godfather of surgery

Chapter 997

Wen Ru is posting a notice about streaking in the hospital's WeChat group. The official time is three o'clock tomorrow afternoon. At that time, he will streak around the hospital three times to fulfill his bet. This time, the streaking is truly unadulterated.

The whole hospital was in an uproar. Everyone thought that Dr. Wen was a real man who kept his promises. If everyone could do what Dr. Wen did, the world would be full of integrity.

The hospital's WeChat group was immediately filled with discussions. Both men and women were eager to see Dr. Wen's real naked streaking. They were looking at his courage and his upright gentlemanly spirit. The group was filled with excitement. If Director Zhao had not stopped the discussion in time, the entire group would have been filled with discussions about naked streaking.

Yang Ping was not interested in the news of his naked streaking. This guy had a weird temper. He could do whatever he wanted. Naked streaking would not cause any trouble. If he was stopped from streaking, it might cause trouble. Yang Ping was very busy. He had to rush to Nandu Medical University to participate in the review of Guan Ruyan's scientific research project. The funding for this project was 50 million yuan, which was considered a large project in colleges and universities.

Nandu Medical University has very strict controls on key projects, so it invites a group of top scholars from inside and outside the school to conduct careful reviews. Yang Ping was invited as a scholar from the school because he is currently an outstanding young scholar, a candidate for academician, and is also preparing to compete for the Nobel Prize.

Guan Ruyan had also run into some trouble recently. His son won the championship in the National Youth Science and Technology Competition, which was originally a good thing. But a blind reporter went to the school to interview him and caused a lot of trouble.

The principal and teacher of Guan Ruyan's son's school did not inform Guan Ruyan about this interview, perhaps because time was too tight, or perhaps because the reporter did not say that he wanted to interview the child himself, so Guan Ruyan was not informed anyway.

After the reporter arrived at the school, the principal and teachers were very happy and attached great importance to the interview because it could play a certain publicity role for the school. After the reporter interviewed the principal and teachers, he suddenly asked if he could meet this outstanding child. The teacher said yes, since it was an interview, there was nothing wrong in meeting the child himself.

The reporter met the child under the arrangement of the principal. Unexpectedly, the reporter majored in biology in college and was considered a semi-professional in this subject. After meeting the child, he chatted with the child casually and was surprised to find that the child could recite his thesis fluently and knew some concepts in it, but it was obvious that he had memorized it, because when asked in detail, the child knew nothing about it. Then the child was very honest and said that the thesis was written by his father and he was told to memorize it. He did not participate in the experiment, but he went to the laboratory several times and took many photos.

This incident was written into an article by a reporter and published online, which immediately caused a stir. How did the youth science and technology competition become a competition for parents behind the scenes? Is this competition still meaningful? Of course it is meaningful. This is the capital for future academic advancement. The competition is no longer a simple competition.

This incident had a huge impact because in the end the identities of the child's parents were revealed. Both parents were professors at a medical university, and the son was an elementary school student. He took a medical paper to participate in the competition. You can imagine what happened. In fact, some people questioned it at the time, but the organizer announced that after investigation, the doubts were confirmed to be rumors. The contestants' experiments and papers were completed independently, without any fraud, and the doubts were left unresolved.

Everyone can't help but sigh that other people's children are smarter. Our own children can't even figure out how to do their homework, while other people's children are already able to publish papers in internationally renowned medical journals and conduct cutting-edge experiments. Alas, the gap is really too big.

Yang Ping came to the conference room of Nandu Medical University. There were still a few minutes before the meeting started. The review experts and professors had almost arrived. Guan Ruyan had arrived early, and sitting next to Guan Ruyan was his assistant Lu Xiaolu.

Guan Ruyan looked visibly haggard, and it was obvious that she had been very troubled by her child's affairs recently. There were now strong calls online for an investigation into the matter and for the child's championship to be revoked.

"Professor Yang!" Guan Ruyan greeted Yang Ping.

Upon hearing that Yang Ping had arrived, many professors in the conference room stood up to welcome him. Yang Ping smiled and bowed to everyone, then sat down in his seat.

Several professors who arrived later also arrived one after another. Finally, President Rao and Academician Xiang came into the conference room together, and everyone stood up to welcome them.

Guan Ruyan's project is about CAR T cell therapy. Currently, Americans are ahead in this field. Guan Ruyan wants to use this project to catch up with the cell therapy technology of the United States. Yang Ping took a look at the outline of the project. Indeed, the idea is relatively novel. If it can really succeed, it can greatly shorten the gap with them.

Not long ago, Yang Ping used cell therapy to treat a cancer patient and achieved great success.

However, Yang Ping's main focus is not here, and it is impossible for him to study everything, so he shared some of the results of cell therapy with Lu Xiaolu. Lu Xiaolu is very smart. He not only understood the meaning of this topic, but also was able to conduct some research based on this idea.

When communicating with Lu Xiaolu before, Yang Ping felt that his research in this field was very in-depth. In this topic, one can almost see all the new ideas proposed by Lu Xiaolu at that time. So, are these ideas Lu Xiaolu's or Guan Ruyan's? This made Yang Ping a little confused.

The meeting started on time. All the people present were bigwigs, some were invited by friendly schools, some were from our school, and there were two international friends, so the meeting was relatively formal. Although there was some personal connection, it was not much.

"Let me first introduce the basic situation of this topic--" Guan Ruyan knew the importance of this meeting. It would be obviously disrespectful to let his assistant introduce it, so he went in person and needed Lu Xiaolu's help when necessary.

Because this project was entirely designed by Lu Xiaolu, the idea was his, the details were his, and he also wrote the final project plan. Guan Ruyan has been very busy recently, with many academic conferences to attend and his son's affairs to deal with, so he has only recently become familiar with this project. The experts attending the conference will inevitably be ruthless and picky, so Lu Xiaolu can help deal with it at critical moments.

"We add specific chimeric antigen receptor genes to T cells separated from white blood cells and modify them into the CAR T cells we want. We then grow and multiply them in the laboratory, waiting for them to be transformed into warriors that can recognize and destroy cancer cells. At this time, we inject them into the human blood and transport them to the target tumor through the blood. These special warrior cells recognize and kill tumor cells. This is the common practice of CAR T cell therapy for tumors in the world."

"CAR-T therapy, as a revolutionary tumor treatment method that uses genetic engineering technology to transform the body's own immune cells, has brought new hope to countless patients with blood cancers. However, there is also an unavoidable problem at present - CAR-T cells cannot treat solid tumors because solid tumors lack the relevant binding antigens of blood tumors, which makes CAR-T unable to identify and locate solid tumor cells." Our project is to solve this problem - using a special CAR-T cell to treat solid tumors. If successful, it will be a huge breakthrough."

After Guan Ruyan briefly introduced the topic, the audience burst into warm applause. It has to be admitted that this topic has captured the biggest pain point of CAR-T therapy. Currently, many pharmaceutical companies promoting CAR-T therapy are investing heavily in researching this pain point, but there has been no obvious breakthrough for the time being. Guan Ruyan's topic solves the pain point of CAR-T therapy from a completely new perspective. If successful, it can expand the indications of CAR-T therapy. This is good news for both patients and pharmaceutical companies.

"Professor Guan, you use CAR-T therapy to treat solid tumors. Can you tell us the specific implementation method? We know that CAR-T cells are currently limited to the treatment of blood tumors. Because most solid tumors lack antigens that bind to CAR-T cells, they cannot be recognized and eliminated."

“Although neoantigens, a class of HLA-binding peptides generated by tumor-specific mutations, are highly immunogenic and can bypass central thymic tolerance because they are not present in normal tissues, avoiding common problems in selecting antigen targets for CAR-T cell therapy, they are not suitable for a large number of patients.

"In addition, even after selecting the optimal antigen target, the function of CAR-T depends on factors such as the ability to prevent tumors from escaping immunogenic epitopes. In other words, there is still the possibility of tumor escape. All of these factors lead to poor therapeutic effects of this therapy in solid tumors."

“You think that CAR-T cells, when combined with targeted drugs, can more effectively delay the emergence of complete drug resistance by targeting a specific cell surface protein expressed by CAR-T cells against drug-resistant persistent cells—”

The expert who raised a series of questions was Professor Shen Xuebin from the imperial capital. Professor Shen was a professor who had returned from studying abroad and a talent introduced by the Thousand Talents Plan. He was very optimistic about this project and had long admired Guan Ruyan's talent. This time he took this opportunity to communicate with Guan Ruyan face to face.

"Our idea is to modify the new antigens and transform them into antigens that can be widely found in certain solid tumors, so that the scope of application can be expanded." Guan Ruyan answered with a smile and then took a sip of water.

"I mean, how do you achieve modification and what modification tools to use? I don't think the currently known antigen modification tools can do this. Do you have any unique insights on the application of modification tools? Secondly, how to avoid the controllability of modification by new tools so that it does not produce some negative reactions that are out of control, because almost all new tools face the problem of being out of control."

Indeed, Guan Ruyan had not studied the issue of retouching tools in depth, and Lu Xiaolu had always been in charge of it. So he took another sip of water and cleared his throat: "Sorry, sorry, I have a cold these two days, and my throat is not very good. Xiaolu, can you introduce the details of the retouching tools to everyone?"

In fact, in this kind of meeting, few people are so serious. It is obviously inappropriate to hold on to these details and insist on asking for the truth. We are all friends in the same circle, so we should forgive others when we can. What if it is your turn next time and others ask such sharp questions? However, Professor Shen is an upright person. He is very interested in this topic and has many questions in his mind. Today is a rare face-to-face communication opportunity, so he naturally wants to clarify his doubts. He has no intention of embarrassing Guan Ruyan at all.

Lu Xiaolu immediately took over the conversation: "Professor Shen asked a very good question. Our retouching tool is a brand new one. This tool was tailor-made for this project. -"

Next, Lu Xiaolu answered Professor Shen's questions in detail. Professor Shen nodded, very satisfied. He was right in his guess. The other party used a brand new modification tool, but the idea of ​​the tool surprised him a little. Why hadn't he thought of it before?

“You had a professor at Heidelberg University in Germany who proposed this idea, but it has never been realized, right?” Professor Shen has a wide range of knowledge.

Lu Xiaolu immediately said, "That's my doctoral advisor. I continued my research along his line of thought. Oh, Professor Guan led me to continue my research along his line of thought. We finally succeeded this year, so we started the current project."

Lu Xiaolu realized that he almost crossed the line, so he handed the initiative to Guan Ruyan again: "If Professor Guan was not in poor health today, he would have explained the modification tools more deeply. My understanding of the tools is far inferior to Professor Guan's."

Guan Ruyan was very satisfied with Lu Xiaolu's performance. This guy was very smart and always gave him great assists. Then Guan Ruyan added some gorgeous words to sum up Lu Xiaolu's speech.

"Professor Guan, my stomach feels a little uncomfortable. I'll be out for a while, at most ten minutes." Lu Xiaolu suddenly felt unwell and asked Guan Ruyan for a temporary "leave".

Guan Ruyan immediately nodded in agreement. This kind of thing had to be allowed even if it was not allowed. It was impossible for him to poop in his crotch.

"Your new modification tool is very clever. I am curious about how the modified antigens can persist at the binding site. As far as I know, new antigens of your type have a common feature, which is the lack of binding persistence. I wonder how Professor Guan solved this problem."

Another professor invited from the United States was interested in another issue and asked the question in English.

"In previous studies, we discovered a new expression protein that contributes to the persistence of binding, so this time we will simulate the mechanism by which tumor cells release the expression protein, and when the new CAR-T cells bind to the new antigen, they will release the expression protein, so that the binding becomes persistent."

"We have also studied this type of expression protein, but it is not widely used. It is easy to fail to express in many scenarios. How do you solve the problem of expression failure? In other words, how can they be accurate and sensitive in identifying the scene and timing of expression, and how can they fully display the expression after the expression is started?"

This question is probably very complicated to explain. Guan Ruyan did not have time to understand it thoroughly at that time, because this problem is not a simple one, but involves the cross-application of many current cutting-edge technologies.

"This issue is very complicated and involves the cross-application of many cutting-edge technologies. If it takes a lot of time to explain, is that okay? I will explain it to you in detail after the meeting." Guan Ruyan glanced to his side, wondering why Lu Xiaolu hadn't come back yet.