Xueba is also open

Chapter 189 Doubts exist
With the previous foundation, Bai Ye is now able to deal with mouse genes with ease.

The research on the gene stability of KM mice must find a starting point. After searching countless information, Bai Ye found out the drugs made in those failed experiments. Perhaps these will be an opportunity.

It's just that those medicines are really not easy to find, Bai Ye spent a lot of effort to find the data of those failed experiments.

The next step is to stimulate under various experiments, hoping to find the RNA sequence of variation, transcription and translation may be the cause of the variation.

However, there was almost no progress in the subsequent research. Bai Ye could hardly find any mutation points, and these genes were very stable.

Shouldn't the genetic state be studied?
Will simply studying a gene sequence and studying it in mice have an ineffective effect?
During lunch, Dong Cunguang found Bai Ye.

"There will be an academic conference at the Hyatt Hotel tomorrow, I suggest you take a look."

At this time, Bai Ye was thinking about mice while eating and sleeping. Hearing Dong Cunguang's words, he raised his eyes and asked, "About what meeting?"

Dong Cunguang mixed his rice: "It was held by Lonka Company to promote SHR and its model mice. Many experts were invited, as well as the staff of the European Gene Bank. I think I can go and listen."

The experiment has come to a standstill, and Bai Ye still feels the need to listen to it, hoping to gain something.

The next morning, the two went to the Hyatt Hotel, paid 2000 yuan, and got two passes for the conference.

The lecture was held in a large conference hall, and the two of Bai Ye chose a good place in order to hear clearly.

On the first day of the conference, the keynote speaker was a domestic leader in the field of genetic engineering: Ph.D. supervisor of medical bioengineering: Zhang Shulan, who graduated from Johns Hopkins University with undergraduate and postgraduate degrees. Academy of Sciences, work in the field of bioengineering.

Zhang Shulan is good at gene splicing technology. Today, the main content of the talk is how to use molecular genetics as the theoretical basis and modern methods of molecular biology and microbiology as means to realize genes from different sources according to the pre-designed blueprint. The hybrid DNA molecules are extracted and constructed, and then introduced into living cells to change the original genetic characteristics of the organisms and obtain new varieties.

This is the use of modern means to break reproductive isolation and realize the development of genetic engineering.

Zhang Shulan spoke very seriously, especially focusing on those basic theories and the exploration of new ideas.

Zhang Shulan's lectures were very basic, and she didn't have much advanced and cutting-edge knowledge, but this kind of conference was not a professional academic conference, but a promotion of her own products in the name of an academic conference.

However, Bai Ye gained a lot. In two days, these experts and professors systematically sorted out the knowledge, which further consolidated Bai Ye's genetics, which was not solid.

On the third day of the meeting, which was the last day, it seemed that a few internationally influential celebrities came to the venue.

"Let us give warm applause to welcome Dr. Macalite from the European Gene Analysis Bank. Dr. Macalite has been engaged in mouse gene analysis for decades and has unique insights into mouse research..."

Dong Cunguang whispered to Bai Ye: "Macarat was one of the main expert members who conducted the SHR research at the beginning. His analysis of the SHR gene is very good, and he has basically completely analyzed it..."

Bai Ye nodded: "Then he didn't come up with the idea of ​​improving SHR?"

Dong Cunguang sneered: "When thoughts are covered by gold coins, knowledge begins to be biased."

"Furthermore, what Margaret is best at researching is to prove the advantages of SHR. He believes that SHR mice are the product of God because of the cultivation of hundreds of generations. Of course, the most important thing is that he has done many experiments on SHR mice. When the gene fragment for high blood pressure is implanted into other mice, it is difficult for those mice to show the general and stable high blood pressure performance like SHR. Of course, I hope to remain skeptical."

"However... gene mutations are indeterminate, including gene grafting. The obtained mice will produce different results according to individual differences, so they are not suitable for mass production and experiments."

Macalite mainly talked about SHR (essentially hypertensive) mice today. I have to say that he is very professional and has made a lot of efforts in the field of SHR's continuous development and innovation.

"Biological evolution is the most perfect genetic engineering. He can get the most suitable genes to change their biological attributes. After hundreds of generations of research in SHR, we have summarized the shortcomings of each time and expect to change from the perspective of genetic engineering. Of course. , this is a process, just like bioengineering is a developing discipline, we can only change when we constantly recognize new things.”

…………

Finally, Maccarette asked, "Do you have any questions?"

Everyone laughed and shook their heads, but at this moment, Bai Ye got up: "I want to ask, why did the first generation choose wistar mice instead of KM mice or guinea pigs?"

Everyone turned their heads to look at Bai Ye. Some were surprised, some were curious, some were dismissive, but some were thinking about this issue.

Macalite was taken aback, and looked at the person who asked the question with great interest. He had held meetings in Kyoto more than once, but he was the first person to ask this question: "This is an interesting question. Actually, I have also used The effect of other mice is not as good as that of Wistar. Generally speaking, the homologous genes of these mice are the same, and even many mice are obtained from hybrid genes. But here is a gene stability and recessive gene Expressive questions."

Bai Ye's eyes suddenly lit up. This was the first time he had heard about genetic stability.

Macalite continued: "It is well known that the gene stability of KM mice is the strongest, and the gene structure is not easy to mutate, and it may take more energy and cycles to cultivate mice with similar high blood pressure, and it is not necessarily possible to obtain such mice. 100% high blood pressure."

"But this kind of wistar mouse found that its gene stability is firm during the experiment, and the stealth gene expression is very good... I think this may be the reason."

Bai Ye kept digesting Macalite's words in his mind, and suddenly there was an idea in his mind: "wistar mice and km mice are very stable mice, and KM mice are also inbred mice. After breeding, there should be recessive gene expression, but why can't it be found? Could it be because of adaptability?"

Bai Ye then asked: "The gene sequences of Wistar mice and KM are not much different. Isn't the gene expression you said contradictory? If it is true to what you said, I would like to ask, what is the adaptability of the mice? Is the strong viability related to the selective expression of genes?"

As soon as Bai Ye finished speaking, there was an uproar at the scene.

(End of this chapter)