Director: The special effects are too expensive, so I had to make real shots

Chapter 73 New Drugs for Effective Inhibition of Multiple Targets

Accumulated entertainment points: 3+1
When Xu Nuo saw that the entertainment points he had accumulated successfully +1, his mood reached the peak today.

Today, not only won the 10 billion Yuzhou smart city project, but also met Li Chengzhu, and He Feiyang also got the advertising sponsorship of Bosideng down jacket for "Transformers".

Guan Ju secretly punched Penguin Films' movie "Smoke from the Wolf" again.

The surrounding crowdfunding of "Transformers" exceeded [-] million.

I also completed the system task and got 1 entertainment point.

Don't be too cool!
It is still 16 points away from the first-generation small reactor of Iron Man that Xu Nuo wants to exchange.

Originally, I finished filming "Terminator" and completed all the tasks of the film, so I got 5 entertainment points.

However, Xu Nuo spent 2 entertainment points in exchange for [a new generation of tyrosine kinase inhibitor], which is the synthetic formula of ponatinib.

With this, Xu Nuo hired a drug research team from his alma mater to study the chemical synthesis and drug action mechanism of ponatinib in his company's biomedical laboratory.

As long as this new drug is developed, the system will allow Xu Nuo to film "I'm Not the God of Medicine".

Xu Nuo plans to shoot this movie after the "Transformers" movie project ends, because although the research and development of drugs can be completed quickly and smoothly, new drugs still have clinical trials.

This clinical stage can be as fast as one or two years, as slow as three to five years, or even longer.

So Xu Nuo made a rough calculation. After he finished the film project of "Transformers", he will finish filming "I'm Not the God of Medicine". Clinical trials can be completed and approved for marketing.

It can be said to be a perfect connection.

Based on Xu Nuo Xu Nuo's experience, after filming "Transformers" and "I'm Not the God of Medicine", each should get 5 entertainment points.

Coupled with the completion of some system tasks during the shooting process, there will also be rewards for task entertainment points like today.

As long as he works hard to save up, there is still hope for Xu Nuo to get the small reactor he has been longing for.

All the good things that should have been done today have been done.

With a happy mood, Xu Nuo looked at the time and it was not too early, so he went to sleep and rest happily.

In two days it will be the National Day holiday.

Xu Nuo didn't have any plans to go on a trip. The only plan was to "dumbly" make an intelligent robotic arm in the modified garage.

After the [-] holiday is over, Xu Nuo will continue to film the urban part of "Transformers" in Yuzhou City. At that time, Zhou Kun's younger sister, the heroine of "Transformers", Zhou Youqing, will be with her. shoot.

I have a lot of scenes with her, and in some scenes, we may have close contact, occasionally mobilize hormones and exciting fights, which is a combination of popcorn commercial movies that will make the audience enjoy.

For example, in the movie, when the hero and heroine and the Autobots had a misunderstanding with the Secret Service, they were taken away for investigation, and they had close-range friction in the car.

And before Optimus Prime delivered a small composition speech at the end of the film, the hero and heroine also had an intimate kiss scene on the hood of the Bumblebee car.

This is definitely not a scene where Xu Nuo blindly changed the script and added random scenes!

These are all found in the original "Transformers". Although Xu Nuo has made some localized adaptations of "Transformers" suitable for the domestic environment, the things that should be changed can be changed, and the things that should not be changed can be changed randomly. right?

After waking up, when Xu Nuo woke up the next day.

I was thinking about going to buy some breakfast, but I came up with whatever I wanted.

Assistant Wen Ruohan came to the modified garage with breakfast early in the morning.

"Boss, good morning."

Wen Ruohan saw the boss, greeted him and said, "A box of milk, four steamed buns with fresh meat, one deep-fried dough stick, and two tea eggs. Boss, come and have breakfast."

"Come here so early?"

Xu Nuo was a little surprised.

It seems that Wen Ruohan really wants to perform well during the one-month housekeeper inspection period.

"Hey, I knew that the boss basically wakes up at this time, so I prepared breakfast in advance."

Wen Ruohan put the breakfast on the table.

"you made it yourself?"

Xu Nuo asked curiously.

"Well, no."

Wen Ruohan shook his head very sincerely and replied: "I only learned how to cook with my dad. For breakfast, I bought it at the breakfast shop."

"Ok."

Xu Nuo said that she could understand it. After all, there are buns, fried dough sticks, and tea eggs. If she wakes up early in the morning and makes them fresh, it will take a lot of time.

It's not bad to buy it from a breakfast shop, as long as it's delicious, it's fine.

"If the boss doesn't want to eat breakfast from the breakfast shop outside, then I can also learn how to make breakfast."

"It's not necessary."

Xu Nuo waved his hand and said with a smile: "After I make a bionic human body for Guan Ju, I can ask Guan Ju to make it for me."

"Happy to be of your service, sir."

Guan Ju's voice suddenly sounded at this moment.

"Wow, Guan Ju can also cook?"

"Not now, because Guan Ju doesn't have a body yet."

"A robot body? Make one."

despair!
Xu Nuo stretched out his hand and flicked a brain crash on the assistant's head, and said: "How can it be so easy, the mechanical structure of the bionic robot is very complicated, and in order to look beautiful, it also needs to use bionic skin cell technology, bioprinting technology Come to shape Guan Ju's skin shape like a real person's."

The combination of these technologies can probably create a structure with internal mechanical and electronic components, but after being covered with bionic skin on the outside, it looks like a human being with smooth skin, long legs and big breasts.

Highlight a realistic!

"I don't know how serious it is."

Although Wen Ruohan doesn't know how to build the robot the boss mentioned, she is still very much looking forward to it.

I wonder what Guan Ju will look like with a robot body?
"With the bionic skin cell tissue printing technology, you can pinch any kind of face for Guan Ju according to your own preferences. It's like a game where you can pinch the face. You should have played it?"

Xu Nuo simply explained to Wen Ruohan.

The bionic skin cell technology that Xu Nuo mentioned can also be exchanged in the system using entertainment points, which is another reason why Xu Nuo wants to set up a biomedical experiment for his company.

At that time, in your own smart villa, you will not only have the intelligent robotic arm "Dazhao", the intelligent mechanical dog "Benben", but also the bionic robot Guanju.

Of course, the difficulty of making Guanju is obviously several levels higher than that of Duda and Benben, and the technology involved is much more complicated.

"Wow boss, you are amazing."

After Wen Ruohan heard the boss's thoughts, his mouth opened involuntarily.

"What's so amazing? These are just ideas that exist in your head. If you really want to create them, it can't be done overnight. Are you still flattering me?"

Xu Nuo glared at the assistant, then picked up the buns and milk, and ate them in big gulps.

"But I really think that you are very powerful, boss. By the way, the company's biomedical experiment yesterday said that the research project of some kind of drug has made great progress. Boss, do you want to go over and have a look today? "

"Is there any significant progress so soon?"

When Xu Nuo heard this, his face immediately showed joy: "I'll go and have a look after breakfast."

Wen Ruohan just said that the company's biomedical laboratory has made significant progress in the experimental project, which must be the research on the new generation of tyrosine kinase inhibitor ponatinib.

Because after Xu Nuo pulled the laboratory team from his alma mater, the company currently only has this new drug research project related to biomedicine.

With the support of the [New Generation Tyrosine Kinase Inhibitor Technology] exchanged by Xu Nuo, the laboratory team has made a major breakthrough so quickly.

This speed is faster than Xu Nuo imagined.

The reason is probably because the research team led by Professor Huang Wenqiang had already done in-depth research on chronic myelogenous leukemia drugs before this.

It's just that the direction of the breakthrough has not been found for a long time.

Now that Xu Nuo is behind the scenes, after the research team successfully finds a breakthrough direction, they will be able to find a successful path to synthesize ponatinib.

Soon, Xu Nuo finished his breakfast, tidied up briefly, and then drove to the company in the city center.

anyway.

Since the company moved to the office building in the city center, Xu Nuo hasn't been to the company much, and spends more time doing his own research in the modified garage and filming in other places.

In fact, Xu Nuo didn't have to worry about the company.

There are corresponding figures in each department, and they must have no problem in terms of ability.

In addition, the assistant Wen Ruohan coordinated the company's information and conveyed it to himself, so Xu Nuo didn't have to worry about the company's affairs so minutely.

Xu Nuo was in the converted garage at the foot of Nanshan Mountain, and when he looked across the river, he could see the office building where his company was located.

But if you drive over, you have to go around a little bit. Go through the cross-river bridge on the right. The distance in a straight line is less than two kilometers, but it takes several kilometers to go around this way.

No way, this is the magical Yuzhou.

Of course, Yuzhou's urban system is even more magical. Things like walking out on the seventh floor and ending up on the first floor of other people's homes are not worth mentioning at all.

After arriving at the company smoothly.

The old employees of the company were a little surprised at first when they saw the boss Xu Nuo.

Because they haven't seen the boss come to the company for a long time.

However, even so, all the operations of the company are going on normally, and the development is also making great strides towards a better future. The employees of the company have to admire this boss, he is really amazing.

On top of that, as the company grows, employees find their salaries rising, and at the end of the year there is said to be a generous annual bonus.

Not to mention that the company also strictly enforces the eight-hour working system and weekends.

Therefore, the employees often ridicule that although the boss Xu Nuo is a director of sci-fi movies, it is the most sci-fi to be able to work in the boss's real media technology company these days.

"Hi boss."

"Good morning, boss."

"Boss, you are here."

After seeing the boss Xu Nuo, the employees greeted each other warmly.

"Xiaowen, the company looks very dynamic now."

Seeing that every employee in the company basically had a relaxed and happy smile on their faces, Xu Nuo felt very relieved.

"Hey, I work eight hours a day, and I don't have to work overtime on weekends. Anyone can be energetic."

Wen Ruohan said proudly.

The reason why Xu Nuo dared to strictly implement the eight-hour working system in his company was because Xu Nuo knew that his company had strong competitiveness in both the film and television field and the technology field, so there was no need to rely on Squeeze employees' overtime hours to achieve more benefits.

Another reason is why did Xu Nuo travel to this parallel world?
Wasn't it because of working overtime every day in a big Internet company and dying suddenly at a young age!

"Boss, this is your office, but you don't usually work in the company, so this office has always been idle."

Wen Ruohan led the boss to his new office to have a look.

Xu Nuo walked into the office and found that it was clean and tidy. Behind the desk was a large curved floor-to-ceiling window, and the big river in Yuzhou City could be seen at a glance.

Jiang Jing's office belongs to it.

However, Xu Nuo still prefers his modified garage, because it is more convenient to do whatever he does there.

Xu Nuo is a practical person.

After the smart villa on Nanshan Mountain is completed, Xu Nuo can live there directly, and the company naturally doesn't bother to come here.

"It's a nice office."

Xu Nuo walked around the office.

"Yes, the view from here is really beautiful."

"Xiaowen, anyway, I don't usually come to the company, or you can work in this office and handle the company's affairs for me."

Xu Nuo suddenly thought of Tony Stark's Pepper.

"what?"

Wen Ruohan thought she had heard wrong.

This is the boss's office, how can an assistant work here.

No, no, my little desk is fine.

"Ah for what."

Xu Nuo turned around, stared at Wen Ruohan and said, "Empty is also empty, don't waste it."

"This"

Wen Ruohan froze for a moment, then muttered, "Boss, I have a desk outside."

"Okay, anyway, you can figure it out."

Xu Nuo didn't force it when he arrived, and walked out of the office after speaking: "Let's go, let's go to the biomedical laboratory."

"it is good."

Wen Ruohan hurriedly followed, took the boss to take the elevator, and arrived at the floor where the biomedical laboratory was located.

The style of this floor is obviously different from the office areas on the lower floors. After all, this is the company's laboratory, and a team is doing experimental research on new drugs here.

After putting on special protective clothing and going through one sterilization procedure after another, he entered the biomedical laboratory.

"Professor Huang."

Xu Nuo met Professor Huang Wenqiang, who was recruited from his alma mater for biomedical research.

"Xiao Xu, no, I should call you the boss."

Huang Wenqiang came forward and said to Xu Nuo with a smile.

"Professor Huang, you should call me Xiao Xu. It sounds kind. Has our research on new drugs made progress?"

"That's right, and it's still a lot of progress." Huang Wenqiang nodded, as if a little excited, said: "We have verified the drug mechanism of ponatinib, as an oral multi-target receptor tyrosine Kinase inhibitors that are effective in treating chronic myeloid leukemia."

Huang Wenqiang gave his boss Xu Nuo a detailed introduction to the drug action mechanism of Ponatinib during the research and development process.

"Because the core imidazo[1-b]pyridazine of ponatinib occupies the adenine port of ABL2 kinase, the methylphenyl group occupies the hydrophobic pocket of the following residues, and the trifluoromethylphenyl group is closely bound by the DFG outer In the conformation-induced pocket, the ethynyl group is more conducive to the formation of van der Waals force between it and the I3151 mutant residue.

So ponatinib can effectively inhibit other clinically important ABL kinase domain mutants.

And also inhibits SRC, vascular endothelial growth factor receptor, FGFR and the PDGFR family of tyrosine kinase receptors"

Xu Nuo heard the words, thought for a moment, and then asked: "Does this reflect the efficacy and selectivity of Ponatinib? Ponatinib can effectively inhibit the expression of BCR expressed by the proliferation of Ba/F3 cells." -ABL, and all BCR-ABL mutants are sensitive to ponatinib?"

In this way, a multi-target inhibitory effect is formed.

"Is such that."

Professor Huang Wenqiang nodded.

Listening to the communication between the boss and Professor Huang, Wen Ruo on the side looked confused: Meow meow? ? ?What are you talking about? ? ?
(End of this chapter)