting the spinal cord injury research laboratory in Berlin, Germany.

"Spinal cord injury is only one of my many topics. Other topics include human anti-rejection research, brain cell ischemic tolerance research, brain and spinal cord non-ischemia transplantation research, etc. All my research revolves around a big problem. project, I hope I can realize this ideal." Maninstein said.

"Professor Maninstein's big topic is head transplant surgery!" August added.

Head transplant surgery!

Song Zimo was very surprised. Maninstein was indeed a Frankenstein, and he actually challenged such a difficult and controversial subject.

This kind of surgery is very controversial in the world, mainly due to ethical controversy. There is actually not much controversy technically, because the head transplant surgeries that have been completed so far are all pseudo-head transplant surgeries. Before the spinal cord repair is solved, any head transplant surgery will definitely fail, without exception.

Apart from the ethical controversy, the biggest technical obstacle to head transplant surgery is spinal cord injury.

If spinal cord injury is overcome, head transplant surgery can be the real first step.

"We cut the spinal cord of the experimental monkey. Even if we use the thinnest and sharpest blade to cut the spinal cord, we can't repair the spinal cord using various methods." Maninstein was very distressed.

In fact, Auguste and Milton were also studying the repair of spinal cord injuries. They also cut off the spinal cord of experimental monkeys and used polyethylene glycol as an adhesive to glue the spinal cord together, but to no avail, regardless of the connection method. No matter how it is improved, it is simply impossible to repair the spinal cord.

Later, they used stem cell filling, hoping to help repair the spinal cord, but it had no effect.

Maninstein's research on this topic is completely different from theirs. He first studied the repair of original cells and how to repair original cells after damage to human tissue. To achieve repair of original cells, we must start from a genetic perspective.

But he didn't think about the space-guiding gene. It wasn't until Yang Ping came up with this hypothesis that he suddenly realized how difficult it was to realize it. It felt like the farther he went, the further away his goal was.

Now that the spatial guidance gene of muscles has been discovered, Maninstein's confidence has greatly increased.

If the spatial guidance gene of the spinal cord can be discovered, it is entirely possible to turn on this gene and allow the spinal cord cells to enter the embryonic state, start to divide locally, and then repair the damage.

Now Maninstein feels that Yang Ping's space-guided gene theory is the most likely method to repair spinal cord injury, so to realize his ideal, he can only cooperate with Yang Ping.

"We were very stupid in the past. We tried head transplant surgery on animals without doing any research on spinal cord injury. It was meaningless. Even if the head was connected through surgery, so what? After the blood vessels were connected, the head survived, but the experimental monkey was left paraplegic at a high level. State, will die soon.”

"Later we realized our stupidity, stopped this head-changing, and started studying the basic theoretical research related to it."

"But it's too difficult. We haven't made breakthroughs in core fields yet. However, we have made some breakthroughs in peripheral fields. If you are interested, we can share scientific research results."

"I'm talking about brain cell ischemia tolerance research, anti-rejection research and ischemia-free transplantation research."

Maninstein had no reservations about Song Zimo and Xu Zhiliang. These achievements were his hard work over the years.

Song Zimo understands that these studies are actually of great significance. For example, if there is progress in the research on brain cell ischemia, it will be possible to better treat cerebrovascular diseases in the future and delay the rescue window period for these diseases.

Therefore, all of Mannstein's achievements are world-class.

However, compared to Professor Yang's achievements, these achievements of Maninstein are much inferior. It is estimated that the sum of his achievements is far less than that of spatial guidance genes, because they are not at the same level at all.

"If we can work together to find the spatial guidance genes of the spinal cord, then this problem will be solved, and the spatial guidance genes will be the key to many fields."

Maninstein is the person who best understands the value of spatially oriented genes. It is like a key that unlocks basic research in the entire biomedical field and can directly push biomedical research into a new era.

Everyone chatted while walking. The laboratory is very large and has many researchers. It is a key laboratory under the Max Planck Society in Germany.

"I will definitely bring your opinions back to China. I believe Professor Yang will be willing to cooperate with you." Song Zimo replied to Maninstein.

Song Zimo doesn't know yet whether Professor Yang is willing to cooperate.

In terms of international cooperation, Yang Ping is an out-and-out pragmatist. He completely follows the principle of "learning from each other's strengths to compensate for weaknesses." If this effect cannot be achieved, no matter how powerful the scientist is or how top-notch the laboratory, Yang Ping will I won't pay attention.

Yang Ping didn't want to waste time on things that were not beneficial to his research.

But Yang Ping is an idealist when it comes to domestic cooperation. He does not look at whether it is beneficial to his own research, but hopes to bring up the level of a group of researchers and laboratories through cooperation.

Therefore, international cooperation depends on interests, and domestic cooperation depends on sincerity. For domestic cooperation, if the other party is really sincere, has the intention to engage in scientific research down-to-earth, and hopes to do something, Yang Ping will happily agree. If it was just for fame and money, Yang Ping would refuse without hesitation.

Regarding Maninstein's proposal to cooperate, Song Zimo had to report to Professor Yang well after returning to China and then make plans together.

After visiting the laboratory, Maninstein made another request to Song Zimo: "I have another request. I hope that I can be the Nobel Prize recommender for Professor Yang's research on spatially oriented genes. I think Professor Yang's research can definitely win the Nobel Prize and should win it." Nobel Prize, I know Professor Yang doesn’t care about these so-called awards, but winning is not a bad thing.”

Song Zimo kept talking to Maninstein, and Xu Zhiliang followed behind with a notebook to take notes. This can also be written down.

I don’t know what Professor Yang thinks. Is he interested in the Nobel Prize? Judging from his normal appearance, he doesn't seem to be interested in these things, but it's not a bad thing to win a prize, and you don't have to worry about it yourself. Someone will do the errands.

"I am very grateful for Professor Maninstein's hospitality. We will definitely consider this matter, and I will also bring Professor Maninstein's hospitality to Professor Yang." Song Zimo also wrote it down and discussed it when he went back.

Visited Professor Mannstein's spinal cord injury research laboratory and visited several of his other laboratories.

This guy is really full of energy. No wonder he is an all-rounder in surgery and a Nobel Prize winner, flourishing in various fields.

Many people are already too busy studying one field, and those who can double-check are very rare. He is simply a madman in researching three or four. Only Professor Yang can surpass him. Professor Yang can easily do more than one.

It seems that I can't go back for less than ten days and a half. There are so many laboratories, many medical universities, and hospitals.

Song Zimo made some calculations and realized that if he moved a little slower, he might not be able to go back for a month.

Alas, the two boys Zhang Lin and Xiaowu were very kind this time. They didn't push me all the time and they understood me very well. It really made things difficult for them. Now I guess the two guys are gritting their teeth and persisting.

It’s really embarrassing for them!