medical simulator

Before applying for a topic, by searching the literature and current research progress, you can only see the published content and published articles.

You will basically not pay attention to and inquire about the experimental progress of other research teams or the proposed projects. Therefore, in fact, for each research direction of the topic, someone may be trying, and the result may be produced at any time.

Once such a situation occurs, then you can only think of other ways to end the subject.

However, this article published in science has done very in-depth research.

Therefore, after Fang Yun told Yang Yifeng about this, Yang Yifeng couldn't sit still, not only Yang Yifeng couldn't sit still, even Ding Changle came out to sit in charge of Yang Yifeng himself at this moment.

Not only did he call all his students, but he also specially invited the director of neurosurgery, Professor Jiang Hong, to help Yang Yifeng think about the follow-up method.

Zhou Cheng and Fang Yun were also invited. At this moment, they gathered in the laboratory that Ding Changle belonged to. The door of the laboratory was closed tightly.

"Yi Feng, tell me what's going on, and then we'll figure out a solution together. After a while, I'll think about other ways out." Seeing that everyone had arrived, Ding Changle gave orders like this, without any special consideration. panic.

Yang Yifeng was his student, staying in the hospital at such a young age and being shot in the face was one of his facades.

Moreover, Yang Yifeng is recognized as a genius by the hospital. If he won the bid, no one would suspect that there was a fake in it, but today's incident can be regarded as bad luck for eight lifetimes.

What's more, the ones that contradict his subject were also published in top journals like science. If this is not handled well, it will really be impossible to finish the question, and it will be difficult to finish.

Even in the end, the management personnel of the National Natural Science Foundation of China would come to trouble Yang Yifeng, saying that when he applied for the project, he had insufficient reserves in the early stage.

Of course, even if it was such a reason, Ding Changle had to find a way to make Yang Yifeng go around.

Yang Yifeng is now holding his tender, the ppt he has already prepared.

At this moment, his face was full of sternness: "Master, Professor Jiang Hong, fellow seniors, thank you for your hard work. This time, the topic I plan to apply for is nerve healing."

"The details are as follows, you can read my ppt content, I don't gossip..."

"Nerve repair is currently a very popular research direction in many departments such as hand surgery and neurosurgery. The significance of the existence of this topic is that after the nerve is broken, even if it is stitched together."

"Even with the best nerve suture technology and the best suture objective conditions, there will be loss of function after nerve healing, or even non-union. This is the background and role of the research significance."

"And the small background of my choice of topic has the following aspects."

While talking, Yang Yifeng clicked on the ppt to introduce everyone.

In fact, at Yang Yifeng's level, the topics he researches are not only the top group of people in the world, but also, in the field of his research, there are not many people who can compare with him in depth and knowledge reserve. He compares.

Because the direction was deliberated by Yang Yifeng himself, and he did a lot of collecting work, so if he wants to find a solution now, he must also present the basic research background.

It is equivalent to explaining all the research mechanisms and ideas of this topic, so that everyone can help to find a solution, instead of asking everyone to find or collect information by themselves, wasting time.

"The concept of neural healing is the process by which damaged parts of the nervous system are restored to normal function."

"In recent years, not only in China, but also more and more research teams all over the world have begun to study the mechanism of nerve healing and explore related popular targets and healing mechanisms. The following are some of the more popular mechanisms. And some of their simple action processes."

"The first, and currently the most popular understanding is that all healing is inflammatory healing, so nerve healing is no exception."

"So?"

"Applications of the inflammatory response and modulation of the immune system to the nervous system are --

"After the nervous system is damaged, the regulation of local inflammatory response and immune system plays a key role in nerve regeneration and repair. Therefore, regulating the inflammatory response and immune system of the nervous system may be an important target to promote nerve healing."

"Nerve growth factors and neurotransmitters: Nerve growth factors and neurotransmitters are important molecules that affect neuronal growth and regeneration to promote nerve regeneration and repair.

"Extracellular Matrix: The extracellular matrix is ​​the supportive tissue surrounding cells that plays an important role in nerve regeneration and repair."

"Gangliosides and other molecules: Gangliosides and other molecules are signaling molecules between neurons and their surroundings, and they can affect neuronal growth and regeneration."

"The above are the popular directions of research, and these directions are covered in the articles published this time. The published articles are the conclusions of a very comprehensive topic and the cooperation of multiple researchers. "

"Regarding the research on inflammatory response and immune system regulation in nerve healing, some studies have shown that local inflammatory response can play a positive role in nerve regeneration and repair, but excessive inflammatory response may negatively affect nerve regeneration. Therefore, Finding molecules and drugs that modulate the inflammatory response and the immune system is a current research hotspot."

"In recent years, some drugs that regulate the immune system have been confirmed to promote nerve healing, such as some antirheumatic drugs, glucocorticoids, neuropeptides, etc. In addition, some cytokines such as interleukin-10 (IL-10), transformation Growth factor-beta (TGF-beta), among others, has also been found to modulate inflammatory responses and the immune system, thereby promoting nerve healing."

"In the paper published this time, it happened to cover the role of interleukin-10, a cytokine, in nerve healing."

"Then if we want to go deeper, we must either do the parallel pathway of IL-10, or do the role of the upstream and downstream pathways of IL-10."

"And when I checked the literature before, I found that the upstream and downstream pathways are basically perfect at present, and there is no groundbreaking significance, so it is a redundant, or exclusionary, tentative research."

When Yang Yifeng said this, he only explained the background of one of the research pathways.

Seeing that no one responded, Yang Yifeng continued to dig deeper:
"And in terms of nerve growth factor and neurotransmitters!"

"The role of nerve growth factor and neurotransmitters in nerve healing has been widely recognized. Nerve growth factor is a class of proteins that promote the growth, differentiation and regeneration of neurons."

“Among them, neurotrophic factor (NGF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and nerve growth inhibitory factor (GDNF) have been shown to promote nerve healing. In addition, neurotransmitters are a A class of chemicals that transmit signals between neurons, of which acetylcholine and norepinephrine are common neurotransmitters."

"Corresponding drugs such as clonidine and lidocaine have also been found to promote the release of neurotransmitters, thereby promoting nerve healing."

"However, there is a certain intersection between neurotrophic factors and inflammation in promoting nerve healing, so this research also covers this aspect of research."

"The drug can also promote nerve healing by promoting the secretion of nerve growth factor."

"The third is the new application of the recognized extracellular matrix."

"The extracellular matrix plays an important role in nerve regeneration and repair. In recent years, many studies have developed some materials with extracellular matrix components that support nerve regeneration, such as nerve regeneration bioscaffolds. These bioscaffolds can provide neurons with Provide a suitable physical and chemical environment to promote the growth and connection of neurons. At the same time, some inhibitors of extracellular matrix degrading enzymes have also been shown to promote nerve healing."

"In this study, it is also applied to this aspect, and they also used this material as a medium to obtain preliminary data in the animal test."

"Then there are neural stem cells and stem cell factors. Neural stem cells are a type of pluripotent stem cells that have the ability to self-renew and differentiate into neurons and glial cells. Some studies have shown that neural regeneration and repair can be promoted by implanting neural stem cells, thereby Improving the recovery of neurological function…”

As Yang Yifeng went deeper, everyone was caught in a brainstorm, and at the same time, almost everyone cast pitiful eyes on Yang Yifeng.

What the fuck is wrong with you that you stumbled into this project?

This person has basically introduced you and done everything that should be done, so what else do you have to do?
This is purely unlucky, because when Yang Yifeng applied, other people's results had not yet been released, and it was impossible to publish half of the results, and then as soon as Yang Yifeng applied for the project, others had already published the article.

The difficulty now is not entirely that Yang Yifeng cannot continue to go deeper, but how to go deeper and how to find the best quality direction with limited funds.

Of course, it will be quite difficult to achieve similar results or go further. Moreover, if we want to go deeper, we will spend according to the temporary funds provided by Yang Yifeng.

At least 500 million or more.

As for the projects Yang Yifeng applied for, the total funding was less than 30 yuan, a gap of more than N times, and this gap could not even be filled by Yang Yifeng himself with his salary.

Ding Changle looked at Jiang Hong.

Jiang Hong sniffed, shrugged his eyelids, and said in a helpless tone, "Yi Feng, are you stabbing a hornet's nest?"

"When you applied for the project, what was the expected result?"

"The expectations are not high, just publish three SCI papers, train a Ph.D. and three master students."

"If the 30 yuan is used, if it is only used to publish articles, to find loopholes and fill in vacancies, it is enough. But if it is used as the basis for subsequent research directions, it is obviously not enough."

"I thought so." Yang Yifeng hesitated to speak.

He is unwilling to waste the country's money on things that don't make much sense, not just because of his pride.

What's more, Zhou Cheng's project and clinical project are going smoothly now, but he turned over the car just now, how will he cooperate in the future, people who don't know think that Yang Yifeng followed Zhou Cheng, just licking the dog.

So, this time, he wanted to brainstorm a discussion, hoping to find a relatively novel angle.

At this moment, Zhou Cheng just finished reading that article. To be honest, the research level of this article is relatively broad and in-depth, and it almost blocks Yang Yifeng's current research direction!

However, Zhou Cheng had seen other things when he was simulating nerve suturing before.

"Yi Feng, if the nerves heal, there should be some pathways besides these pathways, right? Have you ever understood it?" After Zhou Cheng finished reading the article, he opened his mouth without waiting for others to speak.

Now he doesn't need to be too modest to save face for Ding Changle and others.

Big articles, big topics, innovative topics, and global topics, Zhou Chengcheng has a resume, what qualifications do you still talk to me about?
Zhou Cheng was blunt. He believed that Ding Changle would not be offended. If he didn't have such a heart, Ding Changle would not be able to sit as the chief director of orthopedics.

However, it is clear that Ding Changle is more concerned about the progress of this project than Yang Yifeng: "Does Xiao Zhou have a better idea?"

Zhou Cheng shook his head first, thinking to himself, I can understand so deeply beyond Yang Yifeng, isn't it fake?
"I seem to have seen it when I checked the literature. Professor Ding."

These things are not within Yang Yifeng's knowledge threshold, so he needs to search for a while.

Then, Yang Yifeng nodded, unhurriedly showing his strong knowledge and knowledge control ability: "Yes, there are mainly three aspects."

"First, brain-derived neurotrophic factor, brain-derived neurotrophic factor (BDNF) is a nerve growth factor that plays an important role in the growth, differentiation, maturation and survival of neurons. Studies have shown that BDNF can not only promote Neuronal growth and connection, but also improved neuronal metabolism and reduced apoptosis."

"Therefore, by increasing the level of BDNF or enhancing its function, nerve regeneration and repair can be promoted. Some studies have shown that the use of BDNF or its mimics can promote nerve regeneration and repair, and achieved certain clinical effects."

"Second, gene therapy. Ethics fail!"

"Third, optical neuromodulation technology."

"This is a technology that uses light-sensitive proteins or compounds to stimulate and regulate neurons. This technology can precisely control the activity of neurons in space and time, so as to achieve the effect of nerve regeneration and repair..."

"These three aspects are not common because they cost more money to carry out, and the expected effect is very limited."

"Then you have no solution? I think you can spend more money, transfer the funds in the research group, write a few articles and finish the problem." Jiang Hong said.

Nerve healing belongs to relatively basic research, and it is not new. Basic means that the research is extensive and lasts for a long time. After such a large article is published this time, no one will touch it for at least ten years.

Why does Yang Yifeng need to be entangled and persistent?
Ding Changle looked at Yang Yifeng, almost convinced that Yang Yifeng could only use Shui Wenwen to finish the question, and asked, "Yifeng, writing a few articles, you should be fine, right?"

Yang Yifeng did too much homework, and the things he expressed were too detailed, basically there was not much space for others to drill, so stop thinking about big topics and big articles.