Super Chief

As for Jean Agust’s work, Shi Xiong had no other ideas but satisfaction.

　　 This is penicillin.

　　In this age, this thing is the magic medicine to cure diseases and save people! It can definitely exist side by side with vaccinia vaccination.

　　 You must know that in the original historical time and space, penicillin was hailed as one of the three major inventions during World War II. It was an invention that coexisted with mushroom bombs and radar.

　　 The plan for mass production of penicillin in the United States during World War II was second only to the Manhattan Project.

　　 If there is any regret now, it is the production of penicillin. But this is not a problem, as long as a way to purify penicillin is found, the increase in production is only a matter of time.

　　 "Let, how about penicillin experiments on animals?" Shixiong asked.

These words made Agust’s expression of excitement suddenly collapsed, “Boss, before purifying penicillin, we have done many experiments on animals with penicillin culture solution, but the effect is not very satisfactory. I think this It is directly related to the amount of penicillin in the culture medium. However, I think that if the purified penicillin is used to increase the dose for experiments, I think the effect will be better, but it is necessary to experiment with the proportion of penicillin."

　　'S words caused Shi Xiong to sigh inwardly.

　　 Sure enough, this penicillin is not that easy to handle.

　　 Don’t think I have found a way to purify penicillin, and I have also successfully purified penicillin, but just such a small amount is really not enough.

　　 Actually in the original historical time and space, when Fleming discovered penicillin, there were only two poor units of penicillin in a liter of penicillin culture solution. Calculated according to this concentration, if the daily dose of penicillin is estimated by intramuscular injection of 10,000 units per day, it is necessary to pour all the water from a 25-meter short-track swimming pool into the human body to have a curative effect.

　　 This is obviously impossible.

　　 But for penicillin to be effective, the dose must be increased.

　　 Although the culture medium used by AgustaWestland has been replaced with corn steep liquor and the dose of penicillin in the culture medium has been greatly increased, it still fails to meet the standards of clinical trials.

　　 At the time, Fleming was trapped by the inability to purify penicillin, and was unable to realize the transformation of penicillin from 0 to n.

Later, even after Australian pathologist Howard Walter Flory and German bacteriologist Ernst Chann found out how to purify penicillin, at first they were unable to fully exert the great efficacy of penicillin because of the production volume. .

After Flory and Chann found out how to purify penicillin at Oxford University, they began to hire many local girls to cultivate penicillin in various bottles and cans that can be found in Oxford University. It is said that at that time He turned Oxford University into a mold factory.

　　 Even so, the production of penicillin still cannot reach the point where it can be used clinically.

　　 But Flory is a real genius, he is not only proficient in pharmacology, but also an outstanding organizer.

　　 Flory knew that it was impossible to develop penicillin that could be used clinically by relying on his and Qian En's strength alone, so he recruited more experts to jointly study how to increase the production of penicillin.

　　Norman Heatley was among those whom Flory found. So Hitley developed an aqueous solution of penicillin and adjusted the pH of the liquid, which enabled penicillin to be used in animals and humans.

　　 But the penicillin obtained by this conventional method is still very small, not even enough to treat a patient with bacterial infection. So Flory began to seek help from the pharmaceutical factory. He first contacted the British pharmaceutical factory, but all the forces combined were not enough to solve the problem.

　　 So Flory and Heatley went to America for help, and they found the Rockefeller Foundation.

　　 The Rockefeller Foundation is rich. With the money, Flory quickly made breakthroughs in subsequent research.

　　 He used corn syrup instead of the original sucrose solution as the culture solution, which can increase the yield by 20 times.

　　 But the production has increased, and the penicillin strains are not enough.

　　 There are many kinds of molds in this world, some are easy to produce penicillin, some are not at all. In order to find new strains, Flory sent all the people in the laboratory out. As a result, an experimenter named Mary Hunt found a hairy melon on the fruit stand, and found that the yellow-green mold had grown to a deep level, so he brought it back.

　　 This yellow-green mold can refine penicillin very well, so after using new strains and corn steep liquor culture solution, the production of penicillin increased 20,000 times!

However, even so, the production of penicillin was still insufficient. Later, several major pharmaceutical giants in the United States joined in, and thousands of engineers worked together to finally increase the concentration of penicillium by nearly a hundred times, which achieved the requirements of industrial production. .

　　 Therefore, it is far from enough to successfully purify penicillin. How to increase the concentration of penicillium and the production of penicillin is the key.

But as soon as Shi Xiong thought of this, Agusta said: "Boss, we have found a way to cultivate a large amount of penicillin in the kind of melon you mentioned~www.readwn.com~The melon you mentioned is really cultivated. The good thing about penicillin, we no longer have to worry about the source of the strain."

After a pause, AgustaWestland continued: "Furthermore, we also use corn steep liquor as the culture medium according to the method you said at the beginning. The effect of this culture medium is also very good, and the cost is very low, which is fully capable of large-scale cultivation. The conditions of penicillin strains. Now that the problems of strains and culture media are basically solved, the next step is to figure out how to continue to increase the concentration of penicillin strains."

Shi Xiong nodded. He has told Agusta about all the methods he knows how to increase the production of penicillin. At least the output of Agusta’s purified penicillin has reached the threshold of industrialized mass production. If the concentration of penicillin strains is increased, then industrial production can be carried out.

　　 But this process should take a long time. After all, Shixiong does not know how the engineers of the American pharmaceutical giants in the historical time and space continue to increase the concentration of strains, and can only rely on the research team of Agusta to study bit by bit.

Thinking of this, Shi Xiong nodded and said: "Let, although breakthrough progress has been made, the conditions for industrialized mass production are still not available. Therefore, how to further increase the concentration of penicillin strains is your most important next step. You still have a long way to go. If you have any ideas, do it with confidence, don’t have any worries, what you need, I will do our best to satisfy you."

　　 Agusta nodded heavily.