Roaming in the dark night

Chapter 19 A Good News
More than a year ago, Yu Wenhao went to see Professor Zheng and consulted him. He said that he saw some patients in the group who could not wait for a fully compatible match and had a semi-identical transplant. Can't I also do a haploidentical transplant using my bone marrow?
"Of course it can be done. We have done several cases, and there is no problem with the surgery itself."

Professor Zheng crossed his fingers in front of his chest and leaned against each other. He looked at Yu and said hello, and continued:
"But in cases like Qianqian, my suggestion is not to do it, or to wait. Compared with fully compatible transplants, haploidentical transplants have a higher risk of rejection, and the five-year cure rate is definitely lower. In addition, , In terms of recurrence rate, although there is no data to support it, from my experience, it must be higher.

"The haploidentical transplantation is also a helpless choice for those patients who are urgently ill, or whose physical conditions are no longer able to support, or who are not eligible for targeted drugs and have to undergo transplantation immediately. We are friends, and we I can tell you frankly, to put it bluntly, a dead horse is treated as a living horse doctor, let it be a gamble, a gamble.

"If Qianqian has reached this level, I would definitely advise you to perform a haploidentical transplant immediately, but Qianqian has not yet reached this level, she still has time to wait, wait for a fully compatible match, or wait for medical and medical standards. Development, by the way, less than, let me tell you some good news."

As soon as Professor Zheng said the good news, Yu Wenhao's eyes lit up, and he hurried over and asked, "What good news?"

"The new drug Neriq jointly developed by Ascentage Pharma and Innovent Biologics, commonly known as Orebatinib Tablets, is an oral third-generation BCR-ABL inhibitor and the first approved third-generation BCR-ABL target drug in my country." Drug-resistant CML drugs have outstanding effects on BCR-ABL and various BCR-ABL mutants including T315I mutation, which can be said to have reached the world's leading level."

"What do you mean? Professor Zheng, tell me something I can understand." Yu Wenhao was a little anxious.

"Okay, to put it simply, it is very effective for patients with chronic granulomatosis, and it can also be cured without bone marrow transplantation." Professor Zheng said, "I have several cases in hand. After taking this drug, they can now be cured. work and live normally.”

"It can be cured without transplantation? Is there really such a thing? That's great!" Yu Wenhao shouted.

"This drug is not simple. In March 2021, it was listed as a breakthrough drug by CDE. In July 3, it was approved by the US FDA for clinical trials and directly entered Phase Ib clinical trials. The clinical trials have continued for four years, and it has been selected by the American Society of Hematology. Oral presentation at the annual meeting, and was nominated for Best Research at the 2019 ASH Annual Meeting.

"In May 2020, they successively obtained the Orphan Drug Qualification and Fast Track Qualification granted by the US FDA, and also obtained the European Orphan Drug Qualification..."

"Orphan drugs are especially effective for children, right?" Yu Wenhao hastily interrupted Professor Zheng's words.

Professor Zheng couldn't help laughing, he said:
"Don't take it literally. Orphan drugs are not drugs for orphans, but rare drugs, which are used to prevent and treat rare diseases. Because of the small population of rare diseases, low market demand, and high R&D costs, general pharmaceutical companies are very Few will be invested in research and development, so these drugs are vividly called 'orphan drugs'."

Yu Wenhao chuckled, he thought of it immediately, and asked, "Is that very expensive?"

"Yes, orphan drugs are not cheap. The market is small, and the R&D investment is large. They will definitely not be cheap. There are orphan drugs worth millions of dollars abroad. But for some people, he also has to fight, such as Jobs, If any medicine is effective for him and can save his life, let alone a few million, even tens of millions, a dose of [-] million US dollars, he will take it, right?

"There is a saying that sounds cruel, but the truth is true. The more medical science develops, the longer a person lives. It is not determined by God or Hades. In many cases, it is determined by your wallet. People with thicker wallets, compared with If you speak, you will gain more lives than others."

"I don't care, I don't care about Jobs, God and Hades, I just ask, how much does this medicine cost?" Yu Wenhao asked.

"Thirty thousand and seventy-one boxes." Professor Zheng said.

"So expensive?"

Yu Wen was surprised. He knew that even when Novartis imatinib was first imported from Switzerland, it cost more than 2 a box, and it was not covered by medical insurance, which forced many slow-grained patients to buy imatinib from India. The story of "I'm Not the God of Medicine" comes from pharmaceuticals.

Now imatinib is included in the medical insurance, and the price has dropped to more than 4000 yuan. Qianqian only needs to pay more than 1000 yuan a month at his own expense.

Professor Zheng separated his fingers against each other, patted the table with his right hand, and said to Yu Wenhao:
"This is a world-class drug, and the company's pricing must consider the global pricing system. According to the price of this drug, a slow-grain patient needs about 45 yuan a year. But other companies, considering the actual payment ability of domestic patients, have A third-party patient assistance plan, several of my patients, through our application for him, the annual drug fee is about 18.

"Moreover, the National Medical Insurance Bureau has included them in the drug price negotiations. As long as the drug is included in the medical insurance, it will not be a problem for most patients."

"Yeah, Professor Zheng, it's 18 yuan, and you can use it for Qianqian. Before it's included in the medical insurance list, you'll have to pay for it yourself now." Yu Wenhao said.

"I know that for Qianqian's sake, you will try to give her treatment. It's not that I don't use it for her, but there is a special situation."

"What special circumstances?" Yu Wenhao asked.

"This drug is currently used by adult patients with reliable data support, but there is no clinical research data for the following patients." Professor Zheng said, "I have contacted them, and they told me that research in this area has already begun, but As far as the current clinical progress is concerned, no specific data can be provided."

Yu Wenhao understood, he sighed: "Then you just drew a cake for me."

"No, what's the cake, the medicine is there, and the real curative effect is also there. I didn't provide the clinical research data of the following patients, just saying that its side effects on teenagers have not been fully understood. Once there are research data in this regard, our doctor I know how to guide the medicine."

Professor Zheng looked at Yu and said hello, and said to him:
"Why are you so anxious? There are more than 400 million leukemia patients in the country, half of them are teenagers. Do you think pharmaceutical companies will let this market go? They will definitely speed up their progress and make up for this. Don't worry. Waiting for the progress of other pharmaceutical companies, while waiting for a perfect match, I will not use my identity as a doctor, but as a friend to tell you that Qianqian will definitely wait."

Yu Wenhao nodded, he pondered for a while, and asked Professor Zheng:

"Is it possible, Professor Zheng, for example, under your guidance, we can start giving Qianqian this medicine now?"

"I think too, and I want Qianqian to be able to use it right away."

Professor Zheng and Yu Wenhao said:

"But I dare not. This is responsible to you and Qianqian. Before the side effects of this drug on teenagers are fully understood, I have no way to give medication guidance, otherwise, the consequences it causes cannot be controlled. It is also irreversible. I can't take this risk, Qianqian's current situation is not worth taking this risk, or wait."

　Thank you for the reward at 1977 o'clock in the middle of the night, two fish up and down, Xinghai Bookworm [-]!Thank you Sand Mood and Brother Sanpi for your monthly pass!Thanks for all the votes and reading!I wish everyone good health!

　　
　
(End of this chapter)