Start with a college teacher

Chapter 636 Important Invention (1)

The dragon begets the dragon, the phoenix begets the phoenix, and the son of a mouse can make holes.

Scientists have studied human genetic material for a long time, starting with Darwin's theory of evolution.

For quite a long period of time, everyone believed that the human body has 48 chromosomes. This is the result obtained by a scientist from Citigroup using the tablet method, but it is actually wrong.

In fact, chimpanzees have 48 chromosomes, and humans have two fewer than them, that is, these two chromosomes, which caused the reproductive isolation between humans and orangutans.

Reproductive isolation is a wonderful thing.

Like a camel.

No matter what kind of camels, they are not reproductively isolated from each other. Alpacas, dromedary camels, and Bactrian camels, although there are great differences in appearance and spread all over the world, they can intermarry with each other.

This is not the case with cattle, such as buffalo and yellow cattle. Although they look alike, they are not of the same type.

Cattle have 60 chromosomes, while buffaloes have 48. Genetically speaking, this is not a species at all.

So what the Sans said is correct. They believe that buffaloes are not cows, only zebues are cows, and zebues are the gods they can believe in. Cow urine and cow dung can cure all diseases.

In fact, as far as buffaloes are concerned, river buffaloes have 50 chromosomes and swamp buffaloes have 48 chromosomes. They can hybridize and produce offspring, but the reproductive performance of the hybrid offspring will be reduced.

This is miraculous, much more miraculous than horses and donkeys. This is almost saying that mules can also have offspring.

Regarding the number of human chromosomes, it was not until 1956 that the Chinese scientist Jiang Youxing believed through research that the human body does not have 48 chromosomes, but 46.

For this reason, he took the lead in breaking the authoritative thesis and realizing the progress of technology and understanding.

The breakthrough in leukemia research was in 1973. Based on the phenomenon and research basis of the Philadelphia chromosome, Janet Rory put forward an idea: whether all leukemias are caused by a chromosome breakage and fusion with another chromosome? A chromosome is connected, thereby exchanging material and genetic material, which leads to it.

根据这一理论，这个时代的人们经过研究发现：慢性白血病是9号染色体和22号染色体进行的遗传物质交换；急性骨髓性白血病是8号染色体和21号染色体混在一起搞了事情；而早幼粒细胞白血病则是15号染色特和17号染色体之间有暧昧问题.
In short, all leukemias are indeed caused by the loss of a part of the gene on the chromosome and sticking to another chromosome.

It's just that, in this era, they didn't know how to achieve this kind of lesion, until the appearance of Shen Guanglin.

When Shen decided to make this drug for leukemia, the mainstream scientific community had not yet discovered the working mechanism of this lesion, including Shen Guanglin.

After all, Shen Guanglin studies physics, and biology is indeed a monk halfway.

In fact, Shen Guanglin didn't know much about these things, he was just better than ordinary people.

However, he dared to be reckless.

He directly started researching inhibitors of protein kinases, and concluded that this chronic leukemia is caused by a tyrosine kinase. As long as this tyrosine kinase is prevented from continuing to act, leukemia will be cured up.

Shen Guanglin also said that for conventional tyrosine kinases, their activity is strictly controlled and will not suddenly go out of control.

But the BCR-Abl protein after the lesion is different. He can reproduce indefinitely and produce the so-called leukemia, which is blood cancer.

The BCR-Abl protein is not controlled by other molecules and is always active.

It is as if the gas pedal is locked after cell disease, which leads to uncontrolled cell division and blood cancer.

Shen Guanglin's assertion is of course great, so great that no one can believe it or doubt it.

Anyway, his research group is to skip the process and directly use the result to do the next step.

Shen Guanglin also said that time does not wait. You can verify the mechanism while looking for drugs. Anyway, as long as you find this drug, even if it cannot cure leukemia, you will not lose money.

At least we raised a lot of money.

One step closer to the 90s, the attempt to raise money is getting stronger and stronger.

In the next ten years, where will Shen Guanglin's laboratory go?

During the period when the compound was found, Shen Guanglin went to Jinling for vacation, but his laboratory was not idle.

While he was testing the effect of the new drug, he was filling in the working mechanism of the BCR-Abl protein.

It's easier to reverse the problem-solving process based on the answer.

However, the homework that should be supplemented has not been made up yet, but the new test results have come out.

Professor Shen's point of view is correct!

Lao Jiang took the leukemia inhibitor code-named 1605, and the effect was remarkable!
Moreover, Shen Guanglin knew in advance that imatinib would block blood vessels, so he directly made the medicine orally, saving the trial and error of injection.

How much money can this save?
Shen Guanglin received a report: After continuous observation by the medical team of Beijing Medical University, since Lao Jiang took 1605, the diseased white blood cells in his body were completely suppressed, and the effect was surprisingly good!
Almost cured!

Moreover, in Shen Guanglin's view, doctors in this era are really courageous.

No one approved it, and no one discussed it. They talked directly with the family members. This new drug has not yet undergone clinical trials, and they are already using it on other patients.

Do you want to be in such a hurry?
What is even more amazing is that 1605 not only has a good therapeutic effect on chronic myelogenous leukemia, but also has a good therapeutic effect on other chronic malignant tumors.

For other patients in the oncology department of the hospital, after taking 1605, the symptoms of some patients were significantly relieved, and the effect was as good as amazing.

Simply a surprise.

Even, if they hadn't obtained Shen Guanglin's consent, they would have announced that the cancer was cured!
In fact, what they think is still too optimistic.

After hearing the report, Shen Guanglin came to the hospital, and the doctors and family members of the patients were very excited.

"Professor Shen, you are a living god, the hope of our whole family is on you?"

This?
Shen Guanglin was stunned, he didn't know what happened, how could he become a living god.

It turned out that a patient had gastric cancer, a medial tumor, and the treatment effect had not been satisfactory.

He heard that a new drug being tested was particularly effective in treating leukemia, and he wanted to take it too.

Anyway, let's treat a dead horse as a living horse doctor, and the doctor boldly gave him a share of the medicine.

After taking it, the symptoms were really relieved, and this disease is also effective!

Shen Guanglin said no thanks, and continued to think about going inside the hospital. He came to see Lao Jiang, and he only counted if he saw it with his own eyes. As for the unexpected joy, it was an accident, and we will talk about it later.

Moreover, 1605 is really not a panacea, it has no effect on many cancers.

Its advantage is that it can inhibit all types of ABL oncogenes, and it is indeed not only able to treat leukemia, but it cannot treat other types of diseases.

Shen Guanglin met the long-lost Lao Jiang and his girl Xiao Jiang in the ward.

Old Jiang looks good, if he is not in the hospital, he looks no different from a normal person.

If it wasn't for continuous observation, he might even want to be discharged from the hospital.

It can be seen that the father and daughter are in a really good mood, and Xiao Jiang said seriously, "I really envy Sister Rongrong, there is such a good man."

Shen Guang Lin Xin said, you can ask Sister Rong to lend you a night.

Ten dong, is there any?
Shen Guanglin is not a doctor, but everyone still wants to hear his opinion.

What should I do next?

Of course I keep eating it!

You cannot stop taking this medicine, you have to keep taking it.

Moreover, I am trying every day, how much medicine is suitable for the human body, and whether it has any side effects?

All of this is unknown, and a large amount of sample data needs to be collected to improve it. The current stage is to continue testing.

Then recruit patients.

There are not many other things in China, but there are many people.

However, in this era of Huaxia, if you are sick, you don't go to treat it properly, and you often die at home after procrastinating.

Therefore, it is not so easy for Shen Guanglin to recruit patients with chronic myelogenous leukemia.

Some people got chronic myelogenous leukemia, but the doctor couldn't diagnose it, and the family members had no money to see the doctor, so the patients died like this.

Of course, this matter can be handed over to Pfizer and Takeda. Domestic patients are hard to find, but international patients are still available.

When Shen Guanglin mentioned this, their spirits immediately lifted.

"Has the drug for treating leukemia really been successfully developed?"

Of course it is true, Shen Guanglin gave an affirmative answer, the current preliminary research results show that this drug is effective, and the next step is to conduct large-scale human experiments.

Moreover, the case is right in front of you. If you don't believe it, you can test the DNA at any time to verify the actual situation of the patient.

After all, it cost a lot of money, so it is impossible for them not to pay attention to this matter.

Can't wait, they immediately sent a very professional doctor over to check, and these people did a comprehensive physical examination on Lao Jiang as soon as they arrived in Huaxia.

Sure enough, it is the abnormality of chromosome 9 and chromosome 22, which is not fake.

And when they tested Old Jiang's blood indicators, they clearly found that he was no different from a normal person.

Looking at Lao Jiang's hospital records, before he took 1605, his physical condition and various indicators were not satisfactory, but looking at it now, he is a completely different person.

Simply amazing!
"Shen, hurry up and announce the results, the invention that shocked the whole world is just around the corner!"

Shen Guanglin said that there is no rush, let's talk about it after finishing the clinical experiment, he has more important inventions waiting to be announced.

(End of this chapter)