This doctor has a system

Chapter 310 299. Hannuo Medical
Although employees have not been asked to work crazy overtime recently, the progress has not fallen far behind, which makes Hu Jiaran a little confused.

Could it be that all my employees used to work overtime to catch fish?
Next month, the research and development process will enter preclinical testing, also called animal testing.

This step is to subject a newly discovered compound to laboratory and animal testing to prove that the compound has biological activity against a specific target disease and to evaluate the safety of the compound.

When a compound passes preclinical testing, a new drug clinical investigation application needs to be submitted to (C) FDA so that the compound can be used in human trials.

If the FDA does not reject the application within 30 days after submission, the new drug clinical research application will be deemed valid and human trials can be conducted.

The new drug clinical investigation application needs to provide materials from previous trials; and a description of where, by whom and how the clinical trials are planned to be conducted; the structure of the new compound; the method of administration; any toxicities found in animal testing; and the manufacturing and production of the compound. Condition.

All clinical protocols must be reviewed and approved by the Institutional Review Board.The progress and results of clinical trials must be reported to (C) FDA and IRB once a year.

This means that the next research and development process can truly determine the life or death of this new drug.

Hu Jiaran's originally relaxed mood gradually became tense. This is the first new drug developed by the company. If it succeeds, everything will be fine. If it fails,
The blow to morale was huge.

Thinking of this, he decided to go to the boss again, and now Gao Feng was his guiding light.

"I was about to call you." Gao Feng was very happy to see him coming, "I have a new idea."

"Is it about new drugs?" Hu Jiaran asked quickly.

"That's not true," Gao Feng said. "It's a new project and it's very promising in China."

"Once it is implemented, not only will the company gain huge benefits, but it will also improve the ability of domestic hospitals to treat critically ill patients to a higher level."

Hearing that it had nothing to do with the research and development of new drugs, Hu Jiaran was a little uninterested. He was now fully focused on this and didn't want to worry about other things.

"If this is developed, it will be a major event that can change the domestic medical field." Li Youliang said on the side, "Why are you not excited at all?"

"Oh, I have this new drug in my mind right now, and animal experiments will be conducted next month. How can I have time to get excited?" Hu Jiaran said.

"It can be done simultaneously. In fact, the development of ECMO is not difficult." Gao Feng said with a smile, "After all, there are finished products abroad, and we all have reference materials."

"Yes, grab it with both hands, both hands must be hard." Li Youliang said, "Jiaran, you can draw a team of people out, and we can start at any time."

Hu Jiaran

He regretted coming here now.

Gao Feng was not joking. The more he thought about it after he returned, the more he realized that ECMO was very important and crucial to the treatment of critically ill patients.

If a small and portable ECMO device can be developed, it will not only improve the domestic treatment of critically ill patients, but it will be of immeasurable significance to the world.

If the price can still be brought down, that would be even better. His name Gao Feng will surely be resounding across the country.

Now that he has money and a happy family, it seems that his fame is not enough.

People must have pursuits, otherwise they will be useless.

After returning home, he dug around in the system space for a while, and finally spent 240 skill points to redeem the detailed manufacturing methods for extracorporeal membrane oxygenation (ECMO) and portable small extracorporeal membrane oxygenation.

ECMO mainly includes intravascular cannulation, connecting tubes, power pump (artificial heart), oxygenator (artificial lung), oxygen supply tube, monitoring system and other parts.

Among them, the power pump (artificial heart) provides power to drive blood to flow in the pipes.There are two main types of power pumps clinically: rolling pumps and centrifugal pumps.Rolling pumps are difficult to move and difficult to manage.

The centrifugal pump is the first choice for first aid. The advantage is that it is easy to install and move, easy to manage, and has little blood damage.

This is a difficult point, but it can be completely solved with the current methods. The technology Gao Feng exchanged in the system space is more advanced and uses a fully magnetic levitation centrifugal pump.

This centrifugal pump optimizes fluid dynamics, while this fully magnetically levitated centrifugal pump reduces blood stagnation areas with minimal friction and shear stress.

Significantly reduces hemolysis compared to standard vortex bound centrifugal pumps.

What really stumps domestic manufacturers is the oxygenator (artificial lung), which oxygenates the input blood and outputs oxygenated arterial blood.

Oxygenators are divided into two types: silicone membrane type and hollow fiber type. The silicone membrane type has good biocompatibility, but it is difficult to synthesize materials that meet this standard and its service life is too short.

Li Youliang carefully asked his seniors who worked at Medtronic, and they told him that several domestic medical device manufacturers were developing ECMO, but they were all stuck at this step.

The oxygenator they developed was not only expensive, but also had a very short lifespan. It was simply unable to compete with McVision and Medtronic.

This is a life-saving thing. It is impossible to replace parts repeatedly, and it is obviously not good if the quality is not up to standard.

"There is a domestic medical device company called Hannuo." Li Youliang said, "They are the most active in investing R&D funds in this area, but they have not seen any big results."

In fact, Hanno Company is currently in huge trouble.

"I was strongly opposed to it from the beginning." Kang Heng, the vice president of Hannuo Company, had a gloomy face. "How can we possibly make such a high-tech thing!"

"It's fine now. More than 2 million yuan was invested, and not even a splash came out!"

"The company's capital chain is about to be broken. How will this end?"

General Manager Ding Jiantong's face didn't look good either. This matter was promoted with his strong support. It was originally fully evaluated and he thought some breakthroughs could be achieved.

However, they still overestimated the capabilities of the company's R&D team, or underestimated the difficulty of developing oxygenators.

The current situation is very anxious. There is no hope for moving forward. Stopping the project means that the efforts of the past few years have been completely wasted. It is really a dilemma.

"Cousin, if it doesn't work, let it go." Kang Heng said to Ding Jiantong, "It's still too late to let go. The company can always slowly recover."

"If we continue to fight to the death, let alone the company disappear, I will probably be in debt."

"You have to think about your family."

Hearing what his cousin Kang Heng said, Ding Jiantong was shaken. Yes, if he keeps going on, he might really go bankrupt.

The two were originally from a well-to-do family, but after they jointly established Hanno Medical, they were on the rise. When luck came, no one could stop them, and soon their net worth exceeded tens of millions.

After years of hard work and hard work, the company has developed smoothly, and the two of them can be called successful people.

At this moment, Ding Jiantong still regretted investing too much in ECMO research and development. He felt heartbroken when he thought that all his money was wasted.

"Boss, the project cannot be stopped." Mu Yongde on the side persuaded him, "We can reduce funding, but we still have to move forward!" He is the general person in charge of the ECMO R&D project, and it is precisely after following his advice that Ding Jiantong Only then did he grit his teeth and invest more than 2 million in it.

"Shut up!" Kang Heng was very dissatisfied. "Anyway, the company doesn't belong to you, so you won't feel bad if you lose everything."

"Cousin, you can't put any more money into it. This is a bottomless pit."

"Besides us, there are several companies doing this. Do you think any of them have produced results?"

"It won't work at all! The gap between us and foreign medical companies is still irreparable."

"Boss, I don't agree with Mr. Kang's opinion." Mu Yongde also gave up at this time, "Our company seems to be developing well in recent years, but that's just an appearance."

"We don't have anything unique of our own at all. We just follow others in everything we do."

"In the past, the environment was great and everything was possible. But that will definitely not be possible in the future."

There have been too many new registrations of medical companies in recent years, all of which are homogeneous. A medical company without its own core products is destined to be eliminated.

Ding Jiantong also saw this and supported Mu Yongde in the research and development of ECMO equipment. However, it was obvious that they were about to face failure.

"Old Mu, it's not that I don't have vision." Ding Jiantong lit a cigarette for himself, "I completely understand your idea, but the strength of our company does not allow it!"

“If you don’t have core competitiveness, you may be eliminated by the market in the future.”

"But if we continue to throw money into this project, I feel that Hanno will be gone before long."

Mu Yongde was a little silent. What the boss said was actually good. In fact, he had no definite confidence in future research and development, but it would be a pity to abandon this project now.

They have successively conquered intravascular cannulation, connecting tubes, power pumps (artificial hearts), oxygen supply tubes, and monitoring systems. The parameters of intravascular cannulation are even better than those of imported products from abroad.

Pity!
"Let's put it this way, the research and development of ECMO equipment will be put on hold for now." Ding Jiantong took a deep puff and put out the cigarette. "Let's contact our colleagues to see if we can sell the valuable piece."

"Don't we say that our intravascular cannula has many advantages? Sell it to them."

"Or contact Medtronic. Didn't they send someone over to discuss it before?"

At that time, the other party offered a high price, but Hanno rejected it.

"Okay." Mu Yongde sighed. Since the boss has made a decision, he can only implement it with all his strength.

Just as he was about to go out, the secretary in black stockings knocked on the door and walked in. Kang Heng couldn't help but take a few glances at his beautiful legs. He liked it.

He wanted this secretary at the beginning, but my cousin also liked this
"Mr. Ding, someone from a company called Fengxin Technology wants to visit you."

"Fengxin Technology?" Ding Jiantong thought about it carefully in his mind, but seemed to have no impression.

"Did you say what happened?"

"It seems to be about the research and development of ECMO equipment. The other party said that they want to cooperate with us." The black silk secretary was not sure, and this is not her usual job.

"what?!"

"Hello, Mr. Ding, I, Zhao Xingye, come from Fengxin Technology." Zhao Xingzhen took the initiative to hand over his business card, "I'm taking the liberty of paying you a visit, please don't take offense."

"I wonder if Manager Zhao will come here and give you some advice?" Ding Jiantong said with a smile.

Zhao Xingye is on a business trip here these days. The degradable occluder is about to enter the clinical trial stage. He needs to communicate with Pule Medical again on some details.

Originally, he thought of contacting Hannuo Medical by phone first, but after asking about the other party's situation, he decided to pay a visit directly.

"Our company is very optimistic about ECMO equipment." Zhao Xingye said, "I heard that your company seems to have done a lot of work in this area, so I made a special visit to see if there are any opportunities for cooperation."

Ding Jiantong had several thoughts in his mind at once.

"I wonder how your company would like to cooperate?" he said. "We at Hanno Medical have invested a lot of money in the research and development of ECMO equipment, and we have achieved good results so far."

"It may not be what we want if your company joins us at this time."

"Really?" Zhao Xingye smiled, "But I heard that your company is currently facing a shortage of funds, and the ECMO equipment research and development projects have been axed."

"Mr. Zhao, where did you get the news?" Ding Jiantong's expression changed slightly, "I can tell you responsibly that this is completely false news."

"This must be a malicious attempt by our colleagues to slander us!"

cut!Zhao Xingye was very disdainful. Everyone is a thousand-year-old fox. Why are you pretending to be a human being in front of me?
As long as you inquire about the current difficulties faced by Hanno Medical, you will know that there are huge differences of opinion within them regarding the research and development of this ECMO equipment.

Zhao Xingye was afraid that if he arrived a little longer, Hannuo's ECMO equipment research and development project would no longer exist.

This is obviously not in the interests of Fengxin Technology.

"Mr. Ding, we don't speak secretly." Zhao Xingye said with a smile, "We would like to reach a specific cooperation with your company. I wonder if your company is still willing to continue to promote this project?"

"Well." Ding Jiantong was a little hesitant, "Let's do this. I'll discuss it with everyone when I go back and give you an answer tomorrow at the latest."

"Okay, I'll wait for Mr. Ding's reply." Zhao Xingye said goodbye.

Ding Jiantong quickly gathered the company's decision-makers. The research and development of ECMO equipment is related to the company's next strategic direction. Whether to give up decisively or continue to invest requires a decision as soon as possible.

"I object!" Kang Heng was the first to express his opinion. "The other party must not have made any achievements in this area, otherwise they would not come to us."

"I don't think there will be any surprises when working with the other party,"

"I agree with Mr. Kang's opinion. The company's current situation is not optimistic." Someone echoed, "We need to change the track in time."

"Yes! There is no need for a small and micro company like ours to invest so much money in research and development. That is something that only large companies can do."

"Why don't we just follow the big companies and pick up the rest? Some soup and water are enough for us."

It makes sense, but it sounds so disgusting, Kang Heng thought.

(End of this chapter)