God-level academic master: My knowledge is the sum of all my students’ knowledge!

In early June, in

Jinling Medical University, in the professor’s office,

Zhou Jin flipped through the latest issue of Cell, one of the world’s top academic journals.

Every paper published in Cell represents the most cutting-edge level in today’s medical field.

After reading a few papers, he secretly admired them.

The quality of these papers is very top-notch.

Suddenly… a paper titled”A new generation of immune checkpoint inhibitors is about to emerge” caught his attention.

The author of the paper is Zhao Yan, a student from Suzhou University in Xiaguo.

In the paper, Zhao Yan and his team found that

NKG2A antibodies, as a new type of immune checkpoint inhibitor, can potentially promote the anti-tumor ability of T cells and natural killer cells (NK cells), and when combined with existing cancer immunotherapy, can better treat cancer patients.

The key to this study lies in a receptor molecule called NKG2A.

Zhao Yan’s team found that blocking this receptor can enhance the immune activity of NK cells and T cells in mice, thereby improving anti-tumor immune responses.

To this end, they developed an NKG2A antibody called Monalizumab.

It is a humanized monoclonal antibody.

In the experiment, Zhao Yan’s team divided the mice into four groups. The first group of mice was given only Monalizumab monoclonal antibody, the second group of mice was given only PD-L1 monoclonal antibody, the third group of mice was given a combination of Monalizumab monoclonal antibody and PD-L1 monoclonal antibody, and the fourth group of mice served as the control group.

These mice were previously inoculated with B-cell lymphoma cells by subcutaneous injection.

They found that compared with the control group, only PD-L1 monoclonal antibody could allow up to 40% of mice to survive, and Monalizumab monoclonal antibody alone did not bring significant anti-cancer effects, but the combination of these two monoclonal antibodies could allow up to 75% of mice to survive, which revealed that the combination of NKG2A monoclonal antibodies has a strong anti-cancer potential.

In human clinical trials.

Zhao Yan’s team divided 30 patients with squamous cell head and neck cancer into multiple groups and gave them different doses of Monalizumab monoclonal antibody.

The results of clinical trials showed that

Monalizumab monoclonal antibody is very safe, and the most common adverse reactions are fatigue, fever and headache.

As can be seen.

As a new type of immune checkpoint inhibitor.

NKG2A antibody can promote anti-tumor immune response by enhancing the activity of T cells and NK cells, as a supplement to the first generation of cancer immunotherapy.

After reading the whole paper,

Zhou Jin was amazed.

The paper of Zhao Yan’s team is of very high standard.

Obviously, the Cell journal also took this into consideration and published this extremely valuable paper.

……

Next,

Zhou Jin continued to read the Cell journal. He was stunned to see that many of the authors of the papers in this week’s journal were from Suzhou University.

《Cell: Transduction pathways from nasal mucosal sensory nerve fibers to brainstem respiratory nuclei》——First author of the paper: Liu Qi (Soochow University)

《Cell: New map provides new insights into how genes work in early embryonic development》——First author of the paper: Tong Rui (Soochow University)

《Cell: New study reveals the mechanism by which ARID1A gene mutation makes cancer patients sensitive to immunotherapy》——First author of the paper: Huang Teng (Soochow University)

《Cell: Using Perturb-seq technology to explore brain cell types associated with key developmental genes on a large scale》——First author of the paper: Guo Fei (Soochow University)

《Cell: With aging, hematopoietic stem cells produce highly reactive secondary platelet skirts, leading to increased coagulation》——First author of the paper: Fang Lingling (Soochow University)

……

In this week’s journal, there are at least 15 medical papers by students of Suzhou University.

Zhou Jin was speechless.

As a top academic journal with an impact factor of 33.116, every paper published is the most cutting-edge scientific research results in the academic world.

But now… students of Suzhou University seem to have 15 papers published as easily as eating and drinking water.

Are they so amazing?

……

With great curiosity, Zhou Jin quickly opened the latest issue of Nature and Science.

《Science: New research finds that NLRC5 triggers a wide range of cell apoptosis mechanisms》——First author of the paper: Shen Chao (Soochow University)

《Science: Primitive endoderm stem cells have amazing self-regeneration potential and can actually rebuild embryos》——First author of the paper: Li Mo (Soochow University)

《Science: Changes in mRNA levels in biomolecules and somatic cells affect the lifespan of different host individuals》——First author of the paper: Yao Le (Soochow University)

《Science: New research reveals how perivascular neurons build three-dimensional vascular structures to keep the retina healthy》——First author of the paper: Zhang Hao (Soochow University)

《Science: There are unexpected surprises for flatulence? Intestinal bacteria convert corticosteroids into progesterone derivatives in the presence of hydrogen, affecting women’s health and postpartum mood》——First author of the paper: Xia Qian (Soochow University)

……

《Nature: New research finds direct communication pathway between lungs and brain》——First author of the paper: Chen Yu (Soochow University)

《Nature: Lymphatic vessels play a key role in bone and blood cell regeneration》——First author of the paper: Chen Yu (Soochow University)

《Nature: Blocking the reactivation and spread of endogenous retroviruses can alleviate organismal aging》——First author of the paper: Chen Yu (Soochow University)

《Nature: Neonatal neutropenia may be caused by suppression of fetal hematopoietic stem cells》——First author of the paper: Chen Yu (Soochow University)

《Nature: Immunotherapy also has a golden time window! Revealing the importance of the circadian rhythm of the immune system to tumor growth》——First author of the paper: Chen Yu (Soochow University)

……

《Nature: Fetal cells can be traced back to the first day of human embryonic development》——First author of the paper: Wang Xu (Soochow University)

《Nature: Neutrophil responses associated with tumor control during immunotherapy》——First author of the paper: Xu Shi (Soochow University)

《Nature: Single-cell sequencing applied to construct spatiotemporal dynamic map of macrophage development》——First author of the paper: Dong Jun (Soochow University)

……

After reading a series of papers,

Zhou Jin was already amazed.

He roughly counted them.

In this week’s”Science” journal, there are 12 papers from students of Suzhou University.

In this week’s”Nature” journal, there are 20 papers from Suzhou University, 10 of which are from Chen Yu, an associate professor of Suzhou University, and the remaining 10 are from students of Suzhou University.

This is really too exaggerated!

……

At the same time, domestic experts and scholars were discussing Suzhou University.

Not counting Chen Yu’s 10 Nature papers, this week, Suzhou University students published 37 CNS papers, which is ridiculous!

Scholars were shocked and relieved.

What was shocking was that the academic level of Suzhou University students had suddenly improved dramatically, which was astonishing.

What was gratifying was that the higher the medical level of Suzhou University students was, the higher the academic level of the entire Xia country would be.

……

In contrast, the domestic higher education community has astonished students.

What’s going on?

This month, 37 medical papers by Soochow University students have been included in CNS journals?

In their general impression, students focus on GPA in their freshman year, competitions in their sophomore year, and papers in their junior year. If you have published an article in CNS journals during your undergraduate studies, you are a well-deserved academic master.

If you have published an article in CNS journals during your master’s studies, you are the mentor’s favorite son and the face of the school. If you have published an article in CNS journals during your doctoral studies, it is easy to go to a famous foreign university for further studies.

But these Soochow University students are all medical undergraduates!

Do you have to be so arrogant?

Are you all cheating?!