This doctor has a system

Chapter 346 417. Brothers, let’s do it!

Liu Xianfeng? Why does this name sound so familiar?

Li Guanghui was stunned for a moment. He quickly ran to the bedroom and took out a piece of information, which was his mother's hospitalization medical record from two years ago.

At that time, my mother was diagnosed with intestinal cancer at Xingya Hospital and underwent surgery.

Li Guanghui flipped through the medical record, and the surgeon's signature inside was clearly written in three big characters: Liu Xianfeng.

He couldn't help but have an unknown premonition in his heart, so he hurriedly told the whole family about the matter.

"No way? I think Director Liu is pretty good." My mother didn't want to believe it. She had been in good health since the surgery, and she was very grateful to the surgeon.

"Yes, you can't just listen to the news and believe it." My wife said, "These media are always doing things that are based on rumors and rumors."

My father also felt that there was no need to pay attention to this matter. "Your mother is in good health. She recently went to the hospital for a review and nothing happened. I don't think there is any need to pay attention to this."

Old people are like this. As long as their current life is okay, they are generally unwilling to waste energy on anything.

But Li Guanghui is a more serious person, and he feels that he should go to Xingya Hospital to see if there is any problem with this matter.

In response to Li Guanghui's inquiry, Xingya Hospital quickly responded, saying that the pathology report had indeed been tampered with and asked him to keep the information.

"This matter is quite complicated, and the hospital has nothing to say now." The person who received him said, "Let's wait until the investigation team issues a specific conclusion."

From his words, Li Guanghui learned that problems have been discovered in at least 20 patients, most of whom have undergone laparoscopic da Vinci surgery.

Xingya Hospital's reputation in the industry suffered a heavy setback due to this incident, and the client, Liu Xianfeng, was also dubbed the "devil" and what awaits him will be severe punishment by law.

Many people in the hospital were punished, but Director Hou of the Medical Affairs Department suffered the worst. He was beaten to the end.

The reason is that the investigation team found that from March to June last year, many family members of patients went to the medical affairs department to report Liu Xianfeng. The reason was that he tricked the elderly into using the expensive Da Vinci robot even though ordinary laparoscopic surgeries could be performed. .

But due to various problems, no one has really pursued this matter.

Liu Xianfeng mostly selected patients who came from other places for medical treatment. He was sure that even if something went wrong for these patients, the cost of defending their rights would be very high and they would not be able to cause trouble.

And just as he expected, although there have been many problems in the past few years, he has basically solved them one by one.

"This Liu Xianfeng really should be shot." Li Youliang expressed his opinion while scrolling through his mobile phone. "It's a good thing he got it out this time. Otherwise, if he keeps doing it for a few more years, more patients will be harmed."

"Yes." Gao Feng also felt a burst of anger when he mentioned this, "The existence of such people is too serious for the medical industry."

The positive image that many medical staff have built up by working overtime to treat illnesses and save lives has been completely destroyed by him in just a few seconds, which is really frustrating.

Everyone here is in a bad mood, but Gong Fanshun's place in the capital is very lively. The clinical trials are progressing exceptionally smoothly, and everyone is full of expectations for the future.

"Look, you are absolutely right to listen to me and come here." Gong Fanshun said to Zhao Kang, "Our company has great prospects and the working atmosphere is relaxed. How can we find such a good place."

If he had known there was such a good company, he wouldn't have started his own business. If he started a der, wouldn't it be good to eat what the boss does and drink what the boss does?

Zhao Kangshen thought so. Not to mention other things, his salary alone had increased a lot. The future is promising!

A few people here held a small gathering today. After a few glasses of wine, everyone talked a lot, and the eldest brother and the younger brother started shouting.

"We are now partners under Brother Gong. We should keep in close contact when we go back in the future." A team member raised his glass and said, "I will express my attitude to Brother Gong first."

"We are brothers in our hearts, but we can never get through on the phone!"

Zhao Kang almost spit out his drink.

"You're the elder brother, you're the younger brother, I don't care what happens to you!" another team member said.

"My brother and I are from the same family. When my brother gets beaten, I pretend to be blind," someone shouted.

"We are all afraid that our brothers will have a hard time, and we are even more afraid that our brothers will drive a Land Rover!"

"I feel like they are all stupid." Zhao Kang said to his senior brother. He felt that he was a bit out of tune with the company's culture.

"Brother is here, I call you sister-in-law, brother is not here, I call you Bao." Gong Fanshun also picked up the wine and shouted loudly, "Come on, brothers, let's do it!"

Zhao Kang.

Junior brother Zhao Kang is a talent. Gong Fanshun has always believed that talent can shine dazzlingly wherever he goes.

"Has the data been processed?"

"Yes, very simple things." Zhao Kang replied that these were not difficult for him at all. He even had time to help the clinical trialists here design a data processing software.

The data entry work that originally took three people several hours to complete every day now only takes one person more than 3 minutes to complete.

The key is that Zhao Kang is not a computer-related major, this is just the result of his own study.

Gong Fanshun even felt that it was a bit humiliating to put his junior brother here. After all, the main force of clinical trials here are medical staff, and they only do auxiliary work. But how can I put it, if Zhao Kang is transferred back to Z State, he will definitely be disagree.

Zhao Kang's daily job is to use instruments to analyze the drug concentration and excretion properties in the patient's blood in order to obtain information on the highest and lowest doses of the drug and determine the appropriate dose for future use on the patient.

Third-generation TKI preparations are anti-tumor drugs. Generally speaking, the patients selected are drug-resistant lung adenocarcinoma patients, and Cao Huiling is one of them.

She was a nurse and had been working in orthopedics until she became ill. Two years ago, Cao Huiling had a chest CT during her physical examination and found a mass in her right lung. After further examination, she was diagnosed with advanced lung adenocarcinoma, with metastases in the supraclavicular lymph nodes and head.

She has been taking gefitinib tablets, a first-generation targeted drug, which has become resistant and her tumors have progressed. The doctor in charge recommended that she undergo chemotherapy.

But after only two cycles of chemotherapy, Cao Huiling couldn't hold on anymore. Her hair fell out, and she suffered from severe nausea and vomiting. She lost more than 2 kilograms in the past two months. If she hadn't had some fat reserves before, I guess they are no longer human.

As she couldn't endure the chemotherapy, her family planned to switch her to third-generation osimertinib mesylate. However, the latter has just been launched and has not yet been included in medical insurance. The high price puts her off.

And she felt that since the tumor was already in the advanced stage, it would not be appropriate to continue spending money on herself. It's not easy for children to make money. It doesn't matter if she dies, but the living still have to live.

When she was about to give up, a colleague recommended this clinical trial to her. After hearing that it was a TKI preparation similar to osimertinib, Cao Huiling ignited a little hope in her heart. She still had the desire to survive, so she came to the capital with her husband.

With the help of colleagues, enrollment went smoothly, and Cao Huiling was soon taking the experimental drug.

"How do you feel? Are you feeling uncomfortable?" the doctor asked.

"I have a little diarrhea, but it's not severe." Cao Huiling said.

The doctor who made the rounds noted down that the dose of medicine Cao Huiling took was relatively large among the test group. Several patients who took similar doses to hers had some symptoms of diarrhea, but it was not serious.

"This drug is still very safe." The ward rounds doctor reported to the superior doctor, "Currently the main adverse symptoms are mild rash and diarrhea."

"Safety alone is of no use." The superior doctor smiled, "Only if it has an effect on the treatment of tumors, otherwise it is all just talk."

Although it is only the first clinical phase, the therapeutic effect of anti-tumor drugs can also be seen at this stage, especially targeted drugs.

Many people don’t quite understand the difference between targeted drugs and chemotherapy drugs. In fact, there are essential differences between the two.

Chemotherapy drugs in the traditional sense mainly refer to cytotoxic drugs, which are lethal chemicals. Chemotherapy drugs are like bombs, killing tumors and normal tissues regardless of friend or foe.

In addition to its killing effect on tumor cells, it is also toxic to many normal tissue cells that are also dividing vigorously. As long as tissues that grow relatively quickly will be affected, they are highly toxic.

Mainly manifested in gastrointestinal reactions and blood toxicity, targeting white blood cells, platelets, gastrointestinal mucosa, hair follicles, etc. Chemotherapy drugs often cause some related side effects.

In short, it's a matter of shooting and killing the first bird, whoever is active will be killed!

In theory, targeted therapy drugs are like missiles. They have targets and are accurately positioned. They only target a specific target, have little effect on normal tissues, and will not cause chemotherapy-related side effects.

But you need to do necessary genetic testing first to see if there are corresponding targets. Targeted therapy drugs have relatively low toxicity, mainly manifesting as skin toxicity and diarrhea.

If economic conditions are not a problem, targeted therapy is definitely the first choice.

What’s more, it’s worth mentioning that targeted drugs work quickly, and some patients can even see obvious results in half a month.

Cao Huiling has been taking the medicine orally for 28 days. According to the scheduled plan, she will have a chest CT today to see if the lung lesions are different from before.

If the lesions shrink, everyone is happy. If there is no change or progression, many patients may ask to withdraw, which will also cast a shadow on later clinical trials.

After all, drugs that have no therapeutic effect have no research value at all.

"Brother, you think there should be no problem, right?" Zhao Kang was a little worried.

"Don't worry." Gong Fanshun looked relaxed. He had already communicated with the doctors in charge of each group for ventilation in advance. According to everyone's clinical experience, this drug is definitely effective.

Some patients with severe cough and chest tightness feel that their clinical symptoms are significantly relieved after taking the medicine.

"Hey, the lesion has really shrunk." Cao Huiling's doctor in charge was very happy. He pointed at the film and said to the patient, "The previous area can no longer be seen, and the original lesion has become smaller by nearly 2/3!"

The data was quickly compiled, and Gong Fanshun was happy when he saw the final conclusion.

"Mr. Hu, great news!"

"Has the conclusion been drawn?" Hu Jiaran perked up, "Say it quickly!"

"93% of the patients were effective, and the lesions were reduced to varying degrees." Gong Fanshun reported excitedly, "The remaining 7% of patients who were ineffective were taking the lowest dose orally. It should be that the drug concentration in the body could not reach ."

"Okay! Okay!" Hu Jiaran was overjoyed. The results of the first phase of the clinical trial completely exceeded his expectations. In this way, there should be no problems with the second phase.

As long as the effectiveness and tolerability of the Phase III drug are confirmed, the drug will be considered a success!

Thinking of this, Hu Jiaran felt a burning sensation in his heart. If the drug could be successfully launched in the end, he should be able to take it directly in his life.

"Dr. Gong, you must keep an eye on me over there." He explained, "I will apply for a fund later and you will give it to everyone."

The emperor is not short of hungry soldiers, and Hu Jiaran has always done a good job in this regard. The funding application went very smoothly. After Zhao Xingye learned the reason, he even took the initiative to approve more requests, which Hu Jiaran was not used to.

Gao Feng also got the good news quickly, but he didn't feel any excitement. After all, it was expected and it was difficult to cause emotional fluctuations.

It's different here at Xinhua Pharmaceutical. Mr. Jiang from Xinhua Pharmaceutical has been smiling crookedly these days. He is always happy to see everyone, and some uninformed employees thought his wife was gone.

"Huiren, it has to be you!" Mr. Jiang patted Qi Huiren hard on the shoulder, "The company will never forget your contribution to this matter."

"Are you still used to working in the R&D department?" He asked with concern, "Do you have any requirements?"

"I'm quite used to it." Qi Huiren quickly replied, "Mr. Jiang, you have been very kind to me. I don't have any requirements."

Can you get used to it? He couldn't get involved in the R&D department, so he never went there. It was a white-collar salary. As for requests, it's best to think carefully when your boss asks you to make a request. He may just be polite, but it won't be good if you take it seriously.

Mr. Jiang nodded with satisfaction, yes, the young man knows how to advance and retreat.

"I heard that you live quite far away." He said, "Isn't there a staff apartment here in the company? I'll ask the logistics department to allocate one to you."

Qi Huiren was overjoyed. Although the staff apartment was not large in area, every inch of land here was very expensive. Only middle-level and above leaders with senior qualifications were always eligible, and his teacher had a way of doing it.

Although there is no real estate capital, it can be traded privately to other employees of the unit. With one word from Mr. Jiang, Qi Huiren instantly gained an additional 60 to 70 yuan in income.

"Isn't this appropriate?" Qi Huiren was overjoyed, "Thank you, Mr. Jiang, for nurturing me! Huiren will work harder in the future and do his best to repay your kindness!"

"It's to serve the company." Mr. Jiang corrected with a smile.

"Mr. Jiang, you represent the company in my heart. Without you, Xinhua Pharmaceutical will have no future." Qi Huiren said sincerely.

Mr. Jiang looked at his sincere eyes and suddenly felt that he should put more responsibilities on the young man in front of him. Isn't it said that cadres should be younger? He now feels that Xiao Qi is very good.

(End of this chapter)