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Chapter 141 p=0.05?
Chapter 141 p=0.05? (410 for subscription)
Bai Ye booked the train ticket for tomorrow. After seeing his instructor that day, he went to visit all the masters and teachers of traditional Chinese medicine, as well as Mr. Tu.
They have all helped Bai Ye a lot, so since they are in the capital, they cannot afford to be less polite.
After packing up and saluting the next day, I returned to Jinxi.
In the past few days, Bai Ye and Meng Yunxi had chatted several times one after another, each time with a few words, and they staggered each other because they were busy.
The two are a little more familiar than before, at least Meng Yunxi won't ask Bai Ye, 'Who are you now? ', and even made a small joke occasionally, but what embarrassed Bai Ye was that every time he talked about the topic of mice, the other party got busy, so he had to think about formally talking about this issue another day.
But Bai Ye has a lot of things on his shoulders right now, and he doesn't have much time.
After returning to school, I rectified, and went to the library the next day with my notebook and schoolbag on my back.
The library on this day is much cleaner than before. It is neither the exam month nor the preparation period for the postgraduate entrance examination. Everyone is crazily exuding youthful hormones in the spring of May. Only a person like Bai Ye who promises to study with his body will Come to the library.
The purpose of Bai Ye coming to the library is very simple, to give Ke Ao a satisfactory answer.
I now have a level of lv6 in statistics, and the data has been further improved. I should be able to calculate the results of this data in a short time!
Bai Ye also wanted to know what went wrong. If the data was deliberately incomplete, what was the other party's purpose?
The first part of the data is still a record of the concept of the experiment and a process of transcriptional replication of single-cell organisms.
The data is the recorded differentiation of single-cell organisms after carcinogenesis, and changes in the original nucleic acid structure, whether there is a deliberate reduction in the chance of single-cell biomolecules causing cancer.
This process is relatively complicated. First of all, it is necessary to compare the carcinogenic probability of different organisms under the same carcinogenic conditions.
Then find out a single-celled organism, by constantly changing the mutation point of DNA and RNA transcription and translation, after finding it, change the sequence, and observe whether it can effectively reduce the carcinogenic rate.
This is the heart of the experiment.
Bai Ye began to recalculate. The original data only had a ratio of single-celled organisms, and it was not perfect. Their elimination standards were very strict, and any variation in the experimental steps would be eliminated from the observation group.
In this way, after being invisible, the number of cases is reduced, but the success rate of the experiment is also increased.
However, Bai Ye's data was calculated based on the number of cases, and he also included the data that could have been included in the inclusion criteria.
The huge amount of data forced Bai Ye to concentrate on calculations, so Bai Ye simply turned off his phone and focused on analyzing it wholeheartedly.
Time passed quickly, two days later, Bai Ye finished the first set of statistics!
However, it was found that not all changes in DNA and RNA sequences can affect the risk of cancer.
Only certain kinds of single-celled organisms can really affect the chance of carcinogenesis, so changing a certain sequence cannot be applied to all single-celled organisms.
However, there is a single-celled organism that can significantly reduce it!
That is the data from the experiment a few days ago!
What does it mean?
Changing that kind of sequence, what really works is only a certain kind of single-celled organism!
The data in the first part has a conclusion, the data is correct, and the conclusion is also correct.
Bai Ye went on to start the second part of the research. The second part is to model mice that cause cancer and form digestive tract tumors.
Then by injecting drugs to change the nucleic acid structure of the tumor cells, to see whether it can effectively curb the reproduction of tumor cells.
KM mice are used. The advantages of this kind of mice are obvious, such as fast reproduction, fast growth, strong disease resistance and adaptability. They are widely used in pharmacology, toxicology, microbiological research, and effect experiments of drugs and biological products. and safety evaluation.
And in recent years, it has become popular in tumors.
There are more than 20000 cases of cancer-causing mice, and Bai Ye is a bit overwhelmed. After all, there are so many mice, it is difficult to analyze.
And in order to better compare the efficacy, he joined the imatinib group, oxaliplatin group, blank group, placebo group...
The current direction of tumor treatment has been added to the ranks of comparison.
The calculation process is more troublesome, but it is just troublesome.
Bai Ye was not afraid of trouble, and spent the whole day, the A4 papers in his hand piled up into a hill.
Hundreds of draft papers filled with writing and drawing seem to be discarded every minute.
Sunday, that is, Bai Ye's fourth day in the library.
Calculated the result!
An unexpected result surprised Bai Ye, p=0.05!
What does it mean?
It's embarrassing to feel overwhelmed!
If P<0.05, it is generally considered to be a small probability event, less than 5 out of 0.05 times, it can be considered to have no effect, and less than [-] here means that this hypothesis is not established, and the difference is statistically significant!
Means the experiment should hold!
But the threshold value of 0.05 does not mean that it is a small probability thing, it is very likely to be 100% possible and 100% impossible!
How did things come to this point?
What does it mean?
To put it bluntly, this experiment, in fact, can prove to be a success!
It can be proved that this drug has a better effect than other drugs, and it is more effective than those anti-tumor drugs on the market!
but!
Is it really?
Bai Ye was a little skeptical. If that was the case, why was there a missing data in the first place?
Where is the data missing?
So where is the problem!
Therefore, Bai Ye suddenly remembered the original data, as long as he found the original data and compared them, he would know where the gap was.
Then through calculation, you can definitely get the reason!
When the time comes, you will know the result!
Thinking of this, Bai Ye quickly got up, tidied up his surroundings and left the library.
Back in the dormitory, Duan Yue was playing games, while Lu Peiyi was on the phone, Fatty wasn't there. He had rarely seen this guy these days, and he didn't know what he was up to.
Bai Ye picked up the mobile hard drive and walked towards the library. After all, the dormitory...is really not suitable for research.
Bai Ye didn't mean to blame them, after all, you can't ask for too much in the collective dormitory.
Back in the library, Bai Ye couldn't wait to connect to the computer, turn on the hard drive, and compare the data!
There are too many data, and it is not an easy task to compare, Bai Ye is dazzled by looking at it!
After spending almost an entire afternoon, I finally got the result!
Compared with the original data, only one data is lost!
How can one piece of data affect so many people?
Bai Ye was shocked!
(End of this chapter)
Bai Ye booked the train ticket for tomorrow. After seeing his instructor that day, he went to visit all the masters and teachers of traditional Chinese medicine, as well as Mr. Tu.
They have all helped Bai Ye a lot, so since they are in the capital, they cannot afford to be less polite.
After packing up and saluting the next day, I returned to Jinxi.
In the past few days, Bai Ye and Meng Yunxi had chatted several times one after another, each time with a few words, and they staggered each other because they were busy.
The two are a little more familiar than before, at least Meng Yunxi won't ask Bai Ye, 'Who are you now? ', and even made a small joke occasionally, but what embarrassed Bai Ye was that every time he talked about the topic of mice, the other party got busy, so he had to think about formally talking about this issue another day.
But Bai Ye has a lot of things on his shoulders right now, and he doesn't have much time.
After returning to school, I rectified, and went to the library the next day with my notebook and schoolbag on my back.
The library on this day is much cleaner than before. It is neither the exam month nor the preparation period for the postgraduate entrance examination. Everyone is crazily exuding youthful hormones in the spring of May. Only a person like Bai Ye who promises to study with his body will Come to the library.
The purpose of Bai Ye coming to the library is very simple, to give Ke Ao a satisfactory answer.
I now have a level of lv6 in statistics, and the data has been further improved. I should be able to calculate the results of this data in a short time!
Bai Ye also wanted to know what went wrong. If the data was deliberately incomplete, what was the other party's purpose?
The first part of the data is still a record of the concept of the experiment and a process of transcriptional replication of single-cell organisms.
The data is the recorded differentiation of single-cell organisms after carcinogenesis, and changes in the original nucleic acid structure, whether there is a deliberate reduction in the chance of single-cell biomolecules causing cancer.
This process is relatively complicated. First of all, it is necessary to compare the carcinogenic probability of different organisms under the same carcinogenic conditions.
Then find out a single-celled organism, by constantly changing the mutation point of DNA and RNA transcription and translation, after finding it, change the sequence, and observe whether it can effectively reduce the carcinogenic rate.
This is the heart of the experiment.
Bai Ye began to recalculate. The original data only had a ratio of single-celled organisms, and it was not perfect. Their elimination standards were very strict, and any variation in the experimental steps would be eliminated from the observation group.
In this way, after being invisible, the number of cases is reduced, but the success rate of the experiment is also increased.
However, Bai Ye's data was calculated based on the number of cases, and he also included the data that could have been included in the inclusion criteria.
The huge amount of data forced Bai Ye to concentrate on calculations, so Bai Ye simply turned off his phone and focused on analyzing it wholeheartedly.
Time passed quickly, two days later, Bai Ye finished the first set of statistics!
However, it was found that not all changes in DNA and RNA sequences can affect the risk of cancer.
Only certain kinds of single-celled organisms can really affect the chance of carcinogenesis, so changing a certain sequence cannot be applied to all single-celled organisms.
However, there is a single-celled organism that can significantly reduce it!
That is the data from the experiment a few days ago!
What does it mean?
Changing that kind of sequence, what really works is only a certain kind of single-celled organism!
The data in the first part has a conclusion, the data is correct, and the conclusion is also correct.
Bai Ye went on to start the second part of the research. The second part is to model mice that cause cancer and form digestive tract tumors.
Then by injecting drugs to change the nucleic acid structure of the tumor cells, to see whether it can effectively curb the reproduction of tumor cells.
KM mice are used. The advantages of this kind of mice are obvious, such as fast reproduction, fast growth, strong disease resistance and adaptability. They are widely used in pharmacology, toxicology, microbiological research, and effect experiments of drugs and biological products. and safety evaluation.
And in recent years, it has become popular in tumors.
There are more than 20000 cases of cancer-causing mice, and Bai Ye is a bit overwhelmed. After all, there are so many mice, it is difficult to analyze.
And in order to better compare the efficacy, he joined the imatinib group, oxaliplatin group, blank group, placebo group...
The current direction of tumor treatment has been added to the ranks of comparison.
The calculation process is more troublesome, but it is just troublesome.
Bai Ye was not afraid of trouble, and spent the whole day, the A4 papers in his hand piled up into a hill.
Hundreds of draft papers filled with writing and drawing seem to be discarded every minute.
Sunday, that is, Bai Ye's fourth day in the library.
Calculated the result!
An unexpected result surprised Bai Ye, p=0.05!
What does it mean?
It's embarrassing to feel overwhelmed!
If P<0.05, it is generally considered to be a small probability event, less than 5 out of 0.05 times, it can be considered to have no effect, and less than [-] here means that this hypothesis is not established, and the difference is statistically significant!
Means the experiment should hold!
But the threshold value of 0.05 does not mean that it is a small probability thing, it is very likely to be 100% possible and 100% impossible!
How did things come to this point?
What does it mean?
To put it bluntly, this experiment, in fact, can prove to be a success!
It can be proved that this drug has a better effect than other drugs, and it is more effective than those anti-tumor drugs on the market!
but!
Is it really?
Bai Ye was a little skeptical. If that was the case, why was there a missing data in the first place?
Where is the data missing?
So where is the problem!
Therefore, Bai Ye suddenly remembered the original data, as long as he found the original data and compared them, he would know where the gap was.
Then through calculation, you can definitely get the reason!
When the time comes, you will know the result!
Thinking of this, Bai Ye quickly got up, tidied up his surroundings and left the library.
Back in the dormitory, Duan Yue was playing games, while Lu Peiyi was on the phone, Fatty wasn't there. He had rarely seen this guy these days, and he didn't know what he was up to.
Bai Ye picked up the mobile hard drive and walked towards the library. After all, the dormitory...is really not suitable for research.
Bai Ye didn't mean to blame them, after all, you can't ask for too much in the collective dormitory.
Back in the library, Bai Ye couldn't wait to connect to the computer, turn on the hard drive, and compare the data!
There are too many data, and it is not an easy task to compare, Bai Ye is dazzled by looking at it!
After spending almost an entire afternoon, I finally got the result!
Compared with the original data, only one data is lost!
How can one piece of data affect so many people?
Bai Ye was shocked!
(End of this chapter)
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