Conan: The Mechanic

After telling the story, Fujioka Takamichi stood up and turned on the light. "Don't worry too much, kids, this germ is dangerous, but we're on an airship right now, and it's not very contagious and shouldn't be able to infect us."

"Qianyu, what did he just say?" Mitsuhiko asked impatiently. "What gram stain, gram positive bacteria, cefazolin, vancomycin, etc..."

"Well, if you have to ask all these..." Qianyu raised her eyebrows and looked at Haibara Ai. "Are you here?"

"Briefly, Gram staining is a means of distinguishing between the types of aerobic bacteria, by which aerobic bacteria can be divided into two types: Gram-negative and Gram-positive," said Hai Yuan. Ai explained succinctly. "Cefazolin is a common antibiotic against Gram-positive bacteria, and vancomycin is a heavyweight last-minute antibiotic against Gram-positive bacteria."

"Is vancomycin very powerful?" Mitsuhiko asked.

"Very powerful," Hai Yuanai nodded. "So far, the example Mr. Fujioka said should be a very rare vancomycin-resistant bacterium in the world - if it didn't work because vancomycin didn't have time to penetrate the body."

"What about drug resistance?" Ayumi asked this time. "Why do bacteria develop resistance to antibiotics that kill them? Aren't antibiotics their nemesis?"

"In the end, they're just drugs," Haiyuan shook his head with a sad smile. "Antibiotics don't have eyes, they can't see what's bacteria and what's not, and can only rely on some special ingredients they carry with them to identify and come into contact with bacteria. But if bacteria somehow prevent antibiotics from identifying them or coming into contact with them , then antibiotics will not be able to show their power at all - for example, vancomycin works by passing D--D-(D-alanine-D-alanine and D-D-(D-alanine-D-alanine), the precursor of the bacterial cell wall ) bind to catch the bacteria, and then it can work. Once the precursor changes in something that prevents the vancomycin from binding to the precursor, then the vancomycin is useless.”

[Author: In reality, VRB--resistant bacteria (vancomycin-resistant bacteria) is because the structure of the precursor pentapeptide of the cell wall has changed, so that the vancomycin that prevents the synthesis of the cell wall by binding to the end of the pentapeptide is almost ineffective. It is possible that recombination with this D-alanine-D-alanine terminus resulted in resistance to vancomycin. The current way to deal with this drug-resistant bacteria is to combine the bipyridyl and vancomycin to form a bipyridyl vancomycin conjugate, and the bipyridyl and the zinc ion in the bacteria can form a complex, so that Vancomycin will be attached to the bacteria by the bipyridyl group, and it can still continue to achieve the bactericidal function. 】

(If there is a simple way of saying that, vancomycin needs to be hung on the bacteria to take effect, and the drug-resistant bacteria cannot be hung on the vancomycin due to mutation, and then the improved version of vancomycin is holding a Some part of the strong adhesive glue glove, and then the vancomycin can be successfully hung up and the resistant bacteria can be hanged)

"What does that mean..." Yuan Tai was stunned.

This explanation may be able to be understood by Chiba, Conan or Fujioka Takamichi, but it is indeed too difficult for these children.

"Let me give an example," Qianyu sighed. "Like, I'm Vancomycin, and Shirahara is—"

Chiyu's words were cut off instantly after Haibara Ai glanced at him.

"Well, if the cops are vancomycin and the average bad guys are normal bacteria, then the cops just have to figure out a way to find these bad guys, grab them, handcuff them, and the bad guys are done. Do you understand that? "

Genta, Ayumi and Mitsuhiko nodded.

"However, now there are bacteria that are resistant to vancomycin, such as the phantom thief Kidd or something." Chiba spread her hands. "Phantom Thief Kidd's action is very strong. Even if the police encounter Kidd by chance, Kidd can get rid of them through his own action, so the police can't catch Kidd at all, let alone handcuff Kidd."

"You mean, those resistant bacteria won't be caught by vancomycin?" Mitsuhiko asked tentatively.

"That's right," Qianyu nodded. "Do you understand this step?"

"Yeah!" Yuan Tai and Ayumi nodded.

"Then, now, we have equipped the police with a big fishing net," Chiba continued to explain with a brain-drilling idea. "This fishing net is very large and strong. As long as the police encounter the phantom thief Kidd, throw the net out to catch the phantom thief Kidd, and he can no longer escape. He can only be honestly trapped by the police. Handcuffed."

"I think I understand?" After another fifteen seconds, Mitsuhiko asked uncertainly.

"In short, that's about it..." Qianyu sighed. "If I continue to explain it, I may go crazy... If you still don't understand, come to me after takeoff tomorrow, I should have the mind to continue to break it up and explain to you... I hope you can understand what I said. What is it, I don't need to say it again..."

"Children~www.readwn.com~ At this moment, Fujioka Takamichi, who had been watching Haibara Ai and Chiha, spoke up. "You should learn from their two children—perhaps you should learn from the one next to you, who is not even the slightest bit. Confused boy with glasses, the three of them have a lot of knowledge reserves. Talents like them will be very popular in the future whether they go to school or grow up. You must grow into a knowledgeable person like them! "

…………

On the way out of this room, Chiba took the initiative to find Ai Haibara.

"This drug resistance is too abrupt, isn't it?" Qian Yu asked with a frown. "How come a strain that is completely resistant to vancomycin suddenly appeared?"

As biological common sense, the emergence of drug-resistant strains comes from gene mutations that are carried out all the time, and the change of drug-resistant strains comes from the screening of drugs-if there are 100 bacteria, one of them suddenly mutates into a resistant strain. drug-resistant strains, then only 1% of the bacteria are drug-resistant strains. But if these bacteria are now dripped with antibiotics, then except for the only one resistant strain, all the bacteria will die, and there will be only one resistant strain left, so that all the bacteria are resistant strains.

In other words, according to the laws of nature, they should find that vancomycin can kill the vast majority of bacteria perfectly, but it is ineffective against Gram-positive bacteria in a very small number of patients.

Now, however, the vast majority of bacteria are not fatally hit, suggesting that the proportion of these bacteria resistant to vancomycin may be very high.

Under natural circumstances, this is almost impossible, unless...

"What do you mean, these strains were artificially released after they developed enough drug resistance?" Haibara frowned.

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