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Chapter 142 Big Discovery! (510 for subscription)
P<0.05 and P=0.05 were originally a matter of little concern.

It is easy to be ignored, because this matter is not worth studying, and even many research institutions think that P≤0.05 is okay!
But Bai Ye happened to encounter such an extremely probable event.

Of course, even if P<0.05 does not mean that it must be effective, it can only mean that the possibility of 95% is good!

Therefore, in terms of statistics, all of this is a matter of probability. Even if something goes wrong, it may be a Type I error or Type II error or even a small probability error event.

Bai Ye took a deep breath and continued to start a new round of calculations.

Is it a type [-] error and a type [-] error?
Bai Ye was about to start counting when he suddenly found an aunt standing beside him and said, "Young man, why don't you go back so late? The library is closed."

Bai Ye just looked at the time, and it was 10:[-]. When he looked at his aunt, he hurriedly said sorry.

Such a familiar scene... Was it this aunt who closed the library when I was taking the postgraduate entrance examination?
When Bai Ye returned to the dormitory, he did nothing but carefully looked at the lost data.

This data is not much different from others. Maybe it was thought that it would not have much impact if it was lost?
Bai Ye didn't know how to think about this kind of thing, so he consulted Karis and Daisy about the P=0.05 consideration.

They think that the probability of this is very small, and it may be possible to reduce it by changing a calculation method, or put forward some unnecessary data.

But Bai Ye felt that this kind of real data can often reflect the problem, and what is obtained after elimination is not perfect!

How to do?
Why did Bai Ye bother with this problem, because first of all, this problem may be the reason for the failure of the experiment.

First of all, it may be because of the results of this animal experiment: in fact, this drug cannot change or reduce the incidence of tumors.

Another possibility is that although the drug is effective in mice, it has no obvious effect on humans.

The main purpose now is to prove these two points.

Bai Ye thought about it all night, and got up at dawn the next day and went to the library, the same location.

He suddenly remembered that when statistics reached level 6, many new testing methods appeared.

Bai Ye had never tried these methods, so he rearranged the data and started calculations according to the new model.

Not long after, Bai Ye calculated the result!

But the result made Bai Ye stunned!
It's effective!

This drug is effective against gastrointestinal tumors in KM mice...

So why is there such a series of effects?
Even faster?
Could it be that KM mice are not very effective in experiments on digestive tract tumors?
Hasn't anyone worked on the mouse-human fit problem?

In general, KM mice are often used to study tumors, is it unreasonable?Especially in the direction of those digestive tract tumors, is there a problem?
Bai Ye suddenly remembered his own copy of Saker's "Rat Raising Experience", and Bai Ye quickly turned on the virtual screen to check it.

Is there... is there...

Bai Ye is a little moved, if it can be confirmed... This is a new discovery!

KM mice are not suitable for the study of gastrointestinal tumors. Once this theory is confirmed, it will definitely be a big discovery!

found it!found it!
Sacker wrote a sentence in his experience: KM mice will directional change their DNA transcription sequence in certain drug-specific experiments, which belong to special targeted drugs, which are only suitable for KM mice, not for human beings. Trial ends in failure...

Bai Ye suddenly realized!

Is that so?
What drug?what is the reason?
Bai Ye hurriedly continued to look through it, and found that the DNA sequence of KM mice is relatively adaptable, and when faced with some strong stimuli, can it mutate faster than humans?

Then, many examples were given to prove some shortcomings of KM mice. The conclusion of the article also stated that some data gaps were caused by the loss of original data in the original experiment.

In fact, it was an opportunity to further improve the KM experimental mice. If the cause of that part of the mutation can be eliminated, perhaps, it will be perfectly suitable for modern tumor research.

Bai Ye was taken aback, and quickly looked up the name of this experiment: Dr. Mikasu Tranley's research on the use of a synthetic compound to target and curb single-cell canceration.

Dr. Mikasu Tranley?
Bai Ye got up and went to the bathroom, and without caring about the time, he directly dialed Ke Ao's phone number.

But he eased his breathing: "Hello? Ke Ao, are you busy recently?"

Ke Ao's voice was lazy: "oh! Bai Ye, what time is it..."

Only then did Bai Ye say sorry: "I'll calculate the results from your data. By the way, what's the name of your tutor?"

When Ke Ao heard Bai Ye's words, he immediately woke up: "What? Some results? What results?"

Bai Ye was stunned for a moment, shook his head, and continued to ask: "For now, a little bit, after I have the result, I will tell you, who is your mentor?"

Ke Ao sighed: "I'm... Mikasu-Tranley! However, the old man has gone... Depressed and committed suicide."

Bai Ye was taken aback, it was really him, but... why did he commit suicide: "I'm sorry, thank you, wait for my good news."

…………

After chatting with Ke Ao for a few words, Bai Ye hung up the phone. He couldn't tell Ke Ao to complete the data by himself, but he could follow the correct data to study.

Since the data is correct, there is a problem with the mouse, so what is the problem?

Bai Ye returned to the research of the second part of the data, or the key missing data...

For the next day, Bai Ye spent all of it on calculations.

Following the data to dig, Bai Ye is very experienced, and this is not the first time he has done things by following the clues.

On the third night, Bai Ye looked at the data excitedly, and there was a result!
Mainly combined with the first-stage data, it turns out that in a molecular sequence, a guanine can easily change the structure of its DNA during RNA transcription!
If the guanine in the KM mouse can be deleted and its original DNA sequence changed, the rate of its mutation may be slowed down.

In this way, it is not conducive to the mutation of mice, but it is beneficial to the experiment!
Bai Ye was a little excited.

I am destined to be the one who makes history...

A new type of mouse is suitable for tumor research, and even thinking about it, Bai Ye feels very excited.

Now we need to experiment. If the experiment results... I, Bai Ye, am destined to become the mouse king...

Although the name doesn't sound good, but...

To achieve the ultimate in any job is art!
Moreover, now Bai Ye is still carrying this Koao mission, and it is a mission with rich rewards!

(End of this chapter)